{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:30:42Z","timestamp":1792650642300,"version":"4.5.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T00:00:00Z","timestamp":1426809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0121678","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T19:04:34Z","timestamp":1426878274000},"page":"e0121678","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of Normal Saline, Hypertonic Saline Albumin and Terlipressin plus Hypertonic Saline Albumin in an Infant Animal Model of Hypovolemic Shock"],"prefix":"10.1371","volume":"10","author":[{"given":"Javier","family":"Urbano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J","family":"Solana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Bell\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Botr\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah N.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"L\u00f3pez-Herce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0022-3468(89)80312-4","article-title":"Preventable pediatric trauma deaths in a metropolitan region","volume":"24","author":"EH Dykes","year":"1989","journal-title":"J Pediatr Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1097\/00003246-200206000-00040","article-title":"Clinical practice parameters for hemodynamic support of paediatric and neonatal patients in septic shock","volume":"30","author":"JA Carcillo","year":"2002","journal-title":"Crit Care Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1097\/00005373-199010000-00005","article-title":"The effect of prehospital fluids on survival in trauma patients","volume":"30","author":"SM Kaweski","year":"1990","journal-title":"J Trauma"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1007\/s00134-008-1193-6","article-title":"Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis","volume":"34","author":"S Trzeciak","year":"2008","journal-title":"Intensive Care Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01.shk.0000209564.84822.f2","article-title":"The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies","volume":"26","author":"BA Cotton","year":"2006","journal-title":"Shock"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/bja\/88.4.475","article-title":"In vivo effect of haemodilution with saline on coagulation: a randomized controlled trial","volume":"88","author":"KF Ng","year":"2002","journal-title":"Br J Anaesth"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/archsurg.138.6.637","article-title":"Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome","volume":"38","author":"Z Balogh","year":"2003","journal-title":"Arch Surg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/01.ta.0000224211.36154.44","article-title":"Fluid resuscitation increases inflammatory gene transcription after traumatic injury","volume":"61","author":"JM Watters","year":"2006","journal-title":"J Trauma"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/SHK.0b013e3182635aca","article-title":"Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline-without dextran-inhibits neutrophil and endothelial cell activation","volume":"38","author":"WG Junger","year":"2012","journal-title":"Shock"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00024382-199702000-00001","article-title":"Prognostic factors to predict outcome following the administration of hypertonic\/hyperoncotic solution in hypovolemic patients","volume":"7","author":"RN Younes","year":"1997","journal-title":"Shock"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.resuscitation.2004.10.012","article-title":"Titrated hypertonic\/hyperoncotic solution for hypotensive fluid resuscitation during uncontrolled hemorrhagic shock in rats","volume":"65","author":"R Kentner","year":"2005","journal-title":"Resuscitation"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/01.ta.0000222723.54559.47","article-title":"A single bolus of 3% hypertonic saline with 6% dextran provides optimal initial resuscitation after uncontrolled hemorrhagic shock","volume":"61","author":"JM Watters","year":"2006","journal-title":"J Trauma"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.resuscitation.2012.02.003","article-title":"Comparison of normal saline, hypertonic saline and hypertonic saline colloid resuscitation fluids in an infant animal model of hypovolemic shock","volume":"83","author":"J Urbano","year":"2012","journal-title":"Resuscitation"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0039-6060(97)90135-5","article-title":"Efficacy of hypertonic 7.5% saline and 6% dextran-70 in treating trauma: a meta-analysis of controlled clinical studies","volume":"122","author":"CE Wade","year":"1997","journal-title":"Surgery"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1186\/s13054-014-0466-4","article-title":"Early resuscitation of Dengue Shock Syndrome in children with hyperosmolar sodium-lactate: a randomized single blind clinical trial of efficacy and safety","volume":"18","author":"DH Somasetia","year":"2014","journal-title":"Crit Care"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/SLA.0b013e3181fcdb22","article-title":"ROC investigators. Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: a randomized, placebo controlled trial","volume":"253","author":"EM Bulger","year":"2011","journal-title":"Ann Surg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"R76","DOI":"10.1186\/cc12685","article-title":"Management of bleeding and coagulopathy following major trauma: an updated European guideline","volume":"17","author":"DR Spahn","year":"2013","journal-title":"Critical Care"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.ajem.2011.09.007","article-title":"Effects of terlipressin in a rat model of severe uncontrolled hemorrhage via liver injury","volume":"30","author":"B Bayram","year":"2012","journal-title":"Am J Emerg Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1292\/jvms.69.459","article-title":"Vasopressor therapy using vasopressin prior to crystalloid resuscitation in irreversible hemorrhagic shock under isoflurane anesthesia in dogs","volume":"69","author":"JH Yoo","year":"2007","journal-title":"J Vet Med Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jemermed.2012.12.023","article-title":"Terlipressin with limited fluid resuscitation in a swine model of hemorrhage","volume":"45","author":"JJ Devlin","year":"2013","journal-title":"J Emerg Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1053\/j.jvca.2005.11.015","article-title":"Impact of vasopressin on hemodynamic and metabolic function in the decompensatory phase of hemorrhagic shock","volume":"20","author":"KB Johnson","year":"2006","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e95821","DOI":"10.1371\/journal.pone.0095821","article-title":"A comparison of vasopressin, terlipressin, and lactated ringers for resuscitation of uncontrolled hemorrhagic shock in an animal model","volume":"9","author":"CC Lee","year":"2014","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/01.ta.0000240962.62319.c8","article-title":"Small volume resuscitation: a randomized controlled trial with either norepinephrine or vasopressin during severe hemorrhage","volume":"62","author":"P Meybohm","year":"2007","journal-title":"J Trauma"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"421291","DOI":"10.1155\/2014\/421291","article-title":"Vasopressin in Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Randomized Animal Trials","volume":"2014","author":"AP Cossu","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s00101-004-0793-y","article-title":"Employing vasopressin as an adjunct vasopressor in uncontrolled traumatic hemorrhagic shock: three cases and a brief analysis of the literature","volume":"54","author":"AC Krismer","year":"2005","journal-title":"Anaesthesist"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s10354-010-0853-7","article-title":"The role of vasopressin and terlipressin in catecholamine-resistant shock and cardio-circulatory arrest in children: review of the literature","volume":"161","author":"S Meyer","year":"2011","journal-title":"Wien Med Wochenschr"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1164\/rccm.200902-0221OC","article-title":"Canadian Critical Care Trials Group. Vasopressin in pediatric vasodilatory shock: a multicenter randomized controlled trial","volume":"180","author":"K Choong","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.resuscitation.2005.06.014","article-title":"Hemodynamic response to acute hypovolaemia, rapid blood volume expansion and adrenaline administration in an infant animal model","volume":"8","author":"J L\u00f3pez-Herce","year":"2006","journal-title":"Resuscitation"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/00003246-200204000-00023","article-title":"Early albumin infusion improves global and local hemodynamic and reduces inflammatory response in haemorrhagic shock","volume":"30","author":"G Horstick","year":"2002","journal-title":"Crit Care Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1345\/aph.1P254","article-title":"RETSPED-II Working Group of the Spanish Society of Pediatric Intensive Care. Continuous terlipressin infusion as rescue treatment in a case series of children with refractory septic shock","volume":"44","author":"A Rodr\u00edguez-N\u00fa\u00f1ez","year":"2010","journal-title":"Ann Pharmacother"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jss.2012.02.062","article-title":"Arginine vasopressin: the future of pressure-support resuscitation in hemorrhagic shock","volume":"178","author":"T Anand","year":"2012","journal-title":"J Surg Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/00003643-200501000-00013","article-title":"Arginine vasopressin reduces cerebral oxygenation and cerebral blood volume during intact circulation in swine\u2014-a near infrared spectroscopy study","volume":"22","author":"B Bein","year":"2005","journal-title":"Eur J Anaesthesiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/01.PCC.0000216419.84855.D6","article-title":"Severe ischemia of the lower limb and of the intestine associated with systemic vasoconstrictor therapy and femoral arterial catheterization","volume":"7","author":"R Borrego","year":"2006","journal-title":"Pediatr Crit Care Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1164\/rccm.201010-1584CI","article-title":"Use of central venous oxygen saturation to guide therapy","volume":"184","author":"KR Walley","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ajem.2007.01.024","article-title":"A comparison of central venous and arterial base deficit as a predictor of survival in acute trauma","volume":"26","author":"TM Schmelzer","year":"2008","journal-title":"Am J Emerg Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/SHK.0b013e3181b8569d","article-title":"Assessing shock resuscitation strategies by oxygen debt repayment","volume":"33","author":"RW Barbee","year":"2010","journal-title":"Shock"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1590\/S0104-42302008000200012","article-title":"Acid-base disarrangement and gastric intramucosal acidosis predict outcome from major trauma","volume":"54","author":"JO Calvete","year":"2008","journal-title":"Rev Assoc Med Bras"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1203\/PDR.0b013e3181425858","article-title":"Impact of norepinephrine and fluid on cerebral oxygenation in experimental haemorrhagic shock","volume":"62","author":"P Meybohm","year":"2007","journal-title":"Pediatr Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/bja\/aet348","article-title":"Comparison of the effects of albumin 5%, hydroxyethyl starch 130\/0.4 6%, and Ringer's lactate on blood loss and coagulation after cardiac surgery","volume":"112","author":"K Skhirtladze","year":"2014","journal-title":"Br J Anaesth"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/shk.0b013e31804a5791","article-title":"Uncontrolled hemorrhage differs from volume- or pressure-matched controlled hemorrhage in swine","volume":"28","author":"JL Sondeen","year":"2007","journal-title":"Shock"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0121678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T16:49:13Z","timestamp":1651596553000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0121678"}},"subtitle":[],"editor":[{"given":"A.B. Johan","family":"Groeneveld","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,20]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0121678","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,20]]}}}