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Policy on TB Control in Health Care Facilities, Congregate Settings and Households. 2009. WHO\/HTM\/TB\/2009.419 <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/whqlibdoc.who.int\/publications\/2009\/9789241598323_eng.pdf\" xlink:type=\"simple\">http:\/\/whqlibdoc.who.int\/publications\/2009\/9789241598323_eng.pdf<\/ext-link>. Accessed 2013 Oct 15."},{"key":"ref2","first-page":"1","article-title":"Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Settings, 2005","volume":"54","year":"2005","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1001\/jama.1992.03480190074035","article-title":"Nosocomial transmission of tuberculosis in a hospital unit for HIV-infected patients","volume":"267","author":"ME Villarino","year":"1992","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jhin.2012.11.028","article-title":"Extensive nosocomial transmission of tuberculosis in a low-incidence country","volume":"83","author":"J Jonsson","year":"2013","journal-title":"J Hosp Infect"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1001\/jama.1992.03490100078031","article-title":"Hospital Outbreak of multidrug-resistant Mycobacterium tuberculosis infections: factors in transmission to staff and HIV-infected patients","volume":"268","author":"C Beck-Sagu\u00e9","year":"1992","journal-title":"JAMA"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.7326\/0003-4819-117-3-191","article-title":"Nosocomial transmission of multidrug-resistant Mycobacterium tuberculosis. A risk to patients and health care workers","volume":"117","author":"ML Pearson","year":"1992","journal-title":"Ann Intern Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/infdis\/jis631","article-title":"Nosocomial transmission of extensively drug-resistant tuberculosis in a rural hospital in South Africa","volume":"207","author":"NR Gandhi","year":"2013","journal-title":"J Infect Dis"},{"key":"ref8","unstructured":"NICE clinical guideline 117 Tuberculosis: clinical diagnosis and management of tuberculosis, and measures for its prevention and control. Issued: March 2011. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.nice.org.uk\/guidance\/CG117\" xlink:type=\"simple\">http:\/\/www.nice.org.uk\/guidance\/CG117<\/ext-link>. Accessed 2013 Oct 15."},{"key":"ref9","first-page":"7","article-title":"Nurse with TB triggers mass patient testing","volume":"97","year":"2001","journal-title":"Nurs Times"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1056\/NEJMp068015","article-title":"Transmission of Mycobacterium tuberculosis from Health Care Workers","volume":"355","author":"TR Sterling","year":"2006","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"D Moher","year":"2009","journal-title":"PLoS Med"},{"key":"ref12","author":"GA Wells"},{"key":"ref13","first-page":"522","article-title":"Letter: Management of newborns after nursery exposure to tuberculosis","volume":"110","author":"LW Keim","year":"1974","journal-title":"Am Rev Respir Dis"},{"key":"ref14","first-page":"415","article-title":"Management of newborns after nursery exposure to tuberculosis","volume":"109","author":"IJ Light","year":"1974","journal-title":"Am Rev Respir Dis"},{"key":"ref15","first-page":"267","article-title":"Miliary tuberculosis in two infants after nursery exposure: epidemiologic, clinical, and laboratory findings","volume":"113","author":"P Steiner","year":"1976","journal-title":"Am Rev Respir Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1136\/bmj.1.6000.30","article-title":"Tuberculosis infection in a paediatric department","volume":"1","author":"CJ Stewart","year":"1976","journal-title":"Br Med J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00007611-197801000-00004","article-title":"Nursery exposure of 528 newborns to a nurse with pulmonary tuberculosis","volume":"71","author":"JR Burk","year":"1978","journal-title":"South Med J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0140-6736(82)91886-4","article-title":"Intraoral and pulmonary tuberculosis following dental treatment","volume":"1","author":"WH Smith","year":"1982","journal-title":"Lancet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1542\/peds.100.1.19","article-title":"Mycobacterium tuberculosis transmission from a pediatrician to patients","volume":"100","author":"GL Askew","year":"1997","journal-title":"Pediatrics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0022-3476(98)70188-X","article-title":"Evaluation of transmission of Mycobacterium tuberculosis in a pediatric setting","volume":"133","author":"M Moore","year":"1998","journal-title":"J Pediatr"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/00006454-200010000-00006","article-title":"Evaluation of Mycobacterium tuberculosis transmission from a pediatrician and initial compliance to prophylaxis of contacts in an outpatient pediatric clinic","volume":"19","author":"P Brassard","year":"2000","journal-title":"Pediatr Infect Dis J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0300-2977(01)00153-X","article-title":"Nosocomial transmission of tuberculosis to a nurse demonstrated by means of spoligotyping of a formalin-fixed bronchial biopsy","volume":"59","author":"AG van der Zanden","year":"2001","journal-title":"Neth J Med"},{"key":"ref23","first-page":"1280","article-title":"Mycobacterium tuberculosis transmission in a newborn nursery and maternity ward\u2014New York City, 2003","volume":"54","year":"2005","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1503\/cmaj.1031052","article-title":"Neonatal exposure to active pulmonary tuberculosis in a health care professional","volume":"172","author":"M Sen","year":"2005","journal-title":"CMAJ"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1086\/517975","article-title":"Exposure to pulmonary tuberculosis in a neonatal intensive care unit: unique aspects of contact investigation and management of hospitalized neonates","volume":"6","author":"JJ Nania","year":"2007","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref26","first-page":"1637","article-title":"Experience of extensive screening of Mycobacterium tuberculosis transmission to patients exposed to a pediatrician","volume":"11","author":"M Berlioz","year":"2008","journal-title":"Arch Pediatr"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s10156-007-0565-0","article-title":"Hospital Infection Control Committee. A contact investigation of the transmission of Mycobacterium tuberculosis from a nurse working in a newborn nursery and maternity ward","volume":"1","author":"H Ohno","year":"2008","journal-title":"J Infect Chemother"},{"key":"ref28","first-page":"1491","article-title":"Exposure of a cohort of newborn infants to tuberculosis in a neonatology service","volume":"10","author":"S Dubrulle","year":"2010","journal-title":"Arch Pediatr"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Borgia P, Cambieri A, Chini F, Coltella L, Delogu G, Di Rosa E et al. Suspected transmission of tuberculosis in a maternity ward from a smear-positive nurse: preliminary results of clinical evaluations and testing of neonates potentially exposed, Rome, Italy, 1 January to 28 July 2011. Euro Surveill. 2011;16:pii = 19984.","DOI":"10.2807\/ese.16.40.19984-en"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.arcped.2012.01.017","article-title":"Contage tuberculeux n\u00e9onatal en maternit\u00e9: d\u00e9pistage et \u00e9volution d\u2019une cohorte de nourrissons expos\u00e9s","volume":"19","author":"A Perry","year":"2012","journal-title":"Arch Pediatr"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1136\/thx.50.8.863","article-title":"Follow up of an immunocompromised contact group of a case of open pulmonary tuberculosis on a renal unit","volume":"50","author":"FA Drobniewski","year":"1995","journal-title":"Thorax"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1086\/501644","article-title":"Nosocomial tuberculosis exposure in an outpatient setting: evaluation of patients exposed to healthcare providers with tuberculosis","volume":"6","author":"NN Bock","year":"1999","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1067\/mic.2002.123394","article-title":"Tuberculosis exposure of patients and staff in an outpatient hemodialysis unit","volume":"5","author":"JA Linquist","year":"2002","journal-title":"Am J Infect Control"},{"key":"ref34","first-page":"54","article-title":"\u00c9valuation de la transmission nosocomiale de la tuberculose d\u2019un soignant aux patients expos\u00e9s","volume":"10\u201311","author":"M Hillarus","year":"2003","journal-title":"BEH"},{"key":"ref35","first-page":"873","article-title":"Tuberculosis transmission in a renal dialysis center\u2014Nevada, 2003","volume":"53","year":"2004","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"Pt 1","key":"ref36","first-page":"339","article-title":"Contact tracing in a case of tuberculosis in a health care worker","volume":"4","author":"F Trueba","year":"2006","journal-title":"Rev Mal Respir"},{"key":"ref37","first-page":"137","article-title":"Investigation d\u2019un cas de tuberculose pulmonaire diagnostiqu\u00e9 chez un soignant, Lyon, France, 2004\u20132005","volume":"17","author":"D Magnin","year":"2007","journal-title":"BEH"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1086\/592706","article-title":"Active tuberculosis in a healthcare worker: are you ready?","volume":"1","author":"T, G Fraser","year":"2009","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1086\/597230","article-title":"Investigation of individuals exposed to a healthcare worker with cavitary pulmonary tuberculosis","volume":"30","author":"E Singhatiraj","year":"2009","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e20770","DOI":"10.1371\/journal.pone.0020770","article-title":"The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident","volume":"6","author":"L Bradshaw","year":"2011","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1086\/670995","article-title":"Nosocomial pulmonary tuberculosis contact investigation in a neonatal intensive care unit","volume":"34","author":"KE Fisher","year":"2013","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0007-0971(84)90163-3","article-title":"Recent experience of tuberculosis in junior hospital doctors in Leeds and Bradford","volume":"78","author":"PW Belfield","year":"1984","journal-title":"Br J Dis Chest"},{"key":"ref43","first-page":"848","article-title":"Investigation of patient contacts of heath care workers with infectious tuberculosis: 6 cases in the Paris area","volume":"8","author":"A Carbonne","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref44","first-page":"524","article-title":"Tuberculosis among healthcare workers in Northern France (2002\u20132007): descriptive analysis of notified cases and contact tracing","volume":"40","author":"B Migueres","year":"2010","journal-title":"Med Mal Infect"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/pubmed\/fdm042","article-title":"Survey of tuberculosis incidents in hospital healthcare workers, England and Wales, 2005","volume":"29","author":"C Anderson","year":"2007","journal-title":"J Public Health (Oxf)"},{"key":"ref46","first-page":"187","article-title":"Investigations autour d\u2019un cas de tuberculose chez un professionnel en milieu de soin, France, 2004\u20132007 Contact tracing for tuberculosis in healthcare settings, France, 2004\u20132007","volume":"18\u201319","author":"D No\u00ebl","year":"2009","journal-title":"BEH"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/INF.0b013e31823378c9","article-title":"The transmission of tuberculosis in schools involving children 3 to 11 years of age","volume":"31","author":"JR Roberts","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/00006454-198901000-00014","article-title":"An outbreak of tuberculosis in a family day care home","volume":"8","author":"RJ Leggiadro","year":"1989","journal-title":"Pediatr Infect Dis J"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1542\/peds.79.4.630","article-title":"Tuberculosis in a day-care home","volume":"79","author":"CM Nolan","year":"1987","journal-title":"Pediatrics"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1542\/peds.2005-1380","article-title":"A tuberculosis outbreak in a private-home family child care center in San Francisco, 2002 to 2004","volume":"117","author":"PK Dewan","year":"2006","journal-title":"Pediatrics"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/jama.1974.03230320021019","article-title":"Tuberculosis in a family day-care home. Report of an outbreak and recommendations for prevention","volume":"228","author":"V Kaupas","year":"1974","journal-title":"JAMA"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1136\/bmj.281.6234.187","article-title":"Outbreak of tuberculosis after minimal exposure to infection","volume":"281","author":"VR Rao","year":"1980","journal-title":"Br Med J"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1136\/adc.2008.145755","article-title":"BCG protects toddlers during a tuberculosis outbreak","volume":"94","author":"JT Gaensbauer","year":"2009","journal-title":"M. M Arch Dis Child"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1651-2227.2004.tb00689.x","article-title":"Tuberculosis outbreak in a day care centre: always a risk","volume":"93","author":"V Aivazis","year":"2004","journal-title":"Acta Paediatr"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1183\/09031936.00070812","article-title":"Contact investigation for tuberculosis: a systematic review and meta-analysis","volume":"41","author":"GJ Fox","year":"2013","journal-title":"Eur Respir J"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1086\/501972","article-title":"Tuberculosis among adult visitors of children with suspected tuberculosis and employees at a children\u2019s hospital","volume":"23","author":"FM Mu\u00f1oz","year":"2002","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00002030-199809000-00018","article-title":"An outbreak of multidrug-resistant tuberculosis involving HIV-infected patients of two hospitals in Milan, Italy. Italian Multidrug-Resistant Tuberculosis Outbreak Study Group","volume":"12","author":"ML Moro","year":"1998","journal-title":"AIDS"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ajic.2012.02.015","article-title":"Delay in diagnosis leading to nosocomial transmission of tuberculosis at a New York City health care facility","volume":"41","author":"TG Harris","year":"2013","journal-title":"Am J Infect Control"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1086\/516296","article-title":"A continuing outbreak of multidrug-resistant tuberculosis, with transmission in a hospital nursery","volume":"26","author":"P Nicholas","year":"1998","journal-title":"Clin Infect Dis"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0929-6646(07)60002-3","article-title":"Outbreak Investigation Team. Laboratory investigation of a nosocomial transmission of tuberculosis at a district general hospital","volume":"106","author":"WL Huang","year":"2007","journal-title":"J Formos Med Assoc"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1093\/infdis\/172.6.1542","article-title":"Nosocomial transmission of Mycobacterium tuberculosis: role of health care workers in outbreak propagation","volume":"172","author":"S Zaza","year":"1995","journal-title":"J Infect Dis"},{"key":"ref62","first-page":"392","article-title":"The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era","volume":"8","author":"BJ Marais","year":"2004","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1097\/INF.0b013e3181a3d289","article-title":"The risk to infants from nosocomial exposure to tuberculosis","volume":"28","author":"SE Millership","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"ref64","unstructured":"Public Health England. TB incident and outbreak surveillance (TBIOS) <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.hpa.org.uk\/Topics\/InfectiousDiseases\/InfectionsAZ\/Tuberculosis\/TBUKSurveillanceData\/TBIncidentAndOutbreakSurveillance\/\" xlink:type=\"simple\">http:\/\/www.hpa.org.uk\/Topics\/InfectiousDiseases\/InfectionsAZ\/Tuberculosis\/TBUKSurveillanceData\/TBIncidentAndOutbreakSurveillance\/<\/ext-link>(accessed 15 October 2013)."},{"key":"ref65","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/occmed\/kqr033","article-title":"Limited value of annual tuberculosis symptom reminders for health care workers","volume":"61","author":"PR Grime","year":"2011","journal-title":"Occup Med (London.)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0121639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T05:15:23Z","timestamp":1651641323000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0121639"}},"subtitle":[],"editor":[{"given":"Giovanni","family":"Delogu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,2]]},"references-count":65,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0121639","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,2]]}}}