{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T21:54:08Z","timestamp":1753739648999},"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T00:00:00Z","timestamp":1427155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0120530","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T16:45:40Z","timestamp":1427215540000},"page":"e0120530","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["\u03b2-Arrestin Regulates Estradiol Membrane-Initiated Signaling in Hypothalamic Neurons"],"prefix":"10.1371","volume":"10","author":[{"given":"Angela M.","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew C.","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul E.","family":"Micevych","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"12354","DOI":"10.1073\/pnas.0404889101","article-title":"The membrane actions of estrogens can potentiate their lordosis behavior-facilitating genomic actions","volume":"101","author":"LM Kow","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9294","DOI":"10.1523\/JNEUROSCI.0592-07.2007","article-title":"Membrane estrogen receptor-alpha interactions with metabotropic glutamate receptor 1a modulate female sexual receptivity in rats","volume":"27","author":"P Dewing","year":"2007","journal-title":"J Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.1523\/JNEUROSCI.1427-05.2005","article-title":"Estradiol activates group I and II metabotropic glutamate receptor signaling, leading to opposing influences on cAMP response element-binding protein","volume":"25","author":"MI Boulware","year":"2005","journal-title":"J Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.yfrne.2009.04.011","article-title":"Membrane estradiol signaling in the brain","volume":"30","author":"P Micevych","year":"2009","journal-title":"Front Neuroendocrinol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000338400","article-title":"Membrane estrogen receptor regulation of hypothalamic function","volume":"96","author":"PE Micevych","year":"2012","journal-title":"Neuroendocrinol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1126\/science.1071550","article-title":"G protein pathways","volume":"296","author":"SR Neves","year":"2002","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.biochem.68.1.821","article-title":"CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals","volume":"68","author":"AJ Shaywitz","year":"1999","journal-title":"Annual review of biochemistry"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1074\/jbc.M205692200","article-title":"Proximal events in signaling by plasma membrane estrogen receptors","volume":"278","author":"M Razandi","year":"2003","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1210\/en.2003-1676","article-title":"Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in mouse brain","volume":"145","author":"IM Abraham","year":"2004","journal-title":"Endocrinol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.1210\/en.2008-0847","article-title":"Protein kinase C signaling in the hypothalamic arcuate nucleus regulates sexual receptivity in female rats","volume":"149","author":"P Dewing","year":"2008","journal-title":"Endocrinol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jchemneu.2011.02.002","article-title":"Estrogen receptors stimulate brain region specific metabotropic glutamate receptors to rapidly initiate signal transduction pathways","volume":"42","author":"J Meitzen","year":"2011","journal-title":"J Chem Neuroanat"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1210\/en.2008-0994","article-title":"Membrane estrogen receptor-alpha interacts with metabotropic glutamate receptor type 1a to mobilize intracellular calcium in hypothalamic astrocytes","volume":"150","author":"J Kuo","year":"2009","journal-title":"Endocrinol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1210\/mend.16.1.0757","article-title":"ERs associate with and regulate the production of caveolin: Implications for signaling and cellular actions","volume":"16","author":"M Razandi","year":"2002","journal-title":"Mol Endocrinol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1210\/en.2013-1172","article-title":"Palmitoylation of estrogen receptors is essential for neuronal membrane signaling","volume":"154","author":"J Meitzen","year":"2013","journal-title":"Endocrinology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1523\/JNEUROSCI.0550-09.2009","article-title":"17beta-estradiol-mediated neuroprotection and ERK activation require a pertussis toxin-sensitive mechanism involving GRK2 and beta-arrestin-1","volume":"29","author":"R Dominguez","year":"2009","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"12589","DOI":"10.1523\/JNEUROSCI.1038-10.2010","article-title":"Estradiol rapidly regulates membrane estrogen receptor alpha levels in hypothalamic neurons","volume":"30","author":"R Dominguez","year":"2010","journal-title":"J Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Dominguez R, Dewing P, Kuo J, Micevych P. Membrane-initiated estradiol signaling in immortalized hypothalamic N-38 neurons. Steroids. 2013.","DOI":"10.1016\/j.steroids.2012.12.008"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"15323","DOI":"10.1523\/JNEUROSCI.2107-09.2009","article-title":"Estradiol-induced estrogen receptor-alpha trafficking","volume":"29","author":"G Bondar","year":"2009","journal-title":"J Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.1073\/pnas.90.15.7172","article-title":"Identification of an isoform of the estrogen receptor messenger RNA lacking exon four and present in the brain","volume":"90","author":"JK Skipper","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1073\/pnas.94.6.2180","article-title":"Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases","volume":"94","author":"Y Daaka","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0301-0082(01)00023-5","article-title":"Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins","volume":"66","author":"A Claing","year":"2002","journal-title":"Prog Neurobiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/jcs.03338","article-title":"Beta-arrestin signaling and regulation of transcription","volume":"120","author":"L Ma","year":"2007","journal-title":"J Cell Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"27005","DOI":"10.1074\/jbc.272.43.27005","article-title":"A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types","volume":"272","author":"J Zhang","year":"1997","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0955-0674(00)00190-3","article-title":"Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking","volume":"13","author":"WE Miller","year":"2001","journal-title":"Current opinion in cell biology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ceb.2004.01.001","article-title":"beta-arrestins: traffic cops of cell signaling","volume":"16","author":"RJ Lefkowitz","year":"2004","journal-title":"Current opinion in cell biology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1126\/science.1109237","article-title":"Transduction of receptor signals by beta-arrestins","volume":"308","author":"RJ Lefkowitz","year":"2005","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tem.2006.03.008","article-title":"GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling","volume":"17","author":"E Reiter","year":"2006","journal-title":"Trends Endocrinol Metab"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1523\/JNEUROSCI.0514-08.2008","article-title":"Estrogen facilitates both phosphatidylinositol 3-kinase\/Akt and ERK1\/2 mitogen-activated protein kinase membrane signaling required for long-term neuropeptide Y transcriptional regulation in clonal, immortalized neurons","volume":"28","author":"D Titolo","year":"2008","journal-title":"J Neurosci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1523\/JNEUROSCI.1366-03.2004","article-title":"Estrogen-induced mu-opioid receptor internalization in the medial preoptic nucleus is mediated via neuropeptide Y-Y1 receptor activation in the arcuate nucleus of female rats","volume":"24","author":"RH Mills","year":"2004","journal-title":"J Neurosci"},{"key":"ref30","first-page":"151","article-title":"Handbook of Neurochemistry and Molecular Neurobiology","author":"P Micevych","year":"2007"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2826.2009.01833.x","article-title":"Physiology of membrane oestrogen receptor signalling in reproduction","volume":"21","author":"P Micevych","year":"2009","journal-title":"J Neuroendocrinol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1523\/JNEUROSCI.21-15-05723.2001","article-title":"Progesterone blockade of estrogen activation of m-opioid receptors regulates reproductive behavior","volume":"21","author":"K Sinchak","year":"2001","journal-title":"J Neurosci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1210\/me.2006-0027","article-title":"Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) alpha to ERbeta in clonal hypothalamic neurons","volume":"20","author":"D Titolo","year":"2006","journal-title":"Mol Endocrinol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/jnr.490380404","article-title":"Gonadal steroid control of preproenkephalin mRNA expression in the limbic-hypothalamic circuit: Comparison of adult with neonatal steroid treatments","volume":"38","author":"PE Micevych","year":"1994","journal-title":"J of Neurosci Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1210\/en.2012-1312","article-title":"CAV1 siRNA reduces membrane estrogen receptor-alpha levels and attenuates sexual receptivity","volume":"153","author":"A Christensen","year":"2012","journal-title":"Endocrinol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/jne.12103","article-title":"Temporal And Concentration Dependent Estradiol Effects On Neural Pathways Mediating Sexual Receptivity","author":"P Micevych","year":"2013","journal-title":"J Neuroendocrinol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/383447a0","article-title":"Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor","volume":"383","author":"OB Goodman Jr.","year":"1996","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.neuroscience.2008.05.001","article-title":"Estrogen receptor alpha is expressed on the cell-surface of embryonic hypothalamic neurons","volume":"154","author":"SV Gorosito","year":"2008","journal-title":"Neuroscience"},{"key":"ref39","first-page":"741","article-title":"Estrogen receptor variant messenger RNA lacking exon 4 in estrogen-responsive human breast cancer cell lines","volume":"53","author":"U Pfeffer","year":"1993","journal-title":"Cancer Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.1073\/pnas.90.15.7172","article-title":"Identification of an isoform of the estrogen receptor messenger RNA lacking exon four and present in the brain","volume":"90","author":"JK Skipper","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0960-0760(93)90336-U","article-title":"Wild type and alternatively spliced estrogen receptor messenger RNA in human meningioma tissue and MCF7 breast cancer cells","volume":"45","author":"SG Koehorst","year":"1993","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"4926","DOI":"10.1210\/en.2010-0573","article-title":"Contribution of a membrane estrogen receptor to the estrogenic regulation of body temperature and energy homeostasis","volume":"151","author":"TA Roepke","year":"2010","journal-title":"Endocrinol"},{"key":"ref43","first-page":"894","article-title":"Differential subcellular distribution and transcriptional activity of sigmaE3, sigmaE4, and sigmaE3-4 isoforms of the rat estrogen receptor-alpha","volume":"15","author":"C Pasqualini","year":"2001","journal-title":"Mol Endocrinol"},{"key":"ref44","first-page":"634","article-title":"An estrogen receptor-alpha splicing variant mediates both positive and negative effects on gene transcription","volume":"14","author":"A Bollig","year":"2000","journal-title":"Mol Endocrinol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0303-7207(94)90240-2","article-title":"Functional analysis of an alternatively spliced estrogen receptor lacking exon 4 isolated from MCF-7 breast cancer cells and meningioma tissue","volume":"101","author":"SG Koehorst","year":"1994","journal-title":"Mol Cell Endocrinol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1006\/bbrc.1996.0308","article-title":"Identification of a novel isoform of estrogen receptor, a potential inhibitor of estrogen action, in vascular smooth muscle cells","volume":"219","author":"S Inoue","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"ref47","first-page":"2029","article-title":"Identification of a variant estrogen receptor lacking exon 4 and its coexpression with wild-type estrogen receptor in ovarian carcinomas","volume":"2","author":"W Park","year":"1996","journal-title":"Clin Cancer Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2012.12.050","article-title":"Transcriptional activity of human brain estrogen receptor-alpha splice variants: evidence for cell type-specific regulation","volume":"1500","author":"TA Ishunina","year":"2013","journal-title":"Brain Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0960-0760(01)00118-2","article-title":"Expression of alternatively spliced estrogen receptor alpha mRNAs is increased in breast cancer tissues","volume":"78","author":"I Poola","year":"2001","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/BF00301952","article-title":"Demonstration of isoforms of the estrogen receptor in the bone tissues and in osteoblastic cells","volume":"57","author":"S Hoshino","year":"1995","journal-title":"Calcified tissue international"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1210\/endo.140.6.6752","article-title":"Stage- and region-specific expression of estrogen receptor alpha isoforms during ontogeny of the pituitary gland","volume":"140","author":"C Pasqualini","year":"1999","journal-title":"Endocrinology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.pharmtox.38.1.289","article-title":"The role of receptor kinases and arrestins in G protein-coupled receptor regulation","volume":"38","author":"JG Krupnick","year":"1998","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"35518","DOI":"10.1074\/jbc.M405878200","article-title":"Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor","volume":"279","author":"S Ahn","year":"2004","journal-title":"J Biol Chem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1038\/sj.onc.1210407","article-title":"G protein regulation of MAPK networks","volume":"26","author":"ZG Goldsmith","year":"2007","journal-title":"Oncogene"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2174\/2213988501307010009","article-title":"Minireview: Targeting GPCR Activated ERK Pathways for Drug Discovery","volume":"7","author":"H Eishingdrelo","year":"2013","journal-title":"Current chemical genomics and translational medicine"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"34418","DOI":"10.1074\/jbc.M300573200","article-title":"A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis","volume":"278","author":"L Ge","year":"2003","journal-title":"J Biol Chem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"11425","DOI":"10.1074\/jbc.M806395200","article-title":"MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization","volume":"284","author":"D Meng","year":"2009","journal-title":"J Biol Chem"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nrm883","article-title":"Signal transduction and endocytosis: close encounters of many kinds","volume":"3","author":"A Sorkin","year":"2002","journal-title":"Nature reviews Molecular cell biology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ceb.2007.04.021","article-title":"Signaling on the endocytic pathway","volume":"19","author":"M von Zastrow","year":"2007","journal-title":"Current opinion in cell biology"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.molcel.2006.11.007","article-title":"New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors","volume":"24","author":"RJ Lefkowitz","year":"2006","journal-title":"Molecular cell"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.bbamcr.2013.06.013","article-title":"The three alpha1-adrenoceptor subtypes show different spatio-temporal mechanisms of internalization and ERK1\/2 phosphorylation","volume":"1833","author":"M Perez-Aso","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1124\/mol.104.006072","article-title":"Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking","volume":"67","author":"L Stalheim","year":"2005","journal-title":"Mol Pharmacol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"6258","DOI":"10.1074\/jbc.M212231200","article-title":"The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation","volume":"278","author":"A Tohgo","year":"2003","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1074\/jbc.M112.400234","article-title":"Divergent beta-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini","volume":"288","author":"K Pal","year":"2013","journal-title":"J Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nchembio.545","article-title":"Retromer terminates the generation of cAMP by internalized PTH receptors","volume":"7","author":"TN Feinstein","year":"2011","journal-title":"Nat Chem Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"17583","DOI":"10.1523\/JNEUROSCI.3030-11.2011","article-title":"Membrane-initiated estradiol signaling induces spinogenesis required for female sexual receptivity","volume":"31","author":"A Christensen","year":"2011","journal-title":"J Neurosci"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fendo.2011.00026","article-title":"Membrane-initiated estradiol signaling regulating sexual receptivity","volume":"2","author":"PE Micevych","year":"2011","journal-title":"Frontiers in Endocrinology"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.yfrne.2012.07.003","article-title":"Membrane-initiated estradiol actions mediate structural plasticity and reproduction","volume":"33","author":"P Micevych","year":"2012","journal-title":"Front Neuroendocrinol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1210\/en.2013-1235","article-title":"Estradiol dose-dependent regulation of membrane estrogen receptor-alpha, metabotropic glutamate receptor-1a, and their complexes in the arcuate nucleus of the hypothalamus in female rats","volume":"154","author":"M Mahavongtrakul","year":"2013","journal-title":"Endocrinol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s12035-008-8034-z","article-title":"Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain","volume":"38","author":"PE Micevych","year":"2008","journal-title":"Mol Neurobiol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1055\/s-0032-1306301","article-title":"Hormonal regulation of female reproduction","volume":"44","author":"A Christensen","year":"2012","journal-title":"Horm Metab Res"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.yfrne.2010.02.003","article-title":"Neural mechanisms of reproduction in females as a predisposing factor for drug addiction","volume":"31","author":"VL Hedges","year":"2010","journal-title":"Front Neuroendocrinol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0091-3057(99)00091-X","article-title":"Rapid effects of estrogen or progesterone on the amphetamine-induced increase in striatal dopamine are enhanced by estrogen priming: a microdialysis study","volume":"64","author":"JB Becker","year":"1999","journal-title":"Pharmacol Biochem Behav"},{"key":"ref74","article-title":"Estrogen and Visceral Nociception at the Level of Primary Sensory Neurons","volume":"2012","author":"V Chaban","year":"2012","journal-title":"Pain Res Treat"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0120530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T06:33:07Z","timestamp":1566455587000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0120530"}},"subtitle":[],"editor":[{"given":"Ferdinando","family":"Auricchio","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,24]]},"references-count":74,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0120530","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,24]]}}}