{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:13:52Z","timestamp":1789985632837,"version":"4.0.1"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T00:00:00Z","timestamp":1426118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0117848","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T13:50:47Z","timestamp":1426168247000},"page":"e0117848","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Genetic Background Effects on Disease Onset and Lifespan of the Mutant Dynactin p150Glued Mouse Model of Motor Neuron Disease"],"prefix":"10.1371","volume":"10","author":[{"given":"Terry D.","family":"Heiman-Patterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth P.","family":"Blankenhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger B.","family":"Sher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliann","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith C.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy I.","family":"Jeffrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo M.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1212\/01.wnl.0000296811.19811.db","article-title":"Genetics of familial amyotrophic lateral sclerosis","volume":"70","author":"PN Valdmanis","year":"2008","journal-title":"Neurology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00401-012-1022-4","article-title":"The genetics and neuropathology of amyotrophic lateral sclerosis","volume":"124","author":"A Al-Chalabi","year":"2012","journal-title":"Acta Neuropathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/WCO.0b013e328356d328","article-title":"Amyotrophic lateral sclerosis","volume":"25","author":"AC Ludolph","year":"2012","journal-title":"Curr Opin Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1056\/NEJM199105163242001","article-title":"Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity","volume":"324","author":"T Siddique","year":"1991","journal-title":"N. Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"DR Rosen","year":"1993","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrneurol.2011.150","article-title":"Clinical genetics of amyotrophic lateral sclerosis: what do we really know?","volume":"7","author":"PM Andersen","year":"2011","journal-title":"Nat. Rev Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.pnpbp.2010.08.006","article-title":"ALS pathogenesis: recent insights from genetics and mouse models","volume":"35","author":"V Swarup","year":"2011","journal-title":"Prog Neuro-Psychopharmacol Biol Psych"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/brain\/awr365","article-title":"Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72","volume":"135","author":"J Cooper-Knock","year":"2012","journal-title":"Brain"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1093\/hmg\/7.13.2045","article-title":"Recessive amyotrophic lateral sclerosis families with the D90A SOD1 mutation share a common founder: evidence for a linked protective factor","volume":"7","author":"A Al-Chalabi","year":"1998","journal-title":"Hum Mol Genet"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"357.e7","DOI":"10.1016\/j.neurobiolaging.2012.07.017","article-title":"Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1","volume":"34","author":"KB Ahmeti","year":"2013","journal-title":"Neurobiol Aging"},{"key":"ref11","first-page":"1271","article-title":"Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis","volume":"145","author":"MC Dal Canto","year":"1994","journal-title":"Am J Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2005.02.006","article-title":"Background and Gender Effects on Survival in the TgN (SOD1-G93A)1Gur mouse model of ALS","volume":"236","author":"Patterson TD Heiman","year":"2005","journal-title":"J Neuro Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/17482968.2010.550626","article-title":"Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: a window of opportunity in the search for genetic modifiers","volume":"12","author":"TD Heiman-Patterson","year":"2011","journal-title":"Amyotroph Lateral Scler"},{"key":"ref14","first-page":"1","article-title":"A Major QTL on Mouse Chromosome 17 Resulting in Lifespan Variability in SOD1-G93A Transgenic Mouse Models of Amyotrophic Lateral Sclerosis","volume":"10","author":"R Sher","year":"2014","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/ana.20468","article-title":"Distal spinal and bulbar muscular atrophy caused by dynactin mutation","volume":"57","author":"I Puls","year":"2005","journal-title":"Ann Neurol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1523\/JNEUROSCI.4231-07.2008","article-title":"Motor neuron disease occurring in a mutant Dynactin mouse model is characterized by defects in vesicular trafficking","volume":"28","author":"FM Laird","year":"2008","journal-title":"Journal of Neuroscience"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/ana.22642","article-title":"Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis","volume":"70","author":"EP Blankenhorn","year":"2011","journal-title":"Ann Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nrg1206","article-title":"The nature and identification of quantitative trait loci: a community\u2019s view","volume":"4","author":"O Abiola","year":"2003","journal-title":"Nat Rev Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1212\/01.WNL.0000134608.83927.B1","article-title":"Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS","volume":"63","author":"C Munch","year":"2004","journal-title":"Neurology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1073\/pnas.92.5.1634","article-title":"The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1)","volume":"92","author":"CM Waterman-Storer","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"12180","DOI":"10.1073\/pnas.94.22.12180","article-title":"The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport","volume":"94","author":"CM Waterman-Storer","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"e1001611","DOI":"10.1371\/journal.pbio.1001611","article-title":"Dynactin subunit p150 (Glued) is a neuron specific anti-catastrophe factor","volume":"11","author":"JE Lazarus","year":"2013","journal-title":"PLos Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.pneurobio.2008.01.001","article-title":"Transgenics, toxicity, and therapeutics in rodent models of mutant SOD1-mediated familial ALS","volume":"85","author":"BJ Turner","year":"2008","journal-title":"Progress in Neurobiology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.bbadis.2006.03.006","article-title":"Transgenic mouse models of amyotrophic lateral sclerosis","volume":"1762","author":"J-P Julien","year":"2006","journal-title":"Biochimica et Biophysica Acta \u2013Molecular Basis of Disease"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s00401-005-1021-9","article-title":"Impairment of axonal transport in the axon hillock and the initial segment of anterior horn neurons in transgenic mice with a G93A mutant SOD1 gene","volume":"110","author":"S Sasaki","year":"2005","journal-title":"Acta Neuropathol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2174\/187152710791556096","article-title":"Unraveling the complexity of amyotrophic lateral sclerosis: recent advances from the transgenic mutant SOD1 mice","volume":"9","author":"M Peviani","year":"2010","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1093\/hmg\/ddt528","article-title":"Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models","volume":"23","author":"J Magran\u00e9","year":"2014","journal-title":"Hum Mol Genet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0117848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T04:20:01Z","timestamp":1540009201000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0117848"}},"subtitle":[],"editor":[{"given":"Huaibin","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,12]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0117848","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,12]]}}}