{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T06:00:58Z","timestamp":1702879258384},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T00:00:00Z","timestamp":1427932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0121979","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T18:00:30Z","timestamp":1427997630000},"page":"e0121979","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Increased Autoimmune Diabetes in pIgR-Deficient NOD Mice Is Due to a \"Hitchhiking\" Interval that Refines the Genetic Effect of Idd5.4"],"prefix":"10.1371","volume":"10","author":[{"given":"Kim R.","family":"Simpfendorfer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Strugnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Brodnicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odilia L. C.","family":"Wijburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,4,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0065-2776(08)00806-7","article-title":"Gene-gene interactions in the NOD mouse model of type 1 diabetes","volume":"100","author":"WM Ridgway","year":"2008","journal-title":"Adv Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00281-010-0204-1","article-title":"Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease","volume":"33","author":"JP Driver","year":"2011","journal-title":"Semin Immunopathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nri1031","article-title":"Congenic mice: cutting tools for complex immune disorders","volume":"3","author":"UC Rogner","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng0893-404","article-title":"Polygenic control of autoimmune diabetes in nonobese diabetic mice","volume":"4","author":"S Ghosh","year":"1993","journal-title":"Nat Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.2337\/diab.44.10.1186","article-title":"Crosses of NOD mice with the related NON strain. A polygenic model for IDDM","volume":"44","author":"MA McAleer","year":"1995","journal-title":"Diabetes"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2337\/diabetes.52.1.218","article-title":"A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice","volume":"52","author":"TC Brodnicki","year":"2003","journal-title":"Diabetes"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.stem.2009.04.015","article-title":"Metastable pluripotent states in NOD-mouse-derived ESCs","volume":"4","author":"J Hanna","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nm.1996","article-title":"Validated germline-competent embryonic stem cell lines from nonobese diabetic mice","volume":"15","author":"J Nichols","year":"2009","journal-title":"Nat Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e56738","DOI":"10.1371\/journal.pone.0056738","article-title":"The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD mice","volume":"8","author":"MA Morgan","year":"2013","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s00125-001-0743-z","article-title":"Mice with targeted gene disruptions or gene insertions for diabetes research: problems, pitfalls, and potential solutions","volume":"45","author":"EH Leiter","year":"2002","journal-title":"Diabetologia"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00335-005-0123-y","article-title":"Mind the gap: analysis of marker-assisted breeding strategies for inbred mouse strains","volume":"17","author":"NJ Armstrong","year":"2006","journal-title":"Mamm Genome"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/ni0707-669","article-title":"New tools for defining the &apos;genetic background&apos; of inbred mouse strains","volume":"8","author":"WM Ridgway","year":"2007","journal-title":"Nat Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.2337\/db12-0526","article-title":"Fecal microbiota composition differs between children with beta-cell autoimmunity and those without","volume":"62","author":"MC de Goffau","year":"2013","journal-title":"Diabetes"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.2337\/db08-0331","article-title":"The &quot;perfect storm&quot; for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity","volume":"57","author":"O Vaarala","year":"2008","journal-title":"Diabetes"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1084\/jem.190.7.915","article-title":"Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor\/secretory component-deficient mice","volume":"190","author":"FE Johansen","year":"1999","journal-title":"J Exp Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e1001097","DOI":"10.1371\/journal.ppat.1001097","article-title":"The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea","volume":"6","author":"K Endt","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1128\/IAI.01424-12","article-title":"Contribution of secretory antibodies to intestinal mucosal immunity against Helicobacter pylori","volume":"81","author":"RJ Gorrell","year":"2013","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1073\/pnas.1315792111","article-title":"Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression","volume":"111","author":"EW Rogier","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/intimm\/dxl142","article-title":"Secretory antibodies reduce systemic antibody responses against the gastrointestinal commensal flora","volume":"19","author":"LC Sait","year":"2007","journal-title":"Int Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1084\/jem.20052093","article-title":"Strugnell RA Innate secretory antibodies protect against natural Salmonella typhimurium infection","volume":"203","author":"OL Wijburg","year":"2006","journal-title":"J Exp Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.1233521","article-title":"Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity","volume":"339","author":"JG Markle","year":"2013","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/nature07336","article-title":"Innate immunity and intestinal microbiota in the development of Type 1 diabetes","volume":"455","author":"L Wen","year":"2008","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.2337\/diabetes.50.12.2874","article-title":"Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice","volume":"50","author":"SE Lamhamedi-Cherradi","year":"2001","journal-title":"Diabetes"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4049\/jimmunol.173.1.164","article-title":"Fine mapping, gene content, comparative sequencing, and expression analyses support <italic>Ctla4<\/italic> and <italic>Nramp1<\/italic> as candidates for <italic>Idd5<\/italic>.<italic>1<\/italic> and <italic>Idd5<\/italic>.<italic>2<\/italic> in the nonobese diabetic mouse","volume":"173","author":"LS Wicker","year":"2004","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"8341","DOI":"10.4049\/jimmunol.179.12.8341","article-title":"Wicker LS Interactions between Idd5.1\/Ctla4 and Other Type 1 Diabetes Genes","volume":"179","author":"K Hunter","year":"2007","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.4049\/jimmunol.1203422","article-title":"Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes","volume":"190","author":"X Lin","year":"2013","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.4049\/jimmunol.170.5.2531","article-title":"Strugnell RA Role of the polymeric Ig receptor in mucosal B cell homeostasis","volume":"170","author":"TK Uren","year":"2003","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2105\/AJPH.86.5.726","article-title":"Adjusting for multiple testing when reporting research results: the Bonferroni vs Holm methods","volume":"86","author":"M Aickin","year":"1996","journal-title":"Am J Public Health"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/71641","article-title":"Genealogies of mouse inbred strains","volume":"24","author":"JA Beck","year":"2000","journal-title":"Nat Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.4049\/jimmunol.164.7.3919","article-title":"Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci","volume":"164","author":"O Kanagawa","year":"2000","journal-title":"J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-065X.2010.00923.x","article-title":"The PD-1 pathway in tolerance and autoimmunity","volume":"236","author":"LM Francisco","year":"2010","journal-title":"Immunol Rev"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1749-6632.2010.05919.x","article-title":"The role of the PD-1 pathway in autoimmunity and peripheral tolerance","volume":"1217","author":"BT Fife","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"11823","DOI":"10.1073\/pnas.0505497102","article-title":"Establishment of NOD-Pdcd1-\/- mice as an efficient animal model of type I diabetes","volume":"102","author":"J Wang","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.4049\/jimmunol.180.2.1071","article-title":"Genome-Wide Microarray Expression Analysis of CD4+ T Cells from Nonobese Diabetic Congenic Mice Identifies Cd55 (Daf1) and Acadl as Candidate Genes for Type 1 Diabetes","volume":"180","author":"J Irie","year":"2008","journal-title":"J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.immuni.2013.08.013","article-title":"Gender bias in autoimmunity is influenced by microbiota","volume":"39","author":"L Yurkovetskiy","year":"2013","journal-title":"Immunity"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2337\/db13-0192","article-title":"Gene targeting in NOD mouse embryos using zinc-finger nucleases","volume":"63","author":"YG Chen","year":"2014","journal-title":"Diabetes"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.cell.2013.04.025","article-title":"One-step generation of mice carrying mutations in multiple genes by CRISPR\/Cas-mediated genome engineering","volume":"153","author":"H Wang","year":"2013","journal-title":"Cell"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0167-5699(93)90160-M","article-title":"NOD mouse colonies around the world\u2014recent facts and figures","volume":"14","author":"P Pozzilli","year":"1993","journal-title":"Immunol Today"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.2337\/diabetes.54.9.2820","article-title":"Colocalization of mouse autoimmune diabetes loci Idd21.1 and Idd21.2 with IDDM6 (human) and Iddm3 (rat)","volume":"54","author":"JE Hollis-Moffatt","year":"2005","journal-title":"Diabetes"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00335-006-0076-9","article-title":"Mapping of the murine type 1 diabetes locus Idd20 by genetic interaction","volume":"17","author":"J Morin","year":"2006","journal-title":"Mamm Genome"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00251-014-0782-5","article-title":"Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis","volume":"66","author":"N Wang","year":"2014","journal-title":"Immunogenetics"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0121979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T08:34:56Z","timestamp":1540024496000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0121979"}},"subtitle":[],"editor":[{"given":"William","family":"Ridgway","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,2]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0121979","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,2]]}}}