{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:19:30Z","timestamp":1762917570241},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0119067","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T14:03:23Z","timestamp":1425650603000},"page":"e0119067","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Oral Administration of PF-01247324, a Subtype-Selective Nav1.8 Blocker, Reverses Cerebellar Deficits in a Mouse Model of Multiple Sclerosis"],"prefix":"10.1371","volume":"10","author":[{"given":"Shannon D.","family":"Shields","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard P.","family":"Butt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulayman D.","family":"Dib-Hajj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen G.","family":"Waxman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1001\/archneur.59.9.1377","article-title":"Ion channels and neuronal dysfunction in multiple sclerosis","volume":"59","author":"SG Waxman","year":"2002","journal-title":"Arch Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1093\/brain\/aws225","article-title":"Neurological perspectives on voltage-gated sodium channels","volume":"135","author":"N Eijkelkamp","year":"2012","journal-title":"Brain"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"11598","DOI":"10.1073\/pnas.97.21.11598","article-title":"Sensory neuron-specific sodium channel SNS is abnormally expressed in the brains of mice with experimental allergic encephalomyelitis and humans with multiple sclerosis","volume":"97","author":"JA Black","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0006-8993(02)03750-2","article-title":"Expression of Nav1.8 sodium channels perturbs the firing patterns of cerebellar Purkinje cells","volume":"959","author":"M Renganathan","year":"2003","journal-title":"Brain Res"},{"key":"ref5","first-page":"1","article-title":"Abnormal Purkinje cell activity in vivo in experimental allergic encephalomyelitis","volume":"158","author":"CY Saab","year":"2004","journal-title":"Exp Brain Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/ana.22665","article-title":"A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis","volume":"71","author":"SD Shields","year":"2012","journal-title":"Ann Neurol"},{"key":"ref7","unstructured":"England S, Payne L, Krajewski J, Stoehr S, Liu H, Rees H, et al. In vitro characterization of two novel selective Nav1.8 modulators. Program No. 359.6. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2009, Online."},{"key":"ref8","article-title":"A novel selective and orally bioavailable Na<sub>V<\/sub>1.8 blocker PF-01247324 attenuates nociception and sensory neuron excitability","author":"CE Payne","year":"2015","journal-title":"Brit J Pharmacol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1152\/jn.00434.2003","article-title":"Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo","volume":"90","author":"AC Lo","year":"2003","journal-title":"J Neurophysiol"},{"key":"ref10","first-page":"CD005029","article-title":"Treatment for ataxia in multiple sclerosis","volume":"1","author":"RJ Mills","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"ref11","first-page":"325","article-title":"The morbidity of multiple sclerosis","volume":"83","author":"RJ Swingler","year":"1992","journal-title":"Q J Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/jnnp.33.4.528","article-title":"Treatment of paroxysmal disorders in multiple sclerosis with carbamazepine (Tegretol)","volume":"33","author":"ML Espir","year":"1970","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1136\/bmj.320.7242.1113","article-title":"Worsening of symptoms of multiple sclerosis associated with carbamazepine","volume":"320","author":"G Ramsaransing","year":"2000","journal-title":"BMJ"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10072-004-0362-9","article-title":"Antiepileptic medications in multiple sclerosis: adverse effects in a three-year follow-up study","volume":"25","author":"C Solaro","year":"2005","journal-title":"Neurol Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S1474-4422(10)70131-9","article-title":"Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial","volume":"9","author":"R Kapoor","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1113\/jphysiol.1978.sp012384","article-title":"The internodal axon membrane: electrical excitability and continuous conduction in segmental demyelination","volume":"280","author":"H Bostock","year":"1978","journal-title":"J Physiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.6159685","article-title":"Reorganization of the axon membrane in demyelinated peripheral nerve fibers: morphological evidence","volume":"210","author":"RE Foster","year":"1980","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"8168","DOI":"10.1073\/pnas.0402765101","article-title":"Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+\/Ca2+ exchanger","volume":"101","author":"MJ Craner","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nrn2023","article-title":"Axonal conduction and injury in multiple sclerosis: the role of sodium channels","volume":"7","author":"SG Waxman","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/jnnp.41.5.408","article-title":"Conduction through demyelinated plaques in multiple sclerosis: computer simulations of facilitation by short internodes","volume":"41","author":"SG Waxman","year":"1978","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0119067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T21:43:42Z","timestamp":1540331022000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0119067"}},"subtitle":[],"editor":[{"given":"Bradley","family":"Taylor","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,6]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0119067","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,6]]}}}