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(Microsporidia) in an insect host","volume":"104","author":"S Johny","year":"2009","journal-title":"Parasitol Res"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2460\/javma.1999.215.01.28","article-title":"Drugs prohibited from extralabel use in food animals","volume":"215","author":"MA Payne","year":"1999","journal-title":"J Am Vet Med Ass"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.parint.2008.03.002","article-title":"Effect of four antimicrobials against an <italic>Encephalitozoon<\/italic> sp (Microsporidia) in a grasshopper host","volume":"57","author":"S Johny","year":"2008","journal-title":"Parasitol Int"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1128\/AEM.63.1.44-49.1997","article-title":"Antimycoplasma properties and application in cell culture of surfactin, a lipopeptide antibiotic from <italic>Bacillus subtilis<\/italic>","volume":"63","author":"D Vollenbroich","year":"1997","journal-title":"Appl Environ Microbiol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jcis.1998.5558","article-title":"Separation and characterization of surfactin isoforms produced by <italic>Bacillus subtilis<\/italic> OKB 105","volume":"204","author":"M Kowall","year":"1998","journal-title":"J Colloid Interf Sci"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s002530051432","article-title":"Recent trends in the biochemistry of surfactin","volume":"51","author":"F Peypoux","year":"1999","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref78","first-page":"123","article-title":"Review of surfactin chemical properties and the potential biomedical applications","volume":"3","author":"G Seydlov\u00e1","year":"2008","journal-title":"Cent Eur J Med"},{"key":"ref79","first-page":"1656","article-title":"A comparison of the anti-inflammatory activity of surfactin A, B, C, and D from <italic>Bacillus subtilis<\/italic>","volume":"16","author":"SD Kim","year":"2006","journal-title":"J Microbiol Biotechnol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1099-1387(199703)3:2<145::AID-PSC96>3.0.CO;2-Y","article-title":"Lipopeptides with improved properties: structure by NMR, purification by HPLC and structure-activity relationships of new isoleucyl-rich surfactins","volume":"3","author":"I Grangemard","year":"1997","journal-title":"J Peptide Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0117200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T02:04:35Z","timestamp":1717725875000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0117200"}},"subtitle":[],"editor":[{"given":"Wolfgang","family":"Blenau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,6]]},"references-count":80,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0117200","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,6]]}}}