{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:19:49Z","timestamp":1791155989724,"version":"4.1.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0117005","type":"journal-article","created":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T14:20:28Z","timestamp":1424701228000},"page":"e0117005","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Influenza A Virus Infection of Intestinal Epithelial Cells Enhances the Adhesion Ability of Crohn\u2019s Disease Associated Escherichia coli Strains"],"prefix":"10.1371","volume":"10","author":[{"given":"Marta","family":"Aleandri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pia","family":"Conte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Simonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Panella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Celestino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Checconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Marazzato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catia","family":"Longhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Goldoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Barnich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Teresa","family":"Palamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Schippa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Nencioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,2,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","article-title":"Unravelling the pathogenesis of inflammatory bowel disease","volume":"448","author":"RJ Xavier","year":"2007","journal-title":"Nature"},{"key":"ref2","first-page":"163","article-title":"Lessons from genetic models of inflammatory bowel disease","volume":"60","author":"DK Podolsky","year":"1997","journal-title":"Acta Gastroenterol Belg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1136\/gut.2009.199679","article-title":"New IBD genetics: common pathways with other diseases","volume":"60","author":"CW Lees","year":"2011","journal-title":"Gut"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1053\/j.gastro.2007.02.056","article-title":"Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function","volume":"132","author":"E Cario","year":"2007","journal-title":"Gastroenterology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/gut.53.1.1","article-title":"Dysbiosis in inflammatory bowel disease","volume":"53","author":"CP Tamboli","year":"2004","journal-title":"Gut"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1172\/JCI46333","article-title":"Adherent-invasive <italic>E. coli<\/italic> in Crohn disease: bacterial \u201cagent provocateur\u201d","volume":"121","author":"W Strober","year":"2011","journal-title":"The Journal of Clinical Investigation"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/gut.2003.025403","article-title":"Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease","volume":"53","author":"SJ Ott","year":"2004","journal-title":"Gut"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"13780","DOI":"10.1073\/pnas.0706625104","article-title":"Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases","volume":"104","author":"DN Frank","year":"2007","journal-title":"PNAS"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1136\/gut.2005.078824","article-title":"Gut-associated bacterial microbiota in pediatric patients with inflammatory bowel disease","volume":"55","author":"MP Conte","year":"2006","journal-title":"Gut"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0016-5085(98)70019-8","article-title":"Presence of Adherent <italic>Escherichia coli<\/italic> strains in ileal mucosa of patients with Crohn\u2019s disease","volume":"115","author":"A Darfeuille-Michaud","year":"1998","journal-title":"Gastroenterology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/gut.48.3.320","article-title":"Genetically related <italic>Escherichia coli<\/italic> strains associated with Crohn&apos;s disease","volume":"48","author":"E Masseret","year":"2001","journal-title":"Gut"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1053\/j.gastro.2004.04.061","article-title":"High prevalence of adherent-invasive <italic>Escherichia coli<\/italic> associated with ileal mucosa in Crohn\u2019s disease","volume":"127","author":"A Darfeuille-Michaud","year":"2004","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/labinvest.3700661","article-title":"Invasive <italic>Escherichia coli<\/italic> are a feature of Crohn\u2019s disease","volume":"87","author":"M Sasaki","year":"2007","journal-title":"Laboratory Investigation"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1128\/IAI.69.9.5529-5537.2001","article-title":"Adherent invasive <italic>Escherichia coli<\/italic> strains from patients with Crohn\u2019s disease survive and replicate within macrophages without inducing host cell death","volume":"69","author":"AL Glasser","year":"2001","journal-title":"Infect Immun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1462-5822.2005.00639.x","article-title":"The Crohn\u2019s disease-associated adherent-invasive <italic>Escherichia coli<\/italic> strain LF82 replicates in mature phagolysosomes within J774 macrophages","volume":"8","author":"MA Bringer","year":"2006","journal-title":"Cell Microbiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1172\/JCI44632","article-title":"Crohn disease-associated adherent-invasive <italic>E. coli<\/italic> bacteria target mouse and human Peyer\u2019s patches via long polar fimbriae","volume":"121","author":"B Chassaing","year":"2011","journal-title":"J Clin Invest"},{"key":"ref17","first-page":"80","article-title":"Enhanced <italic>Escherichia coli<\/italic> adherence and invasion in Crohn disease and colon cancer","volume":"127","author":"HM Martin","year":"2004","journal-title":"Gastroenterology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/ibd.20818","article-title":"Dominant genotypes in mucosa-associated <italic>Escherichia coli<\/italic> strains from pediatric patients with inflammatory bowel disease","volume":"15","author":"S Schippa","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1023\/A:1022240107040","article-title":"Altered glycosylation in inflammatory bowel disease: a possible role in cancer development","volume":"18","author":"BJ Campbell","year":"2001","journal-title":"Glycoconjugate J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1136\/gut.2005.086413","article-title":"Altered colonic glycoprotein expression in unaffected monozygotic twins of inflammatory bowel disease patients","volume":"55","author":"K Bodger","year":"2006","journal-title":"Gut"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1172\/JCI30504","article-title":"CEACAM6 acts as a receptor for adherent-invasive <italic>E. coli<\/italic>, supporting ileal mucosa colonization in Crohn disease","volume":"117","author":"N Barnich","year":"2007","journal-title":"The Journal Clinical Investigation"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/ibd.20176","article-title":"Adherent-Invasive <italic>Escherichia coli<\/italic> in Inflammatory Bowel Disease","volume":"13","author":"N Rolhion","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"8922","DOI":"10.1073\/pnas.95.15.8922","article-title":"Pathogenic adaptation of <italic>Escherichia coli<\/italic> by natural variation of the FimH adhesin","volume":"95","author":"EV Sokurenko","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10719-007-9034-3","article-title":"The oncofetal Thomsen-Friedenreich carbohydrate antigen in cancer progression","volume":"24","author":"LG Yu","year":"2007","journal-title":"Glycoconj J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"15109","DOI":"10.1074\/jbc.M111.328070","article-title":"Influenza A virus neuraminidase protein enhances cell survival through interaction with Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) proteins","volume":"287","author":"P Gaur","year":"2012","journal-title":"J Biological Chemistry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1086\/651457","article-title":"Avian influenza A (H5N1) Viruses can directly infect and replicate in human gut tissue","volume":"201","author":"Y Shu","year":"2010","journal-title":"J Infectious Disease"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0042-6822(03)00264-2","article-title":"Human influenza A viruses are proteolytically activated and do not induce apoptosis in Caco-2 cells","volume":"313","author":"O Zhirnov","year":"2003","journal-title":"Virology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jcv.2009.09.013","article-title":"Differential susceptibility of different cell lines to swine-origin influenza A H1N1, seasonal human influenza A H1N1, and avian influenza A H5N1 viruses","volume":"46","author":"IW Li","year":"2009","journal-title":"Journal of Clinical Virology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/000992287601500408","article-title":"Influenza virus A2 infections presenting with febrile convulsions and gastrointestinal symptoms in young children","volume":"15","author":"DA Price","year":"1976","journal-title":"Clin Pediatr (Phila)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1056\/NEJMoa044307","article-title":"Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma","volume":"352","author":"MD De Jong","year":"2005","journal-title":"N Engl J Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jcv.2009.06.011","article-title":"Fecal detection of influenza A virus in patients with concurrent respiratory and gastrointestinal symptoms","volume":"45","author":"MCW Chan","year":"2009","journal-title":"J Clin Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1743-422X-9-116","article-title":"Simultaneous investigation of influenza andenteric viruses in the stools of adult patients consulting in general practice for acute diarrhea","volume":"9","author":"C Arena","year":"2012","journal-title":"Virology Journal"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jmv.21664","article-title":"Viral load in patients infected with pandemic H1N1 2009 influenza A virus","volume":"82","author":"KK To","year":"2010","journal-title":"J Med Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/01.inf.0000245097.95543.11","article-title":"Detection of human influenza virus in the stool children","volume":"25","author":"SH Wootton","year":"2006","journal-title":"The Pediatric Inf Dis J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/S0140-6736(13)61125-3","article-title":"Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance","volume":"381","author":"Y Hu","year":"2013","journal-title":"Lancet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jmii.2011.04.003","article-title":"A case of hemorrhagic colitis after influenza A infection","volume":"44","author":"S Okayama","year":"2011","journal-title":"J Microbiol Immunol Infect"},{"key":"ref37","unstructured":"Mahay BW (1991). Virology: a practical approach."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1365-2958.2001.02315.x","article-title":"Type 1 pili-mediated adherence of <italic>Escherichia coli<\/italic> strain LF82 isolated from Crohn\u2019s disease is involved in bacterial invasion of intestinal epithelial cells","volume":"39","author":"J Boudeau","year":"2001","journal-title":"Mol Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1128\/IAI.06181-11","article-title":"Microevolution in fimH gene of mucosa-associated <italic>Escherichia coli<\/italic> strains isolated from pediatric patients with inflammatory bowel disease","volume":"80","author":"V Iebba","year":"2012","journal-title":"Infect Immun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1139\/w2012-007","article-title":"A potential role of <italic>Escherichia coli<\/italic> pathobionts in the pathogenesis of pediatric inflammatory bowel disease","volume":"58","author":"S Schippa","year":"2012","journal-title":"Can J Microbiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4161\/gmic.2.2.15725","article-title":"The endoplasmic reticulum stress response chaperone: Gp96, a host receptor for Crohn disease-associated adherent-invasive <italic>Escherichia coli<\/italic>","volume":"2","author":"N Rolhion","year":"2011","journal-title":"Gut Microbes"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1096\/fj.02-0508fje","article-title":"Influenza A virus replication is dependent on an antioxidant pathway that involves GSH and Bcl-2","volume":"17","author":"L Nencioni","year":"2003","journal-title":"FASEB J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"16004","DOI":"10.1074\/jbc.M900146200","article-title":"Bcl-2 expression and p38MAPK activity in cells infected with influenza A virus: impact on virally induced apoptosis and viral replication","volume":"284","author":"L Nencioni","year":"2009","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1089\/ars.2010.3512","article-title":"Redox regulation of the influenza hemagglutinin maturation process: a new cell-mediated strategy for anti-influenza therapy","volume":"15","author":"R Sgarbanti","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.3390\/ijms14024148","article-title":"The Environmental Pollutant Cadmium Promotes Influenza Virus Replication in MDCK Cells by Altering Their Redox State","volume":"14","author":"P Checconi","year":"2013","journal-title":"Int J Mol Sci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/S0140-6736(13)61125-3","article-title":"Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance","volume":"381","author":"Y Hu","year":"2013","journal-title":"Lancet"},{"key":"ref47","unstructured":"Knipe D M, Howley P (2013) Fields Virology, Sixth Edition."},{"key":"ref48","doi-asserted-by":"crossref","first-page":"13910","DOI":"10.1073\/pnas.1303275110","article-title":"Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I","volume":"110","author":"IK Pang","year":"2013","journal-title":"Proc Natl Acad Sci"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Sakuma S, Yu JYH, Quang T, Hiwatari KI, Kumagai H, et al. (2014) <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1002\/ijc.29093\" xlink:type=\"simple\">10.1002\/ijc.29093<\/ext-link><\/comment>","DOI":"10.1002\/ijc.29093"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0117005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T01:05:41Z","timestamp":1566349541000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0117005"}},"subtitle":[],"editor":[{"given":"Mathias","family":"Chamaillard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,23]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0117005","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,23]]}}}