{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:17:33Z","timestamp":1787588253907,"version":"build-2736575974"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0116799","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T19:08:13Z","timestamp":1424200093000},"page":"e0116799","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Azilsartan Reduced TNF-\u03b1 and IL-1\u03b2 Levels, Increased IL-10 Levels and Upregulated VEGF, FGF, KGF, and TGF-\u03b1 in an Oral Mucositis Model"],"prefix":"10.1371","volume":"10","author":[{"given":"Aurigena Antunes","family":"de Ara\u00fajo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Addison Carvalho Xavier","family":"de Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerly Anne","family":"de Castro Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00eanio Costa","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia Moreno","family":"de Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimundo Fernandes","family":"de Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/hed.10318","article-title":"Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: part 1, pathogenesis and prophylaxis of mucositis","volume":"25","author":"C Scully","year":"2003","journal-title":"Head Neck"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/BF03262792","article-title":"Chemotherapy-induced oral mucositis in a patient with acute lymphoblastic leukaemia","volume":"12","author":"AL Rimulo","year":"2011","journal-title":"Eur Arch Paediatr Dent"},{"key":"ref3","first-page":"215","article-title":"Oral Mucositis: understanding the pathology and management","volume":"16","author":"M Georgiou","year":"2012","journal-title":"Hippokratia"},{"key":"ref4","first-page":"576","article-title":"Use of standardized oral hygiene in the prevention and therapy of mucositis in patients treated with radiochemotherapy of head and neck neoplasms","volume":"67","author":"C Hasenau","year":"1988","journal-title":"Laryngol Rhinol Otol (Stuttg)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1473-3099(03)00668-6","article-title":"Antimicrobial therapy to prevent or treat oral mucositis","volume":"3","author":"JP Donnelly","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1007\/s00520-013-1847-y","article-title":"Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients","volume":"21","author":"O Nicolatou-Galitis","year":"2013","journal-title":"Supportive Care in Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00520-006-0052-7","article-title":"Growth factors and cytokines in the prevention and treatment of oral and gastrointestinal mucositis","volume":"14","author":"I von Bultzingslowen","year":"2006","journal-title":"Supportive Care in Cancer"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"de Castro JF, Abreu EG, Correia AV, Brasil CD, da Cruz Perez DE, et al. (2013) Low-Level Laser in Prevention and Treatment of Oral Mucositis in Pediatric Patients with Acute Lymphoblastic Leukemia. Photomed Laser Surg.","DOI":"10.1089\/pho.2012.3327"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1590\/S1806-83242013005000019","article-title":"Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters","volume":"27","author":"TC Lopez","year":"2013","journal-title":"Braz Oral Res"},{"key":"ref10","first-page":"21","article-title":"Topical curcumin for the prevention of oral mucositis in pediatric patients: case series","volume":"19","author":"S Elad","year":"2013","journal-title":"Altern Ther Health Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.oooo.2012.08.450","article-title":"Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis","volume":"115","author":"N Tanideh","year":"2013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ijom.2011.10.011","article-title":"Cancer treatment-induced oral mucositis: a critical review","volume":"41","author":"A Rodriguez-Caballero","year":"2012","journal-title":"Int J Oral Maxillofac Surg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1146\/annurev.immunol.20.100301.064816","article-title":"The immunology of mucosal models of inflammation","volume":"20","author":"W Strober","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1038\/sj.jid.5700350","article-title":"Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration","volume":"126","author":"Y Li","year":"2006","journal-title":"J Invest Dermatol"},{"key":"ref15","first-page":"293","article-title":"Stimulation of endothelial cell migration by vascular permeability factor vascular endothelial growth factor through cooperative mechanisms involving the alpha(v)beta(3) integrin, osteopontin, and thrombin","volume":"149","author":"DR Senger","year":"1996","journal-title":"American Journal of Pathology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1677\/erc.0.0070165","article-title":"Fibroblast growth factors, their receptors and signaling","volume":"7","author":"CJ Powers","year":"2000","journal-title":"Endocrine-Related Cancer"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/hr.2009.95","article-title":"Telmisartan inhibits cytokine-induced nuclear factor-kappaB activation independently of the peroxisome proliferator-activated receptor-gamma","volume":"32","author":"A Nakano","year":"2009","journal-title":"Hypertens Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e96750","DOI":"10.1371\/journal.pone.0096750","article-title":"Azilsartan Increases Levels of IL-10, Down-Regulates MMP-2, MMP-9, RANKL\/RANK, Cathepsin K and Up-Regulates OPG in an Experimental Periodontitis Model","volume":"9","author":"AA Araujo","year":"2014","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00210-013-0886-8","article-title":"Olmesartan decreases IL-1beta and TNF-alpha levels; downregulates MMP-2, MMP-9, COX-2, and RANKL; and upregulates OPG in experimental periodontitis","volume":"386","author":"AA Araujo","year":"2013","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/jcpe.12160","article-title":"Effect of telmisartan on levels of IL-1, TNF-alpha, down-regulated COX-2, MMP-2, MMP-9 and RANKL\/RANK in an experimental periodontitis model","volume":"40","author":"AA Araujo","year":"2013","journal-title":"J Clin Periodontol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00280-010-1409-7","article-title":"Effect of atorvastatin on 5-fluorouracil-induced experimental oral mucositis","volume":"67","author":"CA Medeiros","year":"2011","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1590\/S0100-879X2003001000015","article-title":"Decreased gastric tone and delayed gastric emptying precede neutrophil infiltration and mucosal lesion formation in indomethacin-induced gastric damage in rats","volume":"36","author":"MH Souza","year":"2003","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0076-6879(90)86134-H","article-title":"Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal","volume":"186","author":"H Esterbauer","year":"1990","journal-title":"Methods Enzymol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1476-5381.1995.tb15035.x","article-title":"Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia","volume":"115","author":"B Safieh-Garabedian","year":"1995","journal-title":"Br J Pharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0022-1759(83)80022-2","article-title":"Utilization of the biotin\/avidin system to amplify the sensitivity of the enzyme-linked immunosorbent assay (ELISA)","volume":"56","author":"C Kendall","year":"1983","journal-title":"J Immunol Methods"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF01966691","article-title":"Blockade by antimacrophage serum of the migration of PMN neutrophils into the inflamed peritoneal cavity","volume":"17","author":"GE de Souza","year":"1985","journal-title":"Agents Actions"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/HYPERTENSIONAHA.110.163402","article-title":"Effects of the angiotensin receptor blocker azilsartan medoxomil versus olmesartan and valsartan on ambulatory and clinic blood pressure in patients with stages 1 and 2 hypertension","volume":"57","author":"WB White","year":"2011","journal-title":"Hypertension"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1042\/CS20120078","article-title":"Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders","volume":"123","author":"JM Saavedra","year":"2012","journal-title":"Clin Sci (Lond)"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.taap.2013.04.026","article-title":"Anti-inflammatory and anti-oxidant activities of olmesartan medoxomil ameliorate experimental colitis in rats","volume":"271","author":"MM Nagib","year":"2013","journal-title":"Toxicology and Applied Pharmacology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ajpath.2010.08.003","article-title":"Wound Macrophages as Key Regulators of Repair Origin, Phenotype, and Function","volume":"178","author":"SK Brancato","year":"2011","journal-title":"American Journal of Pathology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jlb.65.1.35","article-title":"Macrophage phagocytosis of wound neutrophils","volume":"65","author":"AJ Meszaros","year":"1999","journal-title":"J Leukoc Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"S Barrientos","year":"2008","journal-title":"Wound Repair and Regeneration"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1002\/cncr.20162","article-title":"Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients","volume":"100","author":"ST Sonis","year":"2004","journal-title":"Cancer"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cytogfr.2010.09.002","article-title":"Biology of interleukin-10","volume":"21","author":"R Sabat","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1126\/science.3041594","article-title":"Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping","volume":"241","author":"DA Rappolee","year":"1988","journal-title":"Science"},{"key":"ref36","first-page":"2249","article-title":"Wound re-epithelialization: modulating keratinocyte migration in wound healing","volume":"12","author":"Sivamani K Raja","year":"2007","journal-title":"Frontiers in Bioscience"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1074\/jbc.M606878200","article-title":"Keratinocyte growth factor\/fibroblast growth factor-7-regulated cell migration and invasion through activation of NF-kappaB transcription factors","volume":"282","author":"J Niu","year":"2007","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1097\/HJH.0b013e32834c46fd","article-title":"Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker","volume":"29","author":"T Kajiya","year":"2011","journal-title":"J Hypertens"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1124\/jpet.110.176636","article-title":"In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies","volume":"336","author":"M Ojima","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.atherosclerosis.2014.06.011","article-title":"Angiotensin receptor 1 blockade reduces secretion of inflammation associated cytokines from cultured human carotid atheroma and vascular cells in association with reduced extracellular signal regulated kinase expression and activation","volume":"236","author":"P Clancy","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/hr.2013.3","article-title":"Irbesartan, an angiotensin receptor blocker, exhibits metabolic, anti-inflammatory and antioxidative effects in patients with high-risk hypertension","volume":"36","author":"I Taguchi","year":"2013","journal-title":"Hypertens Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2169\/internalmedicine.52.9066","article-title":"Effects of irbesartan on inflammatory cytokine concentrations in patients with chronic glomerulonephritis","volume":"52","author":"S Tsuruoka","year":"2013","journal-title":"Intern Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0116799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:12:35Z","timestamp":1589008355000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0116799"}},"subtitle":[],"editor":[{"given":"Chunxue","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,17]]},"references-count":42,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0116799","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,17]]}}}