{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:53:33Z","timestamp":1775735613486,"version":"3.50.1"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T00:00:00Z","timestamp":1428364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0121483","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T14:45:00Z","timestamp":1428417900000},"page":"e0121483","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["The RGS2 (-391, C&gt;G) Genetic Variation Correlates to Antihypertensive Drug Responses in Chinese Patients with Essential Hypertension"],"prefix":"10.1371","volume":"10","author":[{"given":"Fazhong","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianquan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhitao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiagen","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingilang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinping","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuesheng","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honghao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.yjmcc.2006.04.003","article-title":"Regulation of cardiomyocyte signaling by RGS proteins: differential selectivity towards G proteins and susceptibility to regulation","volume":"41","author":"J Hao","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1097\/01.hjh.0000226202.80689.8f","article-title":"Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1\/2 phosphorylation induced by angiotensin II","volume":"24","author":"A Semplicini","year":"2006","journal-title":"J Hypertens"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/dna.1994.13.125","article-title":"A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells","volume":"13","author":"DP Siderovski","year":"1994","journal-title":"DNA Cell Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/nm958","article-title":"Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure","volume":"9","author":"KM Tang","year":"2003","journal-title":"Nat Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1124\/mol.104.007724","article-title":"RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling","volume":"67","author":"X Sun","year":"2005","journal-title":"Mol Pharmacol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1210\/en.2005-1532","article-title":"RGS2 is regulated by angiotensin II and functions as a negative feedback of aldosterone production in H295R human adrenocortical cells","volume":"147","author":"DG Romero","year":"2006","journal-title":"Endocrinology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1097\/HJH.0b013e328339930f","article-title":"RGS2 expression and aldosterone: renin ratio modulate response to drug therapy in hypertensive patients","volume":"28","author":"A Semplicini","year":"2010","journal-title":"J Hypertens"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"19713","DOI":"10.1073\/pnas.1110226108","article-title":"beta2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids","volume":"108","author":"NS Holden","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.cellsig.2006.01.012","article-title":"RGS2 is upregulated by and attenuates the hypertrophic effect of alpha1-adrenergic activation in cultured ventricular myocytes","volume":"18","author":"MX Zou","year":"2006","journal-title":"Cell Signal"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1124\/jpet.113.204586","article-title":"Induction of regulator of G-protein signaling 2 expression by long-acting beta2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells","volume":"348","author":"NS Holden","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.yjmcc.2011.01.015","article-title":"RGS2 is a primary terminator of beta(2)-adrenergic receptor-mediated G(i) signaling","volume":"50","author":"K Chakir","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"27289","DOI":"10.1074\/jbc.M502365200","article-title":"Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop","volume":"280","author":"C Hague","year":"2005","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/hr.2010.184","article-title":"Impact of RGS2 deficiency on the therapeutic effect of telmisartan in angiotensin II-induced aortic aneurysm","volume":"33","author":"S Matsumoto","year":"2010","journal-title":"Hypertens Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"44646","DOI":"10.1074\/jbc.M111.265462","article-title":"Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured vascular smooth muscles","volume":"286","author":"Z Xie","year":"2011","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/HJH.0b013e3280109c6c","article-title":"-391 C to G substitution in the regulator of G-protein signalling-2 promoter increases susceptibility to the metabolic syndrome in white European men: consistency between molecular and epidemiological studies","volume":"25","author":"K Freson","year":"2007","journal-title":"J Hypertens"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1097\/01.hjh.0000174606.41651.ae","article-title":"Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population","volume":"23","author":"J Yang","year":"2005","journal-title":"J Hypertens"},{"key":"ref17","first-page":"200","article-title":"Detection of genetic variations of regulator of G-protein signaling 2 in hypertensives by sequencing","volume":"33","author":"Z Ju-hong","year":"2011","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e61317","DOI":"10.1371\/journal.pone.0061317","article-title":"The KCNH2 genetic polymorphism (1956, C&gt;T) is a novel biomarker that is associated with CCB and alpha,beta-ADR blocker response in EH patients in China","volume":"8","author":"F He","year":"2013","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1038\/sj.npp.1301557","article-title":"Association of RGS2 gene polymorphisms with suicide and increased RGS2 immunoreactivity in the postmortem brain of suicide victims","volume":"33","author":"H Cui","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1042\/CS20100280","article-title":"Angiotensin-(1\u20137) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy","volume":"120","author":"E Velkoska","year":"2011","journal-title":"Clin Sci (Lond)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.peptides.2011.09.015","article-title":"Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor","volume":"32","author":"H Yang","year":"2011","journal-title":"Peptides"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1097\/HJH.0b013e328339930f","article-title":"RGS2 expression and aldosterone: renin ratio modulate response to drug therapy in hypertensive patients","volume":"28","author":"A Semplicini","year":"2010","journal-title":"J Hypertens"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"196307","DOI":"10.4061\/2010\/196307","article-title":"Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study","volume":"2010","author":"K Sugimoto","year":"2010","journal-title":"Int J Hypertens"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/hr.2010.184","article-title":"Impact of RGS2 deficiency on the therapeutic effect of telmisartan in angiotensin II-induced aortic aneurysm","volume":"33","author":"S Matsumoto","year":"2010","journal-title":"Hypertens Res"},{"key":"ref25","first-page":"1259","article-title":"Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice","volume":"111","author":"SP Heximer","year":"2003","journal-title":"J Clin Invest"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"25278","DOI":"10.1074\/jbc.M611206200","article-title":"Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells","volume":"282","author":"Z Xie","year":"2007","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1113\/expphysiol.2007.038240","article-title":"Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice","volume":"92","author":"HC Hercule","year":"2007","journal-title":"Exp Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"572","DOI":"10.2459\/JCM.0b013e3283629c30","article-title":"Impaired regulator of G protein signaling 2 transcription facilitates vascular remodeling in injured rat aorta","volume":"15","author":"Y Mao","year":"2014","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tcm.2006.10.003","article-title":"The regulation of the inflammatory response through nuclear factor-kappab pathway by angiotensin IV extends the role of the renin angiotensin system in cardiovascular diseases","volume":"17","author":"M Ruiz-Ortega","year":"2007","journal-title":"Trends Cardiovasc Med"},{"key":"ref30","first-page":"329","article-title":"Cerebroprotective effect of angiotensin IV in experimental ischemic stroke in the rat mediated by AT(4) receptors","volume":"57","author":"S Faure","year":"2006","journal-title":"J Physiol Pharmacol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.cellsig.2006.01.012","article-title":"RGS2 is upregulated by and attenuates the hypertrophic effect of alpha1-adrenergic activation in cultured ventricular myocytes","volume":"18","author":"MX Zou","year":"2006","journal-title":"Cell Signal"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0121483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T22:37:29Z","timestamp":1566513449000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0121483"}},"subtitle":[],"editor":[{"given":"Rui","family":"Medeiros","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,7]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0121483","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725424469.793505703","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,7]]}}}