{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:24:46Z","timestamp":1760646286204},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0117935","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T20:13:54Z","timestamp":1422908034000},"page":"e0117935","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nasal Associated Lymphoid Tissue of the Syrian Golden Hamster Expresses High Levels of PrPC"],"prefix":"10.1371","volume":"10","author":[{"given":"Melissa D.","family":"Clouse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald A.","family":"Shikiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason C.","family":"Bartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony E.","family":"Kincaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0092-8674(87)90150-4","article-title":"Scrapie prion protein contains a phosphatidylinositol glycolipid","volume":"51","author":"N Stahl","year":"1987","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1212\/WNL.42.1.149","article-title":"Nearly ubiquitous tissue distribution of the scrapie agent precursor protein","volume":"42","author":"PE Bendheim","year":"1992","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0306-4522(02)00155-0","article-title":"Selective expression of prion protein in peripheral tissues of the adult mouse","volume":"113","author":"MJ Ford","year":"2002","journal-title":"Neuroscience"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s004410051036","article-title":"Distribution and submicroscopic immunogold localization of cellular prion protein (PrP<sup>C<\/sup>) in extracerebral tissues","volume":"292","author":"JG Fournier","year":"1998","journal-title":"Cell Tissue Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1099\/0022-1317-76-10-2583","article-title":"A cellular form of prion protein (PrP<sup>C<\/sup>) exists in many non-neuronal tissues of sheep","volume":"76","author":"M Horiuchi","year":"1995","journal-title":"J Gen Virol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/356577a0","article-title":"Normal development and behavior of mice lacking the neuronal cell-surface PrP protein","volume":"356","author":"H B\u00fceler","year":"1992","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1126\/science.6801762","article-title":"Novel proteinaceous infectious particles cause scrapie","volume":"216","author":"SB Prusiner","year":"1982","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/0092-8674(93)90360-3","article-title":"Mice devoid of PrP are resistant to scrapie","volume":"73","author":"H B\u00fceler","year":"1993","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1128\/JVI.76.11.5759-5768.2002","article-title":"Retrograde transport of transmissible mink encephalopathy within descending motor tracts","volume":"76","author":"JC Bartz","year":"2002","journal-title":"J Virol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/JVI.77.1.583-591.2003","article-title":"Rapid prion neuroinvasion following tongue infection","volume":"77","author":"JC Bartz","year":"2003","journal-title":"J Virol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0021-9975(78)90059-2","article-title":"Pathogenesis of mouse scrapie: effect of route of inoculation on infectivity titres and dose-response curves","volume":"88","author":"RH Kimberlin","year":"1978","journal-title":"J Comp Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1099\/0022-1317-67-2-255","article-title":"Pathogenesis of scrapie (strain 263K) in hamsters infected intracerebrally, intraperitoneally or intraocularly","volume":"67","author":"RH Kimberlin","year":"1986","journal-title":"J Gen Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1128\/JVI.02649-06","article-title":"The nasal cavity is a route for prion infection in hamsters","volume":"81","author":"AE Kincaid","year":"2007","journal-title":"J Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1001257","DOI":"10.1371\/journal.ppat.1001257","article-title":"Aerosols transmit prions to immunocompetent and immunodeficient mice","volume":"7","author":"J Haybaeck","year":"2011","journal-title":"PLoS Pathogens"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1128\/JVI.02852-12","article-title":"Aerosol transmission of chronic wasting disease in white-tailed deer","volume":"87","author":"ND Denker","year":"2013","journal-title":"J Virol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1354\/vp.45-1-7","article-title":"Experimental transmission of US scrapie agent by nasal, peritoneal, and conjunctival routes to genetically susceptible sheep","volume":"45","author":"AN Hamir","year":"2008","journal-title":"Vet Pathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00401-008-0474-z","article-title":"Neuroinvasion of the 263K scrapie strain after intranasal administration occurs through olfactory-unrelated pathways","volume":"117","author":"M Sbriccoli","year":"2008","journal-title":"Acta Neuropathol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/infdis\/117.1.15","article-title":"Pathogenesis of scrapie virus infection in the mouse","volume":"117","author":"CM Eklund","year":"1967","journal-title":"J Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1099\/0022-1317-66-12-2517","article-title":"Agent replication in a long incubation period model of mouse scrapie","volume":"66","author":"ME Bruce","year":"1985","journal-title":"J Gen Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/infdis\/146.5.657","article-title":"Natural infection of Suffolk sheep with scrapie virus","volume":"146","author":"WJ Hadlow","year":"1982","journal-title":"J Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF03403528","article-title":"High prion and PrP<sup>Sc<\/sup> levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene","volume":"1","author":"H B\u00fceler","year":"1994","journal-title":"Mol Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.4049\/jimmunol.0802695","article-title":"The effects of host age on follicular dendritic cell status dramatically impair scrapie agent neuroinvasion in aged mice","volume":"183","author":"KL Brown","year":"2009","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"12731","DOI":"10.1128\/JVI.01930-12","article-title":"Rapid transepithelial transport of prions following inhalation","volume":"86","author":"AE Kincaid","year":"2012","journal-title":"J Virol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1164\/ajrccm.156.4.97-03017","article-title":"Comparison of murine nasal-associated lymphoid tissue and Peyer\u2019s patch","volume":"156","author":"PL Heritage","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1128\/JVI.00243-10","article-title":"Co-infecting prion strains compete for a limiting cellular resource","volume":"84","author":"RA Shikiya","year":"2010","journal-title":"J Virol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1083\/jcb.77.1.148","article-title":"Anatomy of germinal centers in mouse spleen, with special reference to \u201cfollicular dendritic cells\u201d","volume":"77","author":"LL Chen","year":"1978","journal-title":"J Cell Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bbrc.2009.07.163","article-title":"Enhancement of protein misfolding cyclic amplification by using concentrated cellular prion protein source","volume":"388","author":"CE Mays","year":"2009","journal-title":"Biochem Biophysl Res Commun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7586","DOI":"10.1128\/JVI.69.12.7586-7592.1995","article-title":"Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent","volume":"69","author":"S Sakaguchi","year":"1995","journal-title":"J Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"11858","DOI":"10.1128\/JVI.79.18.11858-11863.2005","article-title":"Extraneural prion neuroinvasion without lymphoreticular system infection","volume":"79","author":"JC Bartz","year":"2005","journal-title":"J Virol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1128\/JVI.61.10.3235-3240.1987","article-title":"Temporal distribution of transmissible mink encephalopathy virus in mink inoculated subcutaneously","volume":"61","author":"WJ Hadlow","year":"1987","journal-title":"J Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1099\/0022-1317-80-11-3035","article-title":"Pathogenesis of the oral route of infection of mice with scrapie and bovine spongiform encephalopathy agents","volume":"80","author":"T Maignien","year":"1999","journal-title":"J Gen Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"14129","DOI":"10.1021\/bi061526k","article-title":"The stoichiometry of host PrP<sup>C<\/sup> glycoforms modulates the efficiency of PrP<sup>Sc<\/sup> formation in vitro","volume":"45","author":"KA Nishina","year":"2006","journal-title":"Biochemistry"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"21479","DOI":"10.1074\/jbc.272.34.21479","article-title":"Blockade of glycosylation promotes acquisition of scrapie-like properties by the prion protein in cultured cells","volume":"272","author":"S Lehmann","year":"1997","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"9018","DOI":"10.1016\/S0021-9258(17)38339-4","article-title":"Impaired intracellular migration and altered solubility of nonglycosylated glycoproteins of vesicular stomatitis virus and Sindbis virus","volume":"252","author":"R Leavitt","year":"1977","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"19173","DOI":"10.1074\/jbc.270.32.19173","article-title":"Truncated forms of the human prion protein in normal brain and in prion diseases","volume":"270","author":"SG Chen","year":"1995","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"10252","DOI":"10.1074\/jbc.M109.083857","article-title":"Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent","volume":"285","author":"M Dron","year":"2010","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1074\/jbc.M113.502351","article-title":"A new paradigm for enzymatic control of \u03b1-cleavage and \u03b2-cleavage of the prion protein","volume":"289","author":"AJ McDonald","year":"2014","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1046\/j.1471-4159.2002.00909.x","article-title":"Heterogeneity of normal prion protein in two-dimensional immunoblot: presence of various glycosylated and truncated forms","volume":"81","author":"T Pan","year":"2002","journal-title":"J Neurochem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0117935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T07:06:22Z","timestamp":1651129582000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0117935"}},"subtitle":[],"editor":[{"given":"Ilia V","family":"Baskakov","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,2]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0117935","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,2]]}}}