{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T22:59:42Z","timestamp":1772578782468,"version":"3.50.1"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0120636","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T18:57:56Z","timestamp":1425668276000},"page":"e0120636","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Effects of Prenatal Leydig Cell Function on the Ratio of the Second to Fourth Digit Lengths in School-Aged Children"],"prefix":"10.1371","volume":"10","author":[{"given":"Takahiko","family":"Mitsui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakiko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeya","family":"Kitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimihiko","family":"Moriya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Morioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Kishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Nonomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1093\/humrep\/13.11.3000","article-title":"The ratio of 2nd to 4th digit length: a predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen","volume":"13","author":"JT Manning","year":"1998","journal-title":"Hum Reprod"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"4116","DOI":"10.1210\/en.2010-0041","article-title":"Minireview: Organizational hypothesis: instances of the fingerpost","volume":"151","author":"SM Breedlove","year":"2010","journal-title":"Endocrinology"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s002239900274","article-title":"Estrogen, progesterone and testosterone receptors in human fetal cartilaginous tissue: immunohistochemical studies","volume":"60","author":"H Ben-Hur","year":"1997","journal-title":"Calcif Tissue Int"},{"issue":"1\u20132","key":"ref4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0378-3782(02)00073-7","article-title":"The ratio of second- and fourth-digit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"70","author":"A Okten","year":"2002","journal-title":"Early Hum Dev"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1210\/en.2009-0774","article-title":"Fingers as a marker of prenatal androgen exposure","volume":"150","author":"SA Berenbaum","year":"2009","journal-title":"Endocrinology"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1080\/0301446032000112689","article-title":"Second to fourth digit ratio: ethnic differences and family size in English, Indian and South African populations","volume":"30","author":"JT Manning","year":"2003","journal-title":"Ann Hum Biol"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10508-009-9485-7","article-title":"Sexual dimorphism in the prenatal digit ratio (2D:4D)","volume":"39","author":"F Galis","year":"2010","journal-title":"Arch Sex Behav"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.earlhumdev.2005.12.002","article-title":"Fetal development of the hand, digits and digit ratio (2D:4D)","volume":"82","author":"MA Malas","year":"2006","journal-title":"Early Hum Dev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fendo.2014.00064","article-title":"Measurement of Androgen and Estrogen Concentrations in Cord Blood: Accuracy, Biological Interpretation, and Applications to Understanding Human Behavioral Development","volume":"5","author":"LP Hollier","year":"2014","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"e42827","DOI":"10.1371\/journal.pone.0042827","article-title":"Androgen concentrations in umbilical cord blood and their association with maternal, fetal and obstetric factors","volume":"7","author":"JA Keelan","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.biopsycho.2012.10.016","article-title":"The association between perinatal testosterone concentration and early vocabulary development: a prospective cohort study","volume":"92","author":"LP Hollier","year":"2013","journal-title":"Biol Psychol"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1469-7610.2011.02523.x","article-title":"Keelan JA <italic>et al<\/italic>. Sex-specific associations between umbilical cord blood testosterone levels and language delay in early childhood","volume":"53","author":"AJ Whitehouse","year":"2012","journal-title":"J Child Psychol Psychiatry"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"e59991","DOI":"10.1371\/journal.pone.0059991","article-title":"Keelan JA <italic>et al<\/italic>. Umbilical cord blood testosterone and childhood internalizing and externalizing behavior: a prospective study","volume":"8","author":"M Robinson","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12199-013-0357-3","article-title":"Ten years of progress in the Hokkaido birth cohort study on environment and children\u2019s health: cohort profile\u2014updated 2013","volume":"18","author":"R Kishi","year":"2013","journal-title":"Environ Health Prev Med"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/ije\/dyq071","article-title":"Cohort profile: the Hokkaido study on environment and children\u2019s health in Japan","volume":"40","author":"R Kishi","year":"2011","journal-title":"Int J Epidemiol"},{"issue":"11\u201312","key":"ref16","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.steroids.2007.07.003","article-title":"Highly sensitive determination of estrone and estradiol in human serum by liquid chromatography\u2014electrospray ionization tandem mass spectrometry","volume":"72","author":"K Yamashita","year":"2007","journal-title":"Steroids"},{"issue":"1\u20132","key":"ref17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.chroma.2007.10.023","article-title":"Use of novel picolinoyl derivatization for simultaneous quantification of six corticosteroids by liquid chromatography-electrospray ionization tandem mass spectrometry","volume":"1173","author":"K Yamashita","year":"2007","journal-title":"J Chromatogr A"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.psyneuen.2010.02.013","article-title":"Maternal and umbilical cord androgen concentrations do not predict digit ratio (2D:4D) in girls: a prospective cohort study","volume":"35","author":"M Hickey","year":"2010","journal-title":"Psychoneuroendocrinology"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.yhbeh.2004.06.010","article-title":"Relationships between sex hormones assessed in amniotic fluid, and maternal and umbilical cord serum: what is the best source of information to investigate the effects of fetal hormonal exposure?","volume":"46","author":"C van de Beek","year":"2004","journal-title":"Horm Behav"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/humrep\/den038","article-title":"Insulin-like factor 3 levels in amniotic fluid of human male fetuses","volume":"23","author":"R Anand-Ivell","year":"2008","journal-title":"Hum Reprod"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1530\/REP-13-0486","article-title":"Insulin-like factor 3 as a monitor of endocrine disruption","volume":"147","author":"R Anand-Ivell","year":"2014","journal-title":"Reproduction"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1464-410X.2011.10249.x","article-title":"Second to fourth digit ratio, adult testosterone level and testosterone deficiency","volume":"109","author":"E Garcia-Cruz","year":"2012","journal-title":"BJU Int"},{"issue":"39","key":"ref23","doi-asserted-by":"crossref","first-page":"16289","DOI":"10.1073\/pnas.1108312108","article-title":"Developmental basis of sexually dimorphic digit ratios","volume":"108","author":"Z Zheng","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"39","key":"ref24","doi-asserted-by":"crossref","first-page":"16143","DOI":"10.1073\/pnas.1113312108","article-title":"Resolving the role of prenatal sex steroids in the development of digit ratio","volume":"108","author":"JT Manning","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"e109039","DOI":"10.1371\/journal.pone.0109039","article-title":"Association between maternal exposure to di(2-ethylhexyl) phthalate and reproductive hormone levels in fetal blood: The Hokkaido Study on Environment and Children\u2019s Health","volume":"9","author":"A Araki","year":"2014","journal-title":"PLoS One"},{"issue":"1\u20132","key":"ref26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijheh.2007.04.005","article-title":"Environmental exposure to dioxins and polychlorinated biphenyls reduce levels of gonadal hormones in newborns: results from the Duisburg cohort study","volume":"211","author":"Y Cao","year":"2008","journal-title":"Int J Hyg Environ Health"},{"issue":"17\u201318","key":"ref27","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1080\/15287390590967360","article-title":"Serum hormones in boys prenatally exposed to polychlorinated biphenyls and dibenzofurans","volume":"68","author":"PC Hsu","year":"2005","journal-title":"J Toxicol Environ Health A"},{"issue":"1768","key":"ref28","doi-asserted-by":"crossref","first-page":"20131532","DOI":"10.1098\/rspb.2013.1532","article-title":"Environmental levels of oestrogenic and antiandrogenic compounds feminize digit ratios in male rats and their unexposed male progeny","volume":"280","author":"J Auger","year":"2013","journal-title":"Proc Biol Sci"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ajpa.22044","article-title":"Relationship of 2D:4D finger ratio with muscle strength, testosterone, and androgen receptor CAG repeat genotype","volume":"148","author":"JP Folland","year":"2012","journal-title":"Am J Phys Anthropol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fendo.2013.00185","article-title":"No Evidence that 2D:4D is Related to the Number of CAG Repeats in the Androgen Receptor Gene","volume":"4","author":"J Honekopp","year":"2013","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0120636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T22:17:53Z","timestamp":1588976273000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0120636"}},"subtitle":[],"editor":[{"given":"Bernhard","family":"Fink","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,6]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0120636","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,6]]}}}