{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T14:55:45Z","timestamp":1776524145070,"version":"3.51.2"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0116773","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T18:44:51Z","timestamp":1422384291000},"page":"e0116773","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting \u03b22-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands"],"prefix":"10.1371","volume":"10","author":[{"given":"Christopher F.","family":"Rider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suharsh","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Miller-Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Giembycz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Newton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,1,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ejphar.2013.05.035","article-title":"Anti-inflammatory glucocorticoids: Changing concepts","volume":"724","author":"R Newton","year":"2014","journal-title":"European Journal of Pharmacology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/S0140-6736(09)60326-3","article-title":"Glucocorticoid resistance in inflammatory diseases","volume":"373","author":"PJ Barnes","year":"2009","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.drudis.2012.05.011","article-title":"Glucocorticoid-resistant asthma and novel anti-inflammatory drugs","volume":"17","author":"CR Keenan","year":"2012","journal-title":"Drug Discov Today"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1183\/09031936.04.00004904","article-title":"Asthma severity and medical resource utilisation","volume":"23","author":"L Antonicelli","year":"2004","journal-title":"Eur Respir J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1398-9995.2004.00526.x","article-title":"The global burden of asthma: executive summary of the GINA Dissemination Committee Report","volume":"59","author":"M Masoli","year":"2004","journal-title":"Allergy"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1124\/jpet.111.181016","article-title":"Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists","volume":"338","author":"CF Rider","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1165\/rcmb.2007-0226OC","article-title":"Cytokines Induce an Early Steroid Resistance in Airway Smooth Muscle Cells: Novel Role of Interferon Regulatory Factor-1","volume":"38","author":"O Tliba","year":"2008","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/sj.bjp.0707627","article-title":"A Holy Grail of asthma management: toward understanding how long-acting \u03b22-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids","volume":"153","author":"MA Giembycz","year":"2008","journal-title":"British Journal of Pharmacology"},{"key":"ref9","first-page":"CD002993","article-title":"Cyclosporin as an oral corticosteroid sparing agent in stable asthma","author":"DJ Evans","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pharmthera.2011.12.004","article-title":"Maps and legends: The quest for dissociated ligands of the glucocorticoid receptor. Pharmacology &amp;","volume":"134","author":"AR Clark","year":"2012","journal-title":"Therapeutics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1067\/mai.2002.122465","article-title":"p38 Mitogen-activated protein kinase\u2014induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma","volume":"109","author":"E Irusen","year":"2002","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1096\/fj.05-5045com","article-title":"Inhibition of phosphoinositide 3-kinase \u03b4 attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model","volume":"20","author":"KS Lee","year":"2006","journal-title":"FASEB J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1002\/eji.200425634","article-title":"Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases","volume":"35","author":"MJ Thomas","year":"2005","journal-title":"European Journal of Immunology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1513\/pats.200409-048TA","article-title":"Designing corticosteroid drugs for pulmonary selectivity","volume":"1","author":"K Biggadike","year":"2004","journal-title":"Proc Am Thorac Soc"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"54S","DOI":"10.1378\/chest.130.1_suppl.54S","article-title":"Developing the ideal inhaled corticosteroid","volume":"130","author":"F Cerasoli Jr","year":"2006","journal-title":"Chest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1517\/13543776.18.3.339","article-title":"Dissociated non-steroidal glucocorticoid receptor modulators: an update on new compounds","volume":"18","author":"H Sch\u00e4cke","year":"2008","journal-title":"Expert Opinion on Therapeutic Patents"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1021\/jm100447c","article-title":"Structure Guided Design of 5-Arylindazole Glucocorticoid Receptor Agonists and Antagonists","volume":"53","author":"CM Yates","year":"2010","journal-title":"J Med Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1124\/mol.107.038794","article-title":"Separating Transrepression and Transactivation: A Distressing Divorce for the Glucocorticoid Receptor?","volume":"72","author":"R Newton","year":"2007","journal-title":"Mol Pharmacol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/bph.12232","article-title":"Discovery of GW870086: a potent anti-inflammatory steroid with a unique pharmacological profile","volume":"169","author":"IJ Uings","year":"2013","journal-title":"Br J Pharmacol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1210\/me.11.9.1245","article-title":"Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo","volume":"11","author":"BM Vayssi\u00e8re","year":"1997","journal-title":"Mol Endocrinol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1124\/mol.106.025841","article-title":"Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids","volume":"70","author":"JE Chivers","year":"2006","journal-title":"Mol Pharmacol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"26803","DOI":"10.1074\/jbc.M109.028381","article-title":"Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK","volume":"284","author":"EM King","year":"2009","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1124\/mol.107.040121","article-title":"Long-Acting 2-Adrenoceptor Agonists Synergistically Enhance Glucocorticoid-Dependent Transcription in Human Airway Epithelial and Smooth Muscle Cells","volume":"73","author":"M Kaur","year":"2008","journal-title":"Mol Pharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejphar.2013.02.056","article-title":"Modulation of transcriptional responses by poly(I:C) and human rhinovirus: Effect of long-acting \u03b22-adrenoceptor agonists","volume":"708","author":"CF Rider","year":"2013","journal-title":"European Journal of Pharmacology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1476-5381.2011.01620.x","article-title":"Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide","volume":"165","author":"MM Kelly","year":"2012","journal-title":"Br J Pharmacol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"14389","DOI":"10.1073\/pnas.94.26.14389","article-title":"RGS2\/G0S8 is a selective inhibitor of Gq\u03b1 function","volume":"94","author":"SP Heximer","year":"1997","journal-title":"PNAS"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"19713","DOI":"10.1073\/pnas.1110226108","article-title":"Beta2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of Bronchoprotection that is enhanced by Glucocorticoids","volume":"108","author":"NS Holden","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1124\/jpet.113.204586","article-title":"Induction of regulator of G-protein signaling 2 expression by long-acting \u03b22-adrenoceptor agonists and glucocorticoids in human airway epithelial cells","volume":"348","author":"NS Holden","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.jaci.2012.05.004","article-title":"Regulator of G protein signaling 2 is a key modulator of airway hyperresponsiveness","volume":"130","author":"Y Xie","year":"2012","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"48092","DOI":"10.1074\/jbc.M309421200","article-title":"p57KIP2 Modulates Stress-activated Signaling by Inhibiting c-Jun NH2-terminal Kinase\/Stress-activated Protein Kinase","volume":"278","author":"T-S Chang","year":"2003","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1038\/sj.onc.1210412","article-title":"Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases","volume":"26","author":"DM Owens","year":"2007","journal-title":"Oncogene"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1096\/fj.09-134684","article-title":"Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action","volume":"23","author":"E Ayroldi","year":"2009","journal-title":"FASEB J"},{"key":"ref33","first-page":"1904","article-title":"Transformation of Human Bronchial Epithelial Cells by Infection with SV40 or Adenovirus-12 SV40 Hybrid Virus, or Transfection via Strontium Phosphate Coprecipitation with a Plasmid Containing SV40 Early Region Genes","volume":"48","author":"RR Reddel","year":"1988","journal-title":"Cancer Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1183\/09031936.00128809","article-title":"Cigarette smoke modulates rhinovirus-induced airway epithelial cell chemokine production","volume":"35","author":"MH Hudy","year":"2010","journal-title":"Eur Respir J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1124\/jpet.106.118125","article-title":"Repression of Inflammatory Gene Expression in Human Pulmonary Epithelial Cells by Small-Molecule I\u03baB Kinase Inhibitors","volume":"321","author":"R Newton","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"ref36","article-title":"Roles for the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, in feedback control of inflammatory gene expression and repression by dexamethasone","author":"S Shah","year":"2014","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1021\/jm060199b","article-title":"Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity\u2020","volume":"49","author":"BG Szczepankiewicz","year":"2006","journal-title":"J Med Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1073\/pnas.92.17.7686","article-title":"A synthetic inhibitor of the mitogen-activated protein kinase cascade","volume":"92","author":"DT Dudley","year":"1995","journal-title":"PNAS"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/372739a0","article-title":"A protein kinase involved in the regulation of inflammatory cytokine biosynthesis","volume":"372","author":"JC Lee","year":"1994","journal-title":"Nature"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1164\/rccm.200810-1570OC","article-title":"Inhibition of PI3K{delta} Restores Glucocorticoid Function in Smoking-induced Airway Inflammation in Mice","volume":"179","author":"JA Marwick","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.jaci.2010.02.003","article-title":"A role for phosphoinositol 3\u2013kinase \u03b4 in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease","volume":"125","author":"JA Marwick","year":"2010","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"ref42","first-page":"6847","article-title":"Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110\u03b1 inhibitors. Bioorganic &amp;","volume":"14","author":"M Hayakawa","year":"2006","journal-title":"Medicinal Chemistry"},{"key":"ref43","first-page":"2419","article-title":"Wortmannin, a Potent and Selective Inhibitor of Phosphatidylinositol-3-kinase","volume":"54","author":"G Powis","year":"1994","journal-title":"Cancer Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1016\/S0021-9258(17)37680-9","article-title":"A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)","volume":"269","author":"CJ Vlahos","year":"1994","journal-title":"J Biol Chem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1021\/jm00079a024","article-title":"Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides","volume":"35","author":"PD Davis","year":"1992","journal-title":"J Med Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0960-894X(01)80995-1","article-title":"Non-glycosidic\/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C. Bioorganic &amp;","volume":"3","author":"J Kleinschroth","year":"1993","journal-title":"Medicinal Chemistry Letters"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"15771","DOI":"10.1016\/S0021-9258(18)98476-0","article-title":"The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C","volume":"266","author":"D Toullec","year":"1991","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.4049\/jimmunol.151.7.3460","article-title":"Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids","volume":"151","author":"JC Kam","year":"1993","journal-title":"J Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1111\/j.1476-5381.2012.01885.x","article-title":"Transforming growth factor-beta impairs glucocorticoid activity in the A549 lung adenocarcinoma cell line","volume":"166","author":"S Salem","year":"2012","journal-title":"Br J Pharmacol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s10875-012-9828-3","article-title":"Glucocorticoid Receptor-Beta Up-Regulation and Steroid Resistance Induction by IL-17 and IL-23 Cytokine Stimulation in Peripheral Mononuclear Cells","volume":"33","author":"A Vazquez-Tello","year":"2013","journal-title":"J Clin Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1183\/09031936.00017911","article-title":"Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells","volume":"39","author":"GJ Zijlstra","year":"2012","journal-title":"Eur Respir J"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1124\/mol.105.019679","article-title":"CD38 Expression Is Insensitive to Steroid Action in Cells Treated with Tumor Necrosis Factor-\u03b1 and Interferon-\u03b3 by a Mechanism Involving the Up-Regulation of the Glucocorticoid Receptor \u03b2 Isoform","volume":"69","author":"O Tliba","year":"2006","journal-title":"Mol Pharmacol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1056\/NEJMoa050580","article-title":"Evidence of a role of tumor necrosis factor alpha in refractory asthma","volume":"354","author":"MA Berry","year":"2006","journal-title":"N Engl J Med"},{"key":"ref54","first-page":"345","article-title":"Tumor necrosis factor-alpha: a promising therapeutic target for asthma?","volume":"21","author":"E Heffler","year":"2007","journal-title":"BioDrugs"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1136\/thx.2005.045260","article-title":"Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma","volume":"60","author":"PH Howarth","year":"2005","journal-title":"Thorax"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1136\/thorax.57.9.774","article-title":"Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma","volume":"57","author":"PS Thomas","year":"2002","journal-title":"Thorax"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1164\/ajrccm.152.1.7599866","article-title":"Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects","volume":"152","author":"PS Thomas","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"ref58","first-page":"A4820","article-title":"Cytokines Induce Glucocorticoid Insensitivity Irrespective Of Agonist Efficacy: Effects On Genes And Reversal By Formoterol. C73. Signaling Pathways: Translation into Drug Targets. American Thoracic Society International Conference Abstracts","author":"CF Rider","year":"2013","journal-title":"American Thoracic Society"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"25765","DOI":"10.1074\/jbc.R700053200","article-title":"Role of Dual Specificity Phosphatases in Biological Responses to Glucocorticoids","volume":"283","author":"AR Clark","year":"2008","journal-title":"J Biol Chem"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/path.2287","article-title":"TNF-mediated inflammatory disease","volume":"214","author":"J Bradley","year":"2008","journal-title":"The Journal of Pathology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2174\/092986730609220401153113","article-title":"Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development","volume":"6","author":"PG Goekjian","year":"1999","journal-title":"Curr Med Chem"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bbrc.2006.10.032","article-title":"Mitogen-activated protein kinase kinase 1\/extracellular signal-regulated kinase (MEK-1\/ERK) inhibitors sensitize reduced glucocorticoid response mediated by TNF\u03b1 in human epidermal keratinocytes (HaCaT)","volume":"351","author":"K Onda","year":"2006","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1073\/pnas.95.5.2050","article-title":"Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase","volume":"95","author":"I Rogatsky","year":"1998","journal-title":"PNAS"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1210\/me.2007-0219","article-title":"Glucocorticoid Receptor Phosphorylation Differentially Affects Target Gene Expression","volume":"22","author":"W Chen","year":"2008","journal-title":"Mol Endocrinol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1210\/me.2002-0144","article-title":"Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation","volume":"16","author":"M Itoh","year":"2002","journal-title":"Mol Endocrinol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1165\/rcmb.2011-0364OC","article-title":"Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases","volume":"47","author":"B Bouazza","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.1242\/jcs.01483","article-title":"Linking JNK signaling to NF-\u03baB: a key to survival","volume":"117","author":"S Papa","year":"2004","journal-title":"J Cell Sci"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.pharmthera.2009.11.003","article-title":"Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases","volume":"125","author":"R Newton","year":"2010","journal-title":"Pharmacol Ther"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1074\/jbc.R110.179325","article-title":"Cellular Processing of the Glucocorticoid Receptor Gene and Protein: New Mechanisms for Generating Tissue-specific Actions of Glucocorticoids","volume":"286","author":"RH Oakley","year":"2011","journal-title":"J Biol Chem"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.3109\/02770903.2013.837480","article-title":"Efficacy and safety of once-daily GW870086 a novel selective glucocorticoid in mild-moderate asthmatics: a randomised, two-way crossover, controlled clinical trial","volume":"50","author":"P Bareille","year":"2013","journal-title":"J Asthma"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.4049\/jimmunol.166.3.1975","article-title":"Therapeutic Benefit of a Dissociated Glucocorticoid and the Relevance of In Vitro Separation of Transrepression from Transactivation Activity","volume":"166","author":"MG Belvisi","year":"2001","journal-title":"J Immunol"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0128728","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0116773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T18:22:56Z","timestamp":1690914176000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0116773"}},"subtitle":[],"editor":[{"given":"Zhengqi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,1,27]]},"references-count":71,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0116773","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,27]]}}}