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Neurol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/cne.21279","article-title":"Rat retinal microglial cells under normal conditions, after optic nerve section, and after optic nerve section and intravitreal injection of trophic factors or macrophage inhibitory factor","volume":"501","author":"P Sobrado-Calvo","year":"2007","journal-title":"J Comp Neurol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1167\/iovs.05-0321","article-title":"The effect of experimental glaucoma and optic nerve transection on amacrine cells in the rat retina","volume":"46","author":"JL Kielczewski","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00441-004-1062-8","article-title":"Changes in retinal neuronal populations in the DBA\/2J mouse","volume":"320","author":"JI Moon","year":"2005","journal-title":"Cell Tissue 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Quigley","year":"1979","journal-title":"Ophthalmology"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1350-9462(98)00014-7","article-title":"Neuronal death in glaucoma","volume":"18","author":"HA Quigley","year":"1999","journal-title":"Prog Retin Eye Res"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","article-title":"The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage","volume":"24","author":"CF Burgoyne","year":"2005","journal-title":"Prog Retin Eye Res"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"e15009","DOI":"10.1371\/journal.pone.0015009","article-title":"Dissecting a role for melanopsin in behavioural light aversion reveals a response independent of conventional photoreception","volume":"5","author":"M Semo","year":"2010","journal-title":"PLoS One"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.exer.2013.11.013","article-title":"A role for the ciliary marginal zone in the melanopsin-dependent intrinsic pupillary light reflex","volume":"119","author":"M Semo","year":"2014","journal-title":"Exp Eye Res"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S0952523808080309","article-title":"Survival and remodeling of melanopsin cells during retinal dystrophy","volume":"25","author":"AA Vugler","year":"2008","journal-title":"Vis Neurosci"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.exer.2010.07.012","article-title":"Evaluation of functional integrity of the retinohypothalamic tract in advanced glaucoma using multifocal electroretinography and light-induced melatonin suppression","volume":"91","author":"C P\u00e9rez-Rico","year":"2010","journal-title":"Exp Eye 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