{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:03:01Z","timestamp":1776405781339,"version":"3.51.2"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T00:00:00Z","timestamp":1425859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0119170","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T17:44:20Z","timestamp":1425923060000},"page":"e0119170","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Prevalence and Correlation of Infectious Agents in Hospitalized Children with Acute Respiratory Tract Infections in Central China"],"prefix":"10.1371","volume":"10","author":[{"given":"Jia","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwu","family":"Ai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongya","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingle","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1473-3099(01)00170-0","article-title":"Estimates of world-wide distribution of child deaths from acute respiratory infections","volume":"2","author":"BG Williams","year":"2002","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e79477","DOI":"10.1371\/journal.pone.0079477","article-title":"Prevalence of herpes and respiratory viruses in induced sputum among hospitalized children with non-typical bacterial community-acquired pneumonia","volume":"8","author":"W Zhou","year":"2013","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1056\/NEJMra011994","article-title":"Community-acquired pneumonia in children","volume":"346","author":"K McIntosh","year":"2002","journal-title":"N Engl J Med"},{"key":"ref4","unstructured":"Dwigh A, Powell A. Mycoplasmal infection. In Nellson\u2019 Textbook of Pediatrics, 1996; Vol, Chapter 196:824\u2013827."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/MD.0000000000000218","article-title":"<italic>Coxiella burnetii<\/italic> infection in Hemodialysis and other vascular grafts","volume":"93","author":"VM Gonzalez-Del","year":"2014","journal-title":"Medicine (Baltimore)"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.vetmic.2014.09.034","article-title":"Prevalence of <italic>Coxiella burnetii<\/italic> in environmental samples collected from cattle farms in Eastern and Central Poland (2011\u20132012)","volume":"174","author":"A Bielawska-Drozd","year":"2014","journal-title":"Vet Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1001\/jama.2010.675","article-title":"Viral etiology of severe pneumonia among Kenyan infants and children","volume":"303","author":"JA Berkley","year":"2010","journal-title":"JAMA"},{"key":"ref8","first-page":"133","article-title":"Optimized detection of respiratory viruses in nasopharyngeal secretions","volume":"26","author":"M Zavattoni","year":"2003","journal-title":"New Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3923\/jms.2006.793.799","article-title":"Pneumoslide-M technique for rapid detection of atypical pathogens in critically ILL children with lower respiratory tract infections","volume":"6","author":"AF Sally","year":"2006","journal-title":"J Med Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1186\/1471-2458-14-1304","article-title":"First report on prevalence and risk factors of severe atypical pneumonia in Vietnamese children aged 1\u201315 years","volume":"14","author":"PL Huong","year":"2014","journal-title":"BMC Public Health"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1053\/jinf.2000.0715","article-title":"Epidemiology of acute viral respiratory tract infections in Korean children","volume":"41","author":"MR Kim","year":"2000","journal-title":"J Infect"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1128\/JCM.01117-07","article-title":"Evidence from multiplex molecular assays for complex multipathogen interactions in acute respiratory infections","volume":"46","author":"JD Brunstein","year":"2008","journal-title":"J Clin Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/1743-422X-6-155","article-title":"Multipathogen infections in hospitalized children with acute respiratory infections","volume":"6","author":"D Peng","year":"2009","journal-title":"Virol J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1128\/JCM.01117-07","article-title":"Evidence from multiplex molecular assays for complex multipathogen interactions in acute respiratory infections","volume":"46","author":"JD Brunstein","year":"2008","journal-title":"J Clin Microbiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"20081","DOI":"10.2807\/ese.17.06.20081-en","article-title":"Increased detection of <italic>Mycoplasma pneumoniae<\/italic> infection in children in England and Wales, October 2011 to January 2012","volume":"17","author":"V Chalker","year":"2012","journal-title":"Euro Surveill"},{"key":"ref16","first-page":"20094","article-title":"Increased detection of <italic>Mycoplasma pneumoniae<\/italic> infection in children, Lyon, France, 2010 to 2011","volume":"1717","author":"D Eibach","year":"2012","journal-title":"Euro Surveill"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"20095","DOI":"10.2807\/ese.17.08.20095-en","article-title":"Ongoing epidemic of <italic>Mycoplasma pneumoniae<\/italic> infection in Jerusalem, Israel, 2010 to 2012","volume":"17","author":"R Nir-Paz","year":"2012","journal-title":"Euro Surveill"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1128\/JCM.01117-07","article-title":"Evidence from multiplex molecular assays for complex multipathogen interactions in acute respiratory infections","volume":"46","author":"JD Brunstein","year":"2008","journal-title":"J Clin Microbiol"},{"key":"ref19","first-page":"681","article-title":"Respiratory viruses detected in hospitalised pediatric patients with respiratory infections","volume":"58","author":"S Zamberi","year":"2003","journal-title":"Med J Malaysia"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jcv.2008.03.012","article-title":"Multiple simultaneous viral infections in infants with acute respiratory tract infections in Spain","volume":"42","author":"C Calvo","year":"2008","journal-title":"J Clin Virol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1053\/jinf.2000.0715","article-title":"Epidemiology of acute viral respiratory tract infections in Korean children","volume":"41","author":"MR Kim","year":"2000","journal-title":"J Infect"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jcv.2003.08.014","article-title":"Surveillance of respiratory viral infections among pediatric outpatients in northern Taiwan","volume":"30","author":"TY Lin","year":"2004","journal-title":"J Clin Virol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1128\/JCM.34.12.3007-3011.1996","article-title":"Surveillance of community-acquired viral infections due to respiratory viruses in Rhone-Alpes (France) during winter 1994 to 1995","volume":"4","author":"B Lina","year":"1996","journal-title":"J Clin Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s100960050490","article-title":"Epidemiological investigation of nine respiratory pathogens in hospitalized children in Germany using multiplex reverse-transcriptase polymerase chain reaction","volume":"19","author":"JA Weigl","year":"2000","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref25","unstructured":"Long SS, Pickering LK, Prober CG. Principles and practice of pediatric infectious diseases. 1999; Vol. 0-443-08943-4."},{"key":"ref26","first-page":"971","article-title":"Viral pathogens of acute lower respiratory tract infection in China","volume":"45","author":"LF Tang","year":"2008","journal-title":"Indian Pediatr"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e32174","DOI":"10.1371\/journal.pone.0032174","article-title":"Etiology and clinical characterization of respiratory virus infections in adult patients attending an emergency department in Beijing","volume":"7","author":"X Yu","year":"2012","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1469-0691.2011.03541.x","article-title":"Newly identified respiratory viruses associated with acute lower respiratory tract infections in children in Lanzou, China, from 2006 to 2009","volume":"18","author":"Y Jin","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2807\/esm.03.10.00095-en","article-title":"Epidemiology of <italic>Mycoplasma pneumoniae<\/italic> infections in Poland: 28 years of surveillance in Warsaw 1970\u20131997","volume":"3","author":"W Rastawicki","year":"1998","journal-title":"Euro Surveill"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"20084","DOI":"10.2807\/ese.17.06.20084-en","article-title":"<italic>Mycoplasma pneumoniae<\/italic>: now in the focus of clinicians and epidemiologists","volume":"17","author":"E Jacobs","year":"2012","journal-title":"Euro Surveill"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/00365540050164155","article-title":"Chlamydia pneumoniae and <italic>Mycoplasma pneumoniae<\/italic> in children with acute respiratory infection in general practices in the Netherlands","volume":"32","author":"JH Tjhie","year":"2000","journal-title":"Scand J Infect Dis"},{"issue":"Suppl 2","key":"ref32","first-page":"S126","article-title":"Influenza virus infections in Taiwan from 1979 to 1994","volume":"94","author":"RK Tseng","year":"1995","journal-title":"J Formos Med Assoc"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/infdis\/142.6.844","article-title":"Protection of infants from infection with influenza A virus by transplacentally acquired antibody","volume":"142","author":"JM Puck","year":"1980","journal-title":"J Infect Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"20072","DOI":"10.2807\/ese.17.05.20072-en","article-title":"Increased incidence of <italic>Mycoplasma pneumoniae<\/italic> infection in Finland, 2010\u20132011","volume":"17","author":"A Polkowska","year":"2012","journal-title":"Euro Surveill"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/jmv.21457","article-title":"Epidemiological and clinical study of viral respiratory tract infections in children from Italy","volume":"81","author":"A Polkowska","year":"2009","journal-title":"J Med Virol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1651-2227.2008.01023.x","article-title":"Multiple viral respiratory pathogens in children with bronchiolitis","volume":"98","author":"HE Stempel","year":"2009","journal-title":"Acta Paediatr"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"20081","DOI":"10.2807\/ese.17.06.20081-en","article-title":"Increased detection of <italic>Mycoplasma pneumoniae<\/italic> infection in children in England and Wales, October 2011 to January 2012","volume":"17","author":"V Chalker","year":"2012","journal-title":"Euro Surveill"},{"key":"ref38","first-page":"451","article-title":"Culture vs direct antigen assays for detection of microbial pathogens from lower respiratory tract specimens suspected of containing the respiratory syncytial virus","volume":"115","author":"JA Kellogg","year":"1991","journal-title":"Arch Pathol Lab Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1086\/426457","article-title":"Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis","volume":"191","author":"MG Semple","year":"2005","journal-title":"J Infect Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jcv.2008.08.010","article-title":"Mixed respiratory virus infections","volume":"43","author":"G Paranhos-Baccala","year":"2008","journal-title":"J Clin Virol"},{"key":"ref41","first-page":"834","article-title":"Simultaneous infection with respiratory syncytial virus and other respiratory pathogens","volume":"142","author":"DA Tristram","year":"1998","journal-title":"Am J Dis Child"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e38638","DOI":"10.1371\/journal.pone.0038638","article-title":"Characterization of human coronavirus etiology in Chinese adults with acute upper respiratory tract infection by real-time RT-PCR assays","volume":"7","author":"R Lu","year":"2010","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3201\/eid1004.030555","article-title":"Human metapneumovirus infection among children hospitalized with acute respiratory illness","volume":"10","author":"JA Mullins","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMoa0804877","article-title":"The burden of respiratory syncytial virus infection in young children","volume":"360","author":"CB Hall","year":"2009","journal-title":"N Engl J Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0119170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T19:02:10Z","timestamp":1651431730000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0119170"}},"subtitle":[],"editor":[{"given":"Charles J.","family":"Russell","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,9]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0119170","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,9]]}}}