{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:08:33Z","timestamp":1779221313673,"version":"3.51.4"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0117508","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T21:44:23Z","timestamp":1423259063000},"page":"e0117508","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Anti-HmuY Antibodies Specifically Recognize Porphyromonas gingivalis HmuY Protein but Not Homologous Proteins in Other Periodontopathogens"],"prefix":"10.1371","volume":"10","author":[{"given":"Micha\u0142","family":"\u015amiga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Bielecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz","family":"Olczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Smalley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Olczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00001432-200006000-00005","article-title":"Periodontal disease: bacterial virulence factors, host response and impact on systemic health","volume":"13","author":"DT Graves","year":"2000","journal-title":"Curr Opin Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1902\/jop.2003.74.7.1007","article-title":"Relationship of destructive periodontal disease to the acute-phase response","volume":"74","author":"RG Craig","year":"2003","journal-title":"J Periodontol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1399-302X.2009.00544.x","article-title":"Progression of chronic periodontitis can be predicted by the levels of <italic>Porphyromonas gingivalis<\/italic> and <italic>Treponema denticola<\/italic> in subgingival plaque","volume":"24","author":"SJ Byrne","year":"2009","journal-title":"Oral Microbiol Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1128\/JCM.36.11.3239-3242.1998","article-title":"Prevalence of <italic>Porphyromonas gingivalis<\/italic> and periodontal health status","volume":"36","author":"AL Griffen","year":"1998","journal-title":"J Clin Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral microbiome","volume":"192","author":"FE Dewhirst","year":"2010","journal-title":"J Bacteriol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1600-051X.1998.tb02454.x","article-title":"Subgingival microbiota in healthy, well-maintained elder and periodontitis subjects","volume":"25","author":"AD Haffajee","year":"1998","journal-title":"J Clin Periodontol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1600-0765.2009.01250.x","article-title":"Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR","volume":"45","author":"Y Abiko","year":"2010","journal-title":"J Periodontal Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1128\/MMBR.66.3.486-505.2002","article-title":"Communication among oral bacteria","volume":"66","author":"PE Kolenbrander","year":"2002","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1099\/mic.0.25997-0","article-title":"Adhesins encoded by the gingipain genes of <italic>Porphyromonas gingivalis<\/italic> are responsible for co-aggregation with <italic>Prevotella intermedia<\/italic>","volume":"149","author":"A Kamaguchi","year":"2003","journal-title":"Microbiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1349-0079(11)80006-X","article-title":"Immune evasion strategies of <italic>Porphyromonas gingivalis<\/italic>","volume":"53","author":"G Hajishengallis","year":"2011","journal-title":"J Oral Biosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2012.02579.x","article-title":"<italic>Porphyromonas gingivalis<\/italic>: an invasive and evasive opportunistic pathogen","volume":"333","author":"N Bostanci","year":"2012","journal-title":"FEMS Microbiol Lett"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.femsre.2004.09.001","article-title":"Iron and heme utilization in <italic>Porphyromonas gingivalis<\/italic>","volume":"29","author":"T Olczak","year":"2005","journal-title":"FEMS Microbiol Rev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00203-007-0309-7","article-title":"<italic>Porphyromonas gingivalis<\/italic> HmuY and HmuR: further characterization of a novel mechanism of heme utilization","volume":"183","author":"T Olczak","year":"2008","journal-title":"Arch Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2180-10-134","article-title":"Species specificity, surface exposure, protein expression, immunogenicity, and participation in biofilm formation of <italic>Porphyromonas gingivalis<\/italic> HmuY","volume":"10","author":"T Olczak","year":"2010","journal-title":"BMC Microbiol"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"e1000419","DOI":"10.1371\/journal.ppat.1000419","article-title":"Unique structure and stability of HmuY, a novel heme-binding protein of <italic>Porphyromonas gingivalis<\/italic>","volume":"5","author":"H Wojtowicz","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00203-012-0804-3","article-title":"Gallium(III), cobalt(III) and copper(II) protoporphyrin IX exhibit antimicrobial activity against <italic>Porphyromonas gingivalis<\/italic> by reducing planktonic and biofilm growth and invasion of host epithelial cells","volume":"194","author":"T Olczak","year":"2012","journal-title":"Arch Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbrc.2009.03.148","article-title":"Heme environment of <italic>Porphyromonas gingivalis<\/italic> HmuY heme-binding protein","volume":"382","author":"H Wojtowicz","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1039\/c3mt20215a","article-title":"<italic>Porphyromonas gingivalis<\/italic> HmuY haemophore binds gallium(III), zinc(II), cobalt(III), manganese(III), nickel(II), and copper(II) protoporphyrin IX but in a manner different to iron(III) protoporphyrin IX","volume":"5","author":"H Wojtowicz","year":"2013","journal-title":"Metallomics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bbrc.2011.06.129","article-title":"Iron(III) mesoporphyrin IX and iron(III) deuteroporphyrin IX bind to the <italic>Porphyromonas gingivalis<\/italic> HmuY hemophore","volume":"411","author":"J Wojaczynski","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"e17182","DOI":"10.1371\/journal.pone.0017182","article-title":"HmuY haemophore and gingipain proteases constitute a unique synthrophic system of haem acquisition by <italic>Porphyromonas gingivalis<\/italic>","volume":"6","author":"JW Smalley","year":"2011","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/omi.12018","article-title":"Evidence of mutualism between two periodontal pathogens: co-operative haem acquisition by the HmuY haemophore of <italic>Porphyromonas gingivalis<\/italic> and the cysteine protease interpain A (InpA) of <italic>Prevotella intermedia<\/italic>","volume":"28","author":"DP Byrne","year":"2013","journal-title":"Mol Oral Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1128\/IAI.63.10.3878-3885.1995","article-title":"<italic>Porphyromonas gingivalis<\/italic> invasion of gingival epithelial cells","volume":"63","author":"RJ Lamont","year":"1995","journal-title":"Infect Immun"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1399-302X.2005.00233.x","article-title":"Bacterial internalization in periodontitis","volume":"20","author":"L Vitkov","year":"2005","journal-title":"Oral Microbiol Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1128\/IAI.74.1.703-710.2006","article-title":"Intercellular spreading of <italic>Porphyromonas gingivalis<\/italic> infection in primary gingival epithelial cells","volume":"74","author":"O Yilmaz","year":"2006","journal-title":"Infect Immun"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1574-695X.2011.00877.x","article-title":"Colocalization of <italic>Porphyromonas gingivalis<\/italic> with CD4+ T cells in periodontal disease","volume":"64","author":"H Guyodo","year":"2012","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0266-4356(03)00190-6","article-title":"Brain abscess in which <italic>Porphyromonas gingivalis<\/italic> was detected in cerebrospinal fluid","volume":"42","author":"Y Iida","year":"2004","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.micinf.2005.09.004","article-title":"Detection of bacterial DNA in atheromatous plaques by quantitative PCR","volume":"8","author":"E Kozarov","year":"2006","journal-title":"Microbes Infect"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1902\/jop.2007.060368","article-title":"Detection of <italic>Porphyromonas gingivalis<\/italic> in the amniotic fluid in pregnant women with a diagnosis of threatened premature labor","volume":"78","author":"R Leon","year":"2007","journal-title":"J Periodontol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0765.2011.01401.x","article-title":"<italic>P<\/italic>. <italic>gingivalis<\/italic> HmuY-induced IL-1\u03b2, IL-10, IL-8 and IgG in humans","volume":"47","author":"SC Trindade","year":"2012","journal-title":"J Periodontal Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.archoralbio.2011.09.003","article-title":"<italic>Porphyromonas gingivalis<\/italic> antigens participate differently in the proliferation and cell death of human PBMC","volume":"57","author":"SC Trindade","year":"2012","journal-title":"Arch Oral Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1902\/jop.2012.120230","article-title":"<italic>P<\/italic>. <italic>gingivalis<\/italic> HmuY-induced production of interleukin-6 and IL-6 polymorphism in chronic periodontitis","volume":"84","author":"SC Trindade","year":"2013","journal-title":"J Periodontol"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/1471-2180-13-206","article-title":"<italic>Porphyromonas gingivalis<\/italic> HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells","volume":"13","author":"PC Carvalho-Filho","year":"2013","journal-title":"BMC Microbiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1021\/pr401227e","article-title":"<italic>Porphyromonas gingivalis<\/italic> outer membrane vesicles exclusively contain outer membrane and periplasmic proteins and carry a cargo enriched with virulence factors","volume":"13","author":"PD Veith","year":"2014","journal-title":"J Proteome Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/154411130401500606","article-title":"Oral health, atherosclerosis, and cardiovascular disease","volume":"15","author":"JH Meurman","year":"2004","journal-title":"Crit Rev Oral Biol Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10753-004-6641-z","article-title":"Hypothesis: The humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis","volume":"28","author":"ED Rosenstein","year":"2004","journal-title":"Inflammation"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"e67719","DOI":"10.1371\/journal.pone.0067719","article-title":"The unique <italic>hmuY<\/italic> gene sequence as a specific marker of <italic>Porphyromonas gingivalis<\/italic> infection","volume":"8","author":"A Gmiterek","year":"2013","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1128\/JB.00079-10","article-title":"A novel sialic acid utilization and uptake system in the periodontal pathogen <italic>Tannerella forsythia<\/italic>","volume":"192","author":"S Roy","year":"2010","journal-title":"J Bacteriol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1034\/j.1600-051x.2000.027010769.x","article-title":"Antibody responses against <italic>Porphyromonas gingivalis<\/italic> infection in patients with early-onset periodontitis","volume":"27","author":"S Guo","year":"2000","journal-title":"J Clin Periodontol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1902\/jop.2000.71.6.885","article-title":"&quot;Checkerboard&quot; assessments of periodontal microbiota and serum antibody responses: a case-control study","volume":"71","author":"PN Papapanou","year":"2000","journal-title":"J Periodontol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1034\/j.1600-051x.2001.280116.x","article-title":"Checkerboard assessments of serum antibodies to oral microbiota as surrogate markers of clinical periodontal status","volume":"28","author":"PN Papapanou","year":"2001","journal-title":"J Clin Periodontol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1902\/jop.2001.72.11.1463","article-title":"Associations between serum antibody levels to periodontal pathogens and early-onset periodontitis","volume":"72","author":"JM Albandar","year":"2001","journal-title":"J Periodontol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1902\/jop.2009.080474","article-title":"Serum antibodies to periodontal bacteria as diagnostic markers of periodontitis","volume":"80","author":"BA Dye","year":"2009","journal-title":"J Periodontol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5051\/jpis.2011.41.2.54","article-title":"Identification of mono- or poly-specific monoclonal antibody to <italic>Poprhyromonas gingivalis<\/italic> heat-schock protein 60","volume":"41","author":"J Choi","year":"2011","journal-title":"J Periodontol Implant Sci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ab.2011.04.015","article-title":"Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from <italic>Porphyromonas gingivalis<\/italic>","volume":"415","author":"PD Skottrup","year":"2011","journal-title":"Anal Biochem"},{"key":"ref45","first-page":"2","article-title":"Serum antibodies to oral anaerobic bacteria in patients with rheumatoid arthritis","volume":"7","author":"M Ogrendik","year":"2005","journal-title":"Med Gen Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3899\/jrheum.091323","article-title":"Antibodies to <italic>Porphyromonas gingivalis<\/italic> are associated with anticitrullinated protein antibodies in patients with rheumatoid arthritis and their relatives","volume":"37","author":"CA Hitchon","year":"2010","journal-title":"J Rheumatol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1902\/jop.2009.080464","article-title":"Systemic immune responses in pregnancy and periodontitis: relationship to pregnancy outcomes in the Obstetrics and Periodontal Therapy (OPT) study","volume":"80","author":"JL Ebersole","year":"2009","journal-title":"J Periodontol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.intimp.2008.09.008","article-title":"Antibody responses to <italic>Porphyromonas gingivalis<\/italic> (<italic>P<\/italic>. <italic>gingivalis<\/italic>) in subjects with rheumatoid arthritis and periodontitis","volume":"9","author":"TR Mikuls","year":"2009","journal-title":"Int Immunopharmacol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1177\/0022034510370817","article-title":"High antibody levels to <italic>P<\/italic>. <italic>gingivalis<\/italic> in cardiovascular disease","volume":"89","author":"S Bohnstedt","year":"2010","journal-title":"J Dent Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijcard.2009.10.034","article-title":"<italic>Porphyromonas gingivalis<\/italic> (Pg) a possible link between impaired oral health and acute myocardial infarction","volume":"148","author":"A Holmlund","year":"2011","journal-title":"Int J Cardiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/hr.2013.46","article-title":"Level of serum antibody against a periodontal pathogen is associated with atherosclerosis and hypertension","volume":"36","author":"Y Hanaoka","year":"2013","journal-title":"Hypertens Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"R109","DOI":"10.1186\/ar4289","article-title":"Clinical correlations with <italic>Porphyromonas gingivalis<\/italic> antibody responses in patients with early rheumatoid arthritis","volume":"15","author":"SL Arvikar","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1590\/S1678-77572007000300011","article-title":"Humoral immune response to antigens of <italic>Porphyromonas gingivalis<\/italic> ATCC 33277 in chronic periodontitis","volume":"15","author":"M Franca","year":"2007","journal-title":"J Appl Oral Sci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1600-0765.2007.01078.x","article-title":"Lower antibody response to <italic>Porphyromonas gingivalis<\/italic> associated with immunoglobulin G Fc gamma receptor IIB polymorphism","volume":"43","author":"Y Honma","year":"2008","journal-title":"J Periodontal Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0117508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T18:58:26Z","timestamp":1598727506000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0117508"}},"subtitle":[],"editor":[{"given":"Selvakumar","family":"Subbian","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,6]]},"references-count":54,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0117508","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,6]]}}}