{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:18:38Z","timestamp":1790381918970,"version":"4.1.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0119189","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T18:49:27Z","timestamp":1425408567000},"page":"e0119189","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ectopic Expression of Vaccinia Virus E3 and K3 Cannot Rescue Ectromelia Virus Replication in Rabbit RK13 Cells"],"prefix":"10.1371","volume":"10","author":[{"given":"Erin S.","family":"Hand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry L.","family":"Haller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Rothenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam R.","family":"Hersperger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/icb.1947.39","article-title":"Studies in infectious ectromelia in mice; natural transmission; the portal of entry of the virus","volume":"25","author":"F Fenner","year":"1947","journal-title":"Aust J Exp Biol Med Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1099\/vir.0.81090-0","article-title":"Ectromelia virus: the causative agent of mousepox","volume":"86","author":"DJ Esteban","year":"2005","journal-title":"J Gen Virol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/rmv.506","article-title":"Classic paper: Fenner on the exanthemata","volume":"16","author":"F Fenner","year":"2006","journal-title":"Rev Med Virol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1056\/NEJMra020025","article-title":"Diagnosis and management of smallpox","volume":"346","author":"JG Breman","year":"2002","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.53.1.1","article-title":"The relationship between the virus of infectious ectromelia of mice and vaccinia virus","volume":"53","author":"FM Burnet","year":"1946","journal-title":"J Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/icb.1947.38","article-title":"Studies in infectious ectromelia of mice; immunization of mice against ectromelia with living vaccinia virus","volume":"25","author":"F Fenner","year":"1947","journal-title":"Aust J Exp Biol Med Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1099\/vir.0.19565-0","article-title":"Poxvirus genomes: a phylogenetic analysis","volume":"85","author":"C Gubser","year":"2004","journal-title":"J Gen Virol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e7428","DOI":"10.1371\/journal.pone.0007428","article-title":"One more piece in the VACV ecological puzzle: could peridomestic rodents be the link between wildlife and bovine vaccinia outbreaks in Brazil?","volume":"4","author":"JS Abrah\u00e3o","year":"2009","journal-title":"PLoS ONE"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3201\/eid1606.100315","article-title":"Whence Feral Vaccinia?","volume":"16","author":"RC Condit","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1099\/0022-1317-80-10-2751","article-title":"A model for vaccinia virus pathogenesis and immunity based on intradermal injection of mouse ear pinnae","volume":"80","author":"DC Tscharke","year":"1999","journal-title":"J Gen Virol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrmicro1099","article-title":"Poxvirus tropism","volume":"3","author":"G McFadden","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.meegid.2012.12.002","article-title":"A survey of host range genes in poxvirus genomes","volume":"14","author":"KA Bratke","year":"2013","journal-title":"Infect Genet Evol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.meegid.2013.10.014","article-title":"Poxviruses and the evolution of host range and virulence","volume":"21","author":"SL Haller","year":"2014","journal-title":"Infect Genet Evol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0065-3527(08)00003-1","article-title":"Poxvirus host range genes","volume":"71","author":"SJ Werden","year":"2008","journal-title":"Adv Virus Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev.immunol.21.120601.141049","article-title":"Poxviruses and immune evasion","volume":"21","author":"BT Seet","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.virusres.2005.10.014","article-title":"Inhibition of PKR by RNA and DNA viruses","volume":"119","author":"JO Langland","year":"2006","journal-title":"Virus Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF00370005","article-title":"Host-range restriction of vaccinia virus E3L-specific deletion mutants","volume":"12","author":"E Beattie","year":"1996","journal-title":"Virus Genes"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/viro.2002.1479","article-title":"The role of the PKR-inhibitory genes, E3L and K3L, in determining vaccinia virus host range","volume":"299","author":"JO Langland","year":"2002","journal-title":"Virology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1128\/JVI.76.3.1124-1134.2002","article-title":"Inhibition of Interferons by Ectromelia Virus","volume":"76","author":"VP Smith","year":"2002","journal-title":"Journal of Virology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1074\/jbc.270.6.2601","article-title":"Mutational analysis of the double-stranded RNA (dsRNA) binding domain of the dsRNA-activated protein kinase, PKR","volume":"270","author":"NA McMillan","year":"1995","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1016\/j.febslet.2010.10.003","article-title":"NMR study of hydrogen exchange during the B-Z transition of a DNA duplex induced by the Z\u03b1 domains of yatapoxvirus E3L","volume":"584","author":"E-H Lee","year":"2010","journal-title":"FEBS Lett"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1073\/pnas.0408714102","article-title":"A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains","volume":"102","author":"S Rothenburg","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1073\/pnas.0308260100","article-title":"Evidence that vaccinia virulence factor E3L binds to Z-DNA in vivo: Implications for development of a therapy for poxvirus infection","volume":"101","author":"Y-G Kim","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"12837","DOI":"10.1016\/S0021-9258(18)31463-7","article-title":"Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase","volume":"268","author":"K Carroll","year":"1993","journal-title":"Journal of Biological Chemistry"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0042-6822(03)00520-8","article-title":"The genomic sequence of ectromelia virus, the causative agent of mousepox","volume":"317","author":"N Chen","year":"2003","journal-title":"Virology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0042-6822(92)90445-U","article-title":"Restricted replication of ectromelia virus in cell culture correlates with mutations in virus-encoded host range gene","volume":"187","author":"W Chen","year":"1992","journal-title":"Virology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e1003465","DOI":"10.1371\/journal.ppat.1003465","article-title":"Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA\/DHX9 to promote expanded host tropism and viral replication","volume":"9","author":"MM Rahman","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1371\/journal.ppat.0040030","article-title":"A role for NKG2D in NK cell-mediated resistance to poxvirus disease","volume":"4","author":"M Fang","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e1004002","DOI":"10.1371\/journal.ppat.1004002","article-title":"Adaptive gene amplification as an intermediate step in the expansion of virus host range","volume":"10","author":"G Brennan","year":"2014","journal-title":"PLoS Pathog"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1042\/BC20040058","article-title":"Virus factories: associations of cell organelles for viral replication and morphogenesis","volume":"97","author":"RR Novoa","year":"2005","journal-title":"Biol Cell"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1099\/0022-1317-83-12-2915","article-title":"The formation and function of extracellular enveloped vaccinia virus","volume":"83","author":"GL Smith","year":"2002","journal-title":"J Gen Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.tim.2008.07.009","article-title":"Vaccinia virus morphogenesis and dissemination","volume":"16","author":"KL Roberts","year":"2008","journal-title":"Trends in Microbiology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/MMBR.55.1.80-122.1991","article-title":"Poxvirus pathogenesis","volume":"55","author":"RM Buller","year":"1991","journal-title":"Microbiol Rev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1006\/viro.1993.1302","article-title":"The vaccinia virus 42-kDa envelope protein is required for the envelopment and egress of extracellular virus and for virus virulence","volume":"194","author":"M Engelstad","year":"1993","journal-title":"Virology"},{"key":"ref35","first-page":"319","article-title":"Variable resistance to ectromelia (mousepox) virus among genera of Mus","volume":"127","author":"RM Buller","year":"1986","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1172\/JCI9819","article-title":"Poxvirus vectors: orphaned and underappreciated","volume":"105","author":"MJ Mastrangelo","year":"2000","journal-title":"J Clin Invest"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.4161\/hv.20778","article-title":"Poxvirus vectors as HIV\/AIDS vaccines in humans","volume":"8","author":"CE G\u00f3mez","year":"2012","journal-title":"Hum Vaccin Immunother"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nm.3089","article-title":"Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer","volume":"19","author":"J Heo","year":"2013","journal-title":"Nature Medicine"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.tim.2011.12.001","article-title":"Outbreaks of human monkeypox after cessation of smallpox vaccination","volume":"20","author":"MG Reynolds","year":"2012","journal-title":"Trends in Microbiology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0119189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T15:17:02Z","timestamp":1691507822000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0119189"}},"subtitle":[],"editor":[{"given":"Xiangzhi","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,3]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0119189","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,3]]}}}