{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:35:41Z","timestamp":1791326141664,"version":"4.3.1"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T00:00:00Z","timestamp":1425859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0119275","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T13:41:42Z","timestamp":1425908502000},"page":"e0119275","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficient Differentiation of Steroidogenic and Germ-Like Cells from Epigenetically-Related iPSCs Derived from Ovarian Granulosa Cells"],"prefix":"10.1371","volume":"10","author":[{"given":"Raymond","family":"Anchan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Gerami-Naini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Lindsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua W. K.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kiezun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Lipskind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"LiCausi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Brezina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Tuschl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Maas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Kearns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zev","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,9]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1038\/nprot.2007.418","article-title":"Induction of pluripotent stem cells from fibroblast cultures","volume":"2","author":"K Takahashi","year":"2007","journal-title":"Nat Protoc"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"K Takahashi","year":"2006","journal-title":"Cell"},{"issue":"15","key":"ref3","doi-asserted-by":"crossref","first-page":"5856","DOI":"10.1073\/pnas.0801677105","article-title":"Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson\u2019s disease","volume":"105","author":"M Wernig","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5858","key":"ref4","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1126\/science.1152092","article-title":"Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin","volume":"318","author":"J Hanna","year":"2007","journal-title":"Science"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"e8975","DOI":"10.1371\/journal.pone.0008975","article-title":"Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells","volume":"5","author":"Z Ghosh","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.stem.2009.06.008","article-title":"Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures","volume":"5","author":"MH Chin","year":"2009","journal-title":"Cell Stem Cell"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"e7076","DOI":"10.1371\/journal.pone.0007076","article-title":"Transcriptional signature and memory retention of human-induced pluripotent stem cells","volume":"4","author":"MC Marchetto","year":"2009","journal-title":"PLoS One"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cell.2010.12.032","article-title":"Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines","volume":"144","author":"C Bock","year":"2011","journal-title":"Cell"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/ncb2239","article-title":"Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells","volume":"13","author":"Y Ohi","year":"2011","journal-title":"Nat Cell Biol"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1101\/gad.947102","article-title":"DNA methylation patterns and epigenetic memory","volume":"16","author":"A Bird","year":"2002","journal-title":"Genes Dev"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1242\/dev.020867","article-title":"Epigenetic reprogramming and induced pluripotency","volume":"136","author":"K Hochedlinger","year":"2009","journal-title":"Development"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/bfgp\/elt011","article-title":"Epigenetic memory in the context of nuclear reprogramming and cancer","volume":"12","author":"RP Halley-Stott","year":"2013","journal-title":"Brief Funct Genomics"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.stem.2011.06.007","article-title":"Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells","volume":"9","author":"O Bar-Nur","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1002\/stem.531","article-title":"Memory in induced pluripotent stem cells: reprogrammed human retinal-pigmented epithelial cells show tendency for spontaneous redifferentiation","volume":"28","author":"Q Hu","year":"2010","journal-title":"Stem Cells"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nbt.1667","article-title":"Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells","volume":"28","author":"JM Polo","year":"2010","journal-title":"Nat Biotechnol"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.critrevonc.2009.09.006","article-title":"Fertility concerns and preservation in younger women with breast cancer","volume":"74","author":"RM Anchan","year":"2010","journal-title":"Crit Rev Oncol Hematol"},{"issue":"36","key":"ref17","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1200\/JCO.2006.07.2793","article-title":"Amenorrhea in premenopausal women after adjuvant chemotherapy for breast cancer","volume":"24","author":"JM Walshe","year":"2006","journal-title":"J Clin Oncol"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1177\/107327480200900603","article-title":"Chemotherapy-induced amenorrhea and fertility in women undergoing adjuvant treatment for breast cancer","volume":"9","author":"SE Minton","year":"2002","journal-title":"Cancer Control"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/humupd\/7.6.535","article-title":"The effects of radiotherapy and chemotherapy on female reproduction","volume":"7","author":"D Meirow","year":"2001","journal-title":"Hum Reprod Update"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/humupd\/dmm040","article-title":"Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality","volume":"14","author":"RB Gilchrist","year":"2008","journal-title":"Hum Reprod Update"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1477-7827-4-19","article-title":"Oocyte-granulosa cell interactions during mouse follicular development: regulation of kit ligand expression and its role in oocyte growth","volume":"4","author":"FH Thomas","year":"2006","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/dbio.2000.9947","article-title":"Transcriptional activity of the mouse oocyte genome: companion granulosa cells modulate transcription and chromatin remodeling","volume":"229","author":"R De La Fuente","year":"2001","journal-title":"Dev Biol"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/dbio.2000.9863","article-title":"Oocyte-granulosa cell heterologous gap junctions are required for the coordination of nuclear and cytoplasmic meiotic competence","volume":"226","author":"MJ Carabatsos","year":"2000","journal-title":"Dev Biol"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1095\/biolreprod53.6.1243","article-title":"Differential regulation of progesterone and estradiol production by mouse cumulus and mural granulosa cells by A factor[s] secreted by the oocyte","volume":"53","author":"BC Vanderhyden","year":"1995","journal-title":"Biol Reprod"},{"key":"ref25","unstructured":"Society for Assisted Reproductive Technology CORS. Clinic Reporting Summary for 2011 [All SART Member Clinics]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sart.org\/find_frm.html\" xlink:type=\"simple\">http:\/\/www.sart.org\/find_frm.html<\/ext-link> 2013."},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1210\/en.2003-1241","article-title":"Trophoblast differentiation in embryoid bodies derived from human embryonic stem cells","volume":"145","author":"B Gerami-Naini","year":"2004","journal-title":"Endocrinology"},{"key":"ref27","article-title":"Society for Gynecologic Investigation 2013 Meeting","author":"S Lipskind","year":"2013"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1073\/pnas.0609277104","article-title":"Developmental and adult phenotyping directly from mutant embryonic stem cells","volume":"104","author":"SH George","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s13238-011-1012-7","article-title":"Reprogrammed mouse astrocytes retain a \u201cmemory\u201d of tissue origin and possess more tendencies for neuronal differentiation than reprogrammed mouse embryonic fibroblasts","volume":"2","author":"C Tian","year":"2011","journal-title":"Protein Cell"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0301-472X(03)00260-1","article-title":"Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics","volume":"31","author":"T Kitamura","year":"2003","journal-title":"Exp Hematol"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/hmg\/ddq542","article-title":"Amniocytes can serve a dual function as a source of iPS cells and feeder layers","volume":"20","author":"RM Anchan","year":"2011","journal-title":"Hum Mol Genet"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3727\/096368910X491374","article-title":"The efficient generation of induced pluripotent stem [iPS] cells from adult mouse adipose tissue-derived and neural stem cells","volume":"19","author":"PA Tat","year":"2010","journal-title":"Cell Transplant"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1073\/pnas.0711983105","article-title":"Generation of human induced pluripotent stem cells from dermal fibroblasts","volume":"105","author":"WE Lowry","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"ref34","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/bioinformatics\/btn224","article-title":"lumi: a pipeline for processing Illumina microarray","volume":"24","author":"P Du","year":"2008","journal-title":"Bioinformatics"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1210\/er.2003-0030","article-title":"Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones","volume":"25","author":"AH Payne","year":"2004","journal-title":"Endocr Rev"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"Article3","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"GK Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ymeth.2012.07.030","article-title":"Barcoded cDNA library preparation for small RNA profiling by next-generation sequencing","volume":"58","author":"M Hafner","year":"2012","journal-title":"Methods"},{"issue":"13","key":"ref38","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1158\/0008-5472.CAN-11-0608","article-title":"MicroRNA sequence and expression analysis in breast tumors by deep sequencing","volume":"71","author":"TA Farazi","year":"2011","journal-title":"Cancer Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fgene.2013.00145","article-title":"Mammalian miRNA curation through next-generation sequencing","volume":"4","author":"M Brown","year":"2013","journal-title":"Front Genet"},{"issue":"5819","key":"ref40","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/292154a0","article-title":"Establishment in culture of pluripotential cells from mouse embryos","volume":"292","author":"MJ Evans","year":"1981","journal-title":"Nature"},{"issue":"5391","key":"ref41","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"JA Thomson","year":"1998","journal-title":"Science"},{"issue":"5858","key":"ref42","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.1151526","article-title":"Induced pluripotent stem cell lines derived from human somatic cells","volume":"318","author":"J Yu","year":"2007","journal-title":"Science"},{"issue":"7204","key":"ref43","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nature07061","article-title":"Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors","volume":"454","author":"JB Kim","year":"2008","journal-title":"Nature"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1095\/biolreprod48.4.798","article-title":"Pattern of lactate production and steroidogenesis during growth and maturation of mouse ovarian follicles in vitro","volume":"48","author":"NI Boland","year":"1993","journal-title":"Biol Reprod"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1177\/1933719113483017","article-title":"Embryonic stem cell-derived granulosa cells participate in ovarian follicle formation in vitro and in vivo","volume":"20","author":"DC Woods","year":"2013","journal-title":"Reprod Sci"},{"issue":"9","key":"ref46","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1210\/jc.2012-4302","article-title":"Differentiation of human embryonic stem cells into functional ovarian granulosa-like cells","volume":"98","author":"CW Lan","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/abbs\/gmt008","article-title":"Differentiation of rat iPS cells and ES cells into granulosa cell-like cells in vitro","volume":"45","author":"J Zhang","year":"2013","journal-title":"Acta Biochim Biophys Sin [Shanghai]"},{"issue":"7336","key":"ref48","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature09805","article-title":"Somatic coding mutations in human induced pluripotent stem cells","volume":"471","author":"A Gore","year":"2011","journal-title":"Nature"},{"issue":"7336","key":"ref49","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature09871","article-title":"Copy number variation and selection during reprogramming to pluripotency","volume":"471","author":"SM Hussein","year":"2011","journal-title":"Nature"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.stem.2010.12.003","article-title":"Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture","volume":"8","author":"LC Laurent","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"20","key":"ref51","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1128\/MCB.20.20.7419-7426.2000","article-title":"Retroviral expression in embryonic stem cells and hematopoietic stem cells","volume":"20","author":"SR Cherry","year":"2000","journal-title":"Mol Cell Biol"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrm3043","article-title":"Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration","volume":"12","author":"C Jopling","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"ref53","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1073\/pnas.1016030108","article-title":"Transdifferentiation of glioblastoma cells into vascular endothelial cells","volume":"108","author":"Y Soda","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2010.07.002","article-title":"Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors","volume":"142","author":"M Ieda","year":"2010","journal-title":"Cell"},{"issue":"2","key":"ref55","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ydbio.2013.08.026","article-title":"Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary","volume":"383","author":"DM Maatouk","year":"2013","journal-title":"Dev Biol"},{"issue":"10","key":"ref56","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s10815-013-0068-0","article-title":"Plasticity of granulosa cells: on the crossroad of stemness and transdifferentiation potential","volume":"30","author":"E Dzafic","year":"2013","journal-title":"J Assist Reprod Genet"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1042\/BJ20120172","article-title":"Dedifferentiated follicular granulosa cells derived from pig ovary can transdifferentiate into osteoblasts","volume":"447","author":"Y Oki","year":"2012","journal-title":"Biochem J"},{"issue":"5","key":"ref58","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.gde.2013.06.005","article-title":"Epigenetics of cellular reprogramming","volume":"23","author":"R Krishnakumar","year":"2013","journal-title":"Curr Opin Genet Dev"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1161\/CIRCRESAHA.113.301053","article-title":"Therapeutic transdifferentiation: a novel approach for vascular disease","volume":"112","author":"JP Cooke","year":"2013","journal-title":"Circ Res"},{"issue":"6","key":"ref60","doi-asserted-by":"crossref","first-page":"e65169","DOI":"10.1371\/journal.pone.0065169","article-title":"Lymphoid to myeloid cell trans-differentiation is determined by C\/EBPbeta structure and post-translational modifications","volume":"8","author":"B Stoilova","year":"2013","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0119275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T16:02:32Z","timestamp":1566403352000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0119275"}},"subtitle":[],"editor":[{"given":"Craig N","family":"Robson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,9]]},"references-count":60,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0119275","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,9]]}}}