{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:23:17Z","timestamp":1791912197687,"version":"4.3.4"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0117160","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T13:42:17Z","timestamp":1423748537000},"page":"e0117160","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":81,"title":["Abacavir-Reactive Memory T Cells Are Present in Drug Na\u00efve Individuals"],"prefix":"10.1371","volume":"10","author":[{"given":"Andrew","family":"Lucas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Strhyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh M.","family":"Keane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"McKinnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Pavlos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Moran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Meyer-Pannwitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Gaudieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd","family":"D\u2019Orsogna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyros","family":"Kalams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Ostrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Buus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Mallal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"ref1","article-title":"Avidity determines T-cell reactivity in abacavir hypersensitivity","author":"J Adam","year":"2012","journal-title":"Eur J Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.immuni.2008.04.020","article-title":"Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity","volume":"28","author":"D Chessman","year":"2008","journal-title":"Immunity"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1056\/NEJMoa0706135","article-title":"HLA-B*5701 screening for hypersensitivity to abacavir","volume":"358","author":"S Mallal","year":"2008","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1097\/QAD.0b013e3280119579","article-title":"Immune responses to abacavir in antigen-presenting cells from hypersensitive patients","volume":"21","author":"AM Martin","year":"2007","journal-title":"AIDS"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1073\/pnas.0307067101","article-title":"Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant","volume":"101","author":"AM Martin","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0140-6736(02)08158-8","article-title":"Genetic variations in HLA-B region and hypersensitivity reactions to abacavir","volume":"359","author":"S Hetherington","year":"2002","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0140-6736(02)07873-X","article-title":"Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir","volume":"359","author":"S Mallal","year":"2002","journal-title":"The Lancet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1086\/504874","article-title":"Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study","volume":"43","author":"A Rauch","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1097\/00002030-200211080-00017","article-title":"Utility of patch testing in patients with hypersensitivity syndromes associated with abacavir","volume":"16","author":"EJ Phillips","year":"2002","journal-title":"AIDS"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1086\/529382","article-title":"High sensitivity of human leukocyte antigen-b*5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and blackatients","volume":"46","author":"M Saag","year":"2008","journal-title":"Clin Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1097\/QAD.0b013e3282f7cb60","article-title":"A review of drug patch testing and implications for HIV clinicians","volume":"22","author":"NH Shear","year":"2008","journal-title":"AIDS"},{"key":"ref12","article-title":"Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire","author":"DA Ostrov","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","article-title":"Immune self-reactivity triggered by drug-modified HLA-peptide repertoire","author":"P Illing","year":"2012","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1182\/blood-2009-07-234906","article-title":"Allo-HLA reactivity of virus-specific memory T cells is common","volume":"115","author":"AL Amir","year":"2010","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.4049\/jimmunol.169.8.4667","article-title":"Allograft rejection by primed\/memory CD8+ T cells is CD154 blockade resistant: therapeutic implications for sensitized transplant recipients","volume":"169","author":"Y Zhai","year":"2002","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.immuni.2009.09.007","article-title":"&quot;MIATA&quot;-minimal information about T cell assays","volume":"31","author":"S Janetzki","year":"2009","journal-title":"Immunity"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00262-010-0940-z","article-title":"Minimal information about T cell assays: the process of reaching the community of T cell immunologists in cancer and beyond","volume":"60","author":"CM Britten","year":"2011","journal-title":"Cancer Immunol Immunother"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/icb.2011.34","article-title":"High-avidity, high-IFNgamma-producing CD8 T-cell responses following immune selection during HIV-1 infection","volume":"90","author":"NM Keane","year":"2012","journal-title":"Immunol Cell Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"7284","DOI":"10.1128\/JVI.78.13.7284-7287.2004","article-title":"Ex vivo phenotype and frequency of influenza virus-specific CD4 memory T cells","volume":"78","author":"M Lucas","year":"2004","journal-title":"J Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1172\/JCI117892","article-title":"CD8 naive T cell counts decrease progressively in HIV-infected adults","volume":"95","author":"M Roederer","year":"1995","journal-title":"J Clin Invest"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e1678","DOI":"10.1371\/journal.pone.0001678","article-title":"One-pot, mix-and-read peptide-MHC tetramers","volume":"3","author":"C Leisner","year":"2008","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/01.aids.0000171414.99409.fb","article-title":"Clinical and immunogenetic correlates of abacavir hypersensitivity","volume":"19","author":"EJ Phillips","year":"2005","journal-title":"AIDS"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jaci.2013.04.013","article-title":"HLA-B*57:01(+) abacavir-naive individuals have specific T cells but no patch test reactivity","volume":"132","author":"B Schnyder","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrrheum.2011.39","article-title":"Pathogenesis, classification and treatment of inflammatory myopathies","volume":"7","author":"M Zong","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/icb.1996.71","article-title":"Memory alloreactive cytotoxic T cells do not require costimulation for activation in vitro","volume":"74","author":"K Flynn","year":"1996","journal-title":"Immunol Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.4049\/jimmunol.141.10.3249","article-title":"Differential activation requirements for virgin and memory T cells","volume":"141","author":"JA Byrne","year":"1988","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1084\/jem.186.9.1407","article-title":"Phenotypic and functional separation of memory and effector human CD8+ T cells","volume":"186","author":"D Hamann","year":"1997","journal-title":"J Exp Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0167-5699(98)01429-7","article-title":"The influence of antiviral T-cell responses on the alloreactive repertoire","volume":"20","author":"SR Burrows","year":"1999","journal-title":"Immunol Today"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.immuni.2009.09.025","article-title":"T cell allorecognition via molecular mimicry","volume":"31","author":"WA Macdonald","year":"2009","journal-title":"Immunity"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.it.2008.02.005","article-title":"T-cell allorecognition: a case of mistaken identity or deja vu?","volume":"29","author":"JK Archbold","year":"2008","journal-title":"Trends Immunol"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"e95339","DOI":"10.1371\/journal.pone.0095339","article-title":"Abacavir induced T cell reactivity from drug na\u00efve individuals shares features of allo-immune responses","volume":"9","author":"J1 Adam","year":"2014","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/nm.2446","article-title":"A human memory T cell subject with stem cell-like properties","volume":"17","author":"L Gattinoni","year":"2011","journal-title":"Nat Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.jaci.2011.08.013","article-title":"Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome","volume":"128","author":"TM Ko","year":"2011","journal-title":"J Allergy Clin Immunol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0117160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T09:58:36Z","timestamp":1691229516000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0117160"}},"subtitle":[],"editor":[{"given":"Naglaa H.","family":"Shoukry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,12]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0117160","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,12]]}}}