{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:37:35Z","timestamp":1761709055834},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0120869","type":"journal-article","created":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T02:25:47Z","timestamp":1427595947000},"page":"e0120869","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dicarbonyl L-Xylulose Reductase (DCXR), a \u201cMoonlighting Protein\u201d in the Bovine Epididymis"],"prefix":"10.1371","volume":"10","author":[{"given":"Ayod\u00e9l\u00e9","family":"Akintayo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"L\u00e9gar\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00441-012-1381-0","article-title":"Region-specific gene expression in the epididymis","volume":"349","author":"C Belleannee","year":"2012","journal-title":"Cell and tissue research"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/molehr\/gam051","article-title":"Region-specific gene expression profiling along the human epididymis","volume":"13","author":"V Thimon","year":"2007","journal-title":"Mol Hum Reprod"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1095\/biolreprod.106.059246","article-title":"Gene expression profiling and its relevance to the blood-epididymal barrier in the human epididymis","volume":"76","author":"E Dube","year":"2007","journal-title":"Biology of reproduction"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jprot.2010.07.013","article-title":"Identification of luminal and secreted proteins in bull epididymis","volume":"74","author":"C Belleannee","year":"2011","journal-title":"Journal of proteomics"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1016\/j.biocel.2013.08.010","article-title":"The multifunctional pentosuria enzyme","volume":"45","author":"SK Lee","year":"2013","journal-title":"The international journal of biochemistry & cell biology"},{"key":"ref6","article-title":"Human DCXR\u2014another 'moonlighting protein' involved in sugar metabolism, carbonyl detoxification, cell adhesion and male fertility?","author":"B Ebert","year":"2014","journal-title":"Biological reviews of the Cambridge Philosophical Society"},{"issue":"20","key":"ref7","doi-asserted-by":"crossref","first-page":"17883","DOI":"10.1074\/jbc.M110703200","article-title":"Molecular characterization of mammalian dicarbonyl\/L-xylulose reductase and its localization in kidney","volume":"277","author":"J Nakagawa","year":"2002","journal-title":"The Journal of biological chemistry"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1271\/bbb.60311","article-title":"Suppression of AGE precursor formation following unilateral ureteral obstruction in mouse kidneys by transgenic expression of alpha-dicarbonyl\/L-xylulose reductase","volume":"70","author":"J Asami","year":"2006","journal-title":"Bioscience, biotechnology, and biochemistry"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1158\/1055-9965.EPI-07-0684","article-title":"Dicarbonyl\/L-xylulose reductase: a potential biomarker identified by laser-capture microdissection-micro serial analysis of gene expression of human prostate adenocarcinoma","volume":"16","author":"JH Cho-Vega","year":"2007","journal-title":"Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1095\/biolreprod54.5.1018","article-title":"Cases of human infertility are associated with the absence of P34H an epididymal sperm antigen","volume":"54","author":"F Boue","year":"1996","journal-title":"Biology of reproduction"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/j.1939-4640.2000.tb02138.x","article-title":"Cryopreservation alters the levels of the bull sperm surface protein P25b","volume":"21","author":"C Lessard","year":"2000","journal-title":"Journal of andrology"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1095\/biolreprod.103.019216","article-title":"Aldose reductase and macrophage migration inhibitory factor are associated with epididymosomes and spermatozoa in the bovine epididymis","volume":"69","author":"G Frenette","year":"2003","journal-title":"Biology of reproduction"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1196\/annals.1433.003","article-title":"Suppression of renal alpha-dicarbonyl compounds generated following ureteral obstruction by kidney-specific alpha-dicarbonyl\/L-xylulose reductase","volume":"1126","author":"H Odani","year":"2008","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1600-0560.2006.00661.x","article-title":"Expression of dicarbonyl\/L-xylulose reductase (DCXR) in human skin and melanocytic lesions: morphological studies supporting cell adhesion function of DCXR","volume":"34","author":"JH Cho-Vega","year":"2007","journal-title":"Journal of cutaneous pathology"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1095\/biolreprod51.4.577","article-title":"Human sperm-zona pellucida interaction is inhibited by an antiserum against a hamster sperm protein","volume":"51","author":"F Boue","year":"1994","journal-title":"Biology of reproduction"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/mrd.1050","article-title":"Identification and characterization of P31m, a novel sperm protein in Cynomolgus monkey (Macaca fascicularis)","volume":"59","author":"N Lamontagne","year":"2001","journal-title":"Molecular reproduction and development"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1210\/endo.140.7.6791","article-title":"P34H sperm protein is preferentially expressed by the human corpus epididymidis","volume":"140","author":"C Legare","year":"1999","journal-title":"Endocrinology"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/mrd.20089","article-title":"P26h and dicarbonyl\/L-xylulose reductase are two distinct proteins present in the hamster epididymis","volume":"69","author":"A St-Cyr","year":"2004","journal-title":"Molecular reproduction and development"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1538\/expanim.54.385","article-title":"Transgenic mice over-expressing dicarbonyl\/L-xylulose reductase gene crossed with KK-Ay diabetic model mice: an animal model for the metabolism of renal carbonyl compounds","volume":"54","author":"T Sudo","year":"2005","journal-title":"Experimental animals \/ Japanese Association for Laboratory Animal Science"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.fertnstert.2005.10.070","article-title":"Levels of P34H, a sperm protein of epididymal origin, as a predictor of conventional in vitro fertilization outcome","volume":"85","author":"R Sullivan","year":"2006","journal-title":"Fertility and sterility"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/mrd.1013","article-title":"Prostasome-like particles are involved in the transfer of P25b from the bovine epididymal fluid to the sperm surface","volume":"59","author":"G Frenette","year":"2001","journal-title":"Molecular reproduction and development"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/molehr\/gah087","article-title":"Expression and localization of c-ros oncogene along the human excurrent duct","volume":"10","author":"C Legare","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"ref23","first-page":"225","article-title":"Biochemical aspects of spermatozoa and their environment in the male reproductive tract","volume":"18","author":"IG White","year":"1973","journal-title":"Journal of reproduction and fertility Supplement"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1530\/jrf.0.0560159","article-title":"Investigation by luminal perfusion of the transfer of compounds into the epididymis of the anaesthetized rat","volume":"56","author":"TG Cooper","year":"1979","journal-title":"Journal of reproduction and fertility"},{"issue":"21","key":"ref25","doi-asserted-by":"crossref","first-page":"11614","DOI":"10.1073\/pnas.97.21.11614","article-title":"The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing","volume":"97","author":"J Zabner","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5 Pt 2","key":"ref26","first-page":"R1363","article-title":"Hyperosmolality and sperm storage in hibernating bats: prolongation of sperm life by dehydration","volume":"267","author":"EG Crichton","year":"1994","journal-title":"The American journal of physiology"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/j.1939-4640.1999.tb02508.x","article-title":"Principal cells of the vas deferens are involved in water transport and steroid synthesis in the adult rat","volume":"20","author":"S Andonian","year":"1999","journal-title":"Journal of andrology"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0305-0491(78)90138-4","article-title":"Comparative biochemistry of mammalian epididymal plasma","volume":"61","author":"R Jones","year":"1978","journal-title":"Comparative biochemistry and physiology B, Comparative biochemistry"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2605.1981.tb00730.x","article-title":"The concentration of some inorganic ions and organic compounds in the luminal fluid of the human ductus deferens","volume":"4","author":"BT Hinton","year":"1981","journal-title":"International journal of andrology"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/molehr\/2.12.903","article-title":"Involvement of osmo-sensitive calcium influx in human sperm activation","volume":"2","author":"M Rossato","year":"1996","journal-title":"Molecular human reproduction"},{"issue":"9","key":"ref31","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/molehr\/7.9.819","article-title":"Effects of the ion-channel blocker quinine on human sperm volume, kinematics and mucus penetration, and the involvement of potassium channels","volume":"7","author":"CH Yeung","year":"2001","journal-title":"Molecular human reproduction"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1095\/biolreprod.106.054692","article-title":"Comparison between epididymosomes collected in the intraluminal compartment of the bovine caput and cauda epididymidis","volume":"75","author":"G Frenette","year":"2006","journal-title":"Biology of reproduction"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1095\/biolreprod.108.073551","article-title":"Compartmentalization of proteins in epididymosomes coordinates the association of epididymal proteins with the different functional structures of bovine spermatozoa","volume":"80","author":"J Girouard","year":"2009","journal-title":"Biology of reproduction"},{"issue":"12","key":"ref34","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1002\/jcp.24099","article-title":"Bovine sperm raft membrane associated Glioma Pathogenesis-Related 1-like protein 1 (GliPr1L1) is modified during the epididymal transit and is potentially involved in sperm binding to the zona pellucida","volume":"227","author":"J Caballero","year":"2012","journal-title":"Journal of cellular physiology"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/abio.2001.5564","article-title":"Elimination of primer-dimer artifacts and genomic coamplification using a two-step SYBR green I real-time RT-PCR","volume":"303","author":"J Vandesompele","year":"2002","journal-title":"Analytical biochemistry"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"J Vandesompele","year":"2002","journal-title":"Genome biology"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1095\/biolreprod.109.082438","article-title":"Characterization of two distinct populations of epididymosomes collected in the intraluminal compartment of the bovine cauda epididymis","volume":"83","author":"G Frenette","year":"2010","journal-title":"Biology of reproduction"},{"issue":"5 Pt 2","key":"ref38","doi-asserted-by":"crossref","first-page":"e475","DOI":"10.1111\/j.1365-2605.2011.01203.x","article-title":"Comparative proteome and lipid profiles of bovine epididymosomes collected in the intraluminal compartment of the caput and cauda epididymidis","volume":"34","author":"J Girouard","year":"2011","journal-title":"International journal of andrology"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1095\/biolreprod.108.070367","article-title":"Increased Activity of the Human Sperm Tyrosine Kinase SRC by the cAMP-Dependent Pathway in the Presence of Calcium","volume":"79","author":"C Lawson","year":"2008","journal-title":"Biology of reproduction"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0120869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T02:29:09Z","timestamp":1717813749000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0120869"}},"subtitle":[],"editor":[{"given":"Jean-Marc A","family":"Lobaccaro","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,27]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0120869","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,27]]}}}