{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T12:34:09Z","timestamp":1722342849049},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0121754","type":"journal-article","created":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T02:38:04Z","timestamp":1427596684000},"page":"e0121754","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["NGF and P75NTR Gene Expression Is Associated with the Hepatic Fibrosis Stage Due to Viral and Non-Viral Causes"],"prefix":"10.1371","volume":"10","author":[{"given":"Ednelza da Silva Gra\u00e7a","family":"Amoras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samara Tatielle Monteiro","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Bonfim","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara Brasil","family":"Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldo","family":"Ishak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialva Tereza Ferreira","family":"de Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e2mia","family":"Demachki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Regina Souza","family":"da Silva Conde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlu\u00edsa","family":"de Oliveira Guimar\u00e3es Ishak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ishak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Carlos Ros\u00e1rio","family":"Vallinoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0213-005X(06)73773-9","article-title":"Epidemiology and clinical manifestations of viral hepatitis","volume":"24","author":"Guirao A Aguilera","year":"2006","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.3748\/wjg.v13.i17.2436","article-title":"Epidemiology of hepatitis C virus infections","volume":"13","author":"MJ Alter","year":"2006","journal-title":"World J Gastroenterol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1006\/bbrc.1994.2483","article-title":"Role of Fas ligand in apoptosis induced by hepatitis C virus infection","volume":"204","author":"E Mita","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gut.2004.053850","article-title":"Apoptosis: a mechanism of acute and chronic liver injury","volume":"54","author":"ME Guicciardi","year":"2005","journal-title":"Gut"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1152\/physrev.00061.2009","article-title":"Hepatocyte death: a clear and present danger","volume":"90","author":"H Malhi","year":"2010","journal-title":"Physiol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/gut.46.4.443","article-title":"Is liver fibrosis reversible?","volume":"46","author":"RC Benyon","year":"2000","journal-title":"Gut"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"d69","DOI":"10.2741\/887","article-title":"Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell","volume":"8","author":"E G\u00e4bele","year":"2003","journal-title":"Front Biosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"280.e9","DOI":"10.1016\/j.amjmed.2006.06.044","article-title":"Assessment of FIBROSpect II to detect hepatic fibrosis in chronic hepatitis C patients","volume":"120","author":"A Zaman","year":"2007","journal-title":"Am J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/hep.1840200104","article-title":"Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. The French METAVIR Cooperative Study Group","volume":"20","author":"P Bedossa","year":"1994","journal-title":"Hepatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(03)15109-4","article-title":"Viral hepatitis C","volume":"362","author":"T Poynard","year":"2003","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1136\/gut.2003.021691","article-title":"Progression of hepatic fibrosis in patients with hepatitis C: a prospective repeat liver biopsy study","volume":"53","author":"SD Ryder","year":"2004","journal-title":"Gut"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1073\/pnas.40.10.1014","article-title":"A nerve growth-stimulating factor isolated from sarcomas 37 and 180","volume":"40","author":"S Cohen","year":"1954","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/jez.1401160206","article-title":"Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo","volume":"116","author":"R Levi-Montalcini","year":"1951","journal-title":"J Exp Zool"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1146\/annurev.neuro.24.1.1217","article-title":"Nerve growth factor signaling, neuroprotection, and neural repair","volume":"24","author":"MV Sofroniew","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0002-9440(10)64994-2","article-title":"Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation","volume":"156","author":"N Trim","year":"2000","journal-title":"Am J Pathol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0002-9440(10)63544-4","article-title":"Hepatocytes express nerve growth factor during liver injury: evidence for paracrine regulation of hepatic stellate cell apoptosis","volume":"16","author":"F Oakley","year":"2003","journal-title":"Am J Pathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1126\/science.1137603","article-title":"Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR","volume":"315","author":"MA Passino","year":"2007","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1478-3231.2006.01267.x","article-title":"Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation","volume":"26","author":"K Asai","year":"2006","journal-title":"Liver Int"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/hep.22701","article-title":"p75 Neurotrophin receptor signaling regulates hepatic myofibroblast proliferation and apoptosis in recovery from rodent liver fibrosis","volume":"49","author":"TJ Kendall","year":"2009","journal-title":"Hepatol"},{"key":"ref20","first-page":"137","article-title":"Vis\u00e3o hist\u00f3rica e consenso nacional sobre a classifica\u00e7\u00e3o das hepatites cr\u00f4nicas [Historical vision and national consensus on the classification of chronic hepatitis]. Project of the Liver Pathology Club of the Brazilian society of pathology approved by the Brazilian Society of Hepatology","volume":"19","author":"LC Gayotto","year":"2000","journal-title":"GED Gastroenterol Endosc Dig"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","article-title":"An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group","volume":"24","author":"P Bedossa","year":"1996","journal-title":"Hepatol"},{"key":"ref22","author":"M Ayres","year":"2008"},{"key":"ref23","unstructured":"GraphPad Software Inc. Prism (data analysis software system), version 5. Software e Guia do Usu\u00e1rio, 2007."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nrm1489","article-title":"Liver regeneration: from myth to mechanism","volume":"5","author":"R Taub","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1055\/s-2001-17558","article-title":"Hepatic stellate cells as a target for the treatment of liver fibrosis","volume":"21","author":"R Bataller","year":"2001","journal-title":"Semin Liver Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0163-7258(94)00072-B","article-title":"Novel insights into the biology and physiology of the Ito cell","volume":"66","author":"M Pinzani","year":"1995","journal-title":"Pharmacol Ther"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0016-5085(88)80022-2","article-title":"Ratio of serum aspartate to alanine aminotransferase in chronic hepatitis. Relationship to cirrhosis","volume":"95","author":"AL Williams","year":"1998","journal-title":"Gastroenterol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1572-0241.1998.044_c.x","article-title":"AST\/ALT ratio predicts cirrhosis in patients with chronic hepatitis C virus infection","volume":"93","author":"SG Sheth","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0168-8278(02)00023-5","article-title":"Regulation of cultured rat hepatocyte proliferation by stellate cells","volume":"36","author":"N Uyama","year":"2002","journal-title":"J Hepatol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1053\/j.gastro.2009.02.081","article-title":"Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis","volume":"136","author":"F Oakley","year":"2009","journal-title":"Gastroenterol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1136\/gut.2005.082701","article-title":"Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans","volume":"55","author":"E Novo","year":"2006","journal-title":"Gut"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1053\/j.gastro.2003.11.018","article-title":"Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells","volume":"126","author":"R Bataller","year":"2004","journal-title":"Gastroenterol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/emm.2005.19","article-title":"HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-beta1","volume":"37","author":"JY Shin","year":"2005","journal-title":"Exp Mol Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cld.2007.02.010","article-title":"Pathogenesis of NASH: animal models","volume":"11","author":"RM London","year":"2007","journal-title":"Clin Liver Dis"},{"issue":"Suppl 1","key":"ref35","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1111\/j.1440-1746.2007.04961.x","article-title":"Role of adipocytokines in hepatic fibrogenesis","volume":"22","author":"K Ikejima","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1053\/gast.2002.32995","article-title":"Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat","volume":"122","author":"K Ikejima","year":"2002","journal-title":"Gastroenterol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1210\/me.2006-0177","article-title":"Leptin increases tissue inhibitor of metalloproteinase I (TIMP-1) gene expression by a specificity protein 1\/signal transducer and activator of transcription 3 mechanism","volume":"20","author":"S Lin","year":"2006","journal-title":"Mol Endocrinol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0168-8278(02)00102-2","article-title":"Leptin is essential for the hepatic fibrogenic response to chronic liver injury","volume":"37","author":"IA Leclercq","year":"2002","journal-title":"J Hepatol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1053\/j.gastro.2003.08.029","article-title":"Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin","volume":"125","author":"Y Kamada","year":"2003","journal-title":"Gastroenterol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1053\/j.gastro.2003.11.020","article-title":"Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease","volume":"126","author":"A Lonardo","year":"2004","journal-title":"Gastroenterol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0168-8278(01)00142-8","article-title":"Oxidative stress-related molecules and liver fibrosis","volume":"35","author":"M Parola","year":"2001","journal-title":"J Hepatol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0121754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T01:47:48Z","timestamp":1540345668000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0121754"}},"subtitle":[],"editor":[{"given":"Matias A","family":"Avila","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,27]]},"references-count":41,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0121754","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,27]]}}}