{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:49:37Z","timestamp":1790099377897,"version":"4.0.1"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0121022","type":"journal-article","created":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T18:53:50Z","timestamp":1427136830000},"page":"e0121022","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Enhanced NMDA Receptor-Mediated Modulation of Excitatory Neurotransmission in the Dorsal Vagal Complex of Streptozotocin-Treated, Chronically Hyperglycemic Mice"],"prefix":"10.1371","volume":"10","author":[{"given":"Eva C.","family":"Bach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin Cs.","family":"Halmos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret N.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.physiol.68.040504.094635","article-title":"Brainstem circuits regulating gastric function","volume":"68","author":"RA Travagli","year":"2006","journal-title":"Annu Rev Physiol"},{"issue":"Pt 2","key":"ref2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1113\/jphysiol.2007.137091","article-title":"The nucleus tractus solitarius: an integrative centre with 'task-matching' capabilities","volume":"582","author":"RA Travagli","year":"2007","journal-title":"J Physiol"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/cne.901930211","article-title":"Brain stem projections of sensory and motor components of the vagus complex in the cat: II. Laryngeal, tracheobronchial, pulmonary, cardiac, and gastrointestinal branches","volume":"193","author":"M Kalia","year":"1980","journal-title":"J Comp Neurol"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/cne.901930210","article-title":"Brain stem projections of sensory and motor components of the vagus complex in the cat: I. The cervical vagus and nodose ganglion","volume":"193","author":"M Kalia","year":"1980","journal-title":"J Comp Neurol"},{"issue":"1\u20132","key":"ref5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.autneu.2010.11.001","article-title":"Plasticity of vagal brainstem circuits in the control of gastrointestinal function","volume":"161","author":"KN Browning","year":"2011","journal-title":"Auton Neurosci"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0306-4522(91)90085-3","article-title":"Neurons with access to the general circulation in the central nervous system of the rat: a retrograde tracing study with fluoro-gold","volume":"44","author":"I Merchenthaler","year":"1991","journal-title":"Neuroscience"},{"issue":"6 Pt 2","key":"ref7","first-page":"R1131","article-title":"Microvascular specializations promoting rapid interstitial solute dispersion in nucleus tractus solitarius","volume":"259","author":"PM Gross","year":"1990","journal-title":"Am J Physiol"},{"issue":"1 Pt 1","key":"ref8","first-page":"G73","article-title":"Localization of sites within dorsal motor nucleus of vagus that affect gastric motility","volume":"249","author":"FD Pagani","year":"1985","journal-title":"Am J Physiol"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cmet.2004.11.001","article-title":"A brain-liver circuit regulates glucose homeostasis","volume":"1","author":"A Pocai","year":"2005","journal-title":"Cell Metab"},{"issue":"3","key":"ref10","first-page":"179","article-title":"Diabetes and the stomach","volume":"56","author":"MB Saltzman","year":"1983","journal-title":"Yale J Biol Med"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF00400669","article-title":"Blockade of muscarinic transmission increases the frequency of diabetes after low-dose alloxan challenge in the mouse","volume":"39","author":"B Ahren","year":"1996","journal-title":"Diabetologia"},{"issue":"Pt 1","key":"ref12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1469-7793.1999.00243.x","article-title":"Role of glutamate receptors in transmission of vagal cardiac input to neurones in the nucleus tractus solitarii in dogs","volume":"520","author":"JL Seagard","year":"1999","journal-title":"J Physiol"},{"issue":"Pt 1","key":"ref13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1469-7793.1998.149bf.x","article-title":"Vagally evoked synaptic currents in the immature rat nucleus tractus solitarii in an intact in vitro preparation","volume":"512","author":"BN Smith","year":"1998","journal-title":"J Physiol"},{"issue":"5 Pt 2","key":"ref14","first-page":"H1695","article-title":"Non-NMDA and NMDA receptors transmit area postrema input to aortic baroreceptor neurons in NTS","volume":"275","author":"CY Chen","year":"1998","journal-title":"Am J Physiol"},{"issue":"34","key":"ref15","doi-asserted-by":"crossref","first-page":"8979","DOI":"10.1523\/JNEUROSCI.1105-07.2007","article-title":"Functional organization of presynaptic metabotropic glutamate receptors in vagal brainstem circuits","volume":"27","author":"KN Browning","year":"2007","journal-title":"J Neurosci"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/pr.109.002451","article-title":"Glutamate receptor ion channels: structure, regulation, and function","volume":"62","author":"SF Traynelis","year":"2010","journal-title":"Pharmacol Rev"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0306-4522(96)00301-6","article-title":"Tonic facilitation of glutamate release by presynaptic N-methyl-D-aspartate autoreceptors in the entorhinal cortex","volume":"75","author":"N Berretta","year":"1996","journal-title":"Neuroscience"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1523\/JNEUROSCI.19-02-00511.1999","article-title":"Presynaptic effects of NMDA in cerebellar Purkinje cells and interneurons","volume":"19","author":"M Glitsch","year":"1999","journal-title":"J Neurosci"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1523\/JNEUROSCI.14-09-05202.1994","article-title":"Cellular and subcellular localization of NMDA-R1 subunit immunoreactivity in the visual cortex of adult and neonatal rats","volume":"14","author":"C Aoki","year":"1994","journal-title":"J Neurosci"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1152\/jn.01036.2011","article-title":"Presynaptic NMDA receptor-mediated modulation of excitatory neurotransmission in the mouse dorsal motor nucleus of the vagus","volume":"108","author":"EC Bach","year":"2012","journal-title":"J Neurophysiol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.physbeh.2011.02.042","article-title":"A tale of two endings: modulation of satiation by NMDA receptors on or near central and peripheral vagal afferent terminals","volume":"105","author":"RC Ritter","year":"2011","journal-title":"Physiology & behavior"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2337\/db10-0994","article-title":"Hypothalamic nutrient sensing activates a forebrain-hindbrain neuronal circuit to regulate glucose production in vivo","volume":"60","author":"CK Lam","year":"2011","journal-title":"Diabetes"},{"issue":"3 Pt 1","key":"ref23","first-page":"G531","article-title":"Glutamate and GABA-mediated synaptic currents in neurons of the rat dorsal motor nucleus of the vagus","volume":"260","author":"RA Travagli","year":"1991","journal-title":"Am J Physiol"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jchemneu.2006.04.004","article-title":"Vesicular glutamate transporters and neuronal nitric oxide synthase colocalize in aortic depressor afferent neurons","volume":"32","author":"LH Lin","year":"2006","journal-title":"J Chem Neuroanat"},{"issue":"1\u20132","key":"ref25","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.brainres.2004.05.049","article-title":"Excitatory and inhibitory local circuit input to the rat dorsal motor nucleus of the vagus originating from the nucleus tractus solitarius","volume":"1017","author":"SF Davis","year":"2004","journal-title":"Brain research"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"G757","DOI":"10.1152\/ajpgi.00576.2007","article-title":"D-glucose modulates synaptic transmission from the central terminals of vagal afferent fibers","volume":"294","author":"S Wan","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"Pt 1","key":"ref27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1469-7793.2001.t01-1-00141.x","article-title":"Glucose effects on gastric motility and tone evoked from the rat dorsal vagal complex","volume":"536","author":"M Ferreira Jr","year":"2001","journal-title":"J Physiol"},{"issue":"39","key":"ref28","doi-asserted-by":"crossref","first-page":"14024","DOI":"10.1523\/JNEUROSCI.2081-11.2011","article-title":"Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice","volume":"31","author":"A Zsombok","year":"2011","journal-title":"J Neurosci"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neuron.2004.09.012","article-title":"LTP and LTD: an embarrassment of riches","volume":"44","author":"RC Malenka","year":"2004","journal-title":"Neuron"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nrn1556","article-title":"Receptor trafficking and synaptic plasticity","volume":"5","author":"GL Collingridge","year":"2004","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1152\/jn.00336.2007","article-title":"Endomorphin-1 modulates intrinsic inhibition in the dorsal vagal complex","volume":"98","author":"NR Glatzer","year":"2007","journal-title":"J Neurophysiol"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.physbeh.2012.06.019","article-title":"Early and late neurodegeneration and memory disruption after intracerebroventricular streptozotocin","volume":"107","author":"TO Santos","year":"2012","journal-title":"Physiology & behavior"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0006-8993(96)01387-X","article-title":"Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration","volume":"751","author":"LC Schmued","year":"1997","journal-title":"Brain research"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.brainres.2009.07.024","article-title":"Morphological and electrophysiological features of motor neurons and putative interneurons in the dorsal vagal complex of rats and mice","volume":"1291","author":"H Gao","year":"2009","journal-title":"Brain research"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1756-6606-6-58","article-title":"\u03b17nAchR\/NMDAR coupling affects NMDAR function and object recognition","volume":"6","author":"S Li","year":"2013","journal-title":"Mol Brain"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"C347","DOI":"10.1152\/ajpcell.00473.2010","article-title":"Mechanisms of facilitation of synaptic glutamate release by nicotinic agonists in the nucleus of the solitary tract","volume":"301","author":"BI Kalappa","year":"2011","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1161\/01.RES.83.12.1241","article-title":"Nicotine enhances presynaptic and postsynaptic glutamatergic neurotransmission to activate cardiac parasympathetic neurons","volume":"83","author":"RA Neff","year":"1998","journal-title":"Circ Res"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1210\/en.2006-1098","article-title":"Rapid inhibition of neurons in the dorsal motor nucleus of the vagus by leptin","volume":"148","author":"KW Williams","year":"2007","journal-title":"Endocrinology"},{"issue":"5965","key":"ref39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/309261a0","article-title":"Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones","volume":"309","author":"ML Mayer","year":"1984","journal-title":"Nature"},{"issue":"38","key":"ref40","doi-asserted-by":"crossref","first-page":"9666","DOI":"10.1523\/JNEUROSCI.1591-06.2006","article-title":"Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus","volume":"26","author":"AV Derbenev","year":"2006","journal-title":"J Neurosci"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1152\/jn.00429.2004","article-title":"Modulation of synaptic transmission in the rat nucleus of the solitary tract by endomorphin-1","volume":"93","author":"NR Glatzer","year":"2005","journal-title":"J Neurophysiol"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neures.2009.01.013","article-title":"The influences of juvenile diabetes on memory and hippocampal plasticity in rats: improving effects of glucagon-like peptide-1","volume":"64","author":"T Iwai","year":"2009","journal-title":"Neuroscience research"},{"issue":"1\u20133","key":"ref43","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejphar.2004.02.055","article-title":"Hippocampal synaptic plasticity and glutamate receptor regulation: influences of diabetes mellitus","volume":"490","author":"F Trudeau","year":"2004","journal-title":"European journal of pharmacology"},{"issue":"8","key":"ref44","doi-asserted-by":"crossref","first-page":"R807","DOI":"10.1152\/ajpregu.00276.2012","article-title":"Insulin reduces excitation in gastric-related neurons of the dorsal motor nucleus of the vagus","volume":"303","author":"CB Blake","year":"2012","journal-title":"American journal of physiology Regulatory, integrative and comparative physiology"},{"issue":"9","key":"ref45","doi-asserted-by":"crossref","first-page":"e46196","DOI":"10.1371\/journal.pone.0046196","article-title":"In vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin","volume":"7","author":"A Kraska","year":"2012","journal-title":"PloS one"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pbb.2013.11.035","article-title":"Glial activation and post-synaptic neurotoxicity: the key events in Streptozotocin (ICV) induced memory impairment in rats","volume":"117","author":"S Rai","year":"2014","journal-title":"Pharmacology, biochemistry, and behavior"},{"issue":"Pt 3","key":"ref47","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1113\/jphysiol.2006.126094","article-title":"Ionic currents underlying the response of rat dorsal vagal neurones to hypoglycaemia and chemical anoxia","volume":"579","author":"RH Balfour","year":"2007","journal-title":"J Physiol"},{"issue":"Pt 3","key":"ref48","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1113\/jphysiol.2005.098822","article-title":"Neuronal responses to transient hypoglycaemia in the dorsal vagal complex of the rat brainstem","volume":"570","author":"RH Balfour","year":"2006","journal-title":"J Physiol"},{"issue":"1\u20132","key":"ref49","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0006-8993(99)02327-6","article-title":"Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose","volume":"856","author":"S Ritter","year":"2000","journal-title":"Brain research"},{"issue":"4506","key":"ref50","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1126\/science.6264602","article-title":"Glucoreceptors controlling feeding and blood glucose: location in the hindbrain","volume":"213","author":"RC Ritter","year":"1981","journal-title":"Science"},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","first-page":"e476","DOI":"10.1111\/j.1365-2982.2012.01987.x","article-title":"Glucose-dependent trafficking of 5-HT3 receptors in rat gastrointestinal vagal afferent neurons","volume":"24","author":"T Babic","year":"2012","journal-title":"Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.2337\/diabetes.52.11.2767","article-title":"Extracellular glucose in rat ventromedial hypothalamus during acute and recurrent hypoglycemia","volume":"52","author":"MG De Vries","year":"2003","journal-title":"Diabetes"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1523\/JNEUROSCI.4413-05.2006","article-title":"Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats","volume":"26","author":"J Yang","year":"2006","journal-title":"J Neurosci"},{"issue":"6","key":"ref54","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn3504","article-title":"NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease","volume":"14","author":"P Paoletti","year":"2013","journal-title":"Nat Rev Neurosci"},{"issue":"9","key":"ref55","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1523\/JNEUROSCI.23-09-03844.2003","article-title":"Selective enhancement of synaptic inhibition by hypocretin (orexin) in rat vagal motor neurons: implications for autonomic regulation","volume":"23","author":"SF Davis","year":"2003","journal-title":"J Neurosci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cmet.2005.03.003","article-title":"Input organization and plasticity of hypocretin neurons: Possible clues to obesity's association with insomnia","volume":"1","author":"TL Horvath","year":"2005","journal-title":"Cell Metabolism"},{"issue":"6477","key":"ref57","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/369233a0","article-title":"Regulation of NMDA receptors by tyrosine kinases and phosphatases","volume":"369","author":"YT Wang","year":"1994","journal-title":"Nature"},{"issue":"5300","key":"ref58","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.275.5300.674","article-title":"NMDA channel regulation by channel-associated protein tyrosine kinase Src","volume":"275","author":"XM Yu","year":"1997","journal-title":"Science"},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.neuroscience.2008.11.006","article-title":"Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices","volume":"158","author":"SM Goebel-Goody","year":"2009","journal-title":"Neuroscience"},{"issue":"3","key":"ref60","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/00365529850170784","article-title":"Gastric meal accommodation studied by ultrasound in diabetes. Relation to vagal tone","volume":"33","author":"KA Undeland","year":"1998","journal-title":"Scand J Gastroenterol"},{"issue":"11","key":"ref61","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.2337\/diacare.26.11.3035","article-title":"Influence of autonomic nervous system dysfunction on the development of type 2 diabetes: the CARDIA study","volume":"26","author":"MR Carnethon","year":"2003","journal-title":"Diabetes Care"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0121022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T08:56:20Z","timestamp":1566464180000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0121022"}},"subtitle":[],"editor":[{"given":"Leonardo Barbosa Moraes","family":"Resstel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,23]]},"references-count":61,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0121022","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,23]]}}}