{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:28:28Z","timestamp":1783650508114,"version":"3.55.0"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T00:00:00Z","timestamp":1427673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0119863","type":"journal-article","created":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T12:10:48Z","timestamp":1427803848000},"page":"e0119863","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lesion of the Olfactory Epithelium Accelerates Prion Neuroinvasion and Disease Onset when Prion Replication Is Restricted to Neurons"],"prefix":"10.1371","volume":"10","author":[{"given":"Jenna","family":"Crowell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Wiley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Bessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1128\/JCM.34.5.1228-1231.1996","article-title":"Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie","volume":"34","author":"LJ van Keulen","year":"1996","journal-title":"J Clin Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1053\/jcpa.1998.0300","article-title":"Scrapie-associated prion protein in the gastrointestinal tract of sheep with natural scrapie","volume":"121","author":"LJ van Keulen","year":"1999","journal-title":"J Comp Pathol"},{"issue":"Pt 12","key":"ref3","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1099\/0022-1317-81-12-3115","article-title":"Early accumulation of PrP(Sc) in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie","volume":"81","author":"O Andreoletti","year":"2000","journal-title":"J Gen Virol"},{"issue":"Pt 9","key":"ref4","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1099\/0022-1317-81-9-2327","article-title":"Distribution of prion protein in the ileal Peyer&apos;s patch of scrapie- free lambs and lambs naturally and experimentally exposed to the scrapie agent","volume":"81","author":"R Heggebo","year":"2000","journal-title":"J Gen Virol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1099\/0022-1317-80-10-2757","article-title":"Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus)","volume":"80","author":"CJ Sigurdson","year":"1999","journal-title":"J Gen Virol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"9320","DOI":"10.1128\/JVI.75.19.9320-9327.2001","article-title":"Early spread of scrapie from the gastrointestinal tract to the central nervous system involves autonomic fibers of the splanchnic and vagus nerves","volume":"75","author":"PA McBride","year":"2001","journal-title":"J Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1053\/jcpa.2002.0625","article-title":"Detection of PrPSc in lymphoid tissues of lambs experimentally exposed to the scrapie agent","volume":"128","author":"R Heggebo","year":"2003","journal-title":"J Comp Pathol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.immuni.2004.12.007","article-title":"Prions, cytokines, and chemokines: a meeting in lymphoid organs","volume":"22","author":"A Aguzzi","year":"2005","journal-title":"Immunity"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrmicro1346","article-title":"Prions and their lethal journey to the brain","volume":"4","author":"NA Mabbott","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"747892","DOI":"10.1155\/2010\/747892","article-title":"Neuroinvasion in prion diseases: the roles of ascending neural infection and blood dissemination","volume":"2010","author":"S Siso","year":"2010","journal-title":"Interdiscip Perspect Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"11858","DOI":"10.1128\/JVI.79.18.11858-11863.2005","article-title":"Extraneural prion neuroinvasion without lymphoreticular system infection","volume":"79","author":"JC Bartz","year":"2005","journal-title":"J Virol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6435","DOI":"10.1128\/JVI.00018-09","article-title":"Role of the lymphoreticular system in prion neuroinvasion from the oral and nasal mucosa","volume":"83","author":"RA Bessen","year":"2009","journal-title":"J Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e1001257","DOI":"10.1371\/journal.ppat.1001257","article-title":"Aerosols transmit prions to immunocompetent and immunodeficient mice","volume":"7","author":"J Haybaeck","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/JVI.77.1.583-591.2003","article-title":"Rapid prion neuroinvasion following tongue infection","volume":"77","author":"JC Bartz","year":"2003","journal-title":"J Virol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1128\/JVI.01655-10","article-title":"Minor oral lesions facilitate transmission of chronic wasting disease","volume":"85","author":"ND Denkers","year":"2011","journal-title":"J Virol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0009-2797(00)00187-3","article-title":"Target cells for methylsulphonyl-2,6-dichlorobenzene in the olfactory mucosa in mice","volume":"128","author":"F Bahrami","year":"2000","journal-title":"Chem Biol Interact"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/toxsci\/67.2.284","article-title":"Enhancement of nasal inflammatory and epithelial responses after ozone and allergen coexposure in Brown Norway rats","volume":"67","author":"JG Wagner","year":"2002","journal-title":"Toxicol Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1099\/0022-1317-83-9-2109","article-title":"Olfactory receptor neurons prevent dissemination of neurovirulent influenza A virus into the brain by undergoing virus-induced apoptosis","volume":"83","author":"I Mori","year":"2002","journal-title":"J Gen Virol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/chemse\/27.6.521","article-title":"Cell death of olfactory receptor neurons in a rat with nasosinusitis infected artificially with Staphylococcus","volume":"27","author":"Y Ge","year":"2002","journal-title":"Chem Senses"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1080\/01926230390201075","article-title":"Isomer-specific bioactivation and toxicity of dichlorophenyl methylsulphone in rat olfactory mucosa","volume":"31","author":"A Franzen","year":"2003","journal-title":"Toxicol Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1289\/ehp.8854","article-title":"Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain","volume":"114","author":"Z Islam","year":"2006","journal-title":"Environ Health Perspect"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1080\/00016480601002062","article-title":"Lipopolysaccharide-induced apoptosis of olfactory receptor neurons in rats","volume":"127","author":"S Yagi","year":"2007","journal-title":"Acta Otolaryngol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.otohns.2007.11.029","article-title":"Intranasal Aspergillus fumigatus exposure induces eosinophilic inflammation and olfactory sensory neuron cell death in mice","volume":"138","author":"VA Epstein","year":"2008","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1177\/0192623310364026","article-title":"Neurotoxic, inflammatory, and mucosecretory responses in the nasal airways of mice repeatedly exposed to the macrocyclic trichothecene mycotoxin roridin A: dose-response and persistence of injury","volume":"38","author":"KN Corps","year":"2010","journal-title":"Toxicol Pathol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0166-2236(90)90017-5","article-title":"Olfactory neurogenesis: genetic or environmental controls?","volume":"13","author":"AI Farbman","year":"1990","journal-title":"Trends Neurosci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e46338","DOI":"10.1371\/journal.pone.0046338","article-title":"Odor memory stability after reinnervation of the olfactory bulb","volume":"7","author":"E Blanco-Hernandez","year":"2012","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/0896-6273(95)90105-1","article-title":"Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent","volume":"15","author":"RE Race","year":"1995","journal-title":"Neuron"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1128\/JVI.74.2.828-833.2000","article-title":"Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: role of prion protein expression in peripheral nerves and spleen","volume":"74","author":"R Race","year":"2000","journal-title":"J Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1098\/rstb.1994.0037","article-title":"Physicochemical and biological characterizations of distinct strains of the transmissible mink encephalopathy agent","volume":"343","author":"RF Marsh","year":"1994","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"8640","DOI":"10.1128\/JVI.00378-14","article-title":"Axonal and transynaptic spread of prions","volume":"88","author":"H Shearin","year":"2014","journal-title":"J Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1128\/JVI.06626-11","article-title":"Accelerated shedding of prions following damage to the olfactory epithelium","volume":"86","author":"RA Bessen","year":"2012","journal-title":"J Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1000837","DOI":"10.1371\/journal.ppat.1000837","article-title":"Prion shedding from olfactory neurons into nasal secretions","volume":"6","author":"RA Bessen","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1128\/JVI.61.12.3688-3693.1987","article-title":"Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins","volume":"61","author":"RJ Kascsak","year":"1987","journal-title":"J Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1210\/jcem-63-1-125","article-title":"Treatment of hyperthyroidism with a small single daily dose of methimazole","volume":"63","author":"A Shiroozu","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1210\/jc.2006-2135","article-title":"Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves&apos; disease","volume":"92","author":"H Nakamura","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-0773.1995.tb00107.x","article-title":"Metabolism-dependent toxicity of methimazole in the olfactory nasal mucosa","volume":"76","author":"EB Brittebo","year":"1995","journal-title":"Pharmacol Toxicol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/019262339502300404","article-title":"Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa","volume":"23","author":"MB Genter","year":"1995","journal-title":"Toxicol Pathol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/taap.1998.8590","article-title":"Methimazole toxicity in rodents: covalent binding in the olfactory mucosa and detection of glial fibrillary acidic protein in the olfactory bulb","volume":"155","author":"U Bergman","year":"1999","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/jnr.21155","article-title":"Methimazole-induced cell death in rat olfactory receptor neurons occurs via apoptosis triggered through mitochondrial cytochrome c-mediated caspase-3 activation pathway","volume":"85","author":"T Sakamoto","year":"2007","journal-title":"J Neurosci Res"},{"issue":"Pt 2","key":"ref40","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1099\/0022-1317-73-2-329","article-title":"Identification of two biologically distinct strains of transmissible mink encephalopathy in hamsters","volume":"73","author":"RA Bessen","year":"1992","journal-title":"J Gen Virol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00401-008-0474-z","article-title":"Neuroinvasion of the 263K scrapie strain after intranasal administration occurs through olfactory-unrelated pathways","volume":"117","author":"M Sbriccoli","year":"2009","journal-title":"Acta Neuropathol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/infdis\/129.5.559","article-title":"Course of experimental scrapie virus infection in the goat","volume":"129","author":"WJ Hadlow","year":"1974","journal-title":"J Infect Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/infdis\/146.5.657","article-title":"Natural infection of Suffolk sheep with scrapie virus","volume":"146","author":"WJ Hadlow","year":"1982","journal-title":"J Infect Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa022043","article-title":"Detection of pathologic prion protein in the olfactory epithelium in sporadic Creutzfeldt-Jakob disease","volume":"348","author":"G Zanusso","year":"2003","journal-title":"N Engl J Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1128\/JVI.80.9.4546-4556.2006","article-title":"Prion infection of oral and nasal mucosa","volume":"80","author":"C DeJoia","year":"2006","journal-title":"J Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1128\/JVI.01966-08","article-title":"Olfactory system involvement in natural scrapie disease","volume":"83","author":"C Corona","year":"2009","journal-title":"J Virol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e1001217","DOI":"10.1371\/journal.ppat.1001217","article-title":"Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays","volume":"6","author":"JM Wilham","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1056\/NEJMoa1315200","article-title":"A test for Creutzfeldt-Jakob disease using nasal brushings","volume":"371","author":"CD Orru","year":"2014","journal-title":"N Engl J Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1099\/vir.0.81999-0","article-title":"Patterns of PrPCWD accumulation during the course of chronic wasting disease infection in orally inoculated mule deer (Odocoileus hemionus)","volume":"87","author":"KA Fox","year":"2006","journal-title":"J Gen Virol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1354\/vp.45-3-297","article-title":"Experimental transmission of chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni), white-tailed deer (Odocoileus virginianus), and mule deer (Odocoileus hemionus hemionus) to white-tailed deer by intracerebral route","volume":"45","author":"AN Hamir","year":"2008","journal-title":"Vet Pathol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e5916","DOI":"10.1371\/journal.pone.0005916","article-title":"Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure","volume":"4","author":"CK Mathiason","year":"2009","journal-title":"PLoS One"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1128\/JVI.02852-12","article-title":"Aerosol transmission of chronic wasting disease in white-tailed deer","volume":"87","author":"ND Denkers","year":"2013","journal-title":"J Virol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1099\/vir.0.82421-0","article-title":"Bovine spongiform encephalopathy: the effect of oral exposure dose on attack rate and incubation period in cattle","volume":"88","author":"GA Wells","year":"2007","journal-title":"J Gen Virol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e23664","DOI":"10.1371\/journal.pone.0023664","article-title":"There is no safe dose of prions","volume":"6","author":"HR Fryer","year":"2011","journal-title":"PLoS One"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1136\/vr.148.6.165","article-title":"Clinical signs, histopathology and genetics of experimental transmission of BSE and natural scrapie to sheep and goats","volume":"148","author":"JD Foster","year":"2001","journal-title":"Vet Rec"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/104063870501700103","article-title":"Experimental transmission of sheep scrapie by intracerebral and oral routes to genetically susceptible Suffolk sheep in the United States","volume":"17","author":"AN Hamir","year":"2005","journal-title":"J Vet Diagn Invest"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1354\/vp.45-1-7","article-title":"Experimental transmission of US scrapie agent by nasal, peritoneal, and conjunctival routes to genetically susceptible sheep","volume":"45","author":"AN Hamir","year":"2008","journal-title":"Vet Pathol"},{"key":"ref58","first-page":"63","article-title":"Experimental transmission of scrapie agent to susceptible sheep by intralingual or intracerebral inoculation","volume":"72","author":"AN Hamir","year":"2008","journal-title":"Can J Vet Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0021-9975(78)90059-2","article-title":"Pathogenesis of mouse scrapie: effect of route of inoculation on infectivity titres and dose-response curves","volume":"88","author":"RH Kimberlin","year":"1978","journal-title":"J Comp Pathol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1099\/vir.0.19394-0","article-title":"Delay in onset of prion disease for the HY strain of transmissible mink encephalopathy as a result of prior peripheral inoculation with the replication-deficient DY strain","volume":"85","author":"JC Bartz","year":"2004","journal-title":"J Gen Virol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1128\/JVI.76.11.5759-5768.2002","article-title":"Retrograde transport of transmissible mink encephalopathy within descending motor tracts","volume":"76","author":"JC Bartz","year":"2002","journal-title":"J Virol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0896-6273(01)00331-2","article-title":"Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion","volume":"31","author":"M Glatzel","year":"2001","journal-title":"Neuron"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nature02072","article-title":"Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion","volume":"425","author":"M Prinz","year":"2003","journal-title":"Nature"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1365-2990.2006.00737.x","article-title":"The olfactory route for cerebrospinal fluid drainage into the peripheral lymphatic system","volume":"32","author":"BA Walter","year":"2006","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/jnr.490260105","article-title":"Neuroplasticity in the olfactory system: differential effects of central and peripheral lesions of the primary olfactory pathway on the expression of B-50\/GAP43 and the olfactory marker protein","volume":"26","author":"J Verhaagen","year":"1990","journal-title":"J Neurosci Res"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0014-4886(92)90221-B","article-title":"Ablation of the olfactory bulb up-regulates the rate of neurogenesis and induces precocious cell death in olfactory epithelium","volume":"115","author":"VM Carr","year":"1992","journal-title":"Exp Neurol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/(SICI)1096-9861(20000605)421:3<362::AID-CNE5>3.0.CO;2-8","article-title":"Pattern of olfactory bulb innervation returns after recovery from reversible peripheral deafferentation","volume":"421","author":"DM Cummings","year":"2000","journal-title":"J Comp Neurol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ar.10047","article-title":"Neural regeneration and the peripheral olfactory system","volume":"269","author":"JE Schwob","year":"2002","journal-title":"Anat Rec"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0306-4522(02)00155-0","article-title":"Selective expression of prion protein in peripheral tissues of the adult mouse","volume":"113","author":"MJ Ford","year":"2002","journal-title":"Neuroscience"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/cne.21698","article-title":"Expression and localization of the prion protein PrP(C) in the olfactory system of the mouse","volume":"508","author":"CE Le Pichon","year":"2008","journal-title":"J Comp Neurol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"e28026","DOI":"10.1371\/journal.pone.0028026","article-title":"Transmission of chronic wasting disease identifies a prion strain causing cachexia and heart infection in hamsters","volume":"6","author":"RA Bessen","year":"2011","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0119863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T08:59:10Z","timestamp":1598864350000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0119863"}},"subtitle":[],"editor":[{"given":"Gianluigi","family":"Zanusso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,30]]},"references-count":71,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0119863","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,30]]}}}