{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:04:40Z","timestamp":1790096680837,"version":"4.0.1"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0117825","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T18:55:15Z","timestamp":1422471315000},"page":"e0117825","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Milk-Based Nutraceutical for Treating Autoimmune Arthritis via the Stimulation of IL-10- and TGF-\u03b2-producing CD39+ Regulatory T Cells"],"prefix":"10.1371","volume":"10","author":[{"given":"Massimo","family":"Maddaloni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Kochetkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SangMu","family":"Jun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayle","family":"Callis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Thornburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1136\/annrheumdis-2013-204627","article-title":"The global burden of rheumatoid arthritis: estimates from the Global Burden of Disease 2010 study","author":"M Cross","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.berh.2010.10.001","article-title":"Rheumatoid arthritis","volume":"24","author":"L Carmona","year":"2010","journal-title":"Best Pract. Res. Clin. Rheumatol"},{"key":"ref3","first-page":"1261","article-title":"Prevalence of doctor diagnosed arthritis and arthritis attributable activity limitation\u2014United States, 2007\u20132009","volume":"59","year":"2010","journal-title":"MMWR Morb. Mortal. Wkly. Rep"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(10)60826-4","article-title":"Rheumatoid arthritis","volume":"376","author":"DL Scott","year":"2012","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.joca.2012.08.027","article-title":"Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review","volume":"12","author":"BJ de Lange-Brokaar","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"ref6","first-page":"295","article-title":"The mouse model of collagen-induced arthritis","volume":"102","author":"DD Brand","year":"2004","journal-title":"Methods Mol. Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.pathophys.2005.07.011","article-title":"Animal models of rheumatoid arthritis and their relevance to human disease","volume":"12","author":"K Kannan","year":"2005","journal-title":"Pathophysiology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10067-012-2041-1","article-title":"Advances in research on animal models of rheumatoid arthritis","volume":"32","author":"Y Hu","year":"2013","journal-title":"Clin. Rheumatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.autrev.2011.04.010","article-title":"Anti-TNF therapy: safety aspects of taking the risk","volume":"10","author":"H Rosenblum","year":"2011","journal-title":"Autoimmun. Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2174\/157339711794474620","article-title":"Choice of biologic therapy for patients with rheumatoid arthritis: the infection perspective","volume":"7","author":"FD Keyser","year":"2011","journal-title":"Curr. Rheumatol. Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1126\/science.1223490","article-title":"Interactions between the microbiota and the immune system","volume":"336","author":"LV Hooper","year":"2012","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"a010074","DOI":"10.1101\/cshperspect.a010074","article-title":"Probiotics: properties, examples, and specific applications","volume":"3","author":"J Behnsen","year":"2013","journal-title":"Cold Spring Harb. Perspect Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev-food-022510-133640","article-title":"Mucosal vaccination and therapy with genetically modified lactic acid bacteria","volume":"2","author":"J Wells","year":"2011","journal-title":"Annu. Rev. Food Sci. Technol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.tibtech.2011.05.002","article-title":"Recombinant lactic acid bacteria as mucosal biotherapeutic agents","volume":"10","author":"C Daniel","year":"2011","journal-title":"Trends Biotechnol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"7190","DOI":"10.1128\/IAI.72.12.7190-7201.2004","article-title":"Evolutionary and functional relationships of colonization factor antigen I and other class 5 adhesive fimbriae of enterotoxigenic <italic>Escherichia coli<\/italic>","volume":"72","author":"RP Anantha","year":"2004","journal-title":"Infect. Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1128\/IAI.63.12.4933-4938.1995","article-title":"Immune responses to novel <italic>Escherichia coli<\/italic> and <italic>Salmonella typhimurium<\/italic> vectors that express colonization factor antigen I (CFA\/I) of enterotoxigenic <italic>E<\/italic>. <italic>coli<\/italic> in the absence of the CFA\/I positive regulator <italic>cfaR<\/italic>","volume":"63","author":"S Wu","year":"1995","journal-title":"Infect. Immun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1099\/mic.0.2008\/019265-0","article-title":"Shuttle expression plasmids for genetic studies in <italic>Streptococcus mutans<\/italic>","volume":"154","author":"I Biswas","year":"2008","journal-title":"Microbiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.plasmid.2008.12.001","article-title":"Incorporation of nisI-mediated nisin immunity improves vector-based nisin-controlled gene expression in lactic acid bacteria","volume":"61","author":"GM Oddone","year":"2009","journal-title":"Plasmid"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.4049\/jimmunol.1100530","article-title":"Segregated regulatory CD39<sup>+<\/sup> CD4<sup>+<\/sup> T cell function: TGF-\u03b2-producing Foxp3<sup>-<\/sup> and IL-10-producing Foxp3<sup>+<\/sup> cells are interdependent for protection against collagen-induced arthritis","volume":"187","author":"I Kochetkova","year":"2011","journal-title":"J. Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"7144","DOI":"10.4049\/jimmunol.0902739","article-title":"IL-35 stimulation of CD39<sup>+<\/sup> regulatory T cells confers protection against collagen II-induced arthritis via the production of IL-10","volume":"184","author":"I Kochetkova","year":"2010","journal-title":"J. Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"804","DOI":"10.4049\/jimmunol.1302018","article-title":"Oral <italic>Escherichia coli<\/italic> colonization factor antigen I (CFA\/I) fimbriae ameliorate arthritis via IL-35, not IL-27","volume":"192","author":"I Kochetkova","year":"2014","journal-title":"J. Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1128\/JB.149.1.264-275.1982","article-title":"Mapping of a plasmid, coding for colonization factor antigen I and heat-stable enterotoxin production, isolated from an enterotoxigenic strain of <italic>Escherichia coli<\/italic>","volume":"149","author":"HR Smith","year":"1982","journal-title":"J. Bacteriol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"10793","DOI":"10.1073\/pnas.0812843106","article-title":"Structure of CFA\/I fimbriae from enterotoxigenic <italic>Escherichia coli<\/italic>","volume":"106","author":"YF Li","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.4049\/jimmunol.178.3.1791","article-title":"Regulatory T cell vaccination without autoantigen protects against experimental autoimmune encephalomyelitis","volume":"178","author":"J Ochoa-Rep\u00e1raz","year":"2007","journal-title":"J. Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2174\/187153007781662549","article-title":"Tolerance in the absence of auto-antigen","volume":"7","author":"DW Pascual","year":"2007","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1749-6632.2009.05067.x","article-title":"Actobiotics as a novel method for cytokine delivery","volume":"1182","author":"L Steidler","year":"2009","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1128\/AEM.03221-12","article-title":"Bioluminescent <italic>Lactobacillus plantarum<\/italic> and <italic>Lactococcus lactis<\/italic> to study spatial and temporal persistence in living mice","volume":"79","author":"C Daniel","year":"2013","journal-title":"Appl. Environ. Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1146\/annurev-immunol-020711-075043","article-title":"Induced CD4<sup>+<\/sup>Foxp3<sup>+<\/sup> regulatory T cells in immune tolerance","volume":"30","author":"AM Bilate","year":"2012","journal-title":"Annu. Rev. Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1182\/blood-2006-12-064527","article-title":"Expression of ectonucleotidase CD39 by Foxp3<sup>+<\/sup> Treg cells: hydrolysis of extracellular ATP and immune suppression","volume":"110","author":"G Borsellino","year":"2007","journal-title":"Blood"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1084\/jem.20062512","article-title":"Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression","volume":"204","author":"S Deaglio","year":"2007","journal-title":"J. Exp. Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.4049\/jimmunol.181.4.2741","article-title":"Vaccination without auto-antigen protects against collagen II-induced arthritis via immune deviation and regulatory T cells","volume":"181","author":"I Kochetkova","year":"2008","journal-title":"J. Immunol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0117825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T12:08:39Z","timestamp":1598702919000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0117825"}},"subtitle":[],"editor":[{"given":"Deyu","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,1,28]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0117825","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,28]]}}}