{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:08:43Z","timestamp":1791443323320,"version":"4.3.3"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0122335","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T17:47:53Z","timestamp":1431452873000},"page":"e0122335","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Progressive Cognitive Deficit, Motor Impairment and Striatal Pathology in a Transgenic Huntington Disease Monkey Model from Infancy to Adulthood"],"prefix":"10.1371","volume":"10","author":[{"given":"Anthony W. S.","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiju","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda S.","family":"Prucha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Moran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayeb","family":"Rahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Zola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia M.","family":"Testa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Villalba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoland","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyne","family":"Bachevalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0301-0082(99)00005-2","article-title":"Replicating Huntington's disease phenotype in experimental animals","volume":"59","author":"E Brouillet","year":"1999","journal-title":"Prog Neurobiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nrn3570","article-title":"Choosing an animal model for the study of Huntington's disease","volume":"14","author":"MA Pouladi","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-2202-15-36","article-title":"A two years longitudinal study of a transgenic Huntington disease monkey","volume":"15","author":"AW Chan","year":"2014","journal-title":"BMC Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nature06975","article-title":"Towards a transgenic model of Huntington's disease in a non-human primate","volume":"453","author":"SH Yang","year":"2008","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1471-2202-14-88","article-title":"Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington's disease monkeys","volume":"14","author":"J Kocerha","year":"2013","journal-title":"BMC Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.biopsych.2011.07.030","article-title":"Striatal volume contributes to the prediction of onset of Huntington disease in incident cases","volume":"71","author":"EH Aylward","year":"2012","journal-title":"Biol Psychiatry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresbull.2010.04.003","article-title":"Striatal and white matter predictors of estimated diagnosis for Huntington disease","volume":"82","author":"JS Paulsen","year":"2010","journal-title":"Brain Res Bull"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","article-title":"Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis","volume":"10","author":"SJ Tabrizi","year":"2011","journal-title":"Lancet Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1474-4422(13)70088-7","article-title":"Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data","volume":"12","author":"SJ Tabrizi","year":"2013","journal-title":"Lancet Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1089\/scd.2012.0469","article-title":"Pathogenic cellular phenotypes are germline transmissible in a transgenic primate model of Huntington's disease","volume":"22","author":"K Putkhao","year":"2013","journal-title":"Stem Cells Dev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/jnnp.2008.170902","article-title":"Late-onset Huntington disease with intermediate CAG repeats: true or false?","volume":"81","author":"JL Groen","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref12","first-page":"16","article-title":"Phenotypic characterization of individuals with 30\u201340 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36\u201339 repeats","volume":"59","author":"DC Rubinsztein","year":"1996","journal-title":"Am J Hum Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1002\/mds.25172","article-title":"Huntington's disease: how intermediate are intermediate repeat lengths?","volume":"27","author":"F Squitieri","year":"2012","journal-title":"Mov Disord"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/mds.25801","article-title":"Neurochemical correlates of caudate atrophy in Huntington's disease","volume":"29","author":"JM Padowski","year":"2014","journal-title":"Mov Disord"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/mds.25010","article-title":"Brain metabolite alterations and cognitive dysfunction in early Huntington's disease","volume":"27","author":"PG Unschuld","year":"2012","journal-title":"Mov Disord"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1089\/10430340050015220","article-title":"Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease","volume":"11","author":"V Mittoux","year":"2000","journal-title":"Hum Gene Ther"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm0898-963","article-title":"Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease","volume":"4","author":"S Palfi","year":"1998","journal-title":"Nat Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1523\/JNEUROSCI.16-09-03019.1996","article-title":"Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease","volume":"16","author":"S Palfi","year":"1996","journal-title":"J Neurosci"},{"key":"ref19","first-page":"137","article-title":"Behavioral and morphological comparison of two nonhuman primate models of Huntington's disease","volume":"50","author":"BZ Roitberg","year":"2002","journal-title":"Neurosurgery"},{"issue":"Pt 3","key":"ref20","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/brain\/113.3.617","article-title":"Cognitive and motor deficits in the acquisition of an object retrieval\/detour task in MPTP-treated monkeys","volume":"113","author":"JR Taylor","year":"1990","journal-title":"Brain"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1038\/mt.2011.219","article-title":"Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease","volume":"19","author":"JL McBride","year":"2011","journal-title":"Mol Ther"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0197-4580(91)90048-O","article-title":"Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction","volume":"12","author":"J Bachevalier","year":"1991","journal-title":"Neurobiol Aging"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jneumeth.2005.11.013","article-title":"Measurement of coordination of object manipulation in non-human primates","volume":"154","author":"WG Darling","year":"2006","journal-title":"J Neurosci Methods"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.neurobiolaging.2004.05.007","article-title":"Sex differences in age-related motor slowing in the rhesus monkey: behavioral and neuroimaging data","volume":"26","author":"A Lacreuse","year":"2005","journal-title":"Neurobiol Aging"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"B473","DOI":"10.1093\/gerona\/55.10.B473","article-title":"Motor slowing and parkinsonian signs in aging rhesus monkeys mirror human aging","volume":"55","author":"Z Zhang","year":"2000","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/archneur.64.6.783","article-title":"Juvenile-onset huntington disease: a matter of perspective","volume":"64","author":"K Biglan","year":"2007","journal-title":"Arch Neurol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1002\/mds.25237","article-title":"Seizures in juvenile Huntington's disease: frequency and characterization in a multicenter cohort","volume":"27","author":"LJ Cloud","year":"2012","journal-title":"Mov Disord"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1440-1754.2006.00921.x","article-title":"Juvenile Huntington disease","volume":"42","author":"N Geevasinga","year":"2006","journal-title":"J Paediatr Child Health"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.mad.2005.09.012","article-title":"Juvenile Huntington's disease: does a dosage-effect pathogenic mechanism differ from the classical adult disease?","volume":"127","author":"F Squitieri","year":"2006","journal-title":"Mech Ageing Dev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1136\/jnnp-2013-305114","article-title":"Cognitive decline in prodromal Huntington Disease: implications for clinical trials","volume":"84","author":"JS Paulsen","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nm1595","article-title":"Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?","volume":"13","author":"G Courtine","year":"2007","journal-title":"Nat Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1749-6632.2011.06211.x","article-title":"Behavioral outcomes of late-onset or early-onset orbital frontal cortex (areas 11\/13) lesions in rhesus monkeys","volume":"1239","author":"J Bachevalier","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ijdevneu.2011.07.004","article-title":"Social communication in young children with traumatic brain injury: Relations with corpus callosum morphometry","volume":"30","author":"L Ewing-Cobbs","year":"2012","journal-title":"Int J Dev Neurosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1038\/nature11102","article-title":"Animal models: Not close enough","volume":"484","author":"J Rice","year":"2012","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1136\/jnnp.2009.191833","article-title":"Systemic energy homeostasis in Huntington's disease patients","volume":"81","author":"NA Aziz","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/ajcn\/81.6.1335","article-title":"Energy balance in early-stage Huntington disease","volume":"81","author":"AM Gaba","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/jnnp.2003.017822","article-title":"Rate and correlates of weight change in Huntington's disease","volume":"75","author":"JM Hamilton","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/ajp.1072","article-title":"Survival, growth, health, and reproduction following nursery rearing compared with mother rearing in pigtailed monkeys (Macaca nemestrina)","volume":"56","author":"GP Sackett","year":"2002","journal-title":"Am J Primatol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbr.2006.09.020","article-title":"Social attachment in juvenile monkeys with neonatal lesion of the hippocampus, amygdala and orbital frontal cortex","volume":"176","author":"AP Goursaud","year":"2007","journal-title":"Behav Brain Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neulet.2013.02.007","article-title":"Dose-dependent effect of isoflurane on regional cerebral blood flow in anesthetized macaque monkeys","volume":"541","author":"CX Li","year":"2013","journal-title":"Neurosci Lett"},{"issue":"Suppl 1","key":"ref41","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"SM Smith","year":"2004","journal-title":"Neuroimage"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.neuroimage.2011.07.029","article-title":"A diffusion tensor brain template for rhesus macaques","volume":"59","author":"N Adluru","year":"2012","journal-title":"Neuroimage"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mrm.1910300604","article-title":"Estimation of metabolite concentrations from localized in vivo proton NMR spectra","volume":"30","author":"SW Provencher","year":"1993","journal-title":"Magn Reson Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neurobiolaging.2007.07.005","article-title":"A systematic review of brain metabolite changes, measured with 1H magnetic resonance spectroscopy, in healthy aging","volume":"30","author":"KK Haga","year":"2009","journal-title":"Neurobiol Aging"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1097\/00001756-199806220-00040","article-title":"Age-related brain changes in rhesus monkeys: a magnetic resonance spectroscopic study","volume":"9","author":"JG Herndon","year":"1998","journal-title":"Neuroreport"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2818.1986.tb02764.x","article-title":"Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson","volume":"143","author":"HJ Gundersen","year":"1986","journal-title":"J Microsc"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0122335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T00:37:32Z","timestamp":1566693452000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0122335"}},"subtitle":[],"editor":[{"given":"David","family":"Blum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,12]]},"references-count":46,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0122335","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,12]]}}}