{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:23:35Z","timestamp":1776356615912,"version":"3.51.2"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0118405","type":"journal-article","created":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T19:08:48Z","timestamp":1424718528000},"page":"e0118405","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Isolation of Highly Active Monoclonal Antibodies against Multiresistant Gram-Positive Bacteria"],"prefix":"10.1371","volume":"10","author":[{"given":"Friederike S.","family":"Rossmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Laverde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Kropec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Romero-Saavedra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Meyer-Buehn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Huebner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,2,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000","volume":"348","author":"GS Martin","year":"2003","journal-title":"N Engl J Med"},{"key":"ref2","unstructured":"Centers for Disease Control and Prevention CDC (2013) Antibiotic resistance threats in the United States 2013. wwwcdcgov: 1\u2013114. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/drugresistance\/threat-report-2013\/\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/drugresistance\/threat-report-2013\/<\/ext-link>. Accessed 3 July 2014."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1177\/039139880502801105","article-title":"Implant infections due to enterococci: role of capsular polysaccharides and biofilm","volume":"28","author":"F Fabretti","year":"2005","journal-title":"Int J Artif Organs"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"8753","DOI":"10.3390\/ijms15058753","article-title":"Colonization and Infection of the Skin by <italic>S. aureus<\/italic>: Immune System Evasion and the Response to Cationic Antimicrobial Peptides","volume":"15","author":"S Ryu","year":"2014","journal-title":"IJMS"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1111\/j.1365-2958.2008.06587.x","article-title":"Glycolipids are involved in biofilm accumulation and prolonged bacteraemia in <italic>Enterococcus faecalis<\/italic>","volume":"71","author":"C Theilacker","year":"2009","journal-title":"Mol Microbiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1086\/381150","article-title":"A putative sugar-binding transcriptional regulator in a novel gene locus in <italic>Enterococcus faecalis<\/italic> contributes to production of biofilm and prolonged bacteremia in mice","volume":"189","author":"M Hufnagel","year":"2004","journal-title":"J INFECT DIS"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/infdis\/jis022","article-title":"Protection against <italic>Staphylococcus aureus<\/italic> by antibody to the polyglycerolphosphate backbone of heterologous lipoteichoic acid","volume":"205","author":"C Theilacker","year":"2012","journal-title":"J INFECT DIS"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e17839","DOI":"10.1371\/journal.pone.0017839","article-title":"Serodiversity of Opsonic Antibodies against <italic>Enterococcus faecalis<\/italic> -Glycans of the Cell Wall Revisited","volume":"6","author":"C Theilacker","year":"2011","journal-title":"PLoS ONE"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Tosato G, Cohen JI (2007) Generation of Epstein-Barr Virus (EBV)-immortalized B cell lines. Current Protocols in Immunology Chapter 7: Unit7.22. <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1002\/0471142735.im0722s76\" xlink:type=\"simple\">10.1002\/0471142735.im0722s76<\/ext-link><\/comment>","DOI":"10.1002\/0471142735.im0722s76"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1128\/IAI.74.5.2742-2750.2006","article-title":"Characterization of the opsonic and protective activity against <italic>Staphylococcus aureus<\/italic> of fully human monoclonal antibodies specific for the bacterial surface polysaccharide poly-N-acetylglucosamine","volume":"74","author":"C Kelly-Quintos","year":"2006","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1128\/IAI.66.9.4137-4142.1998","article-title":"Production and characterization of a set of mouse-human chimeric immunoglobulin G (IgG) subclass and IgA monoclonal antibodies with identical variable regions specific for <italic>Pseudomonas aeruginosa<\/italic> serogroup O6 lipopolysaccharide","volume":"66","author":"MJ Preston","year":"1998","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.4049\/jimmunol.173.9.5671","article-title":"Human monoclonal antibodies to <italic>Pseudomonas aeruginosa<\/italic> alginate that protect against infection by both mucoid and nonmucoid strains","volume":"173","author":"GB Pier","year":"2004","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1084\/jem.166.5.1351","article-title":"Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies","volume":"166","author":"M Br\u00fcggemann","year":"1987","journal-title":"J Exp Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e110953","DOI":"10.1371\/journal.pone.0110953","article-title":"Synthetic Teichoic Acid Conjugate Vaccine against Nosocomial Gram-Positive Bacteria","volume":"9","author":"D Laverde","year":"2014","journal-title":"PLoS ONE"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.4049\/jimmunol.181.12.8258","article-title":"A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact <italic>Streptococcus pneumoniae<\/italic> versus pneumococcal conjugate vaccine","volume":"181","author":"Q Chen","year":"2008","journal-title":"The Journal of Immunology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/infdis\/173.1.142","article-title":"Quantitative determination of antibodies to type III group B streptococcal polysaccharide","volume":"173","author":"HK Guttormsen","year":"1996","journal-title":"J INFECT DIS"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e91863","DOI":"10.1371\/journal.pone.0091863","article-title":"Cell-Wall Glycolipid Mutations and Their Effects on Virulence of <italic>E. faecalis<\/italic> in a Rat Model of Infective Endocarditis","volume":"9","author":"C Haller","year":"2014","journal-title":"PLoS ONE"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/472032a","article-title":"Fix the antibiotics pipeline","volume":"472","author":"MA Cooper","year":"2011","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nm0503-517","article-title":"Novel strategies for the treatment of sepsis","volume":"9","author":"NC Riedemann","year":"2003","journal-title":"Nat Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1172\/JCI200319523","article-title":"The enigma of sepsis","volume":"112","author":"NC Riedemann","year":"2003","journal-title":"J Clin Invest"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1517\/14728214.12.4.525","article-title":"Monoclonal antibodies for prophylaxis and therapy of infectious diseases","volume":"12","author":"J Meulen ter","year":"2007","journal-title":"Expert Opin Emerg Drugs"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrd3003","article-title":"The safety and side effects of monoclonal antibodies","volume":"9","author":"TT Hansel","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nrmicro974","article-title":"Passive antibody therapy for infectious diseases","volume":"2","author":"A Casadevall","year":"2004","journal-title":"Nat Rev Micro"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1741-7015-11-4","article-title":"Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases","volume":"11","author":"M Flego","year":"2013","journal-title":"BMC Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"6868","DOI":"10.1128\/IAI.73.10.6868-6876.2005","article-title":"Poly-N-acetylglucosamine production in <italic>Staphylococcus aureus<\/italic> is essential for virulence in murine models of systemic infection","volume":"73","author":"A Kropec","year":"2005","journal-title":"Infect Immun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/mmi.12551","article-title":"Differential localization of LTA synthesis proteins and their interaction with the cell division machinery in <italic>Staphylococcus aureus<\/italic>","volume":"92","author":"NT Reichmann","year":"2014","journal-title":"Mol Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1128\/IAI.64.8.3318-3325.1996","article-title":"Influence of lipoteichoic acid structure on recognition by the macrophage scavenger receptor","volume":"64","author":"JW Greenberg","year":"1996","journal-title":"Infect Immun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1128\/IAI.69.5.3423-3426.2001","article-title":"Key role of teichoic acid net charge in <italic>Staphylococcus aureus<\/italic> colonization of artificial surfaces","volume":"69","author":"M Gross","year":"2001","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1073\/pnas.91.5.1863","article-title":"The type I macrophage scavenger receptor binds to gram-positive bacteria and recognizes lipoteichoic acid","volume":"91","author":"DW Dunne","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.intimp.2009.02.008","article-title":"Safety and pharmacokinetics of a chimerized anti-lipoteichoic acid monoclonal antibody in healthy adults","volume":"9","author":"LE Weisman","year":"2009","journal-title":"Int Immunopharmacol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1128\/AAC.01565-08","article-title":"A Phase 1\/2 Double Blind, Placebo-Controlled, Dose Escalation, Safety, and Pharmacokinetic Study in Very Low Birth Weight Neonates of Pagibaximab (BSYX-A110), an Anti-Staphylococcal Monoclonal Antibody for the Prevention of Staphylococcal Bloodstream Infections","volume":"53","author":"L Weisman","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1542\/peds.2010-3081","article-title":"A Randomized Study of a Monoclonal Antibody (Pagibaximab) to Prevent Staphylococcal Sepsis","volume":"128","author":"LE Weisman","year":"2011","journal-title":"PEDIATRICS"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1128\/IAI.68.8.4631-4636.2000","article-title":"Prophylactic and therapeutic efficacy of antibodies to a capsular polysaccharide shared among vancomycin-sensitive and -resistant enterococci","volume":"68","author":"J Huebner","year":"2000","journal-title":"Infect Immun"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1128\/IAI.67.3.1213-1219.1999","article-title":"Isolation and chemical characterization of a capsular polysaccharide antigen shared by clinical isolates of <italic>Enterococcus faecalis<\/italic> and vancomycin-resistant <italic>Enterococcus faecium<\/italic>","volume":"67","author":"J Huebner","year":"1999","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"8233","DOI":"10.1128\/JB.01205-07","article-title":"Enterococcal surface protein Esp is important for biofilm formation of <italic>Enterococcus faecium<\/italic> E1162","volume":"189","author":"E Heikens","year":"2007","journal-title":"J Bacteriol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0118405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T06:53:55Z","timestamp":1598770435000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0118405"}},"subtitle":[],"editor":[{"given":"Jan","family":"Kluytmans","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,23]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0118405","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,23]]}}}