{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:41:05Z","timestamp":1773675665756,"version":"3.50.1"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T00:00:00Z","timestamp":1427155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0122388","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T20:11:53Z","timestamp":1427227913000},"page":"e0122388","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cardiovascular Complications Secondary to Graves\u2019 Disease: A Prospective Study from Ukraine"],"prefix":"10.1371","volume":"10","author":[{"given":"Iryna","family":"Tsymbaliuk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmytro","family":"Unukovych","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliia","family":"Shvets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrii","family":"Dinets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"452709","DOI":"10.1155\/2013\/452709","article-title":"Determinants of thyrotoxic cardiomyopathy recovery","volume":"2013","author":"L Oliveros-Ruiz","year":"2013","journal-title":"BioMed research international"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1530\/eje.0.1510549","article-title":"Impaired health-related quality of life in Graves&apos; disease. A prospective study","volume":"151","author":"TV Elberling","year":"2004","journal-title":"European journal of endocrinology \/ European Federation of Endocrine Societies"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000356042","article-title":"Graves&apos; Orbitopathy: Imperfect Treatments for a Rare Disease","volume":"2","author":"L Bartalena","year":"2013","journal-title":"European Thyroid Journal"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1365-2265.2007.02845.x","article-title":"Efficacy and safety of orbital decompression in treatment of thyroid-associated ophthalmopathy: long-term follow-up of 78 patients","volume":"67","author":"M Jernfors","year":"2007","journal-title":"Clinical endocrinology"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s11897-008-0026-9","article-title":"Thyrotoxic cardiac disease","volume":"5","author":"P Dahl","year":"2008","journal-title":"Curr Heart Fail Rep"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1532-5415.1985.tb02854.x","article-title":"The effect of age on blood pressure in hyperthyroidism","volume":"33","author":"I Saito","year":"1985","journal-title":"Journal of the American Geriatrics Society"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000360558","article-title":"Cardiovascular disease and thyroid function","volume":"43","author":"J Faber","year":"2014","journal-title":"Front Horm Res"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.arcmed.2005.05.008","article-title":"Depression, anxiety, health-related quality of life, and disability in patients with overt and subclinical thyroid dysfunction","volume":"37","author":"S Gulseren","year":"2006","journal-title":"Archives of medical research"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.yhbeh.2013.11.008","article-title":"Thyroid hormones regulate anxiety in the male mouse","volume":"65","author":"A Buras","year":"2014","journal-title":"Hormones and behavior"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1089\/thy.2005.15.1279","article-title":"Graves&apos; disease: a long-term quality-of-life follow up of patients randomized to treatment with antithyroid drugs, radioiodine, or surgery","volume":"15","author":"M Abraham-Nordling","year":"2005","journal-title":"Thyroid: official journal of the American Thyroid Association"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1530\/eje.1.02336","article-title":"Thyroid hormone state and quality of life at long-term follow-up after randomized treatment of Graves&apos; disease","volume":"156","author":"M Abraham-Nordling","year":"2007","journal-title":"European journal of endocrinology \/ European Federation of Endocrine Societies"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1089\/thy.2011.0153","article-title":"Quality of life after surgery for Graves&apos; disease: comparison of those having surgery intended to preserve thyroid function with those having ablative surgery","volume":"22","author":"A Al-Adhami","year":"2012","journal-title":"Thyroid: official journal of the American Thyroid Association"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000356954","article-title":"Effect of hyperthyroidism on the hypercoagulable state and thromboembolic events in patients with atrial fibrillation","volume":"127","author":"Q Chen","year":"2014","journal-title":"Cardiology"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1097\/PSY.0b013e3181bd6062","article-title":"Comorbid depression and anxiety symptoms as predictors of cardiovascular events: results from the NHLBI-sponsored Women&apos;s Ischemia Syndrome Evaluation (WISE) study","volume":"71","author":"T Rutledge","year":"2009","journal-title":"Psychosomatic medicine"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000095440","article-title":"Recognizing increased risk of depressive comorbidity after myocardial infarction: looking for 4 symptoms of anxiety-depression","volume":"75","author":"J Denollet","year":"2006","journal-title":"Psychotherapy and psychosomatics"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1176\/jnp.8.2.181","article-title":"A survey study of neuropsychiatric complaints in patients with Graves&apos; disease","volume":"8","author":"RA Stern","year":"1996","journal-title":"The Journal of neuropsychiatry and clinical neurosciences"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/eje.1.01809","article-title":"Subclinical hyperthyroidism: clinical features and treatment options","volume":"152","author":"B Biondi","year":"2005","journal-title":"European journal of endocrinology \/ European Federation of Endocrine Societies"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1089\/thy.1997.7.885","article-title":"Quality of life in patients with Graves&apos; ophthalmopathy is markedly decreased: measurement by the medical outcomes study instrument","volume":"7","author":"MN Gerding","year":"1997","journal-title":"Thyroid: official journal of the American Thyroid Association"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ejheart.2005.01.012","article-title":"The impact of chronic heart failure on health-related quality of life data acquired in the baseline phase of the CARE-HF study","volume":"7","author":"MJ Calvert","year":"2005","journal-title":"European journal of heart failure"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1023\/A:1008973731515","article-title":"Sample size calculations in studies using the EuroQol 5D","volume":"8","author":"M Roset","year":"1999","journal-title":"Quality of life research: an international journal of quality of life aspects of treatment, care and rehabilitation"},{"issue":"21","key":"ref21","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1093\/eurheartj\/ehs253","article-title":"2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association","volume":"33","author":"AJ Camm","year":"2012","journal-title":"European heart journal"},{"issue":"28","key":"ref22","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1093\/eurheartj\/eht151","article-title":"2013 ESH\/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"34","author":"G Mancia","year":"2013","journal-title":"European heart journal"},{"issue":"14","key":"ref23","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC","volume":"33","author":"JJ McMurray","year":"2012","journal-title":"European heart journal"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nrendo.2010.105","article-title":"Cardiovascular involvement in patients with different causes of hyperthyroidism","volume":"6","author":"B Biondi","year":"2010","journal-title":"Nature reviews Endocrinology"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.euje.2005.12.014","article-title":"Recommendations for chamber quantification","volume":"7","author":"RM Lang","year":"2006","journal-title":"European journal of echocardiography: the journal of the Working Group on Echocardiography of the European Society of Cardiology"},{"issue":"17","key":"ref26","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJM198710223171717","article-title":"Simplified calculation of body-surface area","volume":"317","author":"RD Mosteller","year":"1987","journal-title":"The New England journal of medicine"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1136\/hrt.2006.100628","article-title":"Incidence, clinical characteristics and outcome of congestive heart failure as the initial presentation in patients with primary hyperthyroidism","volume":"93","author":"CW Siu","year":"2007","journal-title":"Heart"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00000441-199531030-00003","article-title":"Congestive heart failure due to reversible cardiomyopathy in patients with hyperthyroidism","volume":"310","author":"GE Umpierrez","year":"1995","journal-title":"The American journal of the medical sciences"},{"issue":"12","key":"ref29","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1007\/s00595-012-0442-z","article-title":"Does thyroid surgery for Graves&apos; disease improve health-related quality of life?","volume":"43","author":"G Scerrino","year":"2013","journal-title":"Surgery today"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1210\/jc.2002-021046","article-title":"The effects of early antithyroid therapy for endogenous subclinical hyperthyroidism in clinical and heart abnormalities","volume":"88","author":"JA Sgarbi","year":"2003","journal-title":"The Journal of clinical endocrinology and metabolism"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jacc.2006.08.042","article-title":"Cardiovascular manifestations of hyperthyroidism before and after antithyroid therapy: a matched case-control study","volume":"49","author":"F Osman","year":"2007","journal-title":"Journal of the American College of Cardiology"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1445-5994.1981.tb03519.x","article-title":"Atrial fibrillation and arterial embolism in hyperthyroidism","volume":"11","author":"DM Hurley","year":"1981","journal-title":"Aust N Z J Med"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2265.2010.03957.x","article-title":"Prospective echocardiographic evaluation of patients with endogenous subclinical hyperthyroidism and after restoring euthyroidism","volume":"74","author":"G Kaminski","year":"2011","journal-title":"Clinical endocrinology"},{"issue":"7","key":"ref34","first-page":"CR502","article-title":"Changes of arterial pressure in patients with hyperthyroidism during therapy","volume":"8","author":"C Marcisz","year":"2002","journal-title":"Medical science monitor: international medical journal of experimental and clinical research"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3349\/ymj.2014.55.2.374","article-title":"Relationship between Blood Pressure Variability and the Quality of Life","volume":"55","author":"J Sung","year":"2014","journal-title":"Yonsei medical journal"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1210\/en.2003-1670","article-title":"The metabolic and cardiovascular effects of hyperthyroidism are largely independent of beta-adrenergic stimulation","volume":"145","author":"ES Bachman","year":"2004","journal-title":"Endocrinology"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/j.1440-1681.2010.05404.x","article-title":"A distinct AMP-activated protein kinase phosphorylation site characterizes cardiac hypertrophy induced by L-thyroxine and angiotensin II","volume":"37","author":"SY Jiang","year":"2010","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/S0735-1097(97)00012-0","article-title":"Left ventricular remodeling with carvedilol in patients with congestive heart failure due to ischemic heart disease. Australia-New Zealand Heart Failure Research Collaborative Group","volume":"29","author":"RN Doughty","year":"1997","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1177\/1074248410395018","article-title":"Effect of telmisartan and ramipril on atrial fibrillation recurrence and severity in hypertensive patients with metabolic syndrome and recurrent symptomatic paroxysmal and persistent atrial fibrillation","volume":"17","author":"R Fogari","year":"2012","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/0735-1097(94)00543-Y","article-title":"Time course of improvement in left ventricular function, mass and geometry in patients with congestive heart failure treated with beta-adrenergic blockade","volume":"25","author":"SA Hall","year":"1995","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/thy.2006.16.295","article-title":"Serum thyrotropin receptor antibodies concentrations in patients with Graves&apos; disease before, at the end of methimazole treatment, and after drug withdrawal: evidence that the activity of thyrotropin receptor antibody and\/or thyroid response modify during the observation period","volume":"16","author":"C Carella","year":"2006","journal-title":"Thyroid"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1507\/endocrj.K06-069","article-title":"Prognostic value of thyrotropin receptor antibodies (TRAb) in Graves&apos; disease: a 120 months prospective study","volume":"54","author":"C Cappelli","year":"2007","journal-title":"Endocr J"},{"issue":"12","key":"ref43","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1089\/thy.2000.10.1093","article-title":"Graves&apos; ophthalmopathy in the absence of elevated free thyroxine and triiodothyronine levels: prevalence, natural history, and thyrotropin receptor antibody levels","volume":"10","author":"DH Khoo","year":"2000","journal-title":"Thyroid"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1089\/105072502760143845","article-title":"Cardiovascular hemodynamics and exercise tolerance in thyroid disease","volume":"12","author":"GJ Kahaly","year":"2002","journal-title":"Thyroid: official journal of the American Thyroid Association"},{"issue":"1","key":"ref45","first-page":"e00011","article-title":"Effect of acute hyperthyroidism on blood flow, muscle oxygenation, and sympathetic nerve activity during dynamic handgrip","volume":"1","author":"CA Ray","year":"2013","journal-title":"Physiological reports"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1530\/EJE-13-0708","article-title":"Hyperthyroidism and psychiatric morbidity: evidence from a Danish nationwide register study","volume":"170","author":"F Brandt","year":"2014","journal-title":"European journal of endocrinology \/ European Federation of Endocrine Societies"},{"issue":"12","key":"ref47","first-page":"4701","article-title":"Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology and function in young and middle-aged patients","volume":"85","author":"B Biondi","year":"2000","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"715370","DOI":"10.1155\/2011\/715370","article-title":"Energy Homeostasis and Body Weight before and after Cessation of Block and Replacement Therapy in Euthyroid Patients with Graves&apos; Disease","volume":"2011","author":"LP Klieverik","year":"2011","journal-title":"International journal of endocrinology"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0188-4409(02)00410-1","article-title":"Depression and anxiety in hyperthyroidism","volume":"33","author":"MM Demet","year":"2002","journal-title":"Archives of medical research"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1055\/s-0034-1370920","article-title":"Relationship between autoantibody to the angiotensin II-1 receptor and cardiovascular manifestations of Graves&apos; disease","volume":"122","author":"J Xu","year":"2014","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"9","key":"ref51","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1055\/s-2005-872887","article-title":"Lack of mutations in the TSHr and Gsalpha genes in TSHr antibody negative Graves&apos; disease","volume":"113","author":"A Elgadi","year":"2005","journal-title":"Exp Clin Endocrinol Diabetes"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0122388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T10:25:47Z","timestamp":1566469547000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0122388"}},"subtitle":[],"editor":[{"given":"Peyman","family":"Bj\u00f6rklund","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,24]]},"references-count":51,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0122388","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,24]]}}}