{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:51:15Z","timestamp":1790563875643,"version":"4.1.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0119336","type":"journal-article","created":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T18:58:15Z","timestamp":1427137095000},"page":"e0119336","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["miRNA Expression Profile and Involvement of Let-7d-APP in Aged Rats with Isoflurane-Induced Learning and Memory Impairment"],"prefix":"10.1371","volume":"10","author":[{"given":"Ting","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhou","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengshi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/01.anes.0000299435.59242.0e","article-title":"The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1, 4, 5-trisphosphate receptors","volume":"108","author":"H Wei","year":"2008","journal-title":"Anesthesiology"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/jcbfm.2009.274","article-title":"Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents","volume":"30","author":"C Zhu","year":"2010","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00000542-200402000-00020","article-title":"Long-term impairment of acquisition of a spatial memory task following isoflurane\u00a8Cnitrous oxide anesthesia in rats","volume":"100","author":"DJ Culley","year":"2004","journal-title":"Anesthesiology"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1523\/JNEUROSCI.23-03-00876.2003","article-title":"Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits","volume":"23","author":"V Jevtovic-Todorovic","year":"2003","journal-title":"The Journal of Neuroscience"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.neurobiolaging.2007.02.009","article-title":"Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics","volume":"29","author":"SL Bianchi","year":"2008","journal-title":"Neurobiology of aging"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12630-010-9418-x","article-title":"Brief review: anesthetic neurotoxicity in the elderly, cognitive dysfunction and Alzheimer\u2019s disease","volume":"58","author":"EA Bittner","year":"2011","journal-title":"Canadian Journal of Anesthesia\/Journal canadien d'anesth\u00e9sie"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.molcel.2004.12.002","article-title":"Transcription and processing of human microRNA precursors","volume":"16","author":"BR Cullen","year":"2004","journal-title":"Molecular Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.brainres.2010.03.103","article-title":"MicroRNAs as biomarkers for CNS cancer and other disorders","volume":"1338","author":"E De Smaele","year":"2010","journal-title":"Brain Research"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s12017-009-8066-1","article-title":"microRNAs in CNS disorders","volume":"11","author":"J Kocerha","year":"2009","journal-title":"NeuroMolecular Medicine"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jnr.22701","article-title":"Role of microRNAs in central nervous system development and pathology","volume":"90","author":"KF Meza\u2010Sosa","year":"2012","journal-title":"Journal of neuroscience research"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00001756-199305000-00015","article-title":"Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment <italic>25\u201335<\/italic>","volume":"4","author":"G Forloni","year":"1993","journal-title":"Neuroreport"},{"issue":"17","key":"ref12","doi-asserted-by":"crossref","first-page":"7951","DOI":"10.1073\/pnas.90.17.7951","article-title":"Apoptosis is induced by beta-amyloid in cultured central nervous system neurons","volume":"90","author":"DT Loo","year":"1993","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.neuropharm.2007.09.005","article-title":"Effects of fetal exposure to isoflurane on postnatal memory and learning in rats","volume":"53","author":"Y Li","year":"2007","journal-title":"Neuropharmacology"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.exger.2008.06.004","article-title":"Neuroinflammation and cognitive function in aged mice following minor surgery","volume":"43","author":"HA Rosczyk","year":"2008","journal-title":"Experimental Gerontology"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"CV Vorhees","year":"2006","journal-title":"Nature protocols"},{"issue":"46","key":"ref16","doi-asserted-by":"crossref","first-page":"31315","DOI":"10.1074\/jbc.M805371200","article-title":"An NF-kappa B-sensitive Micro RNA-146a-mediated Inflammatory Circuit in Alzheimer Disease and in Stressed Human Brain Cells","volume":"283","author":"WJ Lukiw","year":"2008","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","article-title":"Identification of miRNA changes in Alzheimer&apos;s disease brain and CSF yields putative biomarkers and insights into disease pathways","volume":"14","author":"JP Cogswell","year":"2008","journal-title":"Journal of Alzheimer's disease"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.nlm.2011.04.004","article-title":"MicroRNA regulation of neural plasticity and memory","volume":"96","author":"WB Timothy","year":"2011","journal-title":"Neurobiol Learn Mem"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1213\/01.ane.0000167382.79889.7c","article-title":"Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures","volume":"101","author":"L Wise-Faberowski","year":"2005","journal-title":"Anesthesia & Analgesia"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1213\/ane.0b013e3181605b71","article-title":"A presenilin-1 mutation renders neurons vulnerable to isoflurane toxicity","volume":"106","author":"G Liang","year":"2008","journal-title":"Anesthesia & Analgesia"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainres.2005.01.009","article-title":"Isoflurane and sevoflurane affect cell survival and BCL-2\/BAX ratio differently","volume":"1037","author":"H Wei","year":"2005","journal-title":"Brain Research"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/gb-2004-5-3-r13","article-title":"Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation","volume":"5","author":"LF Sempere","year":"2004","journal-title":"Genome Biology"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neulet.2009.04.043","article-title":"microRNA involvement in developmental and functional aspects of the nervous system and in neurological diseases","volume":"466","author":"M Christensen","year":"2009","journal-title":"Neuroscience Letters"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.conb.2009.05.015","article-title":"Fine-tuning neural gene expression with microRNAs","volume":"19","author":"G Schratt","year":"2009","journal-title":"Current opinion in neurobiology"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"2316.e17","DOI":"10.1016\/j.neurobiolaging.2010.03.014","article-title":"Genome-wide analysis of miRNA expression reveals a potential role for miR-144 in brain aging and spinocerebellar ataxia pathogenesis","volume":"32","author":"S Persengiev","year":"2011","journal-title":"Neurobiology of aging"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1097\/00000542-200605000-00015","article-title":"The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid \u03b2 protein levels","volume":"104","author":"Z Xie","year":"2006","journal-title":"Anesthesiology"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/00000542-200409000-00019","article-title":"Inhaled anesthetic enhancement of amyloid-\u03b2 oligomerization and cytotoxicity","volume":"101","author":"RG Eckenhof","year":"2004","journal-title":"Anesthesiology"},{"issue":"1","key":"ref28","first-page":"1","article-title":"Are volatile anesthetics neuroprotective or neurotoxic?","volume":"2","author":"Z Zuo","year":"2012","journal-title":"Medical Gas Research"},{"issue":"16","key":"ref29","doi-asserted-by":"crossref","first-page":"7713","DOI":"10.1158\/0008-5472.CAN-07-1083","article-title":"The let-7 microRNA represses cell proliferation pathways in human cells","volume":"67","author":"CD Johnson","year":"2007","journal-title":"Cancer Research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0119336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T08:56:40Z","timestamp":1566464200000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0119336"}},"subtitle":[],"editor":[{"given":"Zhiyi","family":"Zuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,23]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0119336","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,23]]}}}