{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:49:48Z","timestamp":1783468188697,"version":"3.55.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0120023","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T14:35:22Z","timestamp":1427294122000},"page":"e0120023","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Elevated Levels of Mercapturic Acids of Acrolein and Crotonaldehyde in the Urine of Chinese Women in Singapore Who Regularly Cook at Home"],"prefix":"10.1371","volume":"10","author":[{"given":"Stephen S.","family":"Hecht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon-Puay","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Carmella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon E.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Min","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"ref1","article-title":"Trends in cancer incidence in Singapore, 2008\u20132012","year":"2013"},{"key":"ref2","first-page":"16","article-title":"World cancer report 2014","year":"2014"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"DM Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"ref4","first-page":"77","article-title":"Identification of 1,3-butadiene, benzene, and other volatile organics from wok oil emissions","volume":"5","author":"ED Pellizzari","year":"1995","journal-title":"J Expo Anal Environ Epidemiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/jnci\/87.11.836","article-title":"Mutagens from heated Chinese and U.S. cooking oils","volume":"87","author":"PG Shields","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1158\/0008-5472.CAN-05-2932","article-title":"Dose-response relationship between cooking fumes exposures and lung cancer among Chinese nonsmoking women","volume":"66","author":"IT Yu","year":"2006","journal-title":"Cancer Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/ijc.2910400505","article-title":"Lung cancer among Chinese women","volume":"40","author":"YT Gao","year":"1987","journal-title":"Int J Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/ije\/26.1.24","article-title":"Risk factors for primary lung cancer among non-smoking women in Taiwan","volume":"26","author":"YC Ko","year":"1997","journal-title":"Int J Epidemiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/00001648-199909000-00005","article-title":"Lung cancer and indoor air pollution arising from Chinese-style cooking among nonsmoking women living in Shanghai, China","volume":"10","author":"L Zhong","year":"1999","journal-title":"Epidemiology"},{"key":"ref10","first-page":"1215","article-title":"Fumes from meat cooking and lung cancer risk in Chinese women","volume":"9","author":"A Seow","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0169-5002(01)00412-3","article-title":"Cooking oil fumes and risk of lung cancer in women in rural Gansu, China","volume":"35","author":"C Metayer","year":"2002","journal-title":"Lung Cancer"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/annonc\/mdn699","article-title":"The roles of smoking and cooking emissions in lung cancer risk among Chinese women in Hong Kong","volume":"20","author":"XR Wang","year":"2009","journal-title":"Ann Oncol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1080\/01635581.2012.668743","article-title":"Environmental and dietary factors and lung cancer risk among Chinese women: a case-control study in southeast China","volume":"64","author":"Y Lin","year":"2012","journal-title":"Nutr Cancer"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10552-010-9506-9","article-title":"Risk factors for lung cancer: a case-control study in Hong Kong women","volume":"21","author":"YL Chiu","year":"2010","journal-title":"Cancer Causes Control"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10552-012-0130-8","article-title":"Indoor air pollution and risk of lung cancer among Chinese female non-smokers","volume":"24","author":"L Mu","year":"2013","journal-title":"Cancer Causes Control"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1289\/ehp.0901587","article-title":"Lung cancer in Chinese women: evidence for an interaction between tobacco smoking and exposure to inhalants in the indoor environment","volume":"118","author":"L Tang","year":"2010","journal-title":"Environ Health Perspect"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1093\/carcin\/bgt113","article-title":"Fried meat intake is a risk factor for lung adenocarcinoma in a prospective cohort of Chinese men and women in Singapore","volume":"34","author":"LM Butler","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref18","first-page":"392","article-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","volume":"95","year":"2010"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1158\/1055-9965.EPI-09-1291","article-title":"Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home","volume":"19","author":"SS Hecht","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1021\/tx100056m","article-title":"Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention","volume":"23","author":"SS Hecht","year":"2010","journal-title":"Chem Res Toxicol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jchromb.2014.02.057","article-title":"A survey of liquid chromatographic-mass spectrometric analysis of mercapturic acid biomarkers in occupational and environmental exposure monitoring","volume":"964C","author":"PI Mathias","year":"2014","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref22","first-page":"249","article-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","volume":"100F","year":"2012"},{"key":"ref23","first-page":"337","article-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","volume":"63","year":"1995"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jchromb.2013.07.004","article-title":"High throughput liquid chromatography-tandem mass spectrometry assay for mercapturic acids of acrolein and crotonaldehyde in cigarette smokers&apos; urine","volume":"935","author":"SG Carmella","year":"2013","journal-title":"J Chromatog B"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1021\/jf00078a014","article-title":"Analysis of acroelin from heated cooking oils and beef fat","volume":"35","author":"K Umano","year":"1987","journal-title":"J Agric Food Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s0012800076","article-title":"Aliphatic aldehydes produced by heating Chinese cooking oils","volume":"64","author":"JM Lin","year":"2000","journal-title":"Bull Environ Contam Toxicol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"5207","DOI":"10.1021\/jf035241f","article-title":"Comparison of volatile aldehydes present in the cooking fumes of extra virgin olive, olive, and canola oils","volume":"52","author":"A Fullana","year":"2004","journal-title":"J Agric Food Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1021\/jf0734525","article-title":"Influence of time, surface-to-volume ratio, and heating process (continuous or intermittent) on the emission rates of selected carbonyl compounds during thermal oxidation of palm and soybean oils","volume":"56","author":"TO da Silva","year":"2008","journal-title":"J Agric Food Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1021\/es002053m","article-title":"Measurement of emissions from air pollution sources. 4. C1-C27 organic compounds from cooking with seed oils","volume":"36","author":"JJ Schauer","year":"2002","journal-title":"Environ Sci Technol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"12777","DOI":"10.1021\/jf1028575","article-title":"Influence of heating time and metal ions on the amount of free fatty acids and formation rates of selected carbonyl compounds during the thermal oxidation of canola oil","volume":"58","author":"LC Bastos","year":"2010","journal-title":"J Agric Food Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1016\/j.atmosenv.2009.08.043","article-title":"Indoor acrolein emission and decay rates resulting from domestic cooking events","volume":"43","author":"VY Seaman","year":"2009","journal-title":"Atmospheric Environment"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.foodchem.2009.09.070","article-title":"Emissions of volatile aldehydes from heated cooking oils","volume":"120","author":"HR Katragadda","year":"2010","journal-title":"Food Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1080\/10473289.2006.10464532","article-title":"Carbonyl emissions from commercial cooking sources in Hong Kong","volume":"56","author":"SSH Ho","year":"2006","journal-title":"J Air Waste Manage Assoc"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mnfr.200700412","article-title":"Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease","volume":"52","author":"JF Stevens","year":"2008","journal-title":"Mol Nutr Food Res"},{"key":"ref35","first-page":"337","article-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","volume":"63","year":"1995"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.cbi.2009.12.006","article-title":"Toxicity of smoke extracts towards A549 lung cells: role of acrolein and suppression by carbonyl scavengers","volume":"183","author":"PC Burcham","year":"2010","journal-title":"Chem Biol Interact"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bcp.2014.02.009","article-title":"Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism","volume":"89","author":"EY Cheah","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"ref38","first-page":"990","article-title":"Formation of cyclic 1,<italic>N<\/italic><sup><italic>2<\/italic><\/sup>-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde","volume":"44","author":"FL Chung","year":"1984","journal-title":"Cancer Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1021\/tx9000489","article-title":"Chemistry and biology of DNA containing 1,<italic>N<\/italic><sup><italic>2<\/italic><\/sup>-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal","volume":"22","author":"IG Minko","year":"2009","journal-title":"Chem Res Toxicol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"15404","DOI":"10.1073\/pnas.0607031103","article-title":"Acrolein is a major cigarette-related lung cancer agent. Preferential binding at <italic>p53<\/italic> mutational hotspots and inhibition of DNA repair","volume":"103","author":"Z Feng","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref41","first-page":"373","article-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","volume":"63","year":"1995"},{"key":"ref42","first-page":"1285","article-title":"Induction of liver tumors in F344 rats by crotonaldehyde","volume":"46","author":"FL Chung","year":"1986","journal-title":"Cancer Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0120023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T04:55:55Z","timestamp":1540270555000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0120023"}},"subtitle":[],"editor":[{"given":"Yuan-Soon","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,25]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0120023","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,25]]}}}