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Stewart","year":"1986","journal-title":"J Bacteriol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1186\/gb-2012-13-3-r23","article-title":"Efficient and robust RNA-seq process for cultured bacteria and complex community transcriptomes","volume":"13","author":"G Giannoukos","year":"2012","journal-title":"Genome Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-seq","volume":"25","author":"C Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"C Trapnell","year":"2012","journal-title":"Nature 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Bacteriol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1128\/IAI.56.11.2891-2895.1988","article-title":"Iron-regulated hemolysin production and utilization of heme and hemoglobin by Vibrio cholerae","volume":"56","author":"JA Stroebner","year":"1998","journal-title":"Infect Immun"},{"key":"ref48","article-title":"Experiments in molecular genetics","author":"JH Miller","year":"1972"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1128\/IAI.00039-12","article-title":"Mlp24 (McpX) of Vibrio cholerae implicated in pathogenicity functions as a chemoreceptor for multiple amino acids","volume":"80","author":"S Nishiyama","year":"2012","journal-title":"Infect Immun"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1046\/j.1365-2958.2001.02518.x","article-title":"Overlapping binding sites for the virulence gene regulators AphA, AphB and cAMP-CRP at the Vibrio cholerae tcpPH promoter","volume":"41","author":"G Kovacikova","year":"2001","journal-title":"Mol Microbiol"},{"key":"ref51","first-page":"2298","article-title":"Nucleotide sequence and spatiotemporal expression of the Vibrio cholerae vieSAB genes during infection","volume":"180","author":"SH Lee","year":"1998","journal-title":"Infect Immun"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1128\/JB.184.15.4104-4113.2002","article-title":"The Vibrio cholerae vieSAB locus encodes a pathway contributing to cholera toxin production","volume":"184","author":"AD Tischler","year":"2002","journal-title":"J Bacteriol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1128\/IAI.73.9.5873-5882.2005","article-title":"Cyclic diguanylate regulates Vibrio cholerae virulence gene expression","volume":"73","author":"AD Tischler","year":"2005","journal-title":"Infect 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Liang","year":"2007","journal-title":"Microbiology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1128\/JB.00092-09","article-title":"Cell Envelope Perturbation Induces Oxidative Stress and Changes in Iron Homeostasis in Vibrio cholerae","volume":"191","author":"AE Sikora","year":"2009","journal-title":"J Bacteriol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev.micro.55.1.591","article-title":"Periplasmic stress and ECF Sigma factors","volume":"55","author":"TL Raivio","year":"2001","journal-title":"Ann Rev Microbiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.1365-2958.2005.04625.x","article-title":"Envelope stress responses and Gram-negative bacterial pathogenesis","volume":"56","author":"TL Raivio","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.femsle.2004.08.039","article-title":"Chemotaxis in 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