{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T15:20:52Z","timestamp":1774020052015,"version":"3.50.1"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0119122","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T18:57:07Z","timestamp":1425668227000},"page":"e0119122","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Bioactivity-Guided Fractionation of an Antidiarrheal Chinese Herb Rhodiola kirilowii (Regel) Maxim Reveals (-)\u2013Epicatechin-3-Gallate and (-)\u2013Epigallocatechin-3-Gallate as Inhibitors of Cystic Fibrosis Transmembrane Conductance Regulator"],"prefix":"10.1371","volume":"10","author":[{"given":"Lei","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaofang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonghui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"ref1","first-page":"a009563","article-title":"Physiology of epithelial chloride and fluid secretion","volume":"2","author":"RA Frizzell","year":"2012","journal-title":"Cold Spring HarbPerspect Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.physiol.62.1.535","article-title":"Chloride secretion by the intestinal epithelium:molecular basis and regulatory aspects","volume":"62","author":"KE Barrett","year":"2000","journal-title":"Annu Rev Physiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.coph.2013.08.005","article-title":"Chloride channel-targeted therapy for secretory diarrheas","volume":"13","author":"JR Thiagarajah","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/MOG.0b013e3283358a45","article-title":"Ion transport in the small intestine","volume":"26","author":"J Venkatasubramanian","year":"2010","journal-title":"Curr Opin Gastroenterol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1146\/annurev.biochem.75.103004.142532","article-title":"CFTR function and prospects for therapy","volume":"77","author":"JR Riordan","year":"2008","journal-title":"Annu Rev Biochem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jcf.2008.05.003","article-title":"On the measurement of the functional properties of the CFTR","volume":"7","author":"O Moran","year":"2008","journal-title":"J Cyst Fibros"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/j.1460-2075.1994.tb06355.x","article-title":"Activation of intestinal CFTR Cl<sup>-<\/sup> channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase","volume":"13","author":"AC Chao","year":"1994","journal-title":"EMBO"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.7524148","article-title":"Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model","volume":"266","author":"SE Gabriel","year":"1994","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.coph.2003.06.012","article-title":"CFTR pharmacology and its role in intestinal fluid secretion","volume":"3","author":"JR Thiagarajah","year":"2003","journal-title":"Curr Opin Pharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1172\/JCI0216112","article-title":"Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion","volume":"110","author":"T Ma","year":"2002","journal-title":"J Clin Invest"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrd2780","article-title":"Chloride channels as drug targets","volume":"8","author":"AS Verkman","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.2174\/138161206777585148","article-title":"CFTR chloride channel drug discovery\u2014inhibitors as antidiarrheals and activators for therapy of cystic fibrosis","volume":"12","author":"AS Verkman","year":"2006","journal-title":"Curr Pharm Des"},{"key":"ref13","first-page":"287","article-title":"CFTR inhibitors for treating diarrheal disease","volume":"92","author":"JR Thiagarajah","year":"2012","journal-title":"ClinPharmacolTher"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tips.2005.02.003","article-title":"New drug targets for cholera therapy","volume":"26","author":"JR Thiagarajah","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1085\/jgp.200409059","article-title":"Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy","volume":"124","author":"C Muanprasat","year":"2004","journal-title":"J Gen. Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e94302","DOI":"10.1371\/journal.pone.0094302","article-title":"Identification of resveratrol oligomers as inhibitors of cystic fibrosis transmembrane conductance regulator by high-throughput screening of natural products from Chinese medicinal plants","volume":"9","author":"Y Zhang","year":"2014","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1248\/bpb.30.502","article-title":"Identification of new small molecule inhibitors of cystic fibrosis transmembrane conductance regulator protein: in vitro and in vivo studies","volume":"30","author":"C Muanprasat","year":"2007","journal-title":"Biol Pharm Bull"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1254\/jphs.11153FP","article-title":"Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor: potential therapy for cholera and polycystic kidney disease","volume":"118","author":"C Muanprasat","year":"2012","journal-title":"J Pharmacol Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.2174\/13816128113199990321","article-title":"CFTR inhibitors","volume":"19","author":"AS Verkman","year":"2013","journal-title":"Curr Pharm Des"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1113\/expphysiol.2003.027003","article-title":"Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts","volume":"89","author":"XF Wang","year":"2004","journal-title":"Exp Physiol"},{"key":"ref21","first-page":"608","article-title":"The future of natural products as a source of new antibiotics","volume":"8","author":"A Luzhetskyy","year":"2007","journal-title":"CurrOpinInvestig Drugs"},{"key":"ref22","first-page":"3670","article-title":"Natural products: a continuing source of novel drug leads","volume":"1830","author":"GM Cragg","year":"2013","journal-title":"BiochimBiophysActa"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2012.10.006","article-title":"Traditional Chinese herbal medicine as a source of molecules with antiviral activity","volume":"97","author":"T Li","year":"2013","journal-title":"Antiviral Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.2174\/138955711797655362","article-title":"Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine","volume":"11","author":"ZJ Huang","year":"2011","journal-title":"Mini Rev Med Chem"},{"key":"ref25","first-page":"1147","article-title":"Discovery of structurally diverse and bioactive compounds from plant resources in China","volume":"33","author":"SP Yang","year":"2012","journal-title":"ActaPharmacol Sin"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1089\/acm.2011.0587","article-title":"Collections of traditional Chinese medical literature as resources for systematic searches","volume":"18","author":"BH May","year":"2012","journal-title":"J Altern Complement Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.physiol.62.1.467","article-title":"Role of CFTR in the colon","volume":"62","author":"R. Greger","year":"2000","journal-title":"Annu Rev Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1055\/s-0030-1250456","article-title":"Clinical studies with traditional Chinese medicine in the past decade and future research and development","volume":"76","author":"M Jiang","year":"2010","journal-title":"Planta Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/msj.20294","article-title":"Treatment of asthma and food allergy with herbal interventions from traditional Chinese medicine","volume":"78","author":"XM Li","year":"2011","journal-title":"Mt Sinai J Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1055\/s-0030-1250186","article-title":"The role of traditional Chinese herbal medicines in cancer therapy\u2014from TCM theory to mechanistic insights","volume":"76","author":"WL Hsiao","year":"2010","journal-title":"Planta Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1348-0421.1992.tb02103.x","article-title":"The protective activity of tea catechins against experimental infection by Vibrio cholerae O1","volume":"36","author":"M Toda","year":"1992","journal-title":"Microbiol Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jep.2009.09.016","article-title":"Antisecretory activity from the flowers of Chiranthodendron pentadactylon and its flavonoids on intestinal fluid accumulation induced by Vibrio cholerae toxin in rats","volume":"26","author":"C Vel\u00e1zquez","year":"2009","journal-title":"J Ethnopharmacol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.bcp.2011.07.093","article-title":"Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications","volume":"82","author":"BN Singh","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/B978-0-12-385855-9.00007-2","article-title":"EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment","volume":"53","author":"D Chen","year":"2011","journal-title":"Adv Clin Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3389\/fmicb.2013.00162","article-title":"Green tea as an effective antimicrobial for urinary tract infections caused by Escherichia coli","volume":"4","author":"W Reygaert","year":"2013","journal-title":"Front Microbiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1096\/fj.10-160648","article-title":"Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea","volume":"24","author":"W Namkung","year":"2010","journal-title":"FASEB J"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1021\/mp4000794","article-title":"Crystal engineering of green tea epigallocatechin-3-gallate (EGCg) cocrystals and pharmacokinetic modulation in rats","volume":"10","author":"AJ Smith","year":"2013","journal-title":"Mol Pharm"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1152\/ajpcell.2001.281.5.C1734","article-title":"Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists","volume":"281","author":"LV Galietta","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/sj.bjp.0704882","article-title":"Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07","volume":"137","author":"O Zegarra-Moran","year":"2002","journal-title":"Br J Pharmacol"},{"key":"ref40","first-page":"334","article-title":"Synthesis and characterization of a small molecule thiazolidinone CFTR chloride channel inhibitor","volume":"20","author":"C He","year":"2004","journal-title":"Chem Res Chinese U"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"35079","DOI":"10.1074\/jbc.M303098200","article-title":"Nanomolar Affinity Small Molecule Correctors of Defective {Delta}F508-CFTR Chloride Channel Gating","volume":"278","author":"H Yang","year":"2003","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"37235","DOI":"10.1074\/jbc.M205932200","article-title":"High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening","volume":"277","author":"T Ma","year":"2002","journal-title":"J Biol Chem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0119122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T18:50:43Z","timestamp":1566413443000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0119122"}},"subtitle":[],"editor":[{"given":"Ranji","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,6]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0119122","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,6]]}}}