{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T21:05:54Z","timestamp":1772053554054,"version":"3.50.1"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T00:00:00Z","timestamp":1427673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0119325","type":"journal-article","created":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T12:22:59Z","timestamp":1427804579000},"page":"e0119325","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Adult Non-Cystic Fibrosis Bronchiectasis Is Characterised by Airway Luminal Th17 Pathway Activation"],"prefix":"10.1371","volume":"10","author":[{"given":"Alice C.-H.","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan L.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Lourie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraint B.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy D.","family":"Burr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumaira Z.","family":"Hasnain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon D.","family":"Bowler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"McGuckin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Serisier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1440-1843.2009.01569.x","article-title":"Clinical challenges in managing bronchiectasis","volume":"14","author":"KW Tsang","year":"2009","journal-title":"Respirology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.cpm.0000171422.98696.ed","article-title":"Prevalence and economic burden of bronchiectasis","volume":"12","author":"D Weycker","year":"2005","journal-title":"Clin Pulm Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1136\/thorax.55.8.635","article-title":"Physiological and radiological characterization of patients diagnosed with chronic obstructive pulmonary disease in primary care","volume":"55","author":"C O\u2019Brien","year":"2000","journal-title":"Thorax"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1164\/rccm.201208-1518OC","article-title":"Prognostic value of bronchiectasis in patients with moderate-to-severe chronic obstructive pulmonary disease","volume":"187","author":"MA Martinez-Garcia","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1164\/ajrccm.164.9.2105083","article-title":"Bronchial inflammation and colonisation in patients with clinically stable bronchiectasis","volume":"164","author":"J Angrill","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1164\/rccm.201203-0487OC","article-title":"Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-CF bronchiectasis","volume":"186","author":"JD Chalmers","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/thoraxjnl-2012-203105","article-title":"Clinical measures of disease in adult non-CF bronchiectasis correlate with airway microbiota composition","volume":"68","author":"GB Rogers","year":"2013","journal-title":"Thorax"},{"key":"ref8","first-page":"6","article-title":"Inflammation: a two-edged sword\u2014the model of bronchiectasis","volume":"147","author":"PJ Cole","year":"1986","journal-title":"Eur J Respir Dis Suppl"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1056\/NEJMra0707449","article-title":"Interleukin-17 and type 17 helper T cells","volume":"361","author":"P Miossec","year":"2009","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1183\/09031936.02.00282402","article-title":"Overexpression of matrix metalloproteinase-8 and -9 in bronchiectatic airways in vivo","volume":"20","author":"L Zheng","year":"2002","journal-title":"Eur Respir J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1164\/rccm.201102-0236OC","article-title":"The Th17 pathway in cystic fibrosis lung disease","volume":"184","author":"HL Tan","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1164\/rccm.201206-1150OC","article-title":"A Th17- and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for <italic>Pseudomonas aeruginosa<\/italic> infection","volume":"187","author":"K Tiringer","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00408-014-9619-0","article-title":"Low-dose clarithromycin therapy modulates Th17 response in non-cystic fibrosis bronchiectasis patients","volume":"192","author":"E Fouka","year":"2014","journal-title":"Lung"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1001\/jama.2013.2290","article-title":"Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial","volume":"309","author":"DJ Serisier","year":"2013","journal-title":"JAMA"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.rmed.2011.01.009","article-title":"Long-term, low-dose erythromycin in subjects with frequent exacerbations","volume":"105","author":"DJ Serisier","year":"2011","journal-title":"Respir Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/1465-9921-11-177","article-title":"Elevated expression of both mRNA and protein levels of IL-17a in sputum of stable cystic fibrosis patients","volume":"11","author":"A Decraene","year":"2010","journal-title":"Respir Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4049\/jimmunol.175.1.404","article-title":"Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis","volume":"175","author":"F McAllister","year":"2005","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1164\/ajrccm.185.1.108a","article-title":"Interleukin-17 and cystic fibrosis lung disease","volume":"185","author":"M Brodlie","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref19","first-page":"109","article-title":"Response to Brodlie","volume":"185","author":"HL Tan","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1164\/rccm.201007-1196PP","article-title":"Innate and adaptive interleukin-17-producing lymphocytes in chronic inflammatory lung disorders","volume":"183","author":"BM Vanaudenaerde","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/thx.53.8.685","article-title":"Increases in CD4+ T lymphocytes, macrophages, neutrophils and interleukin 8 positive cells in the airways of patients with bronchiectasis","volume":"53","author":"M Gaga","year":"1998","journal-title":"Thorax"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1053\/rmed.2001.1155","article-title":"Macrophages, neutrophils and tumour necrosis factor-alpha expression in bronchiectatic airways in vivo","volume":"95","author":"L Zheng","year":"2001","journal-title":"Respir Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nri2800","article-title":"Innate IL-17-producing cells: the sentinels of the immune system","volume":"10","author":"DJ Cua","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref24","first-page":"267971","article-title":"IL-17a and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection","volume":"2013","author":"H-C Tsai","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1084\/jem.20071978","article-title":"Regulation of inflammatory responses by IL-17F","volume":"205","author":"XO Yang","year":"2008","journal-title":"J Exp Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1128\/IAI.05988-11","article-title":"Differential role of the interleukin-17 axis and neutrophils in resolution of inhalational anthrax","volume":"80","author":"K Garraud","year":"2012","journal-title":"Infect Immun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1513\/AnnalsATS.201310-335OC","article-title":"A novel microbiota stratification system predicts future exacerbations in bronchiectasis","volume":"11","author":"GB Rogers","year":"2014","journal-title":"Ann Am Thorac Soc"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S2213-2600(14)70213-9","article-title":"The effect of long-term macrolide treatment on respiratory microbiota composition in non-cystic fibrosis bronchiectasis: an analysis from the randomised, double-blind, placebo-controlled BLESS trial","volume":"2","author":"GB Rogers","year":"2014","journal-title":"Lancet Respir Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1084\/jem.20071239","article-title":"Immune recognition of <italic>Pseudomonas aeruginosa<\/italic> mediated by the IPAF\/ NRLC4 inflammasome","volume":"204","author":"FS Sutterwala","year":"2007","journal-title":"J Exp Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0119325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T06:47:37Z","timestamp":1589006857000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0119325"}},"subtitle":[],"editor":[{"given":"Jeffrey M.","family":"Beekman","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,30]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0119325","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,30]]}}}