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Disorders of the Autonomic Nervous System 1995."},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/01.RES.78.5.737","article-title":"\u03b11-adrenergic receptor subtypes molecular structure, function, and signaling","volume":"78","author":"RM Graham","year":"1996","journal-title":"Circulation research"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1067\/mcp.2000.106293","article-title":"Human \u03b22-adrenergic receptor polymorphisms: No association with essential hypertension in black or white Americans&amp;ast","volume":"67","author":"H-G Xie","year":"2000","journal-title":"Clinical Pharmacology & Therapeutics"},{"issue":"5527","key":"ref14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.293.5527.98","article-title":"A \u03b22 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1. 2","volume":"293","author":"MA Davare","year":"2001","journal-title":"Science"},{"key":"ref15","first-page":"179","article-title":"Reversible Protein Phosphorylation in Cell Regulation","author":"JL Meinkoth","year":"1994"},{"key":"ref16","unstructured":"Ekokoski E. Extracellular ATP as a regulator of intracellular signaling in Thyroid FRTL-5 cells2000."},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s00586-011-1939-7","article-title":"Equilibrium of the human body and the gravity line: the basics","volume":"20","author":"J Le Huec","year":"2011","journal-title":"European Spine Journal"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.0021-8782.2004.00303.x","article-title":"Mechanisms for the acquisition of habitual bipedality: are there biomechanical reasons for the acquisition of upright bipedal posture?","volume":"204","author":"H Preuschoft","year":"2004","journal-title":"Journal of anatomy"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10286-003-0099-1","article-title":"Fainting in animals","volume":"13","author":"JG van Dijk","year":"2003","journal-title":"Clinical Autonomic Research"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1074\/jbc.M008118200","article-title":"Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization","volume":"276","author":"KM Small","year":"2001","journal-title":"J Biol Chem"},{"issue":"6813","key":"ref21","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/35047064","article-title":"Mitochondrial genome variation and the origin of modern humans","volume":"408","author":"M Ingman","year":"2000","journal-title":"Nature"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1471-2148-14-109","article-title":"The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents","volume":"14","author":"B Secher","year":"2014","journal-title":"BMC Evolutionary Biology"},{"issue":"7117","key":"ref23","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature05336","article-title":"Analysis of one million base pairs of Neanderthal DNA","volume":"444","author":"RE Green","year":"2006","journal-title":"Nature"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/10635150500481390","article-title":"Arrival and diversification of caviomorph rodents and platyrrhine primates in South America","volume":"55","author":"C Poux","year":"2006","journal-title":"Systematic Biology"},{"key":"ref25","unstructured":"Ensemble. 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