{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T06:45:21Z","timestamp":1722753921862},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T00:00:00Z","timestamp":1425859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0118685","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T17:45:01Z","timestamp":1425923101000},"page":"e0118685","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Deficiency in Th2 Cytokine Responses Exacerbate Orthopoxvirus Infection"],"prefix":"10.1371","volume":"10","author":[{"given":"Isaac G.","family":"Sakala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geeta","family":"Chaudhri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preethi","family":"Eldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Mark","family":"Buller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunasegaran","family":"Karupiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,9]]},"reference":[{"key":"ref1","author":"M Oldstone","year":"1998"},{"key":"ref2","author":"J Miller","year":"2001"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrmicro1099","article-title":"Poxvirus tropism","volume":"3","author":"G McFadden","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/sj.icb.7100033","article-title":"Immunopathogenesis of poxvirus infections: forecasting the impending storm","volume":"85","author":"MM Stanford","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/MMBR.55.1.80-122.1991","article-title":"Poxvirus pathogenesis","volume":"55","author":"RM Buller","year":"1991","journal-title":"Microbiol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1099\/vir.0.81090-0","article-title":"Ectromelia virus: the causative agent of mousepox","volume":"86","author":"DJ Esteban","year":"2005","journal-title":"J Gen Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4049\/jimmunol.63.4.341","article-title":"Mouse-pox; infectious ectromelia of mice; a review","volume":"63","author":"F Fenner","year":"1949","journal-title":"J Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"9057","DOI":"10.1073\/pnas.0402949101","article-title":"Polarized type 1 cytokine response and cell-mediated immunity determine genetic resistance to mousepox","volume":"101","author":"G Chaudhri","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1128\/JVI.67.7.4214-4226.1993","article-title":"Importance of interferons in recovery from mousepox","volume":"67","author":"G Karupiah","year":"1993","journal-title":"J Virol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"12921","DOI":"10.1073\/pnas.0505180102","article-title":"Interferon function is not required for recovery from a secondary poxvirus infection","volume":"102","author":"V Panchanathan","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.virol.2010.10.021","article-title":"Poxvirus interleukin-4 expression overcomes inherent resistance and vaccine-induced immunity: pathogenesis, prophylaxis, and antiviral therapy","volume":"409","author":"N Chen","year":"2011","journal-title":"Virology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1128\/JVI.75.3.1205-1210.2001","article-title":"Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox","volume":"75","author":"RJ Jackson","year":"2001","journal-title":"J Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0167-5699(95)80030-1","article-title":"Cytokine receptors encoded by poxviruses: a lesson in cytokine biology","volume":"16","author":"A Alcami","year":"1995","journal-title":"Immunol Today"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0966-842X(96)10051-2","article-title":"Receptors for gamma-interferon encoded by poxviruses: implications for the unknown origin of vaccinia virus","volume":"4","author":"A Alcami","year":"1996","journal-title":"Trends Microbiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/jlb.57.5.731","article-title":"Interruption of cytokine networks by poxviruses: lessons from myxoma virus","volume":"57","author":"G McFadden","year":"1995","journal-title":"J Leukoc Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev.immunol.21.120601.141049","article-title":"Poxviruses and immune evasion","volume":"21","author":"BT Seet","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1128\/JVI.01927-06","article-title":"Poxvirus-encoded gamma interferon binding protein dampens the host immune response to infection","volume":"81","author":"IG Sakala","year":"2007","journal-title":"J Virol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/imr.12032","article-title":"Early signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsets","volume":"252","author":"H Yamane","year":"2013","journal-title":"Immunol Rev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-immunol-030409-101212","article-title":"Differentiation of effector CD4 T cell populations (*)","volume":"28","author":"J Zhu","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.molmed.2004.08.004","article-title":"Interleukin-4 receptor signaling pathways in asthma pathogenesis","volume":"10","author":"TA Chatila","year":"2004","journal-title":"Trends Mol Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1146\/annurev.immunol.17.1.701","article-title":"The IL-4 receptor: signaling mechanisms and biologic functions","volume":"17","author":"K Nelms","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1084\/jem.20020903","article-title":"Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response","volume":"197","author":"MG Chiaramonte","year":"2003","journal-title":"J Exp Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1084\/jem.20020906","article-title":"Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2","volume":"197","author":"N Wood","year":"2003","journal-title":"J Exp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1146\/annurev.immunol.23.021704.115821","article-title":"Regulation of Th2 differentiation and Il4 locus accessibility","volume":"24","author":"KM Ansel","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"6812","DOI":"10.1073\/pnas.111151098","article-title":"Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus","volume":"98","author":"S Mahalingam","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1126\/science.271.5251.987","article-title":"Susceptibility to Leishmania major infection in interleukin-4-deficient mice","volume":"271","author":"N Noben-Trauth","year":"1996","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1074-7613(00)80625-1","article-title":"Impaired development of Th2 cells in IL-13-deficient mice","volume":"9","author":"GJ McKenzie","year":"1998","journal-title":"Immunity"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"10838","DOI":"10.1073\/pnas.94.20.10838","article-title":"An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice","volume":"94","author":"N Noben-Trauth","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1074-7613(00)80439-2","article-title":"Stat6 is required for mediating responses to IL-4 and for development of Th2 cells","volume":"4","author":"MH Kaplan","year":"1996","journal-title":"Immunity"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0042-6822(92)90445-U","article-title":"Restricted replication of ectromelia virus in cell culture correlates with mutations in virus-encoded host range gene","volume":"187","author":"W Chen","year":"1992","journal-title":"Virology"},{"key":"ref31","first-page":"163","article-title":"Techniques for studying murine natural killer cells in defense against viral infection","volume":"121","author":"AA Scalzo","year":"2000","journal-title":"Methods Mol Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1128\/JVI.00427-06","article-title":"Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB\/c mice","volume":"80","author":"DC Tscharke","year":"2006","journal-title":"J Virol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1128\/JVI.02061-06","article-title":"Induction of natural killer cell responses by ectromelia virus controls infection","volume":"81","author":"AK Parker","year":"2007","journal-title":"J Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.immuni.2011.02.015","article-title":"CD94 is essential for NK cell-mediated resistance to a lethal viral disease","volume":"34","author":"M Fang","year":"2011","journal-title":"Immunity"},{"key":"ref35","article-title":"Smallpox and its eradication","author":"F HD Fenner","year":"1988"},{"key":"ref36","year":"1972"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.4049\/jimmunol.151.9.4562","article-title":"Synthesis of T helper 2-type cytokines at the maternal-fetal interface","volume":"151","author":"H Lin","year":"1993","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1600-0897.1997.tb00218.x","article-title":"Modulations of cytokine expression in pregnant women","volume":"37","author":"J Tranchot-Diallo","year":"1997","journal-title":"Am J Reprod Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni1317","article-title":"Mother&apos;s little helpers: mechanisms of maternal-fetal tolerance","volume":"7","author":"J Trowsdale","year":"2006","journal-title":"Nat Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1128\/JVI.00116-06","article-title":"Obligatory requirement for antibody in recovery from a primary poxvirus infection","volume":"80","author":"G Chaudhri","year":"2006","journal-title":"J Virol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"8301","DOI":"10.1128\/JVI.70.12.8301-8309.1996","article-title":"Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection","volume":"70","author":"G Karupiah","year":"1996","journal-title":"J Virol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e55788","DOI":"10.1371\/journal.pone.0055788","article-title":"Reduced interleukin-4 receptor alpha expression on CD8+ T cells correlates with higher quality anti-viral immunity","volume":"8","author":"DK Wijesundara","year":"2013","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.4049\/jimmunol.174.4.2021","article-title":"Progressive differentiation and commitment of CD8+ T cells to a poorly cytolytic CD8low phenotype in the presence of IL-4","volume":"174","author":"N Kienzle","year":"2005","journal-title":"J Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"17475","DOI":"10.1073\/pnas.0809549105","article-title":"Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cells","volume":"105","author":"SH Apte","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1016\/j.vaccine.2013.07.062","article-title":"IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8(+) T cell avidity following HIV-1 recombinant pox viral vaccination","volume":"31","author":"DK Wijesundara","year":"2013","journal-title":"Vaccine"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-2567.2008.02935.x","article-title":"STAT6 signalling is important in CD8 T-cell activation and defence against Toxoplasma gondii infection in the brain","volume":"127","author":"D Jin","year":"2009","journal-title":"Immunology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00002371-199905000-00005","article-title":"IL-13 can substitute for IL-4 in the generation of dendritic cells for the induction of cytotoxic T lymphocytes and gene therapy","volume":"22","author":"SE Alters","year":"1999","journal-title":"J Immunother"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12026-011-8205-2","article-title":"Transcriptional regulation by STAT6","volume":"50","author":"S Goenka","year":"2011","journal-title":"Immunol Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/380627a0","article-title":"Essential role of Stat6 in IL-4 signalling","volume":"380","author":"K Takeda","year":"1996","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/icb.2010.2","article-title":"What determines Th2 differentiation, in vitro and in vivo?","volume":"88","author":"WE Paul","year":"2010","journal-title":"Immunol Cell Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nri2735","article-title":"How are T(H)2-type immune responses initiated and amplified?","volume":"10","author":"WE Paul","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1126\/science.1221064","article-title":"New paradigms in type 2 immunity","volume":"337","author":"B Pulendran","year":"2012","journal-title":"Science"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1073\/pnas.0308697100","article-title":"GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells","volume":"101","author":"SY Pai","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)80240-8","article-title":"The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells","volume":"89","author":"W Zheng","year":"1997","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/ni1128","article-title":"Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses","volume":"5","author":"J Zhu","year":"2004","journal-title":"Nat Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1084\/jem.20052165","article-title":"T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription","volume":"203","author":"T Usui","year":"2006","journal-title":"J Exp Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0118685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T16:54:03Z","timestamp":1691513643000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0118685"}},"subtitle":[],"editor":[{"given":"Mauricio Martins","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,9]]},"references-count":56,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0118685","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,9]]}}}