{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:01:15Z","timestamp":1774584075989,"version":"3.50.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0119578","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T19:02:51Z","timestamp":1425668571000},"page":"e0119578","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Effects of Nutritional Supplementation on Fatigue, and Autonomic and Immune Dysfunction in Patients with End-Stage Renal Disease: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial"],"prefix":"10.1371","volume":"10","author":[{"given":"Sanae","family":"Fukuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisako","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Yamakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osami","family":"Kajimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyoshi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Nishizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1523-1755.2004.00738.x","article-title":"Effects of hemodialysis dose and membrane flux on health-related quality of life in the HEMO Study","volume":"66","author":"M Unruh","year":"2004","journal-title":"Kidney Int"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2215\/CJN.08151109","article-title":"Fatigue is a predictor for cardiovascular outcomes in patients undergoing hemodialysis","volume":"5","author":"H Koyama","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1681\/ASN.V12122797","article-title":"Association among SF36 quality of life measures and nutrition, hospitalization, and mortality in hemodialysis","volume":"12","author":"K Kalantar-Zadeh","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/ndt\/gfm630","article-title":"Sleep quality predicts quality of life and mortality risk in haemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS)","volume":"23","author":"SJ Elder","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0735-1097(95)00615-X","article-title":"Autonomic nervous system and sudden cardiac death","volume":"27","author":"HV Barron","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/ndt\/gfm634","article-title":"Heart rate variability (HRV) in kidney failure: measurement and consequences of reduced HRV","volume":"23","author":"R Ranpuria","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1093\/ndt\/14.6.1480","article-title":"Prognostic value of heart rate variability during long-term follow-up in chronic haemodialysis patients with end-stage renal disease","volume":"14","author":"J Hayano","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1053\/j.jrn.2012.12.008","article-title":"Autonomic function is associated with health-related quality of life in patients with end-stage renal disease: a case-control study","volume":"23","author":"H Fujii","year":"2013","journal-title":"J Renal Nutr"},{"issue":"Suppl 3","key":"ref9","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1177\/089686080802803s30","article-title":"Immune dysfunction in dialysis patients\u2014prevention and treatment strategies","volume":"28","author":"A Tranaeus","year":"2008","journal-title":"Perit Dial Int"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.2215\/CJN.00950208","article-title":"Aspects of immune dysfunction in end-stage renal disease","volume":"3","author":"S Kato","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref11","first-page":"137","article-title":"Fatigue Science for Human Health","author":"K Kondo","year":"2008"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Chapenko S, Krumina A, Logina I, Rasa S, Chistjakovs M, Sultanova A, et al. Association of active human herpesvirus -6, -7 and parvovirus b19 infection with clinical outcomes in patients with myalgic encephalomyelitis\/chronic fatigue syndrome. Adv Virol. 2012: 205085.","DOI":"10.1155\/2012\/205085"},{"issue":"Suppl 1","key":"ref13","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/S1386-6532(06)70009-9","article-title":"Use of valganciclovir in patients with elevated antibody titers against Human Herpesvirus-6 (HHV-6) and Epstein-Barr Virus (EBV) who were experiencing central nervous system dysfunction including long-standing fatigue","volume":"37","author":"AM Kogelnik","year":"2006","journal-title":"J Clin Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.bbmt.2008.04.016","article-title":"Human herpes virus 6 plasma DNA positivity after hematopoietic stem cell transplantation in children: an important risk factor for clinical outcome","volume":"14","author":"PJ de Pagter","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S0272-6386(05)80019-8","article-title":"Intravenous L-carnitine increases plasma carnitine, reduces fatigue, and may preserve exercise capacity in hemodialysis patients","volume":"37","author":"EP Brass","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1046\/j.1523-1755.2001.00971.x","article-title":"Differential effects of growth hormone therapy in malnourished hemodialysis patients","volume":"60","author":"H Kotzmann","year":"2001","journal-title":"Kidney Int"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1681\/ASN.2006111207","article-title":"Growth hormone treatment during hemodialysis in a randomized trial improves nutrition, quality of life, and cardiovascular risk","volume":"18","author":"B Feldt-Rasmussen","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1471-2377-10-73","article-title":"The increase of alpha-melanocyte-stimulating hormone in the plasma of chronic fatigue syndrome patients","volume":"10","author":"N Shishioh-Ikejima","year":"2010","journal-title":"BMC Neurol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1023\/A:1016630825992","article-title":"Translation, cultural adaptation, and initial reliability and multitrait testing of the Kidney Disease Quality of Life instrument for use in Japan","volume":"10","author":"J Green","year":"2001","journal-title":"Qual Life Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00420-009-0499-1","article-title":"Heart rate variability assessment in Japanese workers recovered from depressive disorders resulting from job stress: measurements in the workplace","volume":"83","author":"M Takada","year":"2010","journal-title":"Int Arch Occup Environ Health"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use","volume":"93","year":"1996","journal-title":"Circulation"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.2215\/CJN.00890111","article-title":"The relationship between epicardial adipose tissue and malnutrition, inflammation, atherosclerosis\/calcification syndrome in ESRD patients","volume":"6","author":"K Turkmen","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"F106","DOI":"10.1152\/ajprenal.00126.2009","article-title":"Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertention in rats with chronic renal failure","volume":"297","author":"KH Cho","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1440-1797.2006.00536.x","article-title":"Folic acid 5 or 15 mg\/d similarly reduces plasma homocysteine in patients with moderate-advanced chronic renal failure","volume":"11","author":"AR Bernasconi","year":"2006","journal-title":"Nephrology (Cariton)"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1024\/0300-9831\/a000065","article-title":"Plasma vitamin C concentrations in patients on routine hemodialysis and its relationship to patients&apos; morbidity and mortality","volume":"81","author":"S Dashti-Khavidaki","year":"2011","journal-title":"Int J Vitam Nutr Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0272-6386(03)00115-X","article-title":"The role of carnitine in myocardial dysfunction","volume":"41","author":"DF Pauly","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1161\/CIRCRESAHA.112.277392","article-title":"Metabolic remodeling in the hypertrophic heart: fuel for thought","volume":"111","author":"JC Chatham","year":"2012","journal-title":"Circ Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.amjcard.2003.11.043","article-title":"Influence of L-arginine and vitamin C on the autonomic nervous system in chronic heart failure secondary to ischemic cardiomyopathy","volume":"93","author":"G Piccirillo","year":"2004","journal-title":"Am J Cardiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ijcard.2005.07.020","article-title":"Improvement of sympathetic response to exercise by oral administration of ascorbic acid in patients after myocardial infarction","volume":"111","author":"K Kato","year":"2006","journal-title":"Int J Cardiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3177\/jnsv.54.286","article-title":"Influence of CoQ10 on autonomic nervous activity and energy metabolism during exercise in healthy subjects","volume":"54","author":"A Zheng","year":"2008","journal-title":"J Nutr Sci Vitaminol. (Tokyo)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1093\/ndt\/gfh306","article-title":"Predictors of haemodynamic instability and heart rate variability during haemodialysis","volume":"19","author":"D Rubinger","year":"2004","journal-title":"Nephrol Dial Transplant"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1744-9081-7-46","article-title":"Autonomic nervous alterations associated with daily level of fatigue","volume":"7","author":"M Tanaka","year":"2011","journal-title":"Behav Brain Funct"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0119578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T16:23:38Z","timestamp":1651422218000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0119578"}},"subtitle":[],"editor":[{"given":"Mario D.","family":"Cordero","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,6]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0119578","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,6]]}}}