{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T07:02:13Z","timestamp":1783234933525,"version":"3.54.6"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T00:00:00Z","timestamp":1425859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0118918","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T17:41:15Z","timestamp":1425922875000},"page":"e0118918","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["MASH1\/Ascl1a Leads to GAP43 Expression and Axon Regeneration in the Adult CNS"],"prefix":"10.1371","volume":"10","author":[{"given":"Ryan R.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishwariya","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien D.","family":"Pearse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava J.","family":"Udvadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Bartlett","family":"Bunge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,9]]},"reference":[{"key":"ref1","first-page":"71","article-title":"Adult zebrafish as a model for successful central nervous system regeneration","volume":"26","author":"CG Becker","year":"2008","journal-title":"Restor Neurol Neurosci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1080\/10790268.2008.11760720","article-title":"Novel combination strategies to repair the injured mammalian spinal cord","volume":"31","author":"MB Bunge","year":"2008","journal-title":"J Spinal Cord Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/309791a0","article-title":"Peripheral injury enhances central regeneration of primary sensory neurones","volume":"309","author":"PM Richardson","year":"1984","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1523\/JNEUROSCI.17-24-09583.1997","article-title":"BDNF and NT-4\/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration","volume":"17","author":"NR Kobayashi","year":"1997","journal-title":"J Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"KK Park","year":"2008","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.472734","article-title":"Regrowth of severed axons in the neonatal central nervous system: establishment of normal connections","volume":"205","author":"K Kalil","year":"1979","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/cne.902690406","article-title":"Transplantation of fetal spinal cord tissue into the chronically injured adult rat spinal cord","volume":"269","author":"JD Houl\u00e9","year":"1988","journal-title":"J Comp Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/cne.902820304","article-title":"Extension of the critical period for developmental plasticity of the corticospinal pathway","volume":"282","author":"BS Bregman","year":"1989","journal-title":"J Comp Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0166-2236(92)90338-9","article-title":"Intrinsic neuronal determinants of regeneration","volume":"15","author":"JW Fawcett","year":"1992","journal-title":"Trends Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"7287","DOI":"10.1073\/pnas.92.16.7287","article-title":"Intrinsic changes in developing retinal neurons result in regenerative failure of their axons","volume":"92","author":"DF Chen","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1111\/j.1460-9568.1995.tb01106.x","article-title":"Failure of axon regeneration in postnatal rat entorhinohippocampal slice coculture is due to maturation of the axon, not that of the pathway or target","volume":"7","author":"D Li","year":"1995","journal-title":"Eur J Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0166-2236(96)10021-7","article-title":"Regeneration of immature mammalian spinal cord after injury","volume":"19","author":"J Nicholls","year":"1996","journal-title":"Trends Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1126\/science.1068428","article-title":"Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells","volume":"296","author":"JL Goldberg","year":"2002","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.1175737","article-title":"KLF family members regulate intrinsic axon regeneration ability","volume":"326","author":"DL Moore","year":"2009","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/dev.128.7.1175","article-title":"GAP-43 promoter elements in transgenic zebrafish reveal a difference in signals for axon growth during CNS development and regeneration","volume":"128","author":"AJ Udvadia","year":"2001","journal-title":"Development"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"7663","DOI":"10.1523\/JNEUROSCI.2281-04.2004","article-title":"An element in the alpha1-tubulin promoter is necessary for retinal expression during optic nerve regeneration but not after eye injury in the adult zebrafish","volume":"24","author":"MC Senut","year":"2004","journal-title":"J Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2008.09.071","article-title":"Characterization of a nervous system-specific promoter for growth-associated protein 43 gene in Medaka (Oryzias latipes)","volume":"1245","author":"KE Fujimori","year":"2008","journal-title":"Brain Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/dvdy.22190","article-title":"Transcriptional regulatory regions of gap43 needed in developing and regenerating retinal ganglion cells","volume":"239","author":"BW Kusik","year":"2010","journal-title":"Dev Dyn"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1365-2443.1996.tb00016.x","article-title":"Mash1 promotes neuronal differentiation in the retina","volume":"1","author":"K Tomita","year":"1996","journal-title":"Genes Cells"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/346858a0","article-title":"Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors","volume":"346","author":"JE Johnson","year":"1990","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1101\/gad.627811","article-title":"A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets","volume":"25","author":"DS Castro","year":"2011","journal-title":"Genes Dev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1523\/JNEUROSCI.4853-07.2008","article-title":"The proneural basic helix-loop-helix gene ascl1a is required for retina regeneration","volume":"28","author":"BV Fausett","year":"2008","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.neuroscience.2010.10.026","article-title":"Transcription factor Sox11b is involved in spinal cord regeneration in adult zebrafish","volume":"172","author":"Y Guo","year":"2011","journal-title":"Neuroscience"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/(SICI)1096-9861(19970127)377:4<577::AID-CNE8>3.0.CO;2-#","article-title":"Axonal regrowth after spinal cord transection in adult zebrafish","volume":"377","author":"T Becker","year":"1997","journal-title":"J Comp Neurol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e57280","DOI":"10.1371\/journal.pone.0057280","article-title":"Neurogenesis of retinal ganglion cells is not essential to visual functional recovery after optic nerve injury in adult zebrafish","volume":"8","author":"S Zou","year":"2013","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.gep.2008.05.002","article-title":"3.6 kb genomic sequence from Takifugu capable of promoting axon growth-associated gene expression in developing and regenerating zebrafish neurons","volume":"8","author":"AJ Udvadia","year":"2008","journal-title":"Gene Expr Patterns"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1242\/dev.00452","article-title":"Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesis","volume":"130","author":"E Cau","year":"2003","journal-title":"Development"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ydbio.2007.09.019","article-title":"Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration","volume":"312","author":"MB Veldman","year":"2007","journal-title":"Dev Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/jgm.1628","article-title":"The assessment of adeno-associated vectors as potential intrinsic treatments for brainstem axon regeneration","volume":"14","author":"RR Williams","year":"2012","journal-title":"J Gene Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1523\/JNEUROSCI.11-08-02433.1991","article-title":"Isolation and functional characterization of Schwann cells derived from adult peripheral nerve","volume":"11","author":"TK Morrissey","year":"1991","journal-title":"J Neurosci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/glia.20287","article-title":"Labeled Schwann cell transplantation: cell loss, host Schwann cell replacement, and strategies to enhance survival","volume":"53","author":"CE Hill","year":"2006","journal-title":"Glia"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.10593","article-title":"False resurrections: distinguishing regenerated from spared axons in the injured central nervous system","volume":"459","author":"O Steward","year":"2003","journal-title":"J Comp Neurol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/exnr.1996.0098","article-title":"Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection","volume":"139","author":"DM Basso","year":"1996","journal-title":"Exp Neurol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1089\/neu.2004.21.1601","article-title":"A simple post hoc transformation that improves the metric properties of the BBB scale for rats with moderate to severe spinal cord injury","volume":"21","author":"AR Ferguson","year":"2004","journal-title":"J Neurotrauma"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1266\/ggs.81.29","article-title":"The mitochondrial genome of spotted green pufferfish Tetraodon nigroviridis (Teleostei: Tetraodontiformes) and divergence time estimation among model organisms in fishes","volume":"81","author":"Y Yamanoue","year":"2006","journal-title":"Genes Genet Syst"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/284264a0","article-title":"Axons from CNS neurons regenerate into PNS grafts","volume":"284","author":"PM Richardson","year":"1980","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3727\/096368913X674657","article-title":"Permissive schwann cell Graft\/spinal cord interfaces for axon regeneration","volume":"24","author":"RR Williams","year":"2015","journal-title":"Cell Transplant"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.expneurol.2007.08.004","article-title":"Growth factors and combinatorial therapies for CNS regeneration","volume":"209","author":"P Lu","year":"2008","journal-title":"Exp Neurol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1242\/dev.125.4.609","article-title":"MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity","volume":"125","author":"L Lo","year":"1998","journal-title":"Development"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1073\/pnas.0306988101","article-title":"RNA interference of achaete-scute homolog 1 in mouse prostate neuroendocrine cells reveals its gene targets and DNA binding sites","volume":"101","author":"Y Hu","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.mcn.2003.10.021","article-title":"Interaction of Mash1 and Phox2b in sympathetic neuron development","volume":"25","author":"M Stanke","year":"2004","journal-title":"Mol Cell Neurosci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.nbd.2005.12.020","article-title":"Introduction of the MASH1 gene into mouse embryonic stem cells leads to differentiation of motoneuron precursors lacking Nogo receptor expression that can be applicable for transplantation to spinal cord injury","volume":"22","author":"M Hamada","year":"2006","journal-title":"Neurobiol Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.neuron.2011.02.018","article-title":"Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling","volume":"69","author":"E Pacary","year":"2011","journal-title":"Neuron"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"22035","DOI":"10.1074\/jbc.271.36.22035","article-title":"The GAP-43 gene is a direct downstream target of the basic helix-loop-helix transcription factors","volume":"271","author":"A Chiaramello","year":"1996","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1073\/pnas.86.14.5434","article-title":"Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD","volume":"86","author":"H Weintraub","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/75753","article-title":"Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears","volume":"3","author":"JL Zheng","year":"2000","journal-title":"Nat Neurosci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1523\/JNEUROSCI.23-11-04395.2003","article-title":"Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo","volume":"23","author":"K Kawamoto","year":"2003","journal-title":"J Neurosci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nm867","article-title":"NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice","volume":"9","author":"H Kojima","year":"2003","journal-title":"Nat Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature07314","article-title":"In vivo reprogramming of adult pancreatic exocrine cells to beta-cells","volume":"455","author":"Q Zhou","year":"2008","journal-title":"Nature"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1242\/dev.127.4.693","article-title":"Generation of neurons by transient expression of neural bHLH proteins in mammalian cells","volume":"127","author":"MH Farah","year":"2000","journal-title":"Development"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"8654","DOI":"10.1523\/JNEUROSCI.1615-07.2007","article-title":"Functional properties of neurons derived from in vitro reprogrammed postnatal Astroglia","volume":"27","author":"B Berninger","year":"2007","journal-title":"J Neurosci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nature08797","article-title":"Direct conversion of fibroblasts to functional neurons by defined factors","volume":"463","author":"T Vierbuchen","year":"2010","journal-title":"Nature"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature10284","article-title":"Direct generation of functional dopaminergic neurons from mouse and human fibroblasts","volume":"476","author":"M Caiazzo","year":"2011","journal-title":"Nature"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"10343","DOI":"10.1073\/pnas.1105135108","article-title":"Direct conversion of human fibroblasts to dopaminergic neurons","volume":"08","author":"U Pfisterer","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature10323","article-title":"MicroRNA-mediated conversion of human fibroblasts to neurons","volume":"476","author":"AS Yoo","year":"2011","journal-title":"Nature"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1242\/dev.091355","article-title":"ASCL1 reprograms mouse Muller glia into neurogenic retinal progenitors","volume":"140","author":"J Pollak","year":"2013","journal-title":"Development"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1093\/brain\/awr142","article-title":"The histone acetyltransferase p300 promotes intrinsic axonal regeneration","volume":"134","author":"P Gaub","year":"2011","journal-title":"Brain"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1016\/j.yexcr.2008.06.002","article-title":"MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation","volume":"314","author":"JY Yu","year":"2008","journal-title":"Exp Cell Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nature08139","article-title":"MicroRNA-mediated switching of chromatin-remodelling complexes in neural development","volume":"460","author":"AS Yoo","year":"2009","journal-title":"Nature"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1093\/nar\/gkq904","article-title":"MiR-124 regulates early neurogenesis in the optic vesicle and forebrain, targeting NeuroD1","volume":"39","author":"K Liu","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1097\/00001756-200212200-00002","article-title":"Neuronal injury affects expression of helix-loop-helix transcription factors","volume":"13","author":"P Kabos","year":"2002","journal-title":"Neuroreport"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1101\/gad.9.24.3136","article-title":"Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects","volume":"9","author":"M Ishibashi","year":"1995","journal-title":"Genes Dev"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/(SICI)1097-4547(19990501)56:3<229::AID-JNR2>3.0.CO;2-Z","article-title":"Regulation of hippocampal neuronal differentiation by the basic helix-loop-helix transcription factors HES-1 and MASH-1","volume":"56","author":"P Castella","year":"1999","journal-title":"J Neurosci Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"9118","DOI":"10.1074\/jbc.M107713200","article-title":"Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation","volume":"277","author":"A J\u00f6gi","year":"2002","journal-title":"J Biol Chem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1128\/MCB.22.9.3129-3139.2002","article-title":"Notch signaling induces rapid degradation of achaete-scute homolog 1","volume":"22","author":"V Sriuranpong","year":"2002","journal-title":"Mol Cell Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/emm.2002.52","article-title":"Inhibition of BETA2\/NeuroD by Id2","volume":"34","author":"SH Ghil","year":"2002","journal-title":"Exp Mol Med"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1038\/sj.emboj.7600360","article-title":"BMP-2 decreases Mash1 stability by increasing Id1 expression","volume":"23","author":"F Vi\u00f1als","year":"2004","journal-title":"EMBO J"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/stem.17","article-title":"Engineering of dominant active basic helix-loop-helix proteins that are resistant to negative regulation by postnatal central nervous system antineurogenic cues","volume":"27","author":"CG Geoffroy","year":"2009","journal-title":"Stem Cells"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10571-008-9338-2","article-title":"Gene expression profiling of human neural progenitor cells following the serum-induced astrocyte differentiation","volume":"29","author":"S Obayashi","year":"2009","journal-title":"Cell Mol Neurobiol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1128\/MCB.24.7.2662-2672.2004","article-title":"Basic helix-loop-helix proteins bind to TrkB and p21(Cip1) promoters linking differentiation and cell cycle arrest in neuroblastoma cells","volume":"24","author":"Y Liu","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"14074","DOI":"10.1523\/JNEUROSCI.3188-08.2008","article-title":"Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis","volume":"28","author":"MC Havrda","year":"2008","journal-title":"J Neurosci"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nature04895","article-title":"Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth","volume":"442","author":"A Lasorella","year":"2006","journal-title":"Nature"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.expneurol.2011.05.013","article-title":"Inhibitor of DNA binding 2 promotes sensory axonal growth after SCI","volume":"231","author":"P Yu","year":"2011","journal-title":"Exp Neurol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/B978-0-444-59544-7.00014-7","article-title":"Schwann cell transplantation: a repair strategy for spinal cord injury?","volume":"201","author":"RR Williams","year":"2012","journal-title":"Prog Brain Res"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1749-6632.1998.tb09061.x","article-title":"Pharmacological activation and modulation of the central pattern generator for locomotion in the cat","volume":"860","author":"S Rossignol","year":"1998","journal-title":"Ann NY Acad Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0118918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T19:01:51Z","timestamp":1651431711000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0118918"}},"subtitle":[],"editor":[{"given":"Subhabrata","family":"Sanyal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,9]]},"references-count":76,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0118918","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,9]]}}}