{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:10:35Z","timestamp":1782551435075,"version":"3.54.5"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0118451","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T18:14:54Z","timestamp":1426270494000},"page":"e0118451","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Iron Prevents the Development of Experimental Cerebral Malaria by Attenuating CXCR3-Mediated T Cell Chemotaxis"],"prefix":"10.1371","volume":"10","author":[{"given":"Kristin M.","family":"Van Den Ham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Tiemi","family":"Shio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Rainone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie M.","family":"Krawczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Olivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1126\/science.3306918","article-title":"Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria","volume":"237","author":"GE Grau","year":"1987","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0165-2478(90)90113-5","article-title":"Significance of cytokine production and adhesion molecules in malarial immunopathology","volume":"25","author":"GE Grau","year":"1990","journal-title":"Immunol Lett"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1128\/IAI.68.9.5364-5376.2000","article-title":"Immunopathology of cerebral malaria: morphological evidence of parasite sequestration in murine brain microvasculature","volume":"68","author":"J Hearn","year":"2000","journal-title":"Infect Immun"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1073\/pnas.86.14.5572","article-title":"Monoclonal antibody against interferon gamma can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor","volume":"86","author":"GE Grau","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1600-065X.1989.tb00552.x","article-title":"Tumor-necrosis factor and other cytokines in cerebral malaria: experimental and clinical data","volume":"112","author":"GE Grau","year":"1989","journal-title":"Immunol Rev"},{"key":"ref6","first-page":"1121","article-title":"Early microvascular changes in murine cerebral malaria detected in retinal wholemounts","volume":"140","author":"T Chang-Ling","year":"1992","journal-title":"Am J Pathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.ijpara.2006.02.016","article-title":"Immunopathogenesis of cerebral malaria","volume":"36","author":"NH Hunt","year":"2006","journal-title":"Int J Parasitol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.4049\/jimmunol.169.11.6369","article-title":"On the pathogenic role of brain-sequestered alphabeta CD8+ T cells in experimental cerebral malaria","volume":"169","author":"E Belnoue","year":"2002","journal-title":"J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.4049\/jimmunol.170.4.2221","article-title":"Perforin-dependent brain-infiltrating cytotoxic CD8+ T lymphocytes mediate experimental cerebral malaria pathogenesis","volume":"170","author":"J Nitcheu","year":"2003","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.4049\/jimmunol.157.4.1620","article-title":"Participation of lymphocyte subpopulations in the pathogenesis of experimental murine cerebral malaria","volume":"157","author":"DM Yanez","year":"1996","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1073\/pnas.0801544105","article-title":"Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria","volume":"105","author":"GS Campanella","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/eji.200737906","article-title":"CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines","volume":"38","author":"PE Van den Steen","year":"2008","journal-title":"Eur J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1365-3024.2008.01053.x","article-title":"Control of pathogenic CD8+ T cell migration to the brain by IFN-gamma during experimental cerebral malaria","volume":"30","author":"E Belnoue","year":"2008","journal-title":"Parasite Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"968","DOI":"10.4049\/jimmunol.1200688","article-title":"IFN-gamma-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain","volume":"189","author":"A Villegas-Mendez","year":"2012","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1086\/515691","article-title":"Convulsions due to increased permeability of the blood-brain barrier in experimental cerebral malaria can be prevented by splenectomy or anti-T cell treatment","volume":"178","author":"CC Hermsen","year":"1998","journal-title":"J Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.4049\/jimmunol.178.10.6033","article-title":"Cutting edge: conventional dendritic cells are the critical APC required for the induction of experimental cerebral malaria","volume":"178","author":"S deWalick","year":"2007","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"14509","DOI":"10.1073\/pnas.0806727105","article-title":"Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells","volume":"105","author":"RJ Lundie","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.4049\/jimmunol.1201171","article-title":"Cutting edge: Clec9A+ dendritic cells mediate the development of experimental cerebral malaria","volume":"189","author":"L Piva","year":"2012","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.4049\/jimmunol.178.9.5779","article-title":"NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malaria","volume":"178","author":"DS Hansen","year":"2007","journal-title":"J Immunol"},{"issue":"12","key":"ref20","doi-asserted-by":"crossref","first-page":"e1001221","DOI":"10.1371\/journal.ppat.1001221","article-title":"CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo","volume":"6","author":"E Haque","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.4049\/jimmunol.173.5.2942","article-title":"CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion","volume":"173","author":"N Sarween","year":"2004","journal-title":"J Immunol"},{"key":"ref22","first-page":"375","article-title":"The effect of experimental iron-overload on splenic T cell function: analysis using cloning techniques","volume":"68","author":"MF Good","year":"1987","journal-title":"Clin Exp Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1073\/pnas.022630299","article-title":"Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation","volume":"99","author":"G Angelini","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"8440","DOI":"10.1073\/pnas.88.19.8440","article-title":"Direct evidence for in vivo hydroxyl-radical generation in experimental iron overload: an ESR spin-trapping investigation","volume":"88","author":"MJ Burkitt","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nchembio.212","article-title":"Extracellular redox modulation by regulatory T cells","volume":"5","author":"Z Yan","year":"2009","journal-title":"Nat Chem Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1286-4579(02)01541-1","article-title":"Cerebral malaria: the contribution of studies in animal models to our understanding of immunopathogenesis","volume":"4","author":"JB de Souza","year":"2002","journal-title":"Microbes Infect"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1074-7613(03)00052-9","article-title":"Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex","volume":"18","author":"DS Hansen","year":"2003","journal-title":"Immunity"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"e18720","DOI":"10.1371\/journal.pone.0018720","article-title":"CD8+ T cells and IFN-gamma mediate the time-dependent accumulation of infected red blood cells in deep organs during experimental cerebral malaria","volume":"6","author":"C Claser","year":"2011","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.4049\/jimmunol.1000944","article-title":"Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria","volume":"185","author":"FH Amante","year":"2010","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1128\/IAI.00079-10","article-title":"Accumulation of Plasmodium berghei-infected red blood cells in the brain is crucial for the development of cerebral malaria in mice","volume":"78","author":"FG Baptista","year":"2010","journal-title":"Infect Immun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.4049\/jimmunol.1003955","article-title":"Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria","volume":"186","author":"A Haque","year":"2011","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijpara.2010.08.003","article-title":"Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria","volume":"41","author":"JA McQuillan","year":"2011","journal-title":"Int J Parasitol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"11468","DOI":"10.1073\/pnas.0503386102","article-title":"Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration","volume":"102","author":"B Franke-Fayard","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/1521-4141(200006)30:6<1646::AID-IMMU1646>3.0.CO;2-0","article-title":"Involvement of IFN-gamma receptor-medicated signaling in pathology and anti-malarial immunity induced by Plasmodium berghei infection","volume":"30","author":"V Amani","year":"2000","journal-title":"Eur J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1046\/j.1365-2567.1997.00290.x","article-title":"Interleukin-10 modulates susceptibility in experimental cerebral malaria","volume":"91","author":"S Kossodo","year":"1997","journal-title":"Immunology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/eji.200939996","article-title":"Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome","volume":"40","author":"T Reimer","year":"2010","journal-title":"Eur J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1084\/jem.172.5.1505","article-title":"Interleukin 6 production in experimental cerebral malaria: modulation by anticytokine antibodies and possible role in hypergammaglobulinemia","volume":"172","author":"GE Grau","year":"1990","journal-title":"J Exp Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ijpara.2005.12.005","article-title":"Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria","volume":"36","author":"S Potter","year":"2006","journal-title":"Int J Parasitol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1182\/blood-2002-05-1493","article-title":"CCR5 deficiency decreases susceptibility to experimental cerebral malaria","volume":"101","author":"E Belnoue","year":"2003","journal-title":"Blood"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nri3536","article-title":"T-bet: a bridge between innate and adaptive immunity","volume":"13","author":"V Lazarevic","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1126\/science.270.5239.1215","article-title":"Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets","volume":"270","author":"EA Bach","year":"1995","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1182\/blood-2004-07-2686","article-title":"Iron regulates T-lymphocyte sensitivity to the IFN-gamma\/STAT1 signaling pathway in vitro and in vivo","volume":"105","author":"G Regis","year":"2005","journal-title":"Blood"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.nutr.012809.104804","article-title":"Iron homeostasis and the inflammatory response","volume":"30","author":"M Wessling-Resnick","year":"2010","journal-title":"Annu Rev Nutr"},{"issue":"125","key":"ref44","first-page":"e2014.00125","article-title":"Iron, anemia and hepcidin in malaria","volume":"5","author":"N Spottiswoode","year":"2014","journal-title":"Front Pharmacol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/cid\/cis010","article-title":"Iron deficiency protects against severe Plasmodium falciparum malaria and death in young children","volume":"54","author":"M Gwamaka","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"12","key":"ref46","doi-asserted-by":"crossref","first-page":"e1972","DOI":"10.1371\/journal.pntd.0001972","article-title":"Severe anemia in Papua New Guinean children from a malaria-endemic area: a case-control etiological study","volume":"6","author":"L Manning","year":"2012","journal-title":"PloS Negl Trop Dis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/eji.201040942","article-title":"A critical role for phagocytosis in resistance to malaria in iron-deficient mice","volume":"41","author":"C Matsuzaki-Moriya","year":"2011","journal-title":"Eur J Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1084\/jem.168.1.375","article-title":"Deferoxamine inhibition of malaria is independent of host iron status","volume":"168","author":"C Hershko","year":"1988","journal-title":"J Exp Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1365-2141.1990.tb07805.x","article-title":"Parasite uptake of desferroxamine: a prerequisite for antimalarial activity","volume":"75","author":"MD Scott","year":"1990","journal-title":"Br J Haematol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0163-7258(98)00037-0","article-title":"Iron chelation therapy for malaria: a review","volume":"81","author":"GF Mabeza","year":"1999","journal-title":"Pharmacol Ther"},{"issue":"1","key":"ref51","first-page":"CD001474","article-title":"Iron-chelating agents for treating malaria","author":"HJ Smith","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1182\/blood-2005-04-1393","article-title":"T-bet is required for optimal proinflammatory CD4+ T-cell trafficking","volume":"106","author":"GM Lord","year":"2005","journal-title":"Blood"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1182\/blood-2007-03-081307","article-title":"IFN-gamma and STAT1 are required for efficient induction of CXC chemokine receptor 3 (CXCR3) on CD4+ but not CD8+ T cells","volume":"110","author":"J Barbi","year":"2007","journal-title":"Blood"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0118451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T19:52:46Z","timestamp":1691524366000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0118451"}},"subtitle":[],"editor":[{"given":"Gordon","family":"Langsley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,13]]},"references-count":53,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0118451","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,13]]}}}