{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:37:39Z","timestamp":1789609059369,"version":"build-2803163510"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T00:00:00Z","timestamp":1424304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0117536","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T18:42:54Z","timestamp":1424371374000},"page":"e0117536","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Defective Differentiation of Adipose Precursor Cells from Lipodystrophic Mice Lacking Perilipin 1"],"prefix":"10.1371","volume":"10","author":[{"given":"Ying","family":"Lyu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingna","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangqiang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suning","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1194\/jlr.R000034","article-title":"Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins","volume":"51","author":"AR Kimmel","year":"2010","journal-title":"J Lipid Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1194\/jlr.R700014-JLR200","article-title":"The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis","volume":"48","author":"DL Brasaemle","year":"2007","journal-title":"J Lipid Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"11341","DOI":"10.1016\/S0021-9258(18)99168-4","article-title":"Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets","volume":"266","author":"AS Greenberg","year":"1991","journal-title":"J Biol Chem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"38486","DOI":"10.1074\/jbc.M007322200","article-title":"Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis","volume":"275","author":"DL Brasaemle","year":"2000","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1083\/jcb.200210169","article-title":"Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation","volume":"161","author":"C Sztalryd","year":"2003","journal-title":"J Cell Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"34538","DOI":"10.1074\/jbc.M109.068478","article-title":"Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl)","volume":"284","author":"JG Granneman","year":"2009","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1124\/mol.107.039479","article-title":"Salicylate blocks lipolytic actions of tumor necrosis factor-\u03b1 in primary rat adipocytes","volume":"73","author":"L Zu","year":"2008","journal-title":"Mol Pharmacol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5915","DOI":"10.1074\/jbc.M807852200","article-title":"Bacterial endotoxin stimulates adipose lipolysis via toll-like receptor 4 and extracellular signal-regulated kinase pathway","volume":"284","author":"L Zu","year":"2009","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1073\/pnas.101042998","article-title":"Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity","volume":"98","author":"JT Tansey","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/82630","article-title":"Absence of perilipin results in leanness and reverses obesity in Lepr(db\/db) mice","volume":"26","author":"J Martinez-Botas","year":"2000","journal-title":"Nat Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-0029-1243599","article-title":"Increased lipolysis in adipose tissues is associated with elevation of systemic free fatty acids and insulin resistance in perilipin null mice","volume":"42","author":"W Zhai","year":"2010","journal-title":"Horm Metab Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1056\/NEJMoa1007487","article-title":"Perilipin deficiency and autosomal dominant partial lipodystrophy","volume":"364","author":"S Gandotra","year":"2011","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/S1098-3597(06)80039-6","article-title":"Adipose tissue dysfunction in obesity and lipodystrophy","volume":"8","author":"A Garg","year":"2006","journal-title":"Clin Cornerstone"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.bbalip.2008.12.014","article-title":"Lipodystrophies: disorders of adipose tissue biology","volume":"1791","author":"A Garg","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng880","article-title":"AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34","volume":"31","author":"AK Agarwal","year":"2002","journal-title":"Nat Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/hmg\/ddr205","article-title":"Seipin ablation in mice results in severe generalized lipodystrophy","volume":"20","author":"X Cui","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.2337\/db08-0184","article-title":"The human lipodystrophy gene BSCL2\/seipin may be essential for normal adipocyte differentiation","volume":"57","author":"VA Payne","year":"2008","journal-title":"Diabetes"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1210\/en.2009-0236","article-title":"The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2\/seipin plays a key role in adipocyte differentiation","volume":"150","author":"W Chen","year":"2009","journal-title":"Endocrinology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1210\/jc.2007-1328","article-title":"Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy","volume":"93","author":"CA Kim","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/hmg\/9.1.109","article-title":"Nuclear lamin A\/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy","volume":"9","author":"H Cao","year":"2000","journal-title":"Hum Mol Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/hmg\/ddi480","article-title":"Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy","volume":"15","author":"RL Boguslavsky","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.2337\/diabetes.51.12.3586","article-title":"PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy","volume":"51","author":"RA Hegele","year":"2002","journal-title":"Diabetes"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/emmm.200900037","article-title":"Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC","volume":"1","author":"O Rubio-Cabezas","year":"2009","journal-title":"EMBO Mol Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(00)80211-7","article-title":"PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro","volume":"4","author":"ED Rosen","year":"1999","journal-title":"Mol Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.tem.2008.11.005","article-title":"New developments in adipogenesis","volume":"20","author":"MI Lefterova","year":"2009","journal-title":"Trends Endocrinol Metab"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"11082","DOI":"10.1074\/jbc.M509612200","article-title":"A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation","volume":"281","author":"SE Gale","year":"2006","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.tem.2011.02.004","article-title":"Seipin, adipogenesis and lipid droplets","volume":"22","author":"W Fei","year":"2011","journal-title":"Trends Endocrinol Metab"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-1-59745-245-8_15","article-title":"Isolation and culture of preadipocytes from rodent white adipose tissue","volume":"456","author":"DB Hausman","year":"2008","journal-title":"Methods Mol Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbalip.2006.10.004","article-title":"Heat shock protein 70 is translocated to lipid droplets in rat adipocytes upon heat stimulation","volume":"1771","author":"H Jiang","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbalip.2006.02.001","article-title":"Calyculin and okadaic acid promote perilipin phosphorylation and increase lipolysis in primary rat adipocytes","volume":"1761","author":"J He","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"42841","DOI":"10.1074\/jbc.M506569200","article-title":"Post-translational regulation of adipose differentiation-related protein by the ubiquitin\/proteasome pathway","volume":"280","author":"G Xu","year":"2005","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1016\/S0022-2275(20)34939-7","article-title":"Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein","volume":"38","author":"DL Brasaemle","year":"1997","journal-title":"J Lipid Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1210\/me.2008-0464","article-title":"Direct effect of glucocorticoids on lipolysis in adipocytes","volume":"23","author":"C Xu","year":"2009","journal-title":"Mol Endocrinol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cell.2008.09.036","article-title":"Identification of white adipocyte progenitor cells in vivo","volume":"135","author":"MS Rodeheffer","year":"2008","journal-title":"Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/ncb2696","article-title":"Characterization of the adipocyte cellular lineage in vivo","volume":"15","author":"R Berry","year":"2013","journal-title":"Nat Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1210\/jc.2008-0044","article-title":"Evidence of in situ proliferation of adult adipose tissue-derived progenitor cells: influence of fat mass microenvironment and growth","volume":"93","author":"M Maumus","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"E1037","DOI":"10.1152\/ajpendo.2001.281.5.E1037","article-title":"Human adipose tissue endothelial cells promote preadipocyte proliferation","volume":"281","author":"LJ Hutley","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"10070","DOI":"10.1074\/jbc.M308522200","article-title":"The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes","volume":"279","author":"N Arimura","year":"2004","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"8811","DOI":"10.1016\/S0021-9258(18)43575-2","article-title":"Control of specific protein biosynthesis during the adipose conversion of 3T3 cells","volume":"255","author":"BM Spiegelman","year":"1980","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00418-003-0575-7","article-title":"Temporal and spatial assembly of lipid droplet-associated proteins in 3T3-L1 preadipocytes","volume":"120","author":"SM Wang","year":"2003","journal-title":"Histochem Cell Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"19146","DOI":"10.1074\/jbc.M500978200","article-title":"S3\u201312, Adipophilin, and TIP47 package lipid in adipocytes","volume":"280","author":"NE Wolins","year":"2005","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1194\/jlr.M600155-JLR200","article-title":"Temporal and spatial variations of lipid droplets during adipocyte division and differentiation","volume":"48","author":"M Nagayama","year":"2007","journal-title":"J Lipid Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/ncomms2581","article-title":"Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes","volume":"4","author":"Z Sun","year":"2013","journal-title":"Nat Commun"},{"key":"ref44","first-page":"2808","article-title":"FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets","volume":"118","author":"N Nishino","year":"2008","journal-title":"J Clin Invest"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1083\/jcb.201104142","article-title":"Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites","volume":"195","author":"J Gong","year":"2011","journal-title":"J Cell Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e14006","DOI":"10.1371\/journal.pone.0014006","article-title":"Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype","volume":"5","author":"T Sawada","year":"2010","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.2337\/diabetes.52.11.2666","article-title":"Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile","volume":"52","author":"F Castro-Chavez","year":"2003","journal-title":"Diabetes"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e2890","DOI":"10.1371\/journal.pone.0002890","article-title":"Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice","volume":"3","author":"SY Toh","year":"2008","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1186\/1471-2164-11-446","article-title":"Regulation of gene expression by FSP27 in white and brown adipose tissue","volume":"11","author":"D Li","year":"2010","journal-title":"BMC Genomics"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1748-1716.2007.01786.x","article-title":"RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27","volume":"192","author":"V Puri","year":"2008","journal-title":"Acta Physiol (Oxf)"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0022-2275(20)38656-9","article-title":"Hormonal regulation of the differentiation of rat adipocyte precursor cells in primary culture","volume":"28","author":"O Wiederer","year":"1987","journal-title":"J Lipid Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0117536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T06:20:22Z","timestamp":1651299622000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0117536"}},"subtitle":[],"editor":[{"given":"Hongyuan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,19]]},"references-count":51,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0117536","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,19]]}}}