{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:18:26Z","timestamp":1761059906160},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0120949","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T18:24:04Z","timestamp":1427307844000},"page":"e0120949","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Pathology of the Calcified Zone of Articular Cartilage in Post-Traumatic Osteoarthritis in Rat Knees"],"prefix":"10.1371","volume":"10","author":[{"given":"Melissa","family":"Schultz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Molligan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lew","family":"Schon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/01.bot.0000246468.80635.ef","article-title":"Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease","volume":"20","author":"TD Brown","year":"2006","journal-title":"J Orthop Trauma"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/01.blo.0000131638.81519.de","article-title":"Joint injury, repair, and remodeling: roles in post-traumatic osteoarthritis","volume":"423","author":"JA Buckwalter","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/BOT.0b013e3181ed298d","article-title":"Basic science of intra-articular fractures and posttraumatic osteoarthritis","volume":"24","author":"TO McKinley","year":"2010","journal-title":"J Orthop Trauma"},{"key":"ref4","first-page":"285","article-title":"Pathogenetic mechanisms of posttraumatic osteoarthritis: opportunities for early intervention","volume":"4","author":"WC Kramer","year":"2011","journal-title":"Int J Clin Exp Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3233\/BIR-2009-0554","article-title":"Traumatic loading of articular cartilage: Mechanical and biological responses and post-injury treatment","volume":"46","author":"RM Natoli","year":"2009","journal-title":"Biorheology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/jor.21359","article-title":"Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention","volume":"29","author":"DD Anderson","year":"2011","journal-title":"J Orthop Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1469-7580.2012.01479.x","article-title":"A multi-modal multiphoton investigation of microstructure in the deep zone and calcified cartilage","volume":"220","author":"JC Mansfield","year":"2012","journal-title":"J Anat"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/jor.20883","article-title":"In situ measurement of transport between subchondral bone and articular cartilage","volume":"27","author":"J Pan","year":"2009","journal-title":"J Orthop Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.joca.2007.10.001","article-title":"Solute transport in the deep and calcified zones of articular cartilage","volume":"16","author":"KP Arkill","year":"2008","journal-title":"Osteoarthritis Cart"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10735-005-3283-x","article-title":"The tidemark of the chondro-osseous junction of the normal human knee joint","volume":"36","author":"TJ Lyons","year":"2005","journal-title":"J Mol Histol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/(SICI)1097-0029(19970515)37:4<324::AID-JEMT7>3.0.CO;2-K","article-title":"The interaction of the zone of calcified cartilage and subchondral bone in osteoarthritis","volume":"37","author":"TR Oegema Jr","year":"1997","journal-title":"Microsc Res Tech"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jsb.2009.08.010","article-title":"Histomorphometric analysis of adult articular calcified cartilage zone","volume":"168","author":"F Wang","year":"2009","journal-title":"J Struct Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.matbio.2004.08.003","article-title":"Do changes in the mechanical properties of articular cartilage promote catabolic destruction of cartilage and osteoarthritis?","volume":"23","author":"FH Silver","year":"2004","journal-title":"Matrix Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/(SICI)1097-0029(19970515)37:4<343::AID-JEMT9>3.0.CO;2-L","article-title":"The involvement of subchondral mineralized tissues in osteoarthrosis: quantitative microscopic evidence","volume":"15","author":"DB Burr","year":"1997","journal-title":"Microsc Res Tech"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrrheum.2010.197","article-title":"The bone-cartilage unit in osteoarthritis","volume":"7","author":"RJ Lories","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/01.blo.0000133567.28491.7d","article-title":"The long-term effects of articular impaction","volume":"423","author":"MS Vrahas","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00167-010-1054-z","article-title":"The basic science of the subchondral bone","volume":"18","author":"H Madry","year":"2010","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2106\/00004623-197153030-00009","article-title":"Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. 2. Correlation of morphology with biochemical and metabolic data","volume":"53","author":"HJ Mankin","year":"1971","journal-title":"J Bone Joint Surg Am"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1023\/B:ABME.0000017541.82498.37","article-title":"A framework for the in vivo pathomechanics of osteoarthritis at the knee","volume":"32","author":"TP Andriacchi","year":"2004","journal-title":"Ann Biomed Eng"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1053\/joca.2002.0867","article-title":"Topographical analysis of the structural, biochemical and dynamic biomechanical properties of cartilage in an ovine model of osteoarthritis","volume":"11","author":"RC Appleyard","year":"2003","journal-title":"Osteoarthritis Cart"},{"issue":"Suppl A","key":"ref21","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.joca.2003.09.016","article-title":"Anatomy and physiology of the mineralized tissues: role in the pathogenesis of osteoarthrosis","volume":"12","author":"DB Burr","year":"2004","journal-title":"Osteoarthritis Cart"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1053\/joca.2002.0814","article-title":"Quantitative structural organization of normal adult human articular cartilage","volume":"10","author":"EB Hunziker","year":"2002","journal-title":"Osteoarthritis Cart"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02274838","article-title":"Metabolic activity in the calcified zone of cartilage: observations on tetracycline labelled articular cartilage in human osteoarthritic hips","volume":"10","author":"PA Revell","year":"1990","journal-title":"Rheumatol Int"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.archoralbio.2011.04.007","article-title":"Study of the tidemark in human mandibular condylar cartilage","volume":"56","author":"R Chen","year":"2011","journal-title":"Arch Oral Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1302\/0301-620X.65B1.6337169","article-title":"The morphology of the calcification front in articular cartilage. Its significance in joint function","volume":"65","author":"PG Bullough","year":"1983","journal-title":"J Bone Joint Surg Br"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1359\/jbmr.1997.12.4.580","article-title":"Unweighting accelerates tidemark advancement in articular cartilage at the knee joint of rats","volume":"12","author":"KM O\u2019Connor","year":"1997","journal-title":"J Bone Min Res"},{"issue":"Pt 2","key":"ref27","first-page":"341","article-title":"Topographical variation in the calcified zone of upper femoral articular cartilage","volume":"139","author":"G Meachim","year":"1984","journal-title":"J Anat"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.joca.2007.04.003","article-title":"Variations in articular calcified cartilage by site and exercise in the 18-month-old equine distal metacarpal condyle","volume":"15","author":"M Doube","year":"2007","journal-title":"Osteoarthritis Cart"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bone.2005.08.007","article-title":"Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis","volume":"38","author":"T Hayami","year":"2006","journal-title":"Bone"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1302\/0301-620X.62B3.7410471","article-title":"Age-related changes in the thickness of the calcified zone and the number of tidemarks in adult human articular cartilage","volume":"62","author":"LB Lane","year":"1980","journal-title":"J Bone Joint Surg Br"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"274","DOI":"10.2746\/042516402776186100","article-title":"Age-related morphometry of equine calcified cartilage","volume":"34","author":"MJ Martinelli","year":"2002","journal-title":"Equine Vet J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1749-6632.2009.05240.x","article-title":"Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis","volume":"1192","author":"MB Goldring","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s11926-003-0071-z","article-title":"Matrix vesicles and calcification","volume":"5","author":"HC Anderson","year":"2003","journal-title":"Curr Rheum Rep"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/1759720X12437353","article-title":"Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis","volume":"4","author":"SR Goldring","year":"2012","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1002\/jor.22124","article-title":"Excessive running induces cartilage degeneration in knee joints and alters gait of rats","volume":"30","author":"J Beckett","year":"2012","journal-title":"J Orthop Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1098\/rsif.2009.0458","article-title":"Mechanical loading of in situ chondrocytes in lapine retropatellar cartilage after anterior cruciate ligament transection","volume":"7","author":"K Han S-","year":"2010","journal-title":"J R Soc Interface"},{"key":"ref37","first-page":"169","article-title":"Analyses of the tidemark on human femoral heads. II. Tidemark changes in osteoarthrosis\u2014a histological and histomorphometric study in non-decalcified preparations","volume":"37","author":"R Oettmeier","year":"1989","journal-title":"Acta Morphol Hung"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/ar2120","article-title":"Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis","volume":"9","author":"CT Appleton","year":"2007","journal-title":"Arthritis Res Ther"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0120949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T05:12:15Z","timestamp":1598850735000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0120949"}},"subtitle":[],"editor":[{"given":"Johnny","family":"Huard","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,25]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0120949","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,25]]}}}