{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:56:21Z","timestamp":1792634181286,"version":"4.5.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0118173","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T14:25:53Z","timestamp":1427898353000},"page":"e0118173","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":156,"title":["Would Older Adults with Mild Cognitive Impairment Adhere to and Benefit from a Structured Lifestyle Activity Intervention to Enhance Cognition?: A Cluster Randomized Controlled Trial"],"prefix":"10.1371","volume":"10","clinical-trial-number":[{"clinical-trial-number":"chictr-trc-11001359","registry":"10.18810\/chictr"}],"author":[{"given":"Linda Chiu-wa","family":"Lam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Chi","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada Wai-tung","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward Man-fuk","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","article-title":"The global prevalence of dementia: a systematic review and metaanalysis","volume":"9","author":"M Prince","year":"2013","journal-title":"Alzheimers Dement"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1371\/journal.pmed.0040338","article-title":"Cholinesterase Inhibitors in Mild Cognitive Impairment: A Systematic Review of Randomised Trials","volume":"4","author":"R Raschetti","year":"2007","journal-title":"PLoS Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1192\/bjp.bp.113.127811","article-title":"Treatment for mild cognitive impairment: systematic review","volume":"203","author":"C Cooper","year":"2013","journal-title":"Br J Psychiatry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1212\/WNL.0b013e3181b04ae3","article-title":"Cognitive activities delay onset of memory decline in persons who develop dementia","volume":"73","author":"CB Hall","year":"2009","journal-title":"Neurology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1212\/WNL.0b013e31824f8c03","article-title":"Influence of late-life cognitive activity on cognitive health","volume":"78","author":"RS Wilson","year":"2012","journal-title":"Neurology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/PSY.0b013e3181d14633","article-title":"Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials","volume":"72","author":"PJ Smith","year":"2010","journal-title":"Psychosom Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1001\/jamainternmed.2013.359","article-title":"Effects of the Finnish Alzheimer disease exercise trial (FINALEX): a randomized controlled trial","volume":"173","author":"KH Pitkala","year":"2013","journal-title":"JAMA Intern Med"},{"key":"ref8","first-page":"743","article-title":"Mild cognitive impairment and dementia: the importance of modifiable risk factors","volume":"108","author":"T Etgen","year":"2011","journal-title":"Dtsch Arztebl Int"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1532-5415.2008.02167.x","article-title":"A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study","volume":"57","author":"GE Smith","year":"2009","journal-title":"J Am Geriatr Soc"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/epirev\/mxn010","article-title":"Dementia prevention: methodological explanations for inconsistent results","volume":"30","author":"N Coley","year":"2008","journal-title":"Epidemiol Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.biopsych.2011.07.036","article-title":"Multiple biological pathways link cognitive lifestyle to protection from dementia","volume":"71","author":"MJ Valenzuela","year":"2012","journal-title":"Biol Psychiatry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2318-11-27","article-title":"Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: the Seniors Health and Activity Research Program Pilot (SHARP-P) study, a randomized controlled trial","volume":"11","author":"C Legault","year":"2011","journal-title":"BMC Geriatr"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1365-2796.2004.01380.x","article-title":"Mild cognitive impairment\u2014beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment","volume":"256","author":"B Winblad","year":"2004","journal-title":"J Intern Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/WAD.0b013e3181eb2f42","article-title":"Combined clinical and cognitive criteria to identify mild cognitive impairment in a southern chinese community","volume":"24","author":"LC Lam","year":"2001","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"Suppl 1","key":"ref15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1017\/S1041610297004870","article-title":"Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type","volume":"9","author":"JC Morris","year":"1997","journal-title":"Int Psychogeriatr"},{"key":"ref16","first-page":"123","article-title":"Classification of late-life leisure activities among elderly Chinese in Hong Kong","volume":"21","author":"GT Leung","year":"2011","journal-title":"East Asian Arch Psychiatry"},{"key":"ref17","first-page":"474","article-title":"The reliability and validity of the Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog) among the elderly Chinese in Hong Kong","volume":"29","author":"LW Chu","year":"2000","journal-title":"Ann Acad Med Singapore"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1212\/WNL.50.4.1002","article-title":"Prevalence of dementia in Chinese elderly in Hong Kong","volume":"50","author":"HF Chiu","year":"1998","journal-title":"Neurology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000094543","article-title":"Reduced semantic fluency as an additional screening tool for subjects with questionable dementia","volume":"22","author":"LC Lam","year":"2006","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/gps.1580","article-title":"Validation of a memory inventory for the assessment of awareness of memory deficits in Alzheimer's disease in Chinese elderly","volume":"21","author":"VW Lui","year":"2006","journal-title":"Int J Geriatr Psychiatry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/gps.1098","article-title":"Depression in dementia: a comparative and validation study of four brief scales in the elderly Chinese","volume":"19","author":"CK Lam","year":"2004","journal-title":"Int J Geriatr Psychiatry"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000086612","article-title":"Functional disabilities profile of chinese elderly people with Alzheimer's disease\u2014a validation study on the chinese version of the disability assessment for dementia","volume":"20","author":"CC Mok","year":"2005","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/sim.3527","article-title":"Sample size requirements to detect an intervention by time interaction in longitudinal cluster randomized clinical trials","volume":"28","author":"M. Heo","year":"2009","journal-title":"Statistics in Medicine"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1002\/sim.2714","article-title":"Sizing a trial to alter the trajectory of health behaviours: methods, parameter estimates, and their application","volume":"26","author":"D.M. Murray","year":"2007","journal-title":"Statistics in Medicine"},{"key":"ref25","first-page":"568 e515","article-title":"A 1-year randomized controlled trial comparing mind body exercise (Tai Chi) with stretching and toning exercise on cognitive function in older Chinese adults at risk of cognitive decline","volume":"13","author":"LC Lam","year":"2012","journal-title":"J Am Med Dir Assoc"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1001\/jama.300.9.1027","article-title":"Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial","volume":"300","author":"NT Lautenschlager","year":"2008","journal-title":"JAMA"},{"key":"ref27","first-page":"861893","article-title":"Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial","author":"LS Nagamatsu","year":"2013","journal-title":"J Aging Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2377-12-128","article-title":"Effects of multicomponent exercise on cognitive function in older adults with amnestic mild cognitive impairment: a randomized controlled trial","volume":"12","author":"T Suzuki","year":"2012","journal-title":"BMC Neurol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1001\/jamainternmed.2013.189","article-title":"The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults","volume":"173","author":"DE Barnes","year":"2013","journal-title":"JAMA Intern Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"f576","DOI":"10.1136\/bmj.f576","article-title":"Promotion of physical activity and fitness in sedentary patients with Parkinson's disease: randomised controlled trial","volume":"346","author":"M van Nimwegen","year":"2013","journal-title":"BMJ"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0118173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:25:12Z","timestamp":1588973112000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0118173"}},"subtitle":[],"editor":[{"given":"Alan","family":"Winston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,31]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0118173","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,31]]}}}