{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T14:54:43Z","timestamp":1792940083074,"version":"4.5.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T00:00:00Z","timestamp":1423612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0117394","type":"journal-article","created":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T13:46:28Z","timestamp":1423662388000},"page":"e0117394","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Bioprospecting the American Alligator (Alligator mississippiensis) Host Defense Peptidome"],"prefix":"10.1371","volume":"10","author":[{"given":"Barney M.","family":"Bishop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie L.","family":"Juba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan C.","family":"Devine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Barksdale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung C.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent A.","family":"Vliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Schnur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique L.","family":"van Hoek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/nbt1267","article-title":"Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies","volume":"24","author":"REW Hancock","year":"2006","journal-title":"Nat Biotechnol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms","volume":"415","author":"M Zasloff","year":"2002","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.vetimm.2005.10.001","article-title":"Broad spectrum antimicrobial activity of leukocyte extracts from the American alligator (Alligator mississippiensis)","volume":"110","author":"ME Merchant","year":"2006","journal-title":"Vet Immunol Immunopathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S1096-4959(03)00256-2","article-title":"Antibacterial properties of serum from the American alligator (Alligator mississippiensis)","volume":"136","author":"ME Merchant","year":"2003","journal-title":"Comp Biochem Physiol Part B Biochem Mol Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.cbd.2010.09.001","article-title":"Proteome analysis of the leukocytes from the American alligator (Alligator mississippiensis) using mass spectrometry","volume":"5","author":"LNF Darville","year":"2010","journal-title":"Comp Biochem Physiol Part D Genomics Proteomics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3390\/ph7060723","article-title":"Antimicrobial peptides in reptiles","volume":"7","author":"ML Van Hoek","year":"2014","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.dci.2010.12.011","article-title":"Characterization of the novel antibacterial peptide Leucrocin from crocodile (Crocodylus siamensis) white blood cell extracts","volume":"35","author":"S Pata","year":"2011","journal-title":"Dev Comp Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/nl072174l","article-title":"Smart hydrogel particles: biomarker harvesting: one-step affinity purification, size exclusion, and protection against degradation","volume":"8","author":"A Luchini","year":"2008","journal-title":"Nano Lett"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e4763","DOI":"10.1371\/journal.pone.0004763","article-title":"Core-shell hydrogel particles harvest, concentrate and preserve labile low abundance biomarkers","volume":"4","author":"C Longo","year":"2009","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"D774","DOI":"10.1093\/nar\/gkp1021","article-title":"CAMP: a useful resource for research on antimicrobial peptides","volume":"38","author":"S Thomas","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref11","first-page":"1","article-title":"Analysis and prediction of antibacterial peptides","volume":"10","author":"S Lata","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"D933","DOI":"10.1093\/nar\/gkn823","article-title":"APD2: the updated antimicrobial peptide database and its application in peptide design","volume":"37","author":"G Wang","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1182\/blood.V90.7.2796","article-title":"The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils","volume":"90","author":"O S\u00f8rensen","year":"1997","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"9528","DOI":"10.1073\/pnas.0402700101","article-title":"Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry","volume":"101","author":"JEP Syka","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.bbapap.2006.10.003","article-title":"The utility of ETD mass spectrometry in proteomic analysis","volume":"1764","author":"LM Mikesh","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1186\/gb-2012-13-1-415","article-title":"Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes","volume":"13","author":"JA St John","year":"2012","journal-title":"Genome Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1128\/IAI.65.8.3193-3198.1997","article-title":"Evaluation of bacterial survival and phagocyte function with a fluorescence-based microplate assay","volume":"65","author":"MU Shiloh","year":"1997","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00253-009-1879-x","article-title":"Fluorescent assay based on resazurin for detection of activity of disinfectants against bacterial biofilm","volume":"82","author":"A Mariscal","year":"2009","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1128\/CVI.05028-11","article-title":"Development of an automated, high-throughput bactericidal assay that measures cellular respiration as a survival readout for Neisseria meningitidis","volume":"18","author":"PA Mak","year":"2011","journal-title":"Clin Vaccine Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jdermsci.2005.03.014","article-title":"Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli","volume":"40","author":"X Chen","year":"2005","journal-title":"J Dermatol Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s00011-004-1323-8","article-title":"Augmentation of the bactericidal activities of human cathelicidin CAP18\/LL-37-derived antimicrobial peptides by amino acid substitutions","volume":"54","author":"I Nagaoka","year":"2005","journal-title":"Inflamm Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1590\/S1517-83822013000100042","article-title":"Measuring of Mycobacterium tuberculosis growth. A correlation of the optical measurements with colony forming units","volume":"44","author":"K Pe\u00f1uelas-Urquides","year":"2013","journal-title":"Braz J Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1128\/AAC.00331-06","article-title":"Determination of the antibacterial and lipopolysaccharide-neutralizing regions of guinea pig neutrophil cathelicidin peptide CAP11","volume":"50","author":"D Okuda","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0014-5793(97)01101-0","article-title":"Chemotherapeutic activity of synthetic antimicrobial peptides: correlation between chemotherapeutic activity and neutrophil-activating activity","volume":"415","author":"Y Nakajima","year":"1997","journal-title":"FEBS Lett"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s00897010471a","article-title":"Visualizing Redox Chemistry: Probing Environmental Oxidation?Reduction Reactions with Indicator Dyes","volume":"6","author":"PG Tratnyek","year":"2001","journal-title":"Chem Educ"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.metabol.2010.04.017","article-title":"Apolipoprotein C-I genotype and serum levels of triglycerides, C-reactive protein and coronary heart disease","volume":"59","author":"B Olsson","year":"2010","journal-title":"Metabolism"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/labinvest.3780324","article-title":"Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects","volume":"81","author":"A Churg","year":"2001","journal-title":"Lab Invest"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1160\/TH12-10-0739","article-title":"Antimicrobial activity of fibrinogen and fibrinogen-derived peptides\u2014a novel link between coagulation and innate immunity","volume":"109","author":"LI P\u00e5hlman","year":"2013","journal-title":"Thromb Haemost"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.4023714","article-title":"Hydrophobicity of amino acid residues in globular proteins","volume":"229","author":"G Rose","year":"1985","journal-title":"Science (80-)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1471-2180-11-114","article-title":"Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus","volume":"11","author":"SN Dean","year":"2011","journal-title":"BMC Microbiol"},{"key":"ref31","first-page":"128","article-title":"Susceptibility of Pseudomonas aeruginosa Biofilm to Alpha-Helical Peptides: D-enantiomer of LL-37","volume":"2","author":"SN Dean","year":"2011","journal-title":"Front Microbiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0117394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T18:42:16Z","timestamp":1598726536000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0117394"}},"subtitle":[],"editor":[{"given":"J\u00fcrgen","family":"Harder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,11]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0117394","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,11]]}}}