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hypoxia and immunity in preeclampsia","volume":"85","author":"S Sharma","year":"2010","journal-title":"J Reprod Immunol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.2353\/ajpath.2010.100475","article-title":"Sera from preeclampsia patients elicit symptoms of human disease in mice and provide a basis for an in vitro predictive assay","volume":"177","author":"S Kalkunte","year":"2010","journal-title":"Am J Pathol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semnephrol.2010.10.004","article-title":"Angiogenic factors and preeclampsia","volume":"31","author":"SE Maynard","year":"2011","journal-title":"Semin Nephrol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"SE Maynard","year":"2003","journal-title":"J Clin Invest"},{"key":"ref88","first-page":"728","article-title":"Recent advances in understanding of preeclampsia","volume":"46","author":"Y Bdolah","year":"2005","journal-title":"Croat Med J"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"1R","DOI":"10.1203\/01.PDR.0000159567.85157.B7","article-title":"Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia","volume":"57","author":"SE Maynard","year":"2005","journal-title":"Pediatr Res"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1429","article-title":"Soluble endoglin contributes to the pathogenesis of preeclampsia","volume":"12","author":"S Venkatesha","year":"2006","journal-title":"Nat Med"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1152\/physiol.00043.2008","article-title":"Preeclampsia: the role of angiogenic factors in its pathogenesis","volume":"24","author":"A Wang","year":"2009","journal-title":"Physiology (Bethesda)"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0165-0378(03)00044-5","article-title":"Trophoblast deportation and the maternal inflammatory response in pre-eclampsia","volume":"59","author":"IL Sargent","year":"2003","journal-title":"J Reprod Immunol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.4049\/jimmunol.178.9.5949","article-title":"Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles","volume":"178","author":"SJ Germain","year":"2007","journal-title":"J Immunol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1161\/CIRCRESAHA.108.171504","article-title":"A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia","volume":"102","author":"S Sela","year":"2008","journal-title":"Circ Res"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"156 e151","DOI":"10.1016\/j.ajog.2011.03.023","article-title":"Placental protein 13 (PP13\/galectin-13) undergoes lipid raft-associated subcellular redistribution in the syncytiotrophoblast in preterm preeclampsia and HELLP syndrome","volume":"205","author":"A Balogh","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1053\/plac.2000.0560","article-title":"Placental debris, oxidative stress and pre-eclampsia","volume":"21","author":"CW Redman","year":"2000","journal-title":"Placenta"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1067\/mob.2001.117311","article-title":"Phenotypic and metabolic characteristics of monocytes and granulocytes in preeclampsia","volume":"185","author":"MT Gervasi","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1067\/mob.2002.127309","article-title":"Maternal lymphocyte subpopulations (CD45RA+ and CD45RO+) in preeclampsia","volume":"187","author":"T Chaiworapongsa","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1600-0897.2008.00631.x","article-title":"A role for mannose-binding lectin, a component of the innate immune system in pre-eclampsia","volume":"60","author":"NG Than","year":"2008","journal-title":"Am J Reprod Immunol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3109\/14767050903216033","article-title":"Leukocytes of pregnant women with small-for-gestational age neonates have a different phenotypic and metabolic activity from those of women with preeclampsia","volume":"23","author":"G Ogge","year":"2010","journal-title":"J Matern Fetal Neonatal 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Gynecol"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-2007-1016249","article-title":"Circulating factors as markers and mediators of endothelial cell dysfunction in preeclampsia","volume":"16","author":"RN Taylor","year":"1998","journal-title":"Semin Reprod Endocrinol"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0002-9378(99)70239-5","article-title":"Preeclampsia: an excessive maternal inflammatory response to pregnancy","volume":"180","author":"CW Redman","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1111\/j.1523-1755.2005.00316.x","article-title":"Preeclampsia: a renal perspective","volume":"67","author":"SA Karumanchi","year":"2005","journal-title":"Kidney Int"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ajog.2007.02.013","article-title":"Preeclampsia and the kidney: footprints in the urine","volume":"196","author":"SA Karumanchi","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/14767050802034859","article-title":"Over-expression of the thrombin receptor (PAR-1) in the placenta in preeclampsia: a mechanism for the intersection of coagulation and inflammation","volume":"21","author":"O Erez","year":"2008","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1080\/14767050802361872","article-title":"Tissue factor and its natural inhibitor in pre-eclampsia and SGA","volume":"21","author":"O Erez","year":"2008","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1080\/14767050902801751","article-title":"Maternal anti-protein Z antibodies in pregnancies complicated by pre-eclampsia, SGA and fetal death","volume":"22","author":"O Erez","year":"2009","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/j.1471-0528.1999.tb08107.x","article-title":"Selective deficit of angiogenic growth factors characterises pregnancies complicated by pre-eclampsia","volume":"106","author":"A Reuvekamp","year":"1999","journal-title":"Br J Obstet Gynaecol"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.ajog.2004.03.043","article-title":"Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia. 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early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia","volume":"22","author":"JP Kusanovic","year":"2009","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/uog.7491","article-title":"Plasma soluble endoglin concentration in pre-eclampsia is associated with an increased impedance to flow in the maternal and fetal circulations","volume":"35","author":"T Chaiworapongsa","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"550 e551","DOI":"10.1016\/j.ajog.2010.04.002","article-title":"A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia","volume":"202","author":"T Chaiworapongsa","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3109\/14767050903366119","article-title":"Serum and plasma determination of angiogenic and anti-angiogenic factors yield different results: the need for standardization in clinical practice","volume":"23","author":"G Ogge","year":"2010","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"Suppl 3","key":"ref130","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1016\/S0049-3848(11)70020-2","article-title":"New insights into the etiology of preeclampsia: identification of key elusive factors for the vascular complications","volume":"127","author":"A Ahmed","year":"2011","journal-title":"Thromb Res"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3109\/14767058.2011.589932","article-title":"Maternal plasma concentrations of angiogenic\/anti-angiogenic factors are of prognostic value in patients presenting to the obstetrical triage area with the suspicion of preeclampsia","volume":"24","author":"T Chaiworapongsa","year":"2011","journal-title":"J Matern Fetal Neonatal 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Angiogenic factors and acute-phase proteins in serum samples of preeclampsia and HELLP patients: a matched-pair analysis. J Matern Fetal Neonatal Med. 2012.","DOI":"10.3109\/14767058.2012.733747"},{"key":"ref137","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/CS20110097","article-title":"Angiogenic growth factors in the diagnosis and prediction of pre-eclampsia","volume":"122","author":"S Verlohren","year":"2012","journal-title":"Clin Sci (Lond)"},{"key":"ref138","doi-asserted-by":"crossref","first-page":"140 e141","DOI":"10.1016\/j.ajog.2012.05.003","article-title":"Examining the correlation between placental and serum placenta growth factor in preeclampsia","volume":"207","author":"S Weed","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"ref139","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1095\/biolreprod59.6.1540","article-title":"A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation","volume":"59","author":"DE Clark","year":"1998","journal-title":"Biol Reprod"},{"key":"ref140","first-page":"353","article-title":"Amniotic fluid\u2014soluble vascular endothelial growth factor receptor-1 in preeclampsia","volume":"95","author":"P Vuorela","year":"2000","journal-title":"Obstet Gynecol"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1210\/jc.2002-021942","article-title":"Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia","volume":"88","author":"K Koga","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref142","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/mrd.10308","article-title":"Expression of vascular endothelial growth factor and its receptors in the rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy","volume":"65","author":"H Wang","year":"2003","journal-title":"Mol Reprod Dev"},{"key":"ref143","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1373\/clinchem.2004.036715","article-title":"Maternal serum sFlt1 concentration is an early and reliable predictive marker of preeclampsia","volume":"50","author":"A Hertig","year":"2004","journal-title":"Clin Chem"},{"key":"ref144","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1210\/jc.2003-031244","article-title":"First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia","volume":"89","author":"R Thadhani","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref145","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1093\/ndt\/gfm429","article-title":"Angiogenic factors in preeclampsia: so complex, so simple?","volume":"22","author":"N Berkane","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"ref146","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejogrb.2007.09.007","article-title":"Soluble endoglin levels during normotensive and hypertensive pregnancies","volume":"140","author":"A Hertig","year":"2008","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref147","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/GCO.0b013e328328cf7d","article-title":"The perinatal implications of angiogenic factors","volume":"21","author":"GC Smith","year":"2009","journal-title":"Curr Opin Obstet Gynecol"},{"key":"ref148","doi-asserted-by":"crossref","first-page":"e13263","DOI":"10.1371\/journal.pone.0013263","article-title":"Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies","volume":"5","author":"RW Powers","year":"2010","journal-title":"PLoS One"},{"key":"ref149","doi-asserted-by":"crossref","first-page":"594 e591","DOI":"10.1016\/j.ajog.2010.03.006","article-title":"Soluble endoglin in preeclamptic patients with or without HELLP syndrome","volume":"202","author":"A Hertig","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"ref150","doi-asserted-by":"crossref","first-page":"e18041","DOI":"10.1371\/journal.pone.0018041","article-title":"Soluble Flt-1 and PlGF: new markers of early pregnancy loss?","volume":"6","author":"S Muttukrishna","year":"2011","journal-title":"PLoS One"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"e110867","DOI":"10.1371\/journal.pone.0110867","article-title":"In vivo experiments reveal the good, the bad and the ugly faces of sFlt-1 in pregnancy","volume":"9","author":"G Szalai","year":"2014","journal-title":"PLoS One"},{"key":"ref152","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1172\/JCI76864","article-title":"Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications","volume":"124","author":"X Fan","year":"2014","journal-title":"J Clin Invest"},{"key":"ref153","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.placenta.2008.12.010","article-title":"Novel splice variants of sFlt1 are upregulated in preeclampsia","volume":"30","author":"M Heydarian","year":"2009","journal-title":"Placenta"},{"key":"ref154","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/HYPERTENSIONAHA.110.164079","article-title":"Expression of placental FLT1 transcript variants relates to both gestational hypertensive disease and fetal growth","volume":"58","author":"J Jebbink","year":"2011","journal-title":"Hypertension"},{"key":"ref155","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1111\/j.1471-0528.2011.02962.x","article-title":"Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia","volume":"118","author":"CL Whitehead","year":"2011","journal-title":"BJOG"},{"key":"ref156","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0002-9378(69)90060-X","article-title":"Glomerular capillary endothelial swelling in a pregnant chimpanzee","volume":"105","author":"C Stout","year":"1969","journal-title":"Am J Obstet Gynecol"},{"key":"ref157","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0002-9378(16)32642-4","article-title":"Eclampsia in a lowland gorilla","volume":"141","author":"JN Baird Jr","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"ref158","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0002-9378(11)91665-2","article-title":"Convulsions in pregnancy in related gorillas","volume":"167","author":"JG Thornton","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"ref159","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bpobgyn.2010.10.010","article-title":"Evolution of invasive placentation with special reference to non-human primates","volume":"25","author":"AM Carter","year":"2011","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref160","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1638\/2010-0237.1","article-title":"Pathologic lesions in chimpanzees (Pan trogylodytes schweinfurthii) from Gombe National Park, Tanzania, 2004\u20132010","volume":"42","author":"KA Terio","year":"2011","journal-title":"J Zoo Wildl Med"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/ajp.20573","article-title":"Causes of death in the Kasekela chimpanzees of Gombe National Park, Tanzania","volume":"70","author":"JM Williams","year":"2008","journal-title":"Am J Primatol"},{"key":"ref162","doi-asserted-by":"crossref","first-page":"e24509","DOI":"10.1371\/journal.pone.0024509","article-title":"Spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes)","volume":"6","author":"DE Wildman","year":"2011","journal-title":"PLoS One"},{"key":"ref163","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/1933719111431678","article-title":"PP13, decidual zones of necrosis, and spiral artery remodeling\u2014preeclampsia revisited?","volume":"19","author":"NG Than","year":"2012","journal-title":"Reprod Sci"},{"key":"ref164","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1387\/ijdb.140020dw","article-title":"The evolution of embryo implantation","volume":"58","author":"MR McGowen","year":"2014","journal-title":"Int J Dev Biol"},{"key":"ref165","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.placenta.2011.03.010","article-title":"Animal models of preeclampsia; uses and limitations","volume":"32","author":"FP McCarthy","year":"2011","journal-title":"Placenta"},{"key":"ref166","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1600-0897.2010.00929.x","article-title":"Animal models of pre-eclampsia","volume":"65","author":"N Sunderland","year":"2011","journal-title":"Am J Reprod Immunol"},{"key":"ref167","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/hy02t2.102904","article-title":"Discovery of a spontaneous genetic mouse model of preeclampsia","volume":"39","author":"RL Davisson","year":"2002","journal-title":"Hypertension"},{"key":"ref168","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1161\/HYPERTENSIONAHA.110.160242","article-title":"Adenoviral delivery of VEGF121 early in pregnancy prevents spontaneous development of preeclampsia in BPH\/5 mice","volume":"57","author":"AK Woods","year":"2011","journal-title":"Hypertension"},{"key":"ref169","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0002-9378(67)90448-6","article-title":"Chronic uterine ischemia and reversible experimental &quot;toxemia of pregnancy&quot;","volume":"97","author":"AA Hodari","year":"1967","journal-title":"Am J Obstet Gynecol"},{"key":"ref170","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0002-9378(77)90296-4","article-title":"Experimental toxemia in the pregnant primate","volume":"128","author":"D Cavanagh","year":"1977","journal-title":"Am J Obstet Gynecol"},{"key":"ref171","first-page":"H297","article-title":"A model for studying chronic reduction in uterine blood flow in pregnant sheep","volume":"242","author":"KE Clark","year":"1982","journal-title":"Am J Physiol"},{"key":"ref172","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00000441-199204000-00005","article-title":"Increased peripheral resistance during reduced uterine perfusion pressure hypertension in pregnant rabbits","volume":"303","author":"G Losonczy","year":"1992","journal-title":"Am J Med Sci"},{"key":"ref173","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0002-9378(93)90171-E","article-title":"Experimental preeclampsia produced by chronic constriction of the lower aorta: validation with longitudinal blood pressure measurements in conscious rhesus monkeys","volume":"169","author":"CA Combs","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"ref174","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/01.HYP.0000175476.26719.36","article-title":"Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of tumor necrosis factor-alpha","volume":"46","author":"BB LaMarca","year":"2005","journal-title":"Hypertension"},{"key":"ref175","first-page":"383","article-title":"Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemia","volume":"122","author":"JP Granger","year":"2006","journal-title":"Methods Mol Med"},{"key":"ref176","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1161\/HYPERTENSIONAHA.107.096594","article-title":"Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble fms-like tyrosine kinase-1 expression","volume":"50","author":"JS Gilbert","year":"2007","journal-title":"Hypertension"},{"key":"ref177","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.ki.5002175","article-title":"Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1","volume":"71","author":"A Makris","year":"2007","journal-title":"Kidney Int"},{"key":"ref178","doi-asserted-by":"crossref","first-page":"H2080","DOI":"10.1152\/ajpheart.00667.2007","article-title":"Systemic hemodynamic and regional blood flow changes in response to chronic reductions in uterine perfusion pressure in pregnant rats","volume":"293","author":"MM Sholook","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref179","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/HYPERTENSIONAHA.108.123513","article-title":"Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression","volume":"53","author":"JS Gilbert","year":"2009","journal-title":"Hypertension"},{"key":"ref180","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.00117.2012","article-title":"A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model","volume":"303","author":"J Li","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/S0002-9378(13)90488-9","article-title":"Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation","volume":"170","author":"M Molnar","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"ref182","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/377239a0","article-title":"Hypertension in mice lacking the gene for endothelial nitric oxide synthase","volume":"377","author":"PL Huang","year":"1995","journal-title":"Nature"},{"key":"ref183","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1161\/01.HYP.26.6.1019","article-title":"Effects of long-term nitric oxide synthesis inhibition on plasma volume expansion and fetal growth in the pregnant rat","volume":"26","author":"SP Salas","year":"1995","journal-title":"Hypertension"},{"key":"ref184","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1067\/mob.2001.118142","article-title":"Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy","volume":"185","author":"EG Shesely","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"ref185","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1681\/ASN.V919","article-title":"Chronic exogenous hyperinsulinemia in pregnancy: a rat model of pregnancy-induced hypertension","volume":"9","author":"E Podjarny","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"ref186","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature06951","article-title":"Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia","volume":"453","author":"K Kanasaki","year":"2008","journal-title":"Nature"},{"key":"ref187","doi-asserted-by":"crossref","first-page":"198 e191","DOI":"10.1016\/j.ajog.2008.10.003","article-title":"Hyperhomocysteinemia is not sufficient to cause preeclampsia in an animal model: the importance of folate intake","volume":"200","author":"S Falcao","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"ref188","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1089\/ars.2013.5661","article-title":"Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene","volume":"21","author":"L Doridot","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"ref189","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1089\/ars.2012.4637","article-title":"Prion protein expression and functional importance in developmental angiogenesis: role in oxidative stress and copper homeostasis","volume":"18","author":"N Alfaidy","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"ref190","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1126\/science.274.5289.995","article-title":"Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen","volume":"274","author":"E Takimoto","year":"1996","journal-title":"Science"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1681\/ASN.V11112056","article-title":"Rats transgenic for human renin and human angiotensinogen as a model for gestational hypertension","volume":"11","author":"J Bohlender","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"ref192","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nm.1856","article-title":"Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice","volume":"14","author":"CC Zhou","year":"2008","journal-title":"Nat Med"},{"key":"ref193","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1161\/HYPERTENSIONAHA.110.150540","article-title":"Autoantibody-mediated angiotensin receptor activation contributes to preeclampsia through tumor necrosis factor-alpha signaling","volume":"55","author":"RA Irani","year":"2010","journal-title":"Hypertension"},{"key":"ref194","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.HYP.0000113044.46326.98","article-title":"Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant rats","volume":"43","author":"JM Orshal","year":"2004","journal-title":"Hypertension"},{"key":"ref195","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/eji.200324469","article-title":"Introducing a mouse model for pre-eclampsia: adoptive transfer of activated Th1 cells leads to pre-eclampsia-like symptoms exclusively in pregnant mice","volume":"34","author":"AC Zenclussen","year":"2004","journal-title":"Eur J Immunol"},{"key":"ref196","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/HYPERTENSIONAHA.107.092098","article-title":"Recombinant vascular endothelial growth factor 121 attenuates hypertension and improves kidney damage in a rat model of preeclampsia","volume":"50","author":"Z Li","year":"2007","journal-title":"Hypertension"},{"key":"ref197","first-page":"396 e391","article-title":"The effect of over-expression of sFlt-1 on blood pressure and the occurrence of other manifestations of preeclampsia in unrestrained conscious pregnant mice","volume":"196","author":"F Lu","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"ref198","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1161\/HYPERTENSIONAHA.109.134668","article-title":"Effect of recombinant placental growth factor 2 on hypertension induced by full-length mouse soluble fms-like tyrosine kinase 1 adenoviral vector in pregnant mice","volume":"54","author":"H Suzuki","year":"2009","journal-title":"Hypertension"},{"key":"ref199","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/j.1582-4934.2009.00820.x","article-title":"Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model","volume":"14","author":"A Bergmann","year":"2010","journal-title":"J Cell Mol Med"},{"key":"ref200","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1073\/pnas.1011293108","article-title":"Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model","volume":"108","author":"K Kumasawa","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"H1781","DOI":"10.1152\/ajpheart.00373.2011","article-title":"Endothelial growth factor therapy improves preeclampsia-like manifestations in a murine model induced by overexpression of sVEGFR-1","volume":"301","author":"J Mateus","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref202","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1681\/ASN.2011040369","article-title":"eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype","volume":"23","author":"F Li","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"ref203","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/35080570","article-title":"Placental development: lessons from mouse mutants","volume":"2","author":"J Rossant","year":"2001","journal-title":"Nat Rev Genet"},{"key":"ref204","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1006\/dbio.2002.0773","article-title":"Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta","volume":"250","author":"SL Adamson","year":"2002","journal-title":"Dev Biol"},{"key":"ref205","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/plac.2001.0738","article-title":"Comparative developmental anatomy of the murine and human definitive placentae","volume":"23","author":"P Georgiades","year":"2002","journal-title":"Placenta"},{"issue":"Suppl A","key":"ref206","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.placenta.2006.11.002","article-title":"Animal models of human placentation\u2014a review","volume":"28","author":"AM Carter","year":"2007","journal-title":"Placenta"},{"key":"ref207","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/msb.2009.37","article-title":"Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology","volume":"5","author":"B Cox","year":"2009","journal-title":"Mol Syst Biol"},{"key":"ref208","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000362552","article-title":"Quantitative T2 changes and susceptibility-weighted magnetic resonance imaging in murine pregnancy","volume":"78","author":"U Krishnamurthy","year":"2014","journal-title":"Gynecol Obstet Invest"},{"key":"ref209","article-title":"National Research Council of the National Academies: Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"ref210","author":"K Theiler","year":"1989"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0895-6111(98)00060-3","article-title":"In utero ultrasound backscatter microscopy of early stage mouse embryos","volume":"23","author":"DH Turnbull","year":"1999","journal-title":"Comput Med Imaging Graph"},{"key":"ref212","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0301-5629(02)00567-7","article-title":"A new ultrasound instrument for in vivo microimaging of mice","volume":"28","author":"FS Foster","year":"2002","journal-title":"Ultrasound Med Biol"},{"key":"ref213","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1152\/physiolgenomics.00119.2001","article-title":"Applications for multifrequency ultrasound biomicroscopy in mice from implantation to adulthood","volume":"10","author":"YQ Zhou","year":"2002","journal-title":"Physiol Genomics"},{"key":"ref214","first-page":"262","article-title":"Ultrasound diagnosis of mouse pregnancy and gestational staging","volume":"56","author":"SD Brown","year":"2006","journal-title":"Comp Med"},{"key":"ref215","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-213X-6-10","article-title":"High resolution ultrasound-guided microinjection for interventional studies of early embryonic and placental development in vivo in mice","volume":"6","author":"JC Slevin","year":"2006","journal-title":"BMC Dev Biol"},{"key":"ref216","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.theriogenology.2008.02.012","article-title":"Non-invasive ultrasonographic characterization of phenotypic changes during embryo development in non-anesthetized mice of different genotypes","volume":"70","author":"P Pallares","year":"2008","journal-title":"Theriogenology"},{"key":"ref217","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1071\/RD08124","article-title":"In vivo virtual histology of mouse embryogenesis by ultrasound biomicroscopy and magnetic resonance imaging","volume":"21","author":"P Pallares","year":"2009","journal-title":"Reprod Fertil Dev"},{"key":"ref218","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ultrasmedbio.2013.09.026","article-title":"Evaluation of utero-placental and fetal hemodynamic parameters throughout gestation in pregnant mice using high-frequency ultrasound","volume":"40","author":"E Hernandez-Andrade","year":"2014","journal-title":"Ultrasound Med Biol"},{"key":"ref219","doi-asserted-by":"crossref","unstructured":"Hoogstraten-Miller SL, Brown PA. Techniques in aseptic rodent surgery. Curr Protoc Immunol. 2008; Chapter 1: Unit 1 12 11\u201311 12\u201314.","DOI":"10.1002\/0471142735.im0112s82"},{"key":"ref220","first-page":"115","article-title":"Growth of microvessels in serum-free matrix culture of rat aorta. A quantitative assay of angiogenesis in vitro","volume":"63","author":"RF Nicosia","year":"1990","journal-title":"Lab Invest"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nprot.2011.435","article-title":"Use of the mouse aortic ring assay to study angiogenesis","volume":"7","author":"M Baker","year":"2012","journal-title":"Nat Protoc"},{"key":"ref222","unstructured":"Jose Pinheiro DB, Saikat DebRoy, Deepayan Sarkar, the R Development Core Team. nlme: Linear and Nonlinear Mixed Effects Models. R package version 3.1\u2013108. 2013."},{"key":"ref223","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2353\/ajpath.2010.091209","article-title":"Myometrial wound healing post-Cesarean delivery in the MRL\/MpJ mouse model of uterine scarring","volume":"177","author":"CS Buhimschi","year":"2010","journal-title":"Am J Pathol"},{"key":"ref224","doi-asserted-by":"crossref","first-page":"H2408","DOI":"10.1152\/ajpheart.01089.2003","article-title":"Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods","volume":"286","author":"SE Whitesall","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref225","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1152\/jappl.2000.88.5.1537","article-title":"A new method for measurement of blood pressure, heart rate, and activity in the mouse by radiotelemetry","volume":"88","author":"PA Mills","year":"2000","journal-title":"J Appl Physiol"},{"key":"ref226","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1258\/002367700780384663","article-title":"Telemetric monitoring of blood pressure in freely moving mice: a preliminary study","volume":"34","author":"K Kramer","year":"2000","journal-title":"Lab Anim"},{"key":"ref227","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1056-8719(00)00126-X","article-title":"Direct and indirect methods used to study arterial blood pressure","volume":"44","author":"BN Van Vliet","year":"2000","journal-title":"J Pharmacol Toxicol Methods"},{"key":"ref228","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1152\/physiolgenomics.00164.2002","article-title":"Evaluation and applications of radiotelemetry in small laboratory animals","volume":"13","author":"K Kramer","year":"2003","journal-title":"Physiol Genomics"},{"key":"ref229","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/9780470942390.mo100149","article-title":"Arterial Pressure Monitoring in Mice","volume":"1","author":"X Zhao","year":"2011","journal-title":"Curr Protoc Mouse Biol"},{"key":"ref230","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/01.HYP.35.2.e1","article-title":"Long-term telemetric recording of arterial pressure and heart rate in mice fed basal and high NaCl diets","volume":"35","author":"SH Carlson","year":"2000","journal-title":"Hypertension"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1152\/physiolgenomics.2001.5.2.89","article-title":"Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool","volume":"5","author":"GM Butz","year":"2001","journal-title":"Physiol Genomics"},{"key":"ref232","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1161\/01.ATV.0000153088.15433.8f","article-title":"Recommendations for blood pressure measurement in animals: summary of an AHA scientific statement from the Council on High Blood Pressure Research, Professional and Public Education Subcommittee","volume":"25","author":"TW Kurtz","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref233","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1258\/002367707781282839","article-title":"Comparison of two methods (left carotid artery and abdominal aorta) for surgical implantation of radiotelemetry devices in CD-1 mice","volume":"41","author":"S Kaidi","year":"2007","journal-title":"Lab Anim"},{"key":"ref234","first-page":"32","year":"2011"},{"key":"ref235","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ogc.2010.02.013","article-title":"Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia","volume":"37","author":"M Silasi","year":"2010","journal-title":"Obstet Gynecol Clin North Am"},{"key":"ref236","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/ajh.2010.247","article-title":"Recombinant vascular endothelial growth factor 121 attenuates autoantibody-induced features of pre-eclampsia in pregnant mice","volume":"24","author":"AH Siddiqui","year":"2011","journal-title":"Am J Hypertens"},{"key":"ref237","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1161\/HYPERTENSIONAHA.109.137356","article-title":"Mice overexpressing both human angiotensinogen and human renin as a model of superimposed preeclampsia on chronic hypertension","volume":"54","author":"S Falcao","year":"2009","journal-title":"Hypertension"},{"key":"ref238","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/HYPERTENSIONAHA.111.175919","article-title":"Role of complement component C1q in the onset of preeclampsia in mice","volume":"58","author":"J Singh","year":"2011","journal-title":"Hypertension"},{"key":"ref239","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0149-7634(80)90012-3","article-title":"Placentophagia: a biobehavioral enigma (or De gustibus non disputandum est)","volume":"4","author":"MB Kristal","year":"1980","journal-title":"Neurosci Biobehav Rev"},{"key":"ref240","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1477-7827-6-34","article-title":"In vivo quantification of embryonic and placental growth during gestation in mice using micro-ultrasound","volume":"6","author":"J Mu","year":"2008","journal-title":"Reprod Biol Endocrinol"},{"key":"ref241","first-page":"519","article-title":"Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family","volume":"5","author":"M Shibuya","year":"1990","journal-title":"Oncogene"},{"key":"ref242","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1247\/csf.26.25","article-title":"Structure and function of VEGF\/VEGF-receptor system involved in angiogenesis","volume":"26","author":"M Shibuya","year":"2001","journal-title":"Cell Struct Funct"},{"key":"ref243","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2183\/pjab.87.167","article-title":"Involvement of Flt-1 (VEGF receptor-1) in cancer and preeclampsia","volume":"87","author":"M Shibuya","year":"2011","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"ref244","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1126\/science.1312256","article-title":"The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor","volume":"255","author":"C de Vries","year":"1992","journal-title":"Science"},{"key":"ref245","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/376066a0","article-title":"Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium","volume":"376","author":"GH Fong","year":"1995","journal-title":"Nature"},{"key":"ref246","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1074\/jbc.271.10.5638","article-title":"Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis","volume":"271","author":"BA Keyt","year":"1996","journal-title":"J Biol Chem"},{"key":"ref247","doi-asserted-by":"crossref","first-page":"31283","DOI":"10.1074\/jbc.273.47.31283","article-title":"Mapping of the sites involved in ligand association and dissociation at the extracellular domain of the kinase insert domain-containing receptor for vascular endothelial growth factor","volume":"273","author":"A Shinkai","year":"1998","journal-title":"J Biol Chem"},{"key":"ref248","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1349-7006.1997.tb00463.x","article-title":"Characterization of the extracellular domain in vascular endothelial growth factor receptor-1 (Flt-1 tyrosine kinase).","volume":"88","author":"K Tanaka","year":"1997","journal-title":"Jpn J Cancer Res"},{"key":"ref249","doi-asserted-by":"crossref","first-page":"10705","DOI":"10.1073\/pnas.90.22.10705","article-title":"Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor","volume":"90","author":"RL Kendall","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref250","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1096\/fj.07-8809com","article-title":"Intronic polyadenylation signal sequences and alternate splicing generate human soluble Flt1 variants and regulate the abundance of soluble Flt1 in the placenta","volume":"21","author":"CP Thomas","year":"2007","journal-title":"Faseb J"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0378-1119(98)00006-7","article-title":"Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors","volume":"208","author":"K Kondo","year":"1998","journal-title":"Gene"},{"key":"ref252","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1210\/mend.13.4.0265","article-title":"Alternative splicing of vascular endothelial growth factor (VEGF)-R1 (FLT-1) pre-mRNA is important for the regulation of VEGF activity","volume":"13","author":"Y He","year":"1999","journal-title":"Mol Endocrinol"},{"key":"ref253","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/bbrc.1996.1355","article-title":"Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR","volume":"226","author":"RL Kendall","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"ref254","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1210\/jc.2009-0017","article-title":"A recently evolved novel trophoblast-enriched secreted form of fms-like tyrosine kinase-1 variant is up-regulated in hypoxia and preeclampsia","volume":"94","author":"CP Thomas","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref255","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/molehr\/7.2.205","article-title":"Expression of vascular endothelial growth factor receptors 1, 2 and 3 in placentas from normal and complicated pregnancies","volume":"7","author":"S Helske","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"ref256","doi-asserted-by":"crossref","first-page":"12605","DOI":"10.1074\/jbc.C300012200","article-title":"Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria","volume":"278","author":"H Sugimoto","year":"2003","journal-title":"J Biol Chem"},{"key":"ref257","first-page":"418 e411","article-title":"Gender-specific effect of overexpression of sFlt-1 in pregnant mice on fetal programming of blood pressure in the offspring later in life","volume":"197","author":"F Lu","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"ref258","doi-asserted-by":"crossref","first-page":"432 e431","DOI":"10.1016\/j.ajog.2009.01.044","article-title":"The effect of prepregnancy obesity and sFlt-1-induced preeclampsia-like syndrome on fetal programming of adult vascular function in a mouse model","volume":"200","author":"BD Byers","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"ref259","doi-asserted-by":"crossref","first-page":"H189","DOI":"10.1152\/ajpheart.00792.2009","article-title":"Long-term maternal cardiovascular function in a mouse model of sFlt-1-induced preeclampsia","volume":"298","author":"E Bytautiene","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref260","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/AOG.0b013e3181e10ebd","article-title":"Using pravastatin to improve the vascular reactivity in a mouse model of soluble fms-like tyrosine kinase-1-induced preeclampsia","volume":"116","author":"MM Costantine","year":"2010","journal-title":"Obstet Gynecol"},{"key":"ref261","first-page":"366 e361","article-title":"Effects of pravastatin on mediators of vascular function in a mouse model of soluble Fms-like tyrosine kinase-1-induced preeclampsia","volume":"205","author":"KA Fox","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"ref262","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/10430340050016247","article-title":"Comparative in vivo approaches for selective adenovirus-mediated gene delivery to the placenta","volume":"11","author":"A Xing","year":"2000","journal-title":"Hum Gene Ther"},{"key":"ref263","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.2353\/ajpath.2010.090800","article-title":"Effects of hypoxia-inducible factor-1alpha overexpression in pregnant mice: possible implications for preeclampsia and intrauterine growth restriction","volume":"177","author":"R Tal","year":"2010","journal-title":"Am J Pathol"},{"key":"ref264","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.placenta.2008.10.006","article-title":"Novel soluble Flt-1 isoforms in plasma and cultured placental explants from normotensive pregnant and preeclamptic women","volume":"30","author":"A Rajakumar","year":"2009","journal-title":"Placenta"},{"key":"ref265","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0272-6386(99)70439-7","article-title":"Objective evidence of endothelial dysfunction in preeclampsia","volume":"33","author":"JM Roberts","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"ref266","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1152\/ajpregu.00762.2001","article-title":"Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models","volume":"283","author":"RA Khalil","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref267","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.yexcr.2008.10.003","article-title":"Expression of RAC2 in endothelial cells is required for the postnatal neovascular response","volume":"315","author":"P De","year":"2009","journal-title":"Exp Cell Res"},{"key":"ref268","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1681\/ASN.2011060577","article-title":"Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy","volume":"23","author":"BR Conway","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"ref269","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0950-3552(05)80330-X","article-title":"Renal pathology in pre-eclampsia","volume":"8","author":"LW Gaber","year":"1994","journal-title":"Baillieres Clin Obstet Gynaecol"},{"key":"ref270","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1681\/ASN.2007020255","article-title":"The glomerular injury of preeclampsia","volume":"18","author":"IE Stillman","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"R86","DOI":"10.1152\/ajpregu.00600.2011","article-title":"eNOS knockout mouse as a model of fetal growth restriction with an impaired uterine artery function and placental transport phenotype","volume":"303","author":"LC Kusinski","year":"2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref272","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.ajog.2005.10.192","article-title":"Serum sFlt1 concentration during preeclampsia and mid trimester blood pressure in healthy nulliparous women","volume":"194","author":"RJ Levine","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"ref273","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/ng1665","article-title":"The origins and uses of mouse outbred stocks","volume":"37","author":"R Chia","year":"2005","journal-title":"Nat Genet"},{"key":"ref274","doi-asserted-by":"crossref","first-page":"e4729","DOI":"10.1371\/journal.pone.0004729","article-title":"Genetic variation and population substructure in outbred CD-1 mice: implications for genome-wide association studies","volume":"4","author":"KA Aldinger","year":"2009","journal-title":"PLoS One"},{"key":"ref275","first-page":"28","article-title":"CD-1 mice Show Individual Differences in Nicotine Preference in a Modified Two-Bottle Oral Self-Administration Model","volume":"3","author":"J Cao","year":"2012","journal-title":"Front Psychiatry"},{"key":"ref276","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1081\/PRG-100100132","article-title":"Maternal and neonatal outcome of preeclamptic pregnancies: the potential roles of factor V Leiden mutation and 5,10 methylenetetrahydrofolate reductase","volume":"19","author":"J Rigo Jr","year":"2000","journal-title":"Hypertens 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