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Population Intervention Causal E ects Based on Stochastic Interventions. Biometrics. 2011;p. In press. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1111\/j.1541-0420.2011.01685.x\" xlink:type=\"simple\">http:\/\/dx.doi.org\/10.1111\/j.1541-0420.2011.01685.x<\/ext-link>.","DOI":"10.1111\/j.1541-0420.2011.01685.x"},{"key":"ref24","first-page":"322","article-title":"PRICAI 2004: Trends in Artificial Intelligence. vol. 3157 of Lecture Notes in Computer Science","author":"K Korb","year":"2004"},{"key":"ref25","article-title":"Direct and Indirect E ects of Sequential Treatments","author":"V Didelez","year":"2006"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Dawid, AP, Didelez V. Identifying the consequences of dynamic treatment strategies: A decision-theoretic overview. 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