{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:57:39Z","timestamp":1773215859111,"version":"3.50.1"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T00:00:00Z","timestamp":1426809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0121470","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T15:40:57Z","timestamp":1426866057000},"page":"e0121470","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["A Comparison of the Effects of Estrogen and Cimicifuga racemosa on the Lacrimal Gland and Submandibular Gland in Ovariectomized Rats"],"prefix":"10.1371","volume":"10","author":[{"given":"Yunmeng","family":"Da","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyu","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangxia","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenpei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,20]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.4065\/70.8.800","article-title":"Hormone replacement therapy: management of common problems","volume":"70","author":"M Evans","year":"1995","journal-title":"Mayo Clin Proc"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/01.GME.0000063568.84134.35","article-title":"Effects of hormone replacement therapy on ocular function in postmenopause","volume":"10","author":"P Affinito","year":"2003","journal-title":"Menopause"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0003-9969(03)00094-3","article-title":"Minor gland and whole saliva in postmenopausal women using a low potency oestrogen (oestriol)","volume":"48","author":"L Eliasson","year":"2003","journal-title":"Arch Oral Biol"},{"issue":"9483","key":"ref4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0140-6736(05)66519-1","article-title":"Treatment of menopausal symptoms: what shall we do now?","volume":"366","author":"M Hickey","year":"2005","journal-title":"The Lancet"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1552-6909.2008.00305.x","article-title":"Complementary and alternative medicine use for vasomotor symptoms among women who have discontinued hormone therapy","volume":"38","author":"EM Kupferer","year":"2009","journal-title":"J Obstet Gynecol Neonatal Nurs"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.amjmed.2005.09.058","article-title":"Other complementary and alternative medicine modalities: acupuncture, magnets, reflexology, and homeopathy","volume":"118","author":"JS Carpenter","year":"2005","journal-title":"Am J Med"},{"key":"ref7","first-page":"457","article-title":"Nonhormonal therapies for hot flashes in menopause","volume":"73","author":"DG Carroll","year":"2006","journal-title":"Am Fam Physician"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1001\/archinte.166.14.1453","article-title":"Complementary and alternative therapies for the management of menopause-related symptoms: a systematic evidence review","volume":"166","author":"A Nedrow","year":"2006","journal-title":"Arch Intern Med"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bpobgyn.2008.10.006","article-title":"Alternative treatments for the menopause","volume":"23","author":"M Rees","year":"2009","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.tem.2005.05.002","article-title":"Black cohosh: just another phytoestrogen?","volume":"16","author":"V Viereck","year":"2005","journal-title":"Trends Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"645","DOI":"10.12968\/bjon.2006.15.12.21395","article-title":"Integrated healthcare: herbal remedies for menopausal symptoms","volume":"15","author":"D Tiran","year":"2006","journal-title":"Br J Nurs"},{"issue":"1","key":"ref12","first-page":"31","article-title":"Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone,Maturitas","volume":"58","author":"W Bai","year":"2007","journal-title":"Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone,Maturitas"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"e82815","DOI":"10.1371\/journal.pone.0082815","article-title":"Effects of Remifemin Treatment on Bone Integrity and Remodeling in Rats with Ovariectomy-Induced Osteoporosis","volume":"8","author":"G Cui","year":"2013","journal-title":"PloS one"},{"issue":"24","key":"ref14","doi-asserted-by":"crossref","first-page":"7022","DOI":"10.1021\/jf020725h","article-title":"Black cohosh (<italic>Cimicifuga racemosa<\/italic> L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles","volume":"50","author":"JE Burdette","year":"2002","journal-title":"J Agric Food Chem"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jep.2010.10.004","article-title":"Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae rhizome inhibit TNF-\u03b1-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-\u03b3 upregulation and PI3K, ERK1\/2, and PKC signal pathways","volume":"133","author":"L Moon","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2014.03.002","article-title":"Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alpha","volume":"1561","author":"L Mosquera","year":"2014","journal-title":"Brain Res"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1258\/mi.2009.009021","article-title":"Depression and the menopause: why antidepressants are not enough?","volume":"15","author":"A Graziottin","year":"2009","journal-title":"Menopause Int."},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"H2105","DOI":"10.1152\/ajpheart.00349.2010","article-title":"Aging and estrogen alter endothelial reactivity to reactive oxygen species in coronary arterioles","volume":"300","author":"LS Kang","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.anl.2005.07.010","article-title":"The role of estrogen and Cu, Zn-SOD on histological changes after menopause in female rat parotid","volume":"33","author":"T Kusunoki","year":"2006","journal-title":"Auris Nasus Larynx"},{"issue":"3\u20134","key":"ref20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.maturitas.2008.06.001","article-title":"Effects of black cohosh extract on body weight gain,intra-abdominal fat accumulation,plasma lipids and glucose tolerance in ovariectomized Sprague-Dawley rats","volume":"60","author":"D Rachon","year":"2008","journal-title":"Maturitas"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jep.2011.08.076","article-title":"Effects of an isopropanolic-aqueous black cohosh extract on central body temperature of ovariectomized rats","volume":"138","author":"X Ma","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1177\/28.8.7003006","article-title":"Biologically active polypeptides in salivary glands","volume":"28","author":"T Barka","year":"1980","journal-title":"J Histochem Cytochem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2152\/jmi.56.290","article-title":"Hormone-induced granular convoluted tubule-like cells in mouse parotid gland","volume":"56","author":"S Kurabuchi","year":"2009","journal-title":"J Med Invest"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1472-6874-13-46","article-title":"Excess weight and abdominal obesity in postmenopausal Brazilian women: a population- based study","volume":"13","author":"AA Gravena","year":"2013","journal-title":"BMC women's health"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1210\/en.2013-1731","article-title":"Estrogen replacement therapy regulation of energy metabolism in female mousehypothalamus","volume":"155","author":"R Fontana","year":"2014","journal-title":"Endocrinology"},{"issue":"Suppl 1","key":"ref26","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/S0378-5122(02)00348-1","article-title":"Cimicifuga extract BNO 1055: reduction of hot flushes and hints on antidepressant activity","volume":"44","author":"H Winterhoff","year":"2003","journal-title":"Maturitas"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1152\/ajplegacy.1954.178.1.155","article-title":"Excretion of sodium, potassium, chloride and carbon dioxide in human parotid saliva","volume":"178","author":"JH Thaysen","year":"1954","journal-title":"Am J Physiol"},{"issue":"3","key":"ref28","first-page":"857","article-title":"Oestrogen receptor alpha and beta in female rat pituitary cells: an immunochemical study, Gen Comp Endocrinol","volume":"155","author":"M Gonz\u00e1lez","year":"2008","journal-title":"Oestrogen receptor alpha and beta in female rat pituitary cells: an immunochemical study, Gen Comp Endocrinol"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3892\/ol.2013.1701","article-title":"Estrogen protects SGC7901 cells from endoplasmic reticulum stress-induced apoptosis by the Akt pathway","volume":"7","author":"Z Fu","year":"2014","journal-title":"Oncol Lett"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"e85272","DOI":"10.1371\/journal.pone.0085272","article-title":"Mitochondrial p38\u03b2 and Manganese Superoxide Dismutase Interaction Mediated by Estrogen in Cardiomyocytes","volume":"9","author":"H Liu","year":"2014","journal-title":"PloS one"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/jat.1784","article-title":"Deoxyactein Isolated from Cimicifuga racemosa protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity","volume":"33","author":"EM Choi","year":"2011","journal-title":"J Appl Toxicol"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.prp.2011.01.002","article-title":"Effect of estrogen therapy, soy isoflavones, and the combination therapy on the salivary gland of ovariectomized rats","volume":"207","author":"VDC Carvalho","year":"2011","journal-title":"Pathol Res Pract"},{"issue":"5 Pt 1","key":"ref33","first-page":"183","article-title":"Is black cohosh estrogenic?","volume":"61","author":"GB Mahady","year":"2003","journal-title":"Nutr Rev."},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1167\/iovs.12-10457","article-title":"The Effects of Estrogen and Androgen on Tear Secretion and Matrix Metalloproteinase-2 Expression in Lacrimal Glands of Ovariectomized Rats","volume":"55","author":"S Xiujun","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1440-1797.2007.00854.x","article-title":"Identification and quantification of apoptosis in the kidney using morphology, biochemical and molecular markers","volume":"12","author":"J Hughes","year":"2007","journal-title":"Nephrology"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1172\/JCI200317261","article-title":"Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids","volume":"111","author":"S Kousteni","year":"2003","journal-title":"J Clin Invest"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0014-4835(86)90037-0","article-title":"Hormonal modulation of tear volume in the rat","volume":"42","author":"DA Sullivan","year":"1986","journal-title":"Exp Eye Res"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0014-4835(03)00120-9","article-title":"Estrogen prevention of lacrimal gland cell death and lymphocytic infiltration","volume":"77","author":"AM Azzarolo","year":"2003","journal-title":"Exp Eye Res"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.exer.2008.05.012","article-title":"Sex hormone regulation of tear lipocalin in the rabbit lacrimal gland","volume":"87","author":"V Seamon","year":"2008","journal-title":"Exp Eye Res"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1600-0722.2009.00659.x","article-title":"Functional estrogen receptors alpha and beta are expressed in normal human salivary gland epithelium and apparently mediate immunomodulatory effects","volume":"117","author":"M Tsinti","year":"2009","journal-title":"Eur J Oral Sci"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF03033273","article-title":"Enhanced free radical generation of FALS-associated Cu, Zn-SOD mutants","volume":"1","author":"MB Yim","year":"1999","journal-title":"Neurotox Res"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1080\/gye.15.4.298.303","article-title":"Serum lipid peroxide levels and erythrocyte glutathione peroxidase and superoxide dismutase activity in premenopausal and postmenopausal women","volume":"15","author":"G Bednarek-Tupikowska","year":"2001","journal-title":"Gynecol Endocrinol"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1210\/jcem.87.6.8543","article-title":"Modulation of endometrial redox balance during the menstrual cycle: relation with sex hormones","volume":"87","author":"G Serviddio","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/01.RES.0000082334.17947.11","article-title":"Modulation of antioxidant enzyme expression and function by estrogen","volume":"93","author":"K Strehlow","year":"2003","journal-title":"Circ Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-4615-5359-5_12","article-title":"Identification and hormonal control of sex steroid receptors in the eye","volume":"438","author":"LA Wickham","year":"1998","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1677\/joe.0.1800055","article-title":"Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands","volume":"180","author":"H Valimaa","year":"2004","journal-title":"J Endocrinol"},{"issue":"7","key":"ref47","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/sj.eye.6701314","article-title":"Detection of Oestrogen receptors (ER) \u03b1 and \u03b2 in conjunctiva, lacrimal gland, and tarsal plates","volume":"18","author":"H Spelsberg","year":"2004","journal-title":"Eye (Lond)"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"e10164","DOI":"10.1371\/journal.pone.0010164","article-title":"Estrogen regulates estrogen receptors and antioxidant gene expression in mouse skeletal muscle","volume":"5","author":"KA Baltgalvis","year":"2010","journal-title":"PLoS One"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/med.20025","article-title":"Fas\/FasL interaction: a novel immune therapy approach with immobilized biologicals","volume":"25","author":"M Scholz","year":"2005","journal-title":"Med Res Rev"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s10495-005-1879-y","article-title":"SOD-1 inhibits FAS expression in cortex of APP transgenic mice","volume":"10","author":"Z Chen","year":"2005","journal-title":"Apoptosis"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.freeradbiomed.2012.05.043","article-title":"<italic>Cimicifuga racemosa<\/italic> impairs fatty acid \u03b2-oxidation and induces oxidative stress in livers of ovariectomized ratswith renovascular hypertension","volume":"53","author":"LB Campos","year":"2012","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1038\/cddis.2010.9","article-title":"The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress","volume":"1","author":"L Deng","year":"2010","journal-title":"Cell Death and Dis"},{"issue":"24","key":"ref53","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.1016\/j.bmcl.2014.10.066","article-title":"New 9, 19-cycloartenol glycosides isolated from the roots of Cimicifuga simplex and their anti-inflammatory effects","volume":"24","author":"Yang Su","year":"2014","journal-title":"Bioorg Med Chem Lett"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0121470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T01:53:51Z","timestamp":1566438831000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0121470"}},"subtitle":[],"editor":[{"given":"Stephen L.","family":"Clarke","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,20]]},"references-count":53,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0121470","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,20]]}}}