{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:07:01Z","timestamp":1776960421222,"version":"3.51.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T00:00:00Z","timestamp":1426723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0120383","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T18:23:30Z","timestamp":1426789410000},"page":"e0120383","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Expression of Toll-Like Receptor -7 and -9 in B Cell Subsets from Patients with Primary Sj\u00f6gren\u2019s Syndrome"],"prefix":"10.1371","volume":"10","author":[{"given":"Marie","family":"Karlsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbj\u00f8rn","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilde H.","family":"Nordal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan G.","family":"Brun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Appel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2011.06.007","article-title":"The complexity of Sj\u00f6gren's syndrome: novel aspects on pathogenesis","volume":"141","author":"R Jonsson","year":"2011","journal-title":"Immunol Lett"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sj\u00f6gren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group","volume":"61","author":"C Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/acr.21591","article-title":"American College of Rheumatology classification criteria for Sj\u00f6gren's syndrome: a data-driven, expert consensus approach in the Sjogren's International Collaborative Clinical Alliance cohort","volume":"64","author":"SC Shiboski","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0714.2004.00264.x","article-title":"Sj\u00f6gren's syndrome: the diagnostic potential of early oral manifestations preceding hyposalivation\/xerostomia","volume":"34","author":"MD Mignogna","year":"2005","journal-title":"J Oral Pathol Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1001\/jama.2013.278448","article-title":"Autoantibodies present before symptom onset in primary Sj\u00f6gren syndrome","volume":"310","author":"R Jonsson","year":"2013","journal-title":"JAMA"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/03009742.2010.536164","article-title":"The point prevalence of clinically relevant primary Sjogren's syndrome in two Norwegian counties","volume":"40","author":"LG Goransson","year":"2011","journal-title":"Scand J Rheumatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1002\/art.27564","article-title":"Significance of B cells and B cell clonality in Sj\u00f6gren's syndrome","volume":"62","author":"P Youinou","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"R172","DOI":"10.1186\/ar4359","article-title":"Efficacy and safety of rituximab treatment in early primary Sj\u00f6gren's syndrome: a prospective, multi-center, follow-up study","volume":"15","author":"F Carubbi","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1136\/ard.2007.083865","article-title":"Reduction of fatigue in Sj\u00f6gren syndrome with rituximab: results of a randomised, double-blind, placebo-controlled pilot study","volume":"67","author":"S Dass","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.7326\/M13-1085","article-title":"Treatment of primary Sj\u00f6gren syndrome with rituximab: a randomized trial","volume":"160","author":"V Devauchelle-Pensec","year":"2014","journal-title":"Ann Intern Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/art.27314","article-title":"Effectiveness of rituximab treatment in primary Sj\u00f6gren's syndrome: a randomized, double-blind, placebo-controlled trial","volume":"62","author":"JM Meijer","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1136\/annrheumdis-2011-201189","article-title":"Persistence of immunoglobulin-producing cells in parotid salivary glands of patients with primary Sj\u00f6gren's syndrome after B cell depletion therapy","volume":"71","author":"N Hamza","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"CA Janeway Jr.","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.coi.2007.04.002","article-title":"Toll-like receptors and innate immunity in B-cell activation and antibody responses","volume":"19","author":"A Lanzavecchia","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/eji.200535744","article-title":"Toll-like receptor stimulation as a third signal required for activation of human naive B cells","volume":"36","author":"CR Ruprecht","year":"2006","journal-title":"Eur J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.autrev.2007.11.027","article-title":"B cell autonomous TLR signaling and autoimmunity","volume":"7","author":"A Meyer-Bahlburg","year":"2008","journal-title":"Autoimmun Rev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nri1957","article-title":"Toll-like receptors in systemic autoimmune disease","volume":"6","author":"A Marshak-Rothstein","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1093\/rheumatology\/keq226","article-title":"Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients","volume":"49","author":"F Capolunghi","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5786","DOI":"10.4049\/jimmunol.1202195","article-title":"B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice","volume":"189","author":"SH Hwang","year":"2012","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3109\/08830180109045588","article-title":"CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction","volume":"20","author":"JC Poe","year":"2001","journal-title":"Int Rev Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1365-3083.2001.00989.x","article-title":"Significantly depressed percentage of CD27+ (memory) B cells among peripheral blood B cells in patients with primary Sj\u00f6gren's syndrome","volume":"54","author":"JO Bohnhorst","year":"2001","journal-title":"Scand J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1002\/art.10445","article-title":"Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sj\u00f6gren's syndrome","volume":"46","author":"A Hansen","year":"2002","journal-title":"Arthritis Rheum"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.humimm.2013.04.007","article-title":"Derailed B cell homeostasis in patients with mixed connective tissue disease","volume":"74","author":"A Hajas","year":"2013","journal-title":"Hum Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1093\/rheumatology\/keq029","article-title":"Alterations on peripheral blood B-cell subpopulations in very early arthritis patients","volume":"49","author":"RA Moura","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.tripleo.2010.01.006","article-title":"Expression of Toll-like receptors 7, 8, and 9 in primary Sj\u00f6gren's syndrome","volume":"109","author":"L Zheng","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1365-2249.2008.03646.x","article-title":"Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus","volume":"152","author":"A Komatsuda","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2249.2009.04036.x","article-title":"Activation profile of Toll-like receptors of peripheral blood lymphocytes in patients with systemic lupus erythematosus","volume":"159","author":"CK Wong","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1007\/s10875-013-9887-0","article-title":"Distinct autoantibody profiles in systemic lupus erythematosus patients are selectively associated with TLR7 and TLR9 upregulation","volume":"33","author":"SK Chauhan","year":"2013","journal-title":"J Clin Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jaut.2010.11.001","article-title":"Cell-specific expression of TLR9 isoforms in inflammation","volume":"36","author":"KJ McKelvey","year":"2011","journal-title":"J Autoimmun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.4049\/jimmunol.174.7.4043","article-title":"Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN","volume":"174","author":"IB Bekeredjian-Ding","year":"2005","journal-title":"J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1016\/j.tripleo.2008.09.015","article-title":"Association between IFN-alpha and primary Sj\u00f6gren's syndrome","volume":"107","author":"L Zheng","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/gene.2009.20","article-title":"Peripheral blood gene expression profiling in Sj\u00f6gren's syndrome","volume":"10","author":"ES Emamian","year":"2009","journal-title":"Genes Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1182\/blood-2002-11-3569","article-title":"A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells","volume":"101","author":"NL Bernasconi","year":"2003","journal-title":"Blood"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/msb.2010.106","article-title":"Defining the transcriptome and proteome in three functionally different human cell lines","volume":"6","author":"E Lundberg","year":"2010","journal-title":"Mol Syst Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"B Schwanhausser","year":"2011","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.4049\/jimmunol.135.2.1299","article-title":"The interaction of murine IgG subclass proteins with human monocyte Fc receptors","volume":"135","author":"MD Lubeck","year":"1985","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"7202","DOI":"10.1128\/IAI.72.12.7202-7211.2004","article-title":"Toll-like receptor 9 can be expressed at the cell surface of distinct populations of tonsils and human peripheral blood mononuclear cells","volume":"72","author":"A Eaton-Bassiri","year":"2004","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1365-2567.2008.02844.x","article-title":"Identification of two subpopulations of purified human blood B cells, CD27- CD23+ and CD27high CD80+, that strongly express cell surface Toll-like receptor 9 and secrete high levels of interleukin-6","volume":"125","author":"F Cognasse","year":"2008","journal-title":"Immunology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jaut.2014.02.005","article-title":"TLR9 expressed on plasma membrane acts as a negative regulator of human B cell response","volume":"51","author":"T Guerrier","year":"2014","journal-title":"J Autoimmun"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0120383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T22:18:42Z","timestamp":1691533122000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0120383"}},"subtitle":[],"editor":[{"given":"Peter","family":"Szodoray","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,19]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0120383","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,19]]}}}