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Microbiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1757-4749-6-7","article-title":"Draft genome sequences of the type strains of <italic>Shigella flexneri<\/italic> held at Public Health England: comparison of classical phenotypic and novel molecular assays with whole genome sequence","volume":"6","author":"PM Ashton","year":"2014","journal-title":"Gut Pathog"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1128\/IAI.74.2.1072-1083.2006","article-title":"Regulation of type 1 fimbriae by unlinked FimB- and FimE-like recombinases in uropathogenic <italic>Escherichia coli<\/italic> strain CFT073","volume":"74","author":"A Bryan","year":"2006","journal-title":"Infect Immun"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1128\/JCM.13.6.1088-1095.1981","article-title":"Screening of uropathogenic <italic>Escherichia coli<\/italic> for expression of mannose-selective adhesins: importance of culture conditions","volume":"13","author":"JE Fein","year":"1981","journal-title":"J Clin Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1128\/IAI.00494-08","article-title":"Characterization of <italic>Klebsiella pneumoniae<\/italic> type 1 fimbriae by detection of phase variation during colonization and infection and impact on virulence","volume":"76","author":"C Struve","year":"2008","journal-title":"Infect Immun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1128\/IAI.48.1.124-129.1985","article-title":"Plaque formation by virulent <italic>Shigella flexneri<\/italic>","volume":"48","author":"EV Oaks","year":"1985","journal-title":"Infect Immun"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00239-006-0052-8","article-title":"Revisiting the molecular evolutionary history of <italic>Shigella<\/italic> spp","volume":"64","author":"J Yang","year":"2007","journal-title":"J Mol Evol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1128\/IAI.65.6.2462-2467.1997","article-title":"Characterization of <italic>Shigella<\/italic> type 1 fimbriae: expression, FimA sequence, and phase variation","volume":"65","author":"NJ Snellings","year":"1997","journal-title":"Infect Immun"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1046\/j.1365-2958.1998.01104.x","article-title":"Role of fimbriae-mediated adherence for neutrophil migration across <italic>Escherichia coli<\/italic>-infected epithelial cell layers","volume":"30","author":"G Godaly","year":"1998","journal-title":"Mol Microbiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nrmicro2265","article-title":"Molecular mechanisms of <italic>Escherichia coli<\/italic> pathogenicity","volume":"8","author":"MA Croxen","year":"2010","journal-title":"Nat Rev 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