{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:05:43Z","timestamp":1791230743691,"version":"4.1.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0117657","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T13:45:01Z","timestamp":1423748701000},"page":"e0117657","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":55,"title":["Mycobacterium abscessus Morphotype Comparison in a Murine Model"],"prefix":"10.1371","volume":"10","author":[{"given":"Lindsay J.","family":"Caverly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia M.","family":"Caceres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cori","family":"Fratelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Happoldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley M.","family":"Kidwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth C.","family":"Malcolm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry A.","family":"Nick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1055\/s-0033-1333573","article-title":"Underlying host risk factors for nontuberculous mycobacterial lung disease","volume":"34","author":"ED Chan","year":"2013","journal-title":"Semin Respir Crit Care Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1164\/rccm.201002-0310OC","article-title":"Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems","volume":"182","author":"DR Prevots","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.3201\/eid1911.130737","article-title":"Pulmonary nontuberculous mycobacterial disease, ontario, Canada, 1998\u20132010","volume":"19","author":"TK Marras","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1164\/rccm.200207-678OC","article-title":"Nontuberculous mycobacteria. I: multicenter prevalence study in cystic fibrosis","volume":"167","author":"KN Olivier","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jcf.2009.12.001","article-title":"Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis","volume":"9","author":"CR Esther Jr","year":"2010","journal-title":"J Cyst Fibros"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/jac\/dkr578","article-title":"Mycobacterium abscessus: a new antibiotic nightmare","volume":"67","author":"R Nessar","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/cid\/ciq237","article-title":"Clinical and microbiologic outcomes in patients receiving treatment for Mycobacterium abscessus pulmonary disease","volume":"52","author":"J Jarand","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1513\/AnnalsATS.201309-310OC","article-title":"Clinical significance of a first positive nontuberculous mycobacteria culture in cystic fibrosis","volume":"11","author":"SL Martiniano","year":"2014","journal-title":"Ann Am Thorac Soc"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1164\/rccm.200207-679OC","article-title":"Nontuberculous mycobacteria. II: nested-cohort study of impact on cystic fibrosis lung disease","volume":"167","author":"KN Olivier","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1128\/IAI.67.9.4700-4707.1999","article-title":"Preliminary characterization of a Mycobacterium abscessus mutant in human and murine models of infection","volume":"67","author":"TF Byrd","year":"1999","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1099\/mic.0.28625-0","article-title":"Spontaneous reversion of Mycobacterium abscessus from a smooth to a rough morphotype is associated with reduced expression of glycopeptidolipid and reacquisition of an invasive phenotype","volume":"152","author":"ST Howard","year":"2006","journal-title":"Microbiology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1128\/JCM.02592-06","article-title":"Molecular epidemiology of Mycobacterium abscessus, with focus on cystic fibrosis","volume":"45","author":"BE Jonsson","year":"2007","journal-title":"J Clin Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1128\/JCM.01478-08","article-title":"Acute respiratory failure involving an R variant of Mycobacterium abscessus","volume":"47","author":"E Catherinot","year":"2009","journal-title":"J Clin Microbiol"},{"key":"ref14","article-title":"Characterization of rough and smooth morphotypes of Mycobacterium abscessus isolated from clinical specimens","author":"K Ruger","year":"2013","journal-title":"J Clin Microbiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1128\/JCM.00319-08","article-title":"Proportions of Mycobacterium massiliense and Mycobacterium bolletii strains among Korean Mycobacterium chelonae-Mycobacterium abscessus group isolates","volume":"46","author":"HY Kim","year":"2008","journal-title":"J Clin Microbiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1128\/JCM.39.2.816-819.2001","article-title":"Fatal pulmonary infection due to multidrug-resistant Mycobacterium abscessus in a patient with cystic fibrosis","volume":"39","author":"M Sanguinetti","year":"2001","journal-title":"J Clin Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1189\/jlb.1007696","article-title":"Animal model of Mycobacterium abscessus lung infection","volume":"83","author":"D Ordway","year":"2008","journal-title":"J Leukoc Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s12275-009-0139-1","article-title":"Comparative analysis of immune responses to Mycobacterium abscessus infection and its antigens in two murine models","volume":"47","author":"BY Jeon","year":"2009","journal-title":"J Microbiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1128\/IAI.00835-06","article-title":"Hypervirulence of a rough variant of the Mycobacterium abscessus type strain","volume":"75","author":"E Catherinot","year":"2007","journal-title":"Infect Immun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1046\/j.1365-3083.1999.00522.x","article-title":"The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity","volume":"49","author":"PJ Cardona","year":"1999","journal-title":"Scand J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1128\/IAI.00014-07","article-title":"Importance of T cells, gamma interferon, and tumor necrosis factor in immune control of the rapid grower Mycobacterium abscessus in C57BL\/6 mice","volume":"75","author":"M Rottman","year":"2007","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Caverly L FC, Caceres S, Nick J, Nichols D. (2012) Importance Of Mycobacterium Abscessus Complex Species And Morphotypes On Host Response AJRCCM 185.","DOI":"10.1164\/ajrccm-conference.2012.185.1_MeetingAbstracts.A4033"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1055\/s-0033-1333574","article-title":"Nontuberculous mycobacteria in patients with cystic fibrosis","volume":"34","author":"JM Leung","year":"2013","journal-title":"Semin Respir Crit Care Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.rmed.2009.04.026","article-title":"Pulmonary nontuberculous mycobacterial infections: antibiotic treatment and associated costs","volume":"103","author":"GJ Ballarino","year":"2009","journal-title":"Respir Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1164\/ajrccm.185.2.231","article-title":"Respiratory outbreak of Mycobacterium abscessus subspecies massiliense in a lung transplant and cystic fibrosis center","volume":"185","author":"ML Aitken","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref26","article-title":"Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study","author":"JM Bryant","year":"2013","journal-title":"Lancet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1164\/ajrccm\/151.3_Pt_2.S59","article-title":"A murine model of cystic fibrosis","volume":"151","author":"JN Snouwaert","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"issue":"Suppl 2","key":"ref28","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1016\/S1569-1993(11)60020-9","article-title":"Mouse models of cystic fibrosis: phenotypic analysis and research applications","volume":"10","author":"M Wilke","year":"2011","journal-title":"J Cyst Fibros"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1172\/JCI119828","article-title":"Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa","volume":"100","author":"A Heeckeren","year":"1997","journal-title":"J Clin Invest"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1258\/0023677054306944","article-title":"Cystic fibrosis lung disease following infection with Pseudomonas aeruginosa in Cftr knockout mice using novel non-invasive direct pulmonary infection technique","volume":"39","author":"C Guilbault","year":"2005","journal-title":"Lab Anim"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1164\/rccm.200506-917OC","article-title":"Response to acute lung infection with mucoid Pseudomonas aeruginosa in cystic fibrosis mice","volume":"173","author":"AM van Heeckeren","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1172\/JCI200419569","article-title":"Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness","volume":"114","author":"SS Wagers","year":"2004","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1164\/ajrccm.155.1.9001337","article-title":"Bronchial casts in children: a proposed classification based on nine cases and a review of the literature","volume":"155","author":"M Seear","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1513\/pats.200808-091RM","article-title":"Physiologic dysfunction of the asthmatic lung: what\u2019s going on down there, anyway?","volume":"6","author":"CG Irvin","year":"2009","journal-title":"Proc Am Thorac Soc"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.prrv.2005.09.001","article-title":"Plastic bronchitis: new insights and a classification scheme","volume":"6","author":"P Madsen","year":"2005","journal-title":"Paediatr Respir Rev"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/bph.12206","article-title":"Nebulized thiocyanate improves lung infection outcomes in mice","volume":"169","author":"JD Chandler","year":"2013","journal-title":"Br J Pharmacol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.4049\/jimmunol.0802181","article-title":"Mycobacterium abscessus Glycopeptidolipids mask underlying cell wall phosphatidyl-myo-inositol mannosides blocking induction of human macrophage TNF-alpha by preventing interaction with TLR2","volume":"183","author":"ER Rhoades","year":"2009","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-0463.2012.02932.x","article-title":"Phagocytosis and cytokine response to rough and smooth colony variants of Mycobacterium abscessus by human peripheral blood mononuclear cells","volume":"121","author":"B Jonsson","year":"2013","journal-title":"APMIS"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1164\/rccm.201011-1892OC","article-title":"Infection, inflammation, and lung function decline in infants with cystic fibrosis","volume":"184","author":"N Pillarisetti","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e57402","DOI":"10.1371\/journal.pone.0057402","article-title":"Mycobacterium abscessus induces a limited pattern of neutrophil activation that promotes pathogen survival","volume":"8","author":"KC Malcolm","year":"2013","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1128\/jcm.5.3.329-331.1977","article-title":"Smear results in the diagnosis of mycobacterioses using blue light fluorescence microscopy","volume":"5","author":"HM Pollock","year":"1977","journal-title":"J Clin Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jcf.2011.05.002","article-title":"Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation?","volume":"10","author":"FA Stressmann","year":"2011","journal-title":"J Cyst Fibros"},{"key":"ref43","article-title":"Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus","author":"A Pawlik","year":"2013","journal-title":"Mol Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.tim.2009.12.007","article-title":"Mycobacterium abscessus: a new player in the mycobacterial field","volume":"18","author":"H Medjahed","year":"2010","journal-title":"Trends Microbiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1164\/ajrccm.154.2.8756832","article-title":"Nontuberculous mycobacteria in cystic fibrosis. An autopsy study","volume":"154","author":"JF Tomashefski Jr","year":"1996","journal-title":"Am J Respir Crit Care Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0117657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T11:16:10Z","timestamp":1651230970000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0117657"}},"subtitle":[],"editor":[{"given":"Nades","family":"Palaniyar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,12]]},"references-count":45,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0117657","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,12]]}}}