{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:17:43Z","timestamp":1793985463862,"version":"4.8.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0122317","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T18:14:18Z","timestamp":1427307258000},"page":"e0122317","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["Transition Diseases in Grazing Dairy Cows Are Related to Serum Cholesterol and Other Analytes"],"prefix":"10.1371","volume":"10","author":[{"given":"Pilar","family":"Sep\u00falveda-Varas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Weary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela","family":"Noro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina A. G.","family":"von Keyserlingk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3168\/jds.S0022-0302(89)79169-4","article-title":"Interrelationships between energy balance and postpartum reproductive function in dairy cattle","volume":"72","author":"WR Butler","year":"1989","journal-title":"J Dairy Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.2527\/1995.7392804x","article-title":"Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation","volume":"73","author":"AW Bell","year":"1995","journal-title":"J Anim Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tvjl.2007.12.020","article-title":"The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows","volume":"176","author":"J Goff","year":"2008","journal-title":"Vet J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.tvjl.2010.03.025","article-title":"Prevalence of subclinical hypocalcemia in dairy herds","volume":"188","author":"TA Reinhardt","year":"2011","journal-title":"Vet J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.3168\/jds.2009-2326","article-title":"Invited review: The welfare of dairy cattle\u2014Key concepts and the role of science","volume":"92","author":"MAG von Keyserlingk","year":"2009","journal-title":"J Dairy Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.tvjl.2007.12.018","article-title":"Production diseases of the transition cow","volume":"176","author":"FJ Mulligan","year":"2008","journal-title":"Vet J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.3168\/jds.2010-4075","article-title":"The association of serum metabolites with clinical disease during the transition period","volume":"94","author":"N Chapinal","year":"2011","journal-title":"J Dairy Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.3168\/jds.2012-5443","article-title":"Epidemiology of subclinical ketosis in early lactation dairy cattle","volume":"95","author":"JAA McArt","year":"2012","journal-title":"J Dairy Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1080\/00480169.2001.36204","article-title":"Effects of periparturient diseases and conditions on the reproductive performance of New Zealand dairy cows","volume":"49","author":"S McDougall","year":"2001","journal-title":"New Zeal Vet J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3168\/jds.S0022-0302(02)74058-7","article-title":"Reproduction, mastitis, and body condition of seasonally calved Holstein and Jersey cows in confinement or pasture systems","volume":"85","author":"SP Washburn","year":"2002","journal-title":"J Dairy Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.3168\/jds.2012-6335","article-title":"Prevalence of periparturient diseases and effects on fertility of seasonally calving grazing dairy cows supplemented with concentrates","volume":"96","author":"ES Ribeiro","year":"2013","journal-title":"J Dairy Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3168\/jds.S0022-0302(05)72674-6","article-title":"Metabolic predictors of displaced abomasum in dairy cattle","volume":"88","author":"SJ LeBlanc","year":"2005","journal-title":"J Dairy Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3168\/jds.2009-2277","article-title":"Evaluation of nonesterified fatty acids and beta-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases","volume":"93","author":"P Ospina","year":"2010","journal-title":"J Dairy Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.anireprosci.2013.11.007","article-title":"Interactions between negative energy balance, metabolic diseases, uterine health and immune response in transition dairy cows","volume":"144","author":"G Esposito","year":"2014","journal-title":"Anim Reprod Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"790","DOI":"10.2460\/javma.234.6.790","article-title":"Evaluation of prepartum serum cholesterol and fatty acids concentrations as predictors of postpartum retention of the placenta in dairy cows","volume":"234","author":"GF Quiroz-Rocha","year":"2009","journal-title":"J Am Vet Med Assoc"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3168\/jds.S0022-0302(06)72083-5","article-title":"Lipid metabolite profiles and milk production for Holstein and Jersey cows fed rumen-protected choline during the periparturient period","volume":"89","author":"NA Guretzky","year":"2006","journal-title":"J Dairy Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0093-691X(03)00135-3","article-title":"Effect of the amount of body condition loss from the dry to near calving periods on the subsequent body condition change, occurrence of postpartum diseases, metabolic parameters and reproductive performance in Holstein dairy cows","volume":"60","author":"IH Kim","year":"2003","journal-title":"Theriogenology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0167-5877(96)01141-5","article-title":"The association of serum nonesterified fatty acids and cholesterol, management and feeding practices with peripartum disease in dairy cows","volume":"31","author":"J Kaneene","year":"1997","journal-title":"Prev Vet Med"},{"key":"ref19","article-title":"Guidelines on: The Care and use of Farm Animals in Research, Teaching and Testing","year":"2009"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6334","DOI":"10.3168\/jds.2014-8357","article-title":"Lying behavior and postpartum health status in grazing dairy cows","volume":"97","author":"P Sepulveda-Varas","year":"2014","journal-title":"J Dairy Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.3168\/jds.2006-807","article-title":"Prepartum Behavior and Dry Matter Intake Identify Dairy Cows at Risk for Metritis","volume":"90","author":"JM Huzzey","year":"2006","journal-title":"J Dairy Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4067\/S0301-732X2014000100016","article-title":"Intervalos de referencia en par\u00e1metros sangu\u00edneos indicadores del balance mineral para grupos de vacas lecheras en el sur de Chile","volume":"46","author":"C Wagemann","year":"2014","journal-title":"Arch Med Vet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.3168\/jds.2010-3391","article-title":"Associations of prepartum plasma cortisol, haptoglobin, fecal cortisol metabolites, and nonesterified fatty acids with postpartum health status in Holstein dairy cows","volume":"94","author":"JM Huzzey","year":"2011","journal-title":"J Dairy Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-5877(99)00082-3","article-title":"Disease incidence in dairy herds in the southern highlands district of New South Wales, Australia","volume":"43","author":"MA Stevenson","year":"2000","journal-title":"Prev Vet Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0301-6226(03)00110-6","article-title":"On the relationship between lactational performance and health: is it yield or metabolic imbalance that cause production diseases in dairy cattle? A position paper","volume":"83","author":"KL Ingvartsen","year":"2003","journal-title":"Lives Prod Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.theriogenology.2009.06.001","article-title":"Relationship between serum nonesterified fatty acids at calving and the incidence of periparturient diseases in Holstein dairy cows","volume":"72","author":"P Melendez","year":"2009","journal-title":"Theriogenology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.3168\/jds.2010-3429","article-title":"Risk factors for postpartum uterine diseases in dairy cows","volume":"93","author":"J Dubuc","year":"2010","journal-title":"J Dairy Sci"},{"key":"ref28","first-page":"387","article-title":"Applying nutrition and physiology to improve reproduction in dairy cattle","volume":"67","author":"JE Santos","year":"2010","journal-title":"Soc Reprod Fertil Suppl"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.theriogenology.2005.08.021","article-title":"Defining postpartum uterine disease in cattle","volume":"65","author":"IM Sheldon","year":"2006","journal-title":"Theriogenology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.3168\/jds.2010-3697","article-title":"Short communication: Metritis affects milk production and cull rate of Holstein multiparous and primiparous dairy cows differently","volume":"94","author":"JM Wittrock","year":"2011","journal-title":"J Dairy Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.2460\/javma.1993.203.11.1576","article-title":"Effect of intrauterine antimicrobial treatment in reducing calving-to-conception interval in cows with endometritis","volume":"203","author":"MC Thurmond","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1751-0813.2008.00301.x","article-title":"Use of postpartum vaginoscopic (visual vaginal) examination of dairy cows for the diagnosis of endometritis and the association of endrometritis with reduced reproductive performance","volume":"86","author":"DJ Runciman","year":"2008","journal-title":"Aust Vet J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.anireprosci.2009.02.001","article-title":"Prevalence of endometritis during the postpartum period and its impact on subsequent reproductive performance in two Japanese dairy herds","volume":"116","author":"G Gautam","year":"2009","journal-title":"Anim Reprod Sci"},{"key":"ref34","first-page":"1","article-title":"Subclinical ketosis: prevalence and associations with production and disease","volume":"48","author":"IR Dohoo","year":"1984","journal-title":"Can J Comp Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.3168\/jds.S0022-0302(98)75846-1","article-title":"Efficacy of monensin for the prevention of subclinical ketosis in lactating dairy cows","volume":"81","author":"TF Duffield","year":"1998","journal-title":"J Dairy Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cvfa.2004.06.006","article-title":"Monitoring and testing dairy herds for metabolic disease","volume":"20","author":"GR Oetzel","year":"2004","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3168\/jds.2008-1507","article-title":"Impact of hyperketonemia in early lactation dairy cows on health and production","volume":"92","author":"TF Duffield","year":"2009","journal-title":"J Dairy Sci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.3168\/jds.2012-6035","article-title":"Prevalence of subclinical ketosis and relationships with postpartum diseases in European dairy cows","volume":"96","author":"VS Suthar","year":"2013","journal-title":"J Dairy Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tvjl.2007.12.029","article-title":"Milk fever in dairy cows: A review of pathophysiology and control principles","volume":"176","author":"PJ DeGaris","year":"2007","journal-title":"Vet J"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0749-0720(15)30167-5","article-title":"Treatment of calcium, phosphorus, and magnesium balance disorders","volume":"15","author":"JP Goff","year":"1999","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.3168\/jds.2012-5812","article-title":"Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease","volume":"95","author":"N Martinez","year":"2012","journal-title":"J Dairy Sci"},{"key":"ref42","first-page":"698","article-title":"Calcium homeostasis in cows, with special reference to parturient hypocalcemia","volume":"246","author":"CF Ramberg Jr.","year":"1984","journal-title":"Am J Physiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.3168\/jds.S0022-0302(94)77140-X","article-title":"Calcium and vitamin D metabolism in the dairy cow","volume":"77","author":"RL Horst","year":"1994","journal-title":"J Dairy Sci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1439-0442.2004.00679.x","article-title":"Studies of the transition cow under a pasture-based milk production system: metabolic profiles","volume":"52","author":"D Cavestany","year":"2005","journal-title":"J Vet Med A Physiol Pathol Clin Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.vetimm.2006.03.022","article-title":"Neutrophil function and energy status in Holstein cows with uterine health disorders","volume":"113","author":"DS Hammon","year":"2006","journal-title":"Vet Immunol Immunopathol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/jn\/108.3.535","article-title":"Cholesterol synthesis in ruminating and nonruminating goats","volume":"108","author":"GU Liepa","year":"1978","journal-title":"J Nutr"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/jn\/122.suppl_3.832","article-title":"Metabolism of long chain fatty acids by ruminant liver","volume":"122","author":"RS Emery","year":"1992","journal-title":"J Nutr"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.3168\/jds.2009-2242","article-title":"Prepartum feeding behavior is an early indicator of subclinical ketosis","volume":"92","author":"C Goldhawk","year":"2009","journal-title":"J Dairy Sci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3168\/jds.2007-0530","article-title":"Changes in feeding behavior as possible indicators for the automatic monitoring of health disorders in dairy cows","volume":"91","author":"LA Gonz\u00e1lez","year":"2008","journal-title":"J Dairy Sci"},{"key":"ref50","article-title":"Changes in behaviour of dairy cows with clinical mastitis","author":"P Sep\u00falveda-Varas","year":"2014","journal-title":"Appl Anim Behav Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0749-0720(15)30102-X","article-title":"Ruminant adaptation to negative energy balance. Influences on the etiology of ketosis and fatty liver","volume":"16","author":"TH Herdt","year":"2000","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2460\/ajvr.1992.53.01.10","article-title":"Relation among body condition score, serum urea nitrogen and cholesterol concentrations, and reproductive performance in high-producing Holstein dairy cows in early lactation","volume":"53","author":"PL Ruegg","year":"1992","journal-title":"Am J Vet Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.tvjl.2013.08.011","article-title":"Elevated non-esterified fatty acids and beta-hydroxybutyrate and their association with transition dairy cow performance","volume":"198","author":"JA McArt","year":"2013","journal-title":"Vet J"},{"key":"ref54","first-page":"153","article-title":"Current veterinary therapy food animal practice","author":"RJ Van Saun","year":"2009"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.3168\/jds.2009-2551","article-title":"Association between uterine disease and indicators of neutrophil and systemic energy status in lactating Holstein cows","volume":"93","author":"KN Galv\u00e3o","year":"2010","journal-title":"J Dairy Sci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.3168\/jds.S0022-0302(05)72965-9","article-title":"Feeding behavior identifies dairy cows at risk for metritis","volume":"88","author":"G Urton","year":"2005","journal-title":"J Dairy Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0122317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T01:18:48Z","timestamp":1717809528000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0122317"}},"subtitle":[],"editor":[{"given":"Glenn Francis","family":"Browning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,25]]},"references-count":56,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0122317","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,25]]}}}