{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:46:09Z","timestamp":1774363569823,"version":"3.50.1"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T00:00:00Z","timestamp":1422576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0116882","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T18:47:14Z","timestamp":1422643634000},"page":"e0116882","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Identification and Validation of a Linear Protective Neutralizing Epitope in the \u03b2-Pore Domain of Alpha Toxin"],"prefix":"10.1371","volume":"10","author":[{"given":"Jon","family":"Oscherwitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemp B.","family":"Cease","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"17880","DOI":"10.1073\/pnas.1004728107","article-title":"Elicitation of structure-specific antibodies by epitope scaffolds","volume":"107","author":"G Ofek","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1073\/pnas.1222845110","article-title":"Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen","volume":"110","author":"E Malito","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","article-title":"Proof of principle for epitope-focused vaccine design","author":"BE Correia","year":"2014","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2165\/00063030-200721030-00002","article-title":"Epitope mapping: the first step in developing epitope-based vaccines","volume":"21","author":"JM Gershoni","year":"2007","journal-title":"BioDrugs"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nrmicro2893","article-title":"Structural vaccinology starts to deliver","volume":"10","author":"PR Dormitzer","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"ref6","article-title":"Vaccination Against Staphylococcus aureus Pneumonia","author":"AR Spaulding","year":"2014","journal-title":"J Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e81212","DOI":"10.1371\/journal.pone.0081212","article-title":"Evaluation of the protective immunity of a novel subunit fusion vaccine in a murine model of systemic MRSA infection","volume":"8","author":"QF Zuo","year":"2013","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1128\/IAI.01050-13","article-title":"Protein antigens increase the protective efficacy of a capsule-based vaccine against Staphylococcus aureus in a rat model of osteomyelitis","volume":"82","author":"SM Lattar","year":"2013","journal-title":"Infect Immun"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1016\/j.vaccine.2008.05.023","article-title":"Domain specificity of the human antibody response to Bacillus anthracis protective antigen","volume":"26","author":"DC Reason","year":"2008","journal-title":"Vaccine"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1128\/IAI.01254-08","article-title":"Frequency and domain specificity of toxin-neutralizing paratopes in the human antibody response to anthrax vaccine adsorbed","volume":"77","author":"D Reason","year":"2009","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/cmdc.201200487","article-title":"Modern subunit vaccines: development, components, and research opportunities","volume":"8","author":"PM Moyle","year":"2013","journal-title":"ChemMedChem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1128\/CVI.00290-09","article-title":"Vaccines: the fourth century","volume":"16","author":"SA Plotkin","year":"2009","journal-title":"Clin Vaccine Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/jama.279.8.593","article-title":"Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk","volume":"279","author":"BC Herold","year":"1998","journal-title":"JAMA"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1001\/jama.298.15.1763","article-title":"Invasive methicillin-resistant Staphylococcus aureus infections in the United States","volume":"298","author":"RM Klevens","year":"2007","journal-title":"JAMA"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1086\/427701","article-title":"Methicillin-resistant Staphylococcus aureus: an evolutionary, epidemiologic, and therapeutic odyssey","volume":"40","author":"S Deresinski","year":"2005","journal-title":"Clin Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1128\/CMR.00081-09","article-title":"Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic","volume":"23","author":"MZ David","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0140-6736(09)61999-1","article-title":"Community-associated meticillin-resistant Staphylococcus aureus","volume":"375","author":"FR DeLeo","year":"2010","journal-title":"Lancet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev.micro.112408.134309","article-title":"Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus","volume":"64","author":"M Otto","year":"2010","journal-title":"Annu Rev Microbiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/nm1656","article-title":"Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA","volume":"13","author":"R Wang","year":"2007","journal-title":"Nat Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/cid\/cir828","article-title":"Progress toward a Staphylococcus aureus vaccine","volume":"54","author":"RS Daum","year":"2012","journal-title":"Clin Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1084\/jem.20080167","article-title":"An antidote for Staphylococcus aureus pneumonia?","volume":"205","author":"FR DeLeo","year":"2008","journal-title":"J Exp Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e75103","DOI":"10.1371\/journal.pone.0075103","article-title":"Staphylococcus aureus Alpha Toxin Suppresses Effective Innate and Adaptive Immune Responses in a Murine Dermonecrosis Model","volume":"8","author":"C Tkaczyk","year":"2013","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3390\/toxins5061140","article-title":"Staphylococcus aureus \u03b1-Toxin: Nearly a Century of Intrigue","volume":"5","author":"B Berube","year":"2013","journal-title":"Toxins"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1172\/JCI40891","article-title":"IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice","volume":"120","author":"JS Cho","year":"2010","journal-title":"J Clin Invest"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1086\/657419","article-title":"Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains","volume":"202","author":"M Li","year":"2010","journal-title":"J Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1073\/pnas.0900743106","article-title":"Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus","volume":"106","author":"M Li","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1086\/656043","article-title":"Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model","volume":"202","author":"AD Kennedy","year":"2010","journal-title":"J Infect Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1128\/IAI.01313-06","article-title":"Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia","volume":"75","author":"J Bubeck Wardenburg","year":"2007","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/infdis\/jis192","article-title":"ADAM10 mediates vascular injury induced by Staphylococcus aureus alpha-hemolysin","volume":"206","author":"ME Powers","year":"2012","journal-title":"J Infect Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1128\/IAI.62.5.1843-1847.1994","article-title":"Site-directed mutagenesis of the alpha-toxin gene of Staphylococcus aureus: role of histidines in toxin activity in vitro and in a murine model","volume":"62","author":"BE Menzies","year":"1994","journal-title":"Infect Immun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e63040","DOI":"10.1371\/journal.pone.0063040","article-title":"Evaluation of genetically inactivated alpha toxin for protection in multiple mouse models of Staphylococcus aureus infection","volume":"8","author":"RA Brady","year":"2013","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1128\/IAI.01304-12","article-title":"Epicutaneous model of community-acquired Staphylococcus aureus skin infections","volume":"81","author":"R Prabhakara","year":"2013","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1128\/IAI.64.5.1839-1841.1996","article-title":"Passive immunization with antiserum to a nontoxic alpha-toxin mutant from Staphylococcus aureus is protective in a murine model","volume":"64","author":"BE Menzies","year":"1996","journal-title":"Infect Immun"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1128\/IAI.00442-12","article-title":"Abscess formation and alpha-hemolysin induced toxicity in a mouse model of Staphylococcus aureus peritoneal infection","volume":"80","author":"S Rauch","year":"2012","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.20072208","article-title":"Vaccine protection against Staphylococcus aureus pneumonia","volume":"205","author":"J Bubeck Wardenburg","year":"2008","journal-title":"J Exp Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1128\/IAI.00115-09","article-title":"Anti-alpha-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia","volume":"77","author":"BE Ragle","year":"2009","journal-title":"Infect Immun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e38567","DOI":"10.1371\/journal.pone.0038567","article-title":"Novel structurally designed vaccine for S. aureus alpha-hemolysin: protection against bacteremia and pneumonia","volume":"7","author":"RP Adhikari","year":"2012","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1128\/MMBR.55.4.733-751.1991","article-title":"Alpha-toxin of Staphylococcus aureus","volume":"55","author":"S Bhakdi","year":"1991","journal-title":"Microbiol Rev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"13473","DOI":"10.1073\/pnas.1001815107","article-title":"Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury","volume":"107","author":"GA Wilke","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1126\/science.274.5294.1859","article-title":"Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore","volume":"274","author":"L Song","year":"1996","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1016\/j.bmc.2007.05.058","article-title":"Inhibition of S. aureus alpha-hemolysin and B. anthracis lethal toxin by beta-cyclodextrin derivatives","volume":"15","author":"VA Karginov","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1128\/CVI.00612-12","article-title":"Recombinant vaccine displaying the loop-neutralizing determinant from protective antigen completely protects rabbits from experimental inhalation anthrax","volume":"20","author":"J Oscherwitz","year":"2013","journal-title":"Clin Vaccine Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1128\/IAI.00899-09","article-title":"A heterologous helper T-cell epitope enhances the immunogenicity of a multiple-antigenic-peptide vaccine targeting the cryptic loop-neutralizing determinant of Bacillus anthracis protective antigen","volume":"77","author":"J Oscherwitz","year":"2009","journal-title":"Infect Immun"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.4049\/jimmunol.1001749","article-title":"A synthetic peptide vaccine directed against the 2\u03b22\u20132\u03b23 loop of domain 2 of protective antigen protects rabbits from inhalation anthrax","volume":"185","author":"J Oscherwitz","year":"2010","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1128\/IAI.00358-09","article-title":"Synthetic peptide vaccine targeting a cryptic neutralizing epitope in domain 2 of Bacillus anthracis protective antigen","volume":"77","author":"J Oscherwitz","year":"2009","journal-title":"Infect Immun"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1073\/pnas.85.15.5409","article-title":"Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system","volume":"85","author":"JP Tam","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.1128\/IAI.01151-06","article-title":"A linear peptide containing minimal T- and B-cell epitopes of Plasmodium falciparum circumsporozoite protein elicits protection against transgenic sporozoite challenge","volume":"74","author":"JM Calvo-Calle","year":"2006","journal-title":"Infect Immun"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/intimm\/3.10.997","article-title":"Cytotoxic CD4+ T cells from a sporozoite-immunized volunteer recognize the Plasmodium falciparum CS protein","volume":"3","author":"A Moreno","year":"1991","journal-title":"Int Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.4049\/jimmunol.159.3.1362","article-title":"Binding of malaria T cell epitopes to DR and DQ molecules in vitro correlates with immunogenicity in vivo: identification of a universal T cell epitope in the Plasmodium falciparum circumsporozoite protein","volume":"159","author":"JM Calvo-Calle","year":"1997","journal-title":"J Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1002\/eji.1830191209","article-title":"Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells","volume":"19","author":"P Panina-Bordignon","year":"1989","journal-title":"Eur J Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1086\/592758","article-title":"Alpha-toxin facilitates the generation of CXC chemokine gradients and stimulates neutrophil homing in Staphylococcus aureus pneumonia","volume":"198","author":"AH Bartlett","year":"2008","journal-title":"J Infect Dis"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0882-4010(86)90015-X","article-title":"Inactivation of the alpha-haemolysin gene of Staphylococcus aureus 8325\u20134 by site-directed mutagenesis and studies on the expression of its haemolysins","volume":"1","author":"M O\u2019Reilly","year":"1986","journal-title":"Microb Pathog"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e59232","DOI":"10.1371\/journal.pone.0059232","article-title":"Stably luminescent Staphylococcus aureus clinical strains for use in bioluminescent imaging","volume":"8","author":"RD Plaut","year":"2013","journal-title":"PLoS One"},{"key":"ref54","article-title":"Role of Antibodies in Protection Elicited by Active Vaccination with Genetically Inactivated Alpha Hemolysin in a Mouse Model of Staphyloccocus aureus Skin and Soft Tissue Infections","author":"CP Mocca","year":"2014","journal-title":"Clin Vaccine Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1039\/a809656b","article-title":"A water-soluble tetrazolium salt useful for colorimetric cell viability assay","volume":"36","author":"H Tominaga","year":"1999","journal-title":"Anal Commun"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.biologicals.2003.09.003","article-title":"Validation of the anthrax lethal toxin neutralization assay","volume":"32","author":"D Hering","year":"2004","journal-title":"Biologicals"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1128\/CVI.05589-11","article-title":"Identification of anti-alpha toxin monoclonal antibodies that reduce the severity of Staphylococcus aureus dermonecrosis and exhibit a correlation between affinity and potency","volume":"19","author":"C Tkaczyk","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e36532","DOI":"10.1371\/journal.pone.0036532","article-title":"Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection","volume":"7","author":"TK Nygaard","year":"2012","journal-title":"PLoS One"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1046\/j.1365-2249.2003.02151.x","article-title":"Role of gamma\/delta T cell receptor-expressing lymphocytes in cutaneous infection caused by Staphylococcus aureus","volume":"132","author":"L Molne","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.4049\/jimmunol.0900729","article-title":"A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome","volume":"183","author":"R Munoz-Planillo","year":"2009","journal-title":"J Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1128\/IAI.67.3.1045-1049.1999","article-title":"Alpha-toxin and gamma-toxin jointly promote Staphylococcus aureus virulence in murine septic arthritis","volume":"67","author":"IM Nilsson","year":"1999","journal-title":"Infect Immun"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2005.11.011","article-title":"MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus","volume":"24","author":"LS Miller","year":"2006","journal-title":"Immunity"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1128\/IAI.46.2.318-323.1984","article-title":"Correlation between toxin binding and hemolytic activity in membrane damage by staphylococcal alpha-toxin","volume":"46","author":"S Bhakdi","year":"1984","journal-title":"Infect Immun"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"23065","DOI":"10.1074\/jbc.270.39.23065","article-title":"Key residues for membrane binding, oligomerization, and pore forming activity of staphylococcal alpha-hemolysin identified by cysteine scanning mutagenesis and targeted chemical modification","volume":"270","author":"B Walker","year":"1995","journal-title":"J Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.molimm.2014.03.012","article-title":"In vivo mapping of a protective linear neutralizing epitope at the N-terminus of alpha hemolysin from Staphylococcus aureus","volume":"60","author":"J Oscherwitz","year":"2014","journal-title":"Mol Immunol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00018-007-7434-y","article-title":"Bacterial pore-forming toxins: the (w)hole story?","volume":"65","author":"MR Gonzalez","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.vaccine.2003.07.004","article-title":"Defining a serological correlate of protection in rabbits for a recombinant anthrax vaccine","volume":"22","author":"SF Little","year":"2004","journal-title":"Vaccine"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/nm.2451","article-title":"A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice","volume":"17","author":"I Inoshima","year":"2011","journal-title":"Nat Med"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/jid.2011.462","article-title":"Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection","volume":"132","author":"N Inoshima","year":"2012","journal-title":"J Invest Dermatol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.jmb.2013.02.008","article-title":"Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus alpha-hemolysin","volume":"425","author":"D Foletti","year":"2013","journal-title":"J Mol Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1128\/CDLI.10.5.903-909.2003","article-title":"Monoclonal antibodies reactive with immunorecessive epitopes of glucuronoxylomannan, the major capsular polysaccharide of Cryptococcus neoformans","volume":"10","author":"S Brandt","year":"2003","journal-title":"Clin Diagn Lab Immunol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1128\/IAI.59.4.1402-1408.1991","article-title":"Identification of linear B-cell determinants of pertussis toxin associated with the receptor recognition site of the S3 subunit","volume":"59","author":"MA Schmidt","year":"1991","journal-title":"Infect Immun"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0116882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T09:05:14Z","timestamp":1690967114000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0116882"}},"subtitle":[],"editor":[{"given":"Michael","family":"Otto","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,1,30]]},"references-count":72,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0116882","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,30]]}}}