{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:26:37Z","timestamp":1788881197490,"version":"build-2803163510"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0122566","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T18:26:21Z","timestamp":1444933581000},"page":"e0122566","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Oral Outbreak of Chagas Disease in Santa Catarina, Brazil: Experimental Evaluation of a Patient\u2019s Strain"],"prefix":"10.1371","volume":"10","author":[{"given":"Carolina S.","family":"Domingues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana J.","family":"Hardoim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste S. F.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via O.","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f4nica G.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Previtalli-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.","family":"Abreu-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Pelajo-Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvio Celso","family":"Gon\u00e7alves da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia S.","family":"Calabrese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"ref1","unstructured":"Pan American Health Organization (PAHO) (2006) Quantitative estimation of Chagas disease in the Americas. Montevideo. OPAS\/HDM\/CD\/425-06."},{"key":"ref2","unstructured":"Pan American Health Organization (PAHO). Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/new.paho.org\/hq\/index.php?option=com_content&view=article&id=2382&Itemid=3921&lang=fr\" xlink:type=\"simple\">http:\/\/new.paho.org\/hq\/index.php?option=com_content&amp;view=article&amp;id=2382&amp;Itemid=3921&amp;lang=fr<\/ext-link>. Accessed 20 March 2014."},{"issue":"1\u20132","key":"ref3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.actatropica.2009.11.003","article-title":"Chagas disease: a Latin American health problem becoming a world health problem","volume":"115","author":"GA Schmunis","year":"2010","journal-title":"Acta Trop"},{"key":"ref4","first-page":"15","article-title":"O Controle da Doen\u00e7a de Chagas nos Pa\u00edses do Cone Sul da Am\u00e9rica: Hist\u00f3ria de uma iniciativa internacional 1991\u20132001","author":"AC Silveira","year":"2002"},{"key":"ref5","unstructured":"Pan American Health Organization (PAHO) (1992) Documento sobre a Iniciativa do Cone Sul. Washington DC. OPAS. PNSP\/92-18."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1590\/S0037-86822011000800010","article-title":"Control of transfusional transmission","volume":"44","author":"H Moraes-Souza","year":"2011","journal-title":"Rev Soc Bras Med Trop"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00436-012-3184-3","article-title":"<italic>Trypanosoma cruzi<\/italic> experimental congenital transmission associated with TcV and TcI subpatent maternal parasitemia","volume":"112","author":"SM Alkmim-Oliveira","year":"2013","journal-title":"Parasitol Research"},{"issue":"1","key":"ref8","first-page":"128","article-title":"Chagas&apos; disease and kidney donation","volume":"33","author":"E M\u00e1rquez","year":"2013","journal-title":"Nefrologia"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1590\/S0037-86822006000400010","article-title":"Notas sobre o <italic>Trypanosoma cruzi<\/italic> e suas caracter\u00edsticas bio-ecol\u00f3gicas, como agente de enfermidades transmitidas por alimentos","volume":"39","author":"JC Dias","year":"2006","journal-title":"Rev Soc Bras Med Trop"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/cid\/cir956","article-title":"Oral transmission of Chagas disease","volume":"54","author":"MA Shikanai-Yasuda","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1128\/CMR.00063-10","article-title":"Pathogenesis of Chagas&apos; Disease: Parasite Persistence and Autoimmunity","volume":"24","author":"ARL Teixeira","year":"2011","journal-title":"Clin Microbiol Rev"},{"issue":"2","key":"ref12","first-page":"258","article-title":"Oral transmission of Chagas&apos; disease","volume":"139","author":"A Toso","year":"2011","journal-title":"Rev Med Chile"},{"key":"ref13","unstructured":"Ministry of Health (Brasil). Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/portal.saude.gov.br\/portal\/saude\/profissional\/visualizar_texto.cfm?idtxt=31454\" xlink:type=\"simple\">http:\/\/portal.saude.gov.br\/portal\/saude\/profissional\/visualizar_texto.cfm?idtxt=31454<\/ext-link>. Accessed 10 January 2014."},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"e711","DOI":"10.1371\/journal.pntd.0000711","article-title":"Clinical Outcomes of Thirteen Patients with Acute Chagas Disease Acquired through Oral Transmission from Two Urban Outbreaks in Northeastern Brazil","volume":"4","author":"CJC Bastos","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"ref15","first-page":"911","article-title":"Microepidemia de doen\u00e7a de Chagas aguda por transmiss\u00e3o oral no Cear\u00e1","volume":"17","author":"LPG Cavalcanti","year":"2009","journal-title":"Cadernos Sa\u00fade Coletiva"},{"issue":"1","key":"ref16","first-page":"19","article-title":"Microepidemia familiar de doen\u00e7a de Chagas em Santar\u00e9m, primeiro registro no oeste do Par\u00e1","volume":"34","author":"SAS Valente","year":"2001","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref17","article-title":"Registro de 15 casos aut\u00f3ctones de doen\u00e7a de Chagas no Estado do Amap\u00e1 com evid\u00eancias de transmiss\u00e3o oral","volume":"53","author":"SAS Valente","year":"1997","journal-title":"XXXIII Congresso da Sociedade Brasileira de Medicina Tropical"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1590\/S0036-46651991000500003","article-title":"Possible Oral-Transmission of Acute Chagas-Disease in Brazil","volume":"33","author":"MA Shikanai-Yasuda","year":"1991","journal-title":"Rev Inst Med Trop"},{"issue":"2","key":"ref19","article-title":"Surto epid\u00eamico de doen\u00e7a de Chagas aguda em Catol\u00e9 do Rocha, Para\u00edba","volume":"20","author":"MA Shikanai-Yasuda","year":"1987","journal-title":"Rev Soc Bras Med Trop"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0031182000044188","article-title":"<italic>Trypanosoma cruzi<\/italic>\u2014Milk Transmission of Infection and Immunity from mother to young","volume":"65","author":"MA Miles","year":"1972","journal-title":"Parasitol"},{"issue":"6","key":"ref21","first-page":"73","article-title":"Um surto epid\u00eamico de doen\u00e7a de Chagas de prov\u00e1vel transmiss\u00e3o digestiva, ocorrido em Teot\u00f4nia (Estr\u00eala-Rio Grande do Sul)","volume":"73","author":"F Nery-Guimar\u00e3es","year":"1968","journal-title":"O Hospital"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.micinf.2006.03.016","article-title":"Involvement of Ssp-4-related carbohydrate epitopes in mammalian cell invasion by <italic>Trypanosoma cruzi<\/italic> amastigotes","volume":"8","author":"CV Silva","year":"2006","journal-title":"Microbes Infect"},{"key":"ref23","author":"J Sambrook","year":"1989"},{"issue":"17","key":"ref24","first-page":"3","article-title":"Estabilizacion de la virulencia de una cepa de <italic>Trypanosoma cruzi<\/italic> por passaje seriado en ratones de constitucion genetica uniforme: analisis cuantitativo del curso de la infection","volume":"16","author":"T Pizzi","year":"1952","journal-title":"Biologica"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1128\/MMBR.42.1.237-249.1978","article-title":"Evaluation of survival in challenge experiments","volume":"42","author":"FD Liddell","year":"1978","journal-title":"Microbiol Rev"},{"key":"ref26","author":"M Langeron","year":"1949"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Dias GB, Gruendling AP, Ara\u00fajo SM, Gomes ML, Toledo MJ (2013) Evolution of infection in mice inoculated by the oral route with different developmental forms of Trypanosoma cruzi I and II. 135(3):511\u20137.","DOI":"10.1016\/j.exppara.2013.08.013"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1084\/jem.141.1.82","article-title":"A stable form of delayed type hypersensitivity","volume":"141","author":"PH Lagrange","year":"1975","journal-title":"J Exp Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"683","DOI":"10.4269\/ajtmh.2003.68.683","article-title":"Chronic Chagas\u2019 disease in rhesus monkeys (Macaca mulatta): evaluation of parasitemia, serology, electrocardiography, echocardiography, and radiology","volume":"68","author":"CME Carvalho","year":"2003","journal-title":"Am J Trop Med Hyg"},{"key":"ref30","first-page":"126","article-title":"<italic>Trypanosoma cruzi<\/italic> e doen\u00e7a de Chagas","author":"W Souza","year":"1999"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"e42153","DOI":"10.1371\/journal.pone.0042153","article-title":"Structural basis of the interaction of a <italic>Trypanosoma cruzi<\/italic> surface molecule implicated in oral infection with host cells and gastric mucin","volume":"7","author":"C Cortez","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"ref32","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1590\/S0074-02762011000800009","article-title":"Biological, biochemical and molecular features of <italic>Trypanosoma cruzi<\/italic> strains isolated from patients infected through oral transmission during a 2005 outbreak in the state of Santa Catarina, Brazil: its correspondence with the new T. cruzi Taxonomy Consensus (2009)","volume":"106","author":"SG Andrade","year":"2011","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1128\/IAI.73.1.201-207.2005","article-title":"The trans-sialidase from <italic>Trypanosoma cruzi<\/italic> induces thrombocytopenia during acute Chagas&apos; disease by reducing the platelet sialic acid contents","volume":"73","author":"MV Tribulatti","year":"2005","journal-title":"Infect Immunol"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1590\/S1984-29612012000200015","article-title":"Hematological alterations during experimental canine infection by <italic>Trypanosoma cruzi<\/italic>","volume":"21","author":"PM Guedes","year":"2012","journal-title":"Rev Bras Parasitol Vet"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1286-4579(00)00333-6","article-title":"Acute <italic>Trypanosoma cruzi<\/italic> infection is associated with anemia, thrombocytopenia, leukopenia, and bone marrow hypoplasia: reversal by nifurtimox treatment","volume":"2","author":"MC Marcondes","year":"2000","journal-title":"Microbes Infect"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"e417","DOI":"10.1371\/journal.pntd.0000417","article-title":"Differential Regional Immune Response in Chagas Disease","volume":"3","author":"J De Meis","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/clc.4960231205","article-title":"Chagas\u2019 heart disease","volume":"23","author":"A Rassi Jr","year":"2000","journal-title":"Clin Cardiol"},{"issue":"9507","key":"ref38","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0140-6736(06)68074-4","article-title":"Controversies in ventricular remodeling","volume":"367","author":"LH Opie","year":"2006","journal-title":"Lancet"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"e1996","DOI":"10.1371\/journal.pntd.0001996","article-title":"Cell Death and Serum Markers of Collagen Metabolism during Cardiac Remodeling in Cavia porcellus Experimentally Infected with <italic>Trypanosoma cruzi<\/italic>","volume":"7","author":"YE Castro-Sesquen","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.meegid.2011.12.009","article-title":"The revised <italic>Trypanosoma cruzi<\/italic> subspecific nomenclature: rationale, epidemiological relevance and research applications","volume":"12","author":"B Zingales","year":"2012","journal-title":"Infect Gen Evol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"635169","DOI":"10.1100\/2012\/635169","article-title":"Evaluation of clinical and immunopathological features of different infective doses of <italic>Trypanosoma cruzi<\/italic> in dogs during the acute phase","volume":"2012","author":"IA Quijano-Hern\u00e1ndez","year":"2012","journal-title":"Scientific World Journal"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"747185","DOI":"10.1155\/2012\/747185","article-title":"Dynamics of lymphocyte populations during <italic>Trypanosoma cruzi<\/italic> Infection: From thymocyte depletion to differential cell expansion\/contraction in peripheral lymphoid organs","volume":"2012","author":"A Morrot","year":"2012","journal-title":"J Trop Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0122566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T20:58:16Z","timestamp":1599685096000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0122566"}},"subtitle":[],"editor":[{"given":"Mauricio Martins","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,15]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0122566","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,15]]}}}